다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도

주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.

수중 방사능 측정시 이온교환농축법과 증발건조법의 비교

지평국,박종묵,노성기 대한방사선 방어학회 1988 방사선방어학회지 Vol.13 No.2

수중의 방사능을 측정하기 위한 전처리과정으로서 이온교환농축법과 증발건조법을 서로 비교하였다. 시료를 증발건조법으로 처리하였을 때 방사성물질의 손실율은 이온교환농축법에 비해 20% 정도 많았다. 또, 1리터의 시료를 처리하는데 소요되는 증발시간은 70℃에서 증발시킨 경우 약20시간이었으나 이온교환농축법으로 같은 양의 시료를 처리하는데 소요된 시간은 약6시간이었다. 따라서 이온교환농축법이 증발건조법에 의해 효과적이며 특히 수중의 저준위 방사성물질 측정에 적합한 것으로 나타났다. An ion-exchange method for the detection of radioactivity in water using ion-exchange resion in concentrating radioactive nuclides was compared with an evaporation method. The loss of the radioactive materials in the sample treated by the ion-exchange method was less by about 20% than that by the evaporation method. In addition, the evaporation method needed about 20 hours for evaporating one liter of the sample at 70℃, while the ion-exchange method spent 6 hours to adsorb and desorbs the same amount of the sample on the resion. Consequently, the ion-exchange method is more effective than the evaporation method for the treatment of the radioactively contaminated water and is especially suitable for detecting the low-level radioactivity in water.

한국인 국소유년형 치주염환자의 치료 전후 임상, 미생물 및 면역학적 연구

손성희,정종평 대한구강생물학회 1989 International Journal of Oral Biology Vol.13 No.1

To investigate on the factors associated with disease progression of 9 early juvenile periodontitis, clinical, microbiological and immunological studies were performed at the mesial pocket of a first molar on the day of first visit, 9 months after observation without treatment and 6 months after treatment. Clinical parameters are included in sulcus bleeding index (S.B.I.), plaque index, alveolar bone resorption, and attachment loss. Microbiological studies are included in the proportion of bacterial morphotype and anaerobic culture of predominant cultivable microflora. Immunological studies are also performed with the assay of PMN chemotaxis dysfunction, and IgG, and IgM antibody levels to A. actinomycetemcomitans. Through subdivision of 9 subjects with non-progressing and progressing based on the changes in value of alveolar bone resorption and attachment loss, 1. Progressing group showes higher values of S.B.I than non-progressing group. 2. In bacterial morphotype analysis, the distribution of spirochetes are higher in the progressing group than non-progressing group based on alveolar bone resorption. 3. The proportion of anaerobic microflora shows higher in the progressing group than non-progressing group based on alveolar bone resorption. 4. A. actinomycetemcomitans revealed significantly higher frequency in progressing group than non-progressing group, and no detection after treatment. 5. There is no significant differences of PMN chemotaxis dysfunction between progressing and non-progressing group, and suggested to be no correlation with disease progression. 6. IgG antibody levels show significantly higher in non-progressing group than progressing group. However, IgM antibody levels show significantly higher in progressing group than non-progressing group based on alveolar bone resorption, and significantly reduced antibody levels after surgery. These results suggested that infection of A. actinomycetemcomitans and their negligible antibody levels might be relevant factors for progression of early juvenile periodontitis.

pH 변화에 따른 클로라민 생성과 분해 특성

조관형,김평청,우달식,조영태 한국환경과학회 2002 한국환경과학회지 Vol.11 No.4

본 연구의 시료는 현재 서울특별시와 수도권 도시들에서 상수원수로 이용하고 있는 한강수를 대상으로 수행되었다. 배·급수계통의 2차 소독을 위한 클로라민소독의 특성에 관하여 고찰하였으며 그 결과는 다음과 같다. 1) 25 ℃, Cl_2 / NH_3-N비 1:1 ~ 14:1에서 pH6, 7, 8의 불연속점은 각각 Cl_2 / NH_3-N비 11:1, 9:1, 10:1이었다. pH6의 경우, Cl_2 / NH_3-N비가 9:1일 때 총 잔류염소량이 최대인 반면, pH7, 8의 경우 Cl_2 / NH_3-N비가 각각 6:1, 5:1일 때 최대가 되었다. 2) pH가 6, 7, 8로 증가함에 따라 모노클로라민이 최대로 생성되는 Cl_2 / NH_3-N비는 7:1에서 5:1로 이동하였으며, pH6 ~ 8 범위에서 pH가 증가함에 따라 모노클로라민의 생성량이 많았다. 3) 클로라민의 분해는 Cl_2 / NH_3-N비가 증가하고 pH가 낮을수록 증가하였다. 클로라민의 잔류성은 유리염소보다 월등히 좋았다. pH6에서 모노클로라민과 디클로라민이 생성된 이후, 접촉시간이 경과함에 따라 디클로라민의 분포비가 증가하였다. This study was conducted to investigate the characteristics of chloramination as a secondary disinfection in a drinking water distribution system. At the range from pH 6 to pH 8, monochloramine was predominant with a trace of dichloramine, and the free chlorine was detected after breakpoint. At 25℃, the breakpoints of pH 6, 7 and 8 appeared when the weight ratios of chlorine to ammonia nitrogen were 11:1, 9:1 and 10:1 respectively, and the peak points on the breakpoint curves at pH 6, 7 and 8 were in the Cl_2 / NH_3-N ratio of 9:1, 6:1 and 5:1 respectively. As pH increased from 6 to 8, maximum point of monochloramine on the breakpoint curve was moved from 7:1 to 5:1 in the weight ratio of chlorine to ammonia nitrogen. The maximum concentration of monochloramine was formed at the pH values of 7~8 and in the Cl_2 / NH_3-N ratio below 5:1. As the Cl_2 / NH_3-N ratio increased and the pH lowered, chloramines decay proceeded at an increased rate, and residual chloramines lasted longer than the residual free chlorine. The monochloramine and the dichloramine were formed at pH 6, and then the dichloramine continued increasing with contact lime.

상부 조기 위암 환자의 복강경하 상부 위절제술 3례 경험

조규석,김형철,박경규,이문수,송옥평,임철완,신웅진,주종우,유기원 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Background : The reported incidence of early gastric cancer located in the upper portion of the stomach has been increasing with the recent advances in its diagnosis and screening. Recently, we have successfully performed laparoscopic assisted proximal gastrectomy and gastric tube reconstruction without pyloroplasty on three patients with early gastric carcinoma localized to the upper third of the stomach. We describe our modification of this procedure in this report. Method : After creating an surgical pneumoperitoneum, the stomach was mobilized using laparoscopic coagulating shears. Upper half of the greater curvature and three-quarters of the lesser curvature were then dissected along with regoinal D2 lymphadenectomy. This was followed by a 5 cm, longitudinal mini-laparotomy in the upper abdomen, and the construction of the exteriorized stomach with a gastric tube measuring 20 cm long and 4 cm wide. Reconstruction with an esophagogastrostomy was performed using a circular stapler. Result : No post-operative morbidity or mortality was observed in this small series of patients. The average operative time was 250 minutes (range 220-300 minutes), and the average blood loss was 150 ml (range 90-180 ml). The mean number of lymph nodes harvested during these laparoscopic proximal gastrectomies was 24 nodes (range 22-25 lymph nodes). The average postoperative hospital stays was 7.5 days (range 7-8 days). Conclusion : Our technique of laparoscopic assisted proximal gastrectomy and gastric tube reconstruction without phloroplasty offers a minimally invasive technique with the potential of impoving the post-operative quality of life patients with an early-stage proximal gastric cancer.

多重모드 및 單一모드 光纖維의 特性의 巡廻測定

安鍾平(Chong Pyung AN),全永允(Young Yun CHUN),李東浩(Dong Ho LEE),朴熙甲(Hee Gap PARK),金容煥(Yong Hwan KIM),姜玟鎬(Min Ho KANG) 한국통신학회 1985 韓國通信學會論文誌 Vol.10 No.6

Melting Characteristics of Metal Wastes in an Electric Arc Furnace

Pyung Seob Song,Byung Youn Min,Wang Kyu Choi,Chong Hun Jung,Won Zin Oh,Jin Ho Park 한국공업화학회 2006 Journal of Industrial and Engineering Chemistry Vol.12 No.2

Characteristics of the Decontamination by the Melting of Aluminum Waste

Pyung-Seob Song,Wang-Kyu Choi,Byung-Youn Min,Hak-I Kim,Chong-Hun Jung,Won-Zin Oh 한국방사성폐기물학회 2005 방사성폐기물학회지 Vol.3 No.2

TRIGA 연구로의 해체 시 발생하는 금속성 폐기물의 용융기술을 확립하기 위한 기초연구로 전기로 내에서 방사성 핵종(Co, Cs, Sr)을 포함한 알루미늄의 용융 시 용융온도, 용융시간 및 플럭스(flux)의 종류가 핵종의 분배 거동에 미치는 영향을 조사하였다. 플럭스의 종류에 따라 다소 차이는 있으나, 플럭스의 첨가로 알루미늄 용융체의 유동성이 증가됨을 확인할 수 있었다 용융 후주괴(ingot) 및 슬래그(slag) 시료의 XRD분석을 통해 핵종이 주괴에서 슬래그 상으로 이동하고 슬래그를 구성하고 있는 산화알루미늄과 결합하여 안정한 화합물을 형성함을 알 수 있었다. 슬래그의 발생량은 용융온도와 용융시간이 증가할수록 증가하는 경향을 보였으며, 증가속도는 플럭스의 종류에 따라 차이를 보였다. 핵종 중 Co는 용융온도가 증가함에 따라 주괴 내 에서는 감소하였으나 슬래그 상에서는 증가하는 경향을 보였으며, 실험조건에 따라 최대 90까지 주괴에서 슬래그로 이동하였다. 휘발성이 강한 Cs과 Sr은 대부분이 슬래그와 분진으로 이동하여 매우 높은 제염계수를 얻을 수 있었다. Effects of the aluminum melting temperature, melting time and a kind of flux agents on the distribution of surrogate nuclide were investigated in the electric furnace at the aluminum melting including surrogate radionuclides(Co, Cs, Sr) in order to establish the fundamental research of the melting technology for the metallic wastes from the decommissioning of the TRIGA research reactor. It was verified that the fluidity of aluminum melt was increased by adding flux agent but it was slightly varied according to the sort of flux agents. The results of the XRD analysis showed that the surrogate nuclides move into the slag phase and then they were combined with aluminum oxide to form more stable compound. The weight of the slag generated from aluminum melting test increased with increasing melting temperature and melting time and the increase rate of the slag depended on the kind of flux agents added in the aluminum waste. The concentration of the cobalt in the ingot phase decreased with increasing reaction temperature but it increased in the slag phase up to 90according to the experimental conditions. The volatile nuclides such as Cs and Sr considerably transferred from the ingot phase to the slag and dust phase.

Characteristics of the Copper Recovery from Wastewater in Two- and Three-Phase Fluidized-Bed Reactors

Pyung Seob Song,Wang Kyu Choi,Chong Hun Jung,Won Zin Oh,Suk Hwan Kang,Yong Kang 한국공업화학회 2006 Journal of Industrial and Engineering Chemistry Vol.12 No.1

Base Specificity for DNA Interstrand Cross-Linking Induced by Anticancer Agent Bizelesin

Lee, Chong-Soon,Myung, Pyung-Keun,Gibson, Neil W. 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

Bizelesin is a promising novel anticancer agent which is known to alkylate N3 of adenine to induce DNA interstrand cross-links (ISC) within 5'-TAATTA and 5'-TAAAAAA. We have investigated the base specificity for DNA ISC induced by bizelesin using oligomers containing the cross-linkable sequence 5'-TAATTN, in which "N" was either A, C, G, or T. An analysis of denaturing polyacrylamide gel showed that bizelesin is able to induce DAN ISC in the duplex oligomer containing sequences 5'-TAATTA and 5'-TAATTG. The formation of interstrand cross-linking did not occur in the sequences 5'-TATTC and 5'-TAATTT. DNA strand cleavage assay to determine the cross-linking site within 5'-TAATTG sequence showed that bizelesin alkylates guanine. These results demonstrate that bizelesin is able to induce DNA ISC at guanine but not at cytosine or thymine. In addition, guanine adducts have been found to be susceptible to DNA strand cleavage by exposure to hot piperidine. The extent of DNA strand cleavage, however, was not 100% efficient in either neutral pH buffer or hot piperidine.