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만성 간질환에서 혈청 retinol binding protein 4의 임상적 의의
권정현 ( Jung Hyun Kwon ),박성태 ( Seong Tae Park ),김기대 ( Gi Dae Kim ),유찬란 ( Chan Ran You ),김진동 ( Jin Dong Kim ),우현영 ( Hyun Young Woo ),장정원 ( Jeong Won Jang ),김창욱 ( Chang Wook Kim ),배시현 ( Si Hyun Bae ),최종영 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.1
만성 C형간염에서 페그인터페론과 리바비린의 병합치료 시 지속바이러스반응에 대한 순응도의 효과
정승원 ( Soung Won Jeong ),김진동 ( Jin Dong Kim ),우현영 ( Hyun Young Woo ),유찬란 ( Chan Ran You ),이승원 ( Sung Won Lee ),송명준 ( Myeong Jun Song ),장정원 ( Jung Won Jang ),배시현 ( Si Hyun Bae ),최종영 ( Jong Young Choi ) 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.3
목적: 만성 C형간염에서 페그인터페론과 리바비린 병합요법 치료 시 지속바이러스반응에 영향을 미치는 다양한 예측인자들이 알려져 있지만, 치료 순응도의 효과에 대해서는 구체적으로 밝혀져 있지 않다. 본 연구에서는 지속바이러스반응에 대한 치료순응도의 효과를 조사하였다. 대상과 방법: 페그인터페론 또는 리바비린 치료를 받은 만성 C형 간염 환자 122명 중에서 페그인터페론과 리바비린 병합치료를 받은 92명의 환자를 후향적으로 분석하였다. 환자들은 유전자 1형과 비1형을 치료 프로토콜에 따라서 각각 3그룹으로 분류하였다. 그룹 1은 80% 이상의 페그인터페론 및 리바비린 용량으로 80% 이상의 치료 기간 동안 치료받은 환자들이고, 그룹 2는 60% 미만의 페그인터페론 및 리바비린의 용량으로 60%미만의 기간 동안 치료받은 환자들이며 그리고 그룹 3은 이 두 그룹에 포함되지 않은 모든 환자들로 분류하였다. 결과: 치료 순응도가 달랐던 세 그룹 사이에 초기바이러스반응(early virologic response: EVR), 치료종료반응(end of treatment response: ETR) 그리고 지속바이러스반응(sustained virologic response: SVR)이 각각 의미있는 차이를 보였다. 유전자 1형 그룹들의 SVR률은 그룹 1이 86.7%, 그룹 2가 26.7% 그리고 그룹 3이 66.7%였다(P=0.003). 유전자 비1형 그룹들의 SVR은 그룹 1이 100%, 그룹 2가 16.7% 그리고 그룹 3이 88.9%였다(P<0.001). 결론: 치료 순응도는 SVR에 도달하는 데 있어서 결정적인 역할을 하며, 치료 순응도를 높이기 위한 여러 가지 지지요법들이 전체적인 SVR률을 높일 것이다. Background/Aims: Various predictive factors for peginterferon alpha and ribavirin therapy in chronic hepatitis C have been reported, but the effect of adherence to therapy has not been established. We investigated how adherence affects the sustained virologic response (SVR). Methods: We analyzed 92 chronic hepatitis C patients receiving peginterferon alpha and ribavirin combination therapy. Patients were first identified as having either genotype 1 or genotype non-1 infection and then categorized into three groups according to their adherence to the treatment protocol: (1) patients who received ≥80% of the recommended dosage of both peginterferon alpha and ribavirin for ≥80% of the intended duration of therapy, (2) patients who received <60% of the recommended dosage of both peginterferon alpha and ribavirin for <60% of the intended duration of therapy, and (3) patients who were not included in either group 1 or 2. Results: The rates of early virologic response, end of treatment response, and SVR differed significantly with the degree of adherence to the treatment. The SVRs of genotype 1 patients were 86.7%, 26.7%, and 66.7% in groups 1, 2, and 3, respectively (P=0.003), and those of genotype non-1 were 100%, 16.7%, and 88.9%, respectively (P<0.001). Conclusions: Adherence to therapy is a key factor in achieving an SVR. Supportive strategies to improve adherence will increase overall SVR rates. (Korean J Hepatol 2009;15:338-349)
만성 B형 간염 환자에서 3년간 라미부딘 투여 후 간의 조직학적 변화
정은선 ( Eun Sun Jung ),배시현 ( Si Hyun Bae ),장정원 ( Jeong Won Jang ),최종영 ( Jong Young Choi ),윤승규 ( Seung Kew Yoon ),정규원 ( Kyu Won Chung ),선희식 ( Hee Sik Sun ),박두호 ( Doo Ho Park ),김병기 ( Byung Ki Kim ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.3
Background/Aims: The aim of this study was to examine the histological changes of the liver after a 3-year lamivudine therapy in patients with chronic hepatitis B. Methods: Seven patients with sustaining virological and biochemical response were enrolled in this study. The patients were given lamivudine orally at a dose of 100 mg for 3 years, and then, the second liver biopsy was performed. The liver biopsies were evaluated using the conventional histological assessment scale and the quantification of fibrosis by an image analysis. Results: All patients showed a reduction in the hepatic necro-inflammatory activity after 3 years of lamividine therapy compared to the pretreatment value as follows: the mean grade of lobular activity, 1.14 vs. 2.28; porto-periportal activity grade, 1 vs. 2.57; fibrosis stage 1.14 vs. 2.14. The quantification by the image analysis showed a significant reduction of the fibrotic area in the mean portal, periportal, and septal portions (17,985 vs. 7,082 um2, p<0.05). The intrahepatic expression of HBcAg turned negative in the liver tissues of five patients. Conclusions: The improvements in liver histology, especially in porto-periportal activity and fibrosis, can be obtained in patients with sustained viral and biochemical response after a long-term lamivudine treatment. (Korean J Gastroenterol 2003;41:204-210)
정종빈 ( Jong Bin Jung ),장정원 ( Jeong Won Jang ),변준기 ( Jun Gi Byun ),황희숙 ( Hee Suk Hwang ),윤주은 ( Ju Eun Yoon ),오승환 ( Seung Hwan Oh ) 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-
본 연구는 기온 차이에 따른 서울 도심공원과 국립수목원 내 주요 목본 수종들의 개화 특성을 비교하고자 수행하였다. 연구 대상지는 서울특별시 노원구에 위치한 느티울근린공원과 경기도 포천시에 위치한 국립수목원 내 전시원이며, 두 지역에 공통적으로 식재된 개나리, 단풍나무, 벚나무, 산수유, 산철쭉, 진달래 등 6분류군을 대상으로 2011년부터 2013년까지 매년 개화시작일과 낙화완료일, 개화기간 등을 기록하였다(Day of Year, DOY). 또한 두 지역에서 수집된 기온 자료를 이용하여 Nuttonson의 온량지수(Tn)와 일적산온량지수(YDI)를 산출하여 비교하였다. 연구 결과, 두 지역 모두 산수유(도심공원: 평균 86 ± 1일, 수목원: 평균 98 ± 3일)가 가장 빨리 개화하였고 그 다음 개나리, 진달래, 벚나무, 단풍나무 순이었으며 산철쭉(도심공원: 평균 112 ± 4일, 수목원: 평균 124 ± 3일)이 가장 늦게 개화하였다. 개화시작일의 경우 도심공원 내 조사 대상들이 평균 12-14일 정도 빨리 개화하는 것으로 나타났다. 개화기 무렵인 DOY 100일 때 도심공원의 지난 3년 간 평균 Tn은 76.1 ± 7.9인 반면 수목원의 경우 평균 34.4 ± 5.2로 개화기 무렵 도심공원 내 Tn이 높게 측정되었다. YDI도 Tn과 같은 경향을 보였다. 지난 3년 간 수종별 개화기간은 산수유는 평균 26일(수목원: 21일), 개나리는 평균 28일(20일), 진달래는 14일(17일), 벚나무는 15일(10일), 단풍나무는 17일(14일), 산철쭉은 19일(11일)로 도심공원에서 평균 3-8일 정도 길게 지속되었다. This study aimed to investigate phenological differences among six woody plants (Forsythia koreana, Acer palmatum, Prunus serrulata var. spontanea, Cornus officinalis, Rhododendron yedoense f. poukhanense, R. mucronulatum). We monitored flowering dates of each species in two regions, in Seoul Neutiul urban park and Korea National Arboretum for three years from 2011 to 2013. Also, Nuttonson`s index (Tn) and Year Day Index (YDI) were calculated from daily temperature data. According to the results, the earliest flowering species was C. officinalis (urban park: DOY 86 ± 1, arboretum: DOY 98 ± 3) followed by F. koreana, R. mucronulatum, P. serrulata var. spontanea, A. palmatum, while R. yedoense f. poukhanense was the late blooming species (urban park: DOY 112 ± 4, arboretum: DOY 124 ± 3). Flowering dates in urban park were earlier than that in arboretum by 12-14 days in average. On DOY 100, average Tn was higher in urban park (76.1 ± 7.9) than in arboretum (34.4 ± 5.2). YDI showed same tendency with Tn. The blooms in urban park seemed to last longer than in arboretum by 3-8 days. Flowers last 26 days (21 days in arboretum) in C. officinalis, 28 days (20 days) in F. koreana, 14 days (17 days) in R. mucronulatum, 15 days (10 days) in P. serrulata var. spontanea, 17 days (14 days) in A. palmatum, 19 days (11 days) in R. yedoense f. poukhanense.
정윤화 ( Yun Hwa Jung ),장정원 ( Jeong Won Jang ),지정선 ( Jeong Seon Ji ),김병욱 ( Byung Wook Kim ),최황 ( Whang Choi ),최규용 ( Gyu Yong Choi ),맹이소 ( I So Maeng ) 대한내과학회 2008 대한내과학회지 Vol.75 No.1
본 저자들은 윌슨씨병으로 진단된 젊은 여자 환자에서 합병된 담도 결석을 내시경적 담석제거술로 제거한 1예를 경험하였기에 보고하는 바이다. 윌슨씨병은 병인론에서 보듯이 간, 신경계 외에도 혈액학적 합병증을 수반할 수 있으며 이에 따라 담도계의 결석을 이차적으로 수반할수 있음을 증례를 들어 제시하며 역으로 고위험요소가 없는 환자에 있어서의 담도결석은 혈액질환이나 대사질환의 가능성을 시사함을 인지해야 할 것으로 생각된다. Wilson`s disease is a rare autosomal recessive metabolic disease. The ATB7B gene mutation results in a defect of biliary copper excretion and subsequent accumulation of copper in the liver, brain, and sclera. The usual clinical signs of Wilson`s disease include hepatitis, liver cirrhosis, movement disorder, or a Kayser-Fleisher ring in the sclera, but patients occasionally present with hepatic failure or hemolytic anemia. Under such metabolic conditions, free copper induce chronic hemolysis with oxidative damage via free radical production, and chronic hemolysis, in turn, can cause secondary pigment bililary stone formation. Herein we report a case of Wilson`s disease associated with cholelithiasis in a young female. (Korean J Med 75:82-87, 2008)
인간 무세포성 진피기질 위에 배양한 가토 구강각화상피세포의 중충화와 기저막 형성에 관한 연구
김용덕,안강민,염학렬,정헌종,김성민,장정원,성미애,박희정,황순정,이종호,Kim, Yong-Deok,Ahn, Kang-Min,Yum, Hak-Yeol,Chung, Hun-Jong,Kim, Soung-Min,Jang, Jeong-Won,Sung, Mi-Ae,Park, Hee-Jung,Hwang, Soon-Jung,Lee, Jong-Ho 대한악안면성형재건외과학회 2005 Maxillofacial Plastic Reconstructive Surgery Vol.27 No.6
To assess the clinical applicability of bio-artificial mucosa which was made with autologous oral keratinocytes and human acellular dermal matrix, the formation of basement membrane and stratification of oral keratinocytes were evaluated. Six New Zealand white rabbits (around 2kg in weight) were anesthetized and its buccal mucosa was harvested (1.0 $\times$ 0.5cm size). Oral keratinicytes were extracted and cultured primarily with the feeder layer of pretreated NIH J2 3T3 fibroblast. These confluent cells were innoculated on the human acellular dermal matrix and cultured in multiple layer by air-rafting method. After 3, 5, 7, 10, 14 days of culture, each cultured bio-artificial mucosa was investigated the number of epthelial layer of by H&E stain and toluidine blue stain. The immuhohistochemical methods were used to evaluate the cell division capacity, the formation of basement membrane, and it's property of specific cells (PCNA, cytokeratin 14, laminin). Transmission electromicroscopy was used for the attachment between cells and matrix with the number of hemidesmosome. In result, the numbers of layer of stratified growth of oral keratinocyte cultured on the human acellular dermal matrix and the number of hemidesomal attachment between epithelial cells and human acellular dermal matrix were similar to the layers of normal oral mucosa after 10 days of culture. The cell division rate, basement membrane formation and proliferation rate increased as culture period increased. With these results, bio-artificial mucosa with autologous oral epithelial cells cultured on the acellular dermal matrix had clinically adaptable properties after 10 days' culture and this new bio-artificial mucosa model with relatively short culture time can be expected clinical applicability.
고빌리루빈혈증과 담도 침범을 동반한 간세포암에 대한 경동맥화학 리피오돌색전술의 안전성과 예후 인자
양경모 ( Keungmo Yang ),성필수 ( Pil Soo Sung ),오정석 ( Jung Suk Oh ),천호종 ( Ho Jong Chun ),장정원 ( Jeong Won Jang ),배시현 ( Si Hyun Bae ),최종영 ( Jong Young Choi ),윤승규 ( Seung Kew Yoon ) 대한간암학회 2018 대한간암학회지 Vol.18 No.2
Background/Aims: The treatments and outcomes of hepatocellular carcinoma (HCC) with bile duct invasion are not well known. We aimed to confirm the safety of transarterial chemolipiodolization (TACL) and identify prognostic factors for patients with bile duct invasion treated with TACL. Methods: Fifty patients with central bile duct invasion treated with TACL between 2005 and 2017 were enrolled. Patients were divided into three groups: hyperbilirubinemia (total bilirubin ≥2.5 mg/dL) with pre-TACL biliary drainage, hyperbilirubinemia without biliary drainage, and without hyperbilirubinemia. Tumor response to TACL, survival outcomes, length of hospitalization, adverse events using Common Terminology Criteria for Adverse Events (CTCAE), and factors affecting overall survival were compared. Results: TACL-induced changes of mean CTCAE grades for albumin, alanine aminotransferase, creatinine, prothrombin time, and platelet were not significantly different among patients with or without initial hyperbilirubinemia. Serum bilirubin level was not significantly changed after TACL in all the three groups. Overall survival was not significantly different among the three groups (P=0.097). On multivariate analysis, alpha-fetoprotein <400 ng/dL (hazard ratio [HR]=0.477, P=0.048) and highest total bilirubin level of <2.5 mg/dL within one month after TACL (HR=0.335, P=0.004) were significantly associated with longer survival. Conclusions: TACL was a safe treatment for HCC patients with central bile duct invasion, irrespective of the presence of initial hyperbilirubinemia. (J Liver Cancer 2018;18:121-129)