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만성 C형 간염에서 Fas/Fas Ligand에 의한 간세포 자멸사
장우임 ( U Im Chang ),한준열 ( Joon Yeol Han ),김진일 ( Jin Il Kim ),최종영 ( Jong Young Choi ),조세현 ( Se Hyun Jo ),한남익 ( Nam Ik Han ),윤승규 ( Seung Kew Yoon ),양진모 ( Jin Mo Yang ),안병민 ( Byung Min Ahn ),김재광 ( Jae Kwa 대한소화기학회 2003 대한소화기학회지 Vol.41 No.4
Background/Aims: In chronic hepatitis C, the Fas/Fas ligand-mediated apoptosis is involved in the hepatic injury. The soluble forms of Fas and Fas ligand have been detected in serum and shown to inhibit Fas-mediated apoptosis. In the present study, we evaluated the relationships between the serum level of soluble Fas/Fas ligand and their histological and biochemical activities to elucidate the role of Fas system in pathogenesis of chronic hepatitis C. Methods: Liver biopsy samples were graded according to the Knodell`s Histologic Activity Index and immunohistochemically stained for Fas and Fas ligand. Serum soluble Fas and Fas ligand levels of chronic hepatitis C patients were compared with those of control group. These levels were compared with histological activities, ALT levels and Fas expression grades. Results: Serum soluble Fas levels in patients with chronic hepatitis C were higher than those in the control group, although it is not statistically significant. Soluble Fas level in patients with moderate and marked intralobular inflammation were higher significantly than those in control group. There was a positive relationship between the grade of Fas expression and HAI score. Conclusions: These findings suggest the possibility that the concentration of soluble Fas is associated with severity of intralobular inflammation in patients with chronic hepatitis C. (Korean J Gastroenterol 2003;41:205-301)
장우석 ( Woo Seok Chang ),정남수 ( Nam Su Jung ),임상봉 ( Sang Bong Im ) 한국농공학회 2011 한국농공학회 학술대회초록집 Vol.2011 No.-
최근 쌀 작물의 가격경쟁력 저하와 함께 농가소득을 높일 수 있는 방안으로써 밭작물에 식재에 대한 관심이 증가하고 있다(성명환 외 2009). 또한 4대강 정비 사업을 통하여 리모델링 되는 경지의 발생 등으로 인하여 적정작물식재와 관련된 지식수요가 증가하고 있는 추세이다. 이와 관련하여 한국토양정보시스템에서는 필지별 토양특성에 따라 61개 작물에 대하여 최적인 작물을 선정해주는 시스템을 개발하여 농민들에게 서비스를 제공하고 있다. 하지만 최적 작물식재계획 수립하기 위해서는 필지별로 적합한 작물을 선정하여야 할 뿐만 아니라 작물을 경작하기 위한 경영자원의 특성, 시장가격 등을 반영한 경영최적화를 달성하여야 하며 경작의 효율성을 기하기 위하여 작물의 배치 등을 고려하여야 한다. 본 연구에서는 필지별 교환분합을 통한 행위자 모델을 구축하기 위하여, 각 필지를 다른 필지와 인접하는 매트릭스구조로 분류하고, 이에 따른 필지별 인접성 자료를 공간 데이터로 구축하여 각 필지의 인접성 매트릭스 점수표를 도출하였다. 또한, 작물적지가 선정되면 가장 큰 효용을 창출해내는 작물이 인접성 매트릭스에 의하여 토지를 확장해 나가는 모델을 개발하는 것을 목적으로 하였다. 행위자 기반 모형이란 구체적인 행위자 수준에 초점을 맞추어 작은 가상세계를 구현하는 모형으로, 대상 시스템의 구성 주체들을 면밀히 관찰하여 주요한 속성과 행동규칙을 추출해내고, 이를 기반으로 직접 상호작용을 하도록 모의하는 기법으로, 질병확산, 교통류 분석 등 전체적인 추세보다 개별적인 특성의 변화를 파악하고자 할 때 주로 활용되고 있어 작물 식재계획과 같이 토지간의 상관관계를 바탕으로 활용방안을 모색하고자 할 때 효과적일 것으로 판단되었다. 연구 수행을 위해 토양도, 기상도, 지형자료 등 관련 자료를 구축하여 환경조건에 따른 필지별 최적 작물을 선정할 수 있도록 작물 적지 선정방안을 마련하였고, 작물별 경작비용, 시장가격 등 경제성을 바탕으로 식재작물의 확장 방법을 마련하였으며, 최종적으로 사용자가 입력한 경영조건에 따른 작물별 식재비율에 도달하도록 모델을 구축하였다.
맥파전도속도(PWV)를 이용한 체질별 죽상동맥경화 위험인자에 대한 상관관계 연구
임은영,이제원,장우석,백경민,전우현,정인권,Im, Eun-Young,Lee, Je-Won,Chang, Woo-Seok,Baek, Kyung-Min,Cheon, Woo-Hyun,Chung, In-Kwon 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3
Object : The purpose of this study was to investigate the correlation of atherosclerosis risk factors and pulse wave velocity (PWV) of carotid-femoral artery with Sasang constitution. This study also aimed to investigate the relationship between PWV and risk factors of atherosclerosis, including serum cholesterol and homosisteine, hs-CRP. Methods : We enrolled 160 patients without experience strokes who visited our hospital for a medical examination from January 1, 2008 to April 30, 2010 except patients whose body constitutions were undetermined according to QSCCII. We investigated the correlation between serum cholesterol values, blood pressure, body mass index(BMI), homosistein, hs-CRP and PWV. Pearson's correlation and partial correlation analysis were applied to examine the relationship between PWV and risk factors of atherosclerosis. Result : Among the 160 subjects, 54 were Taeumin, 54 were Soyangin, and 52 were Soeumin. The prevalences of high BMI (P-value <0.01), high hs-CRP(P-value <0.05), and high PWV(P-value <0.05) of Taeumin were higher than those of the other constitutions. PWV of carotid-femoral artery was significantly different among the three constitutional groups(Taeumin: $8.12{\pm}1.64m/sec$, Soyangin: $7.48{\pm}1.16m/sec$, Soeumin: $7.49{\pm}1.12m/sec$)(P-value <0.05). This research has show a statistical significance between the average amount of carotid-femoral artery PWV that is higher in Taeumin. Age factor of Taeumin was the effective determinant of the increase of mean PWV of carotid-femoral arteries. Conclusions : There were significant differences in the prevalence of atherosclerosis according to Sasang constitution. This study showed that atherosclerosis was more prevalent in Taeumin. Therefore, according to our results, risk of atherosclerosis was higher in Taeumin than among other constitutions.
만성 C형 간염 환자에서 HCV Core Antigen Assay의 임상적 유용성
김창욱 ( Kim Chang Ug ),장우임 ( Jang U Im ),최종영 ( Choe Jong Yeong ),윤승규 ( Yun Seung Gyu ),조세현 ( Jo Se Hyeon ),양진모 ( Yang Jin Mo ),한준열 ( Han Jun Yeol ),안병민 ( An Byeong Min ),최상욱 ( Choe Sang Ug ),이영석 ( Lee Y 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 만성 C형 간염에서 바이러스 정량분석은 치료대상자 선정, 치료판정 예측에 이용되고 있다. 최근 말초혈액에서 HCV core antigen을 단일클론항체(monoclonal antibody)를 이용한 ELISA기법으로 비교적 간편하게 측정할 수 있게 되었으며, PCR 법에 의한 HCV RNA 정량분석과 임상적 유용성이 비교되고 있다. 저자들은 만성 C형 간염환자에서 인터페론과 리바비린 병합치료 전과 후 HCV core antigen assay의
뼈전이에 대한 방사선 치료 이후 압스코팔 효과로 폐전이 호전을 보인 간세포암 1예
송도선 ( Do Seon Song ),장우임 ( U Im Chang ),안호정 ( Ho Jung An ),김성환 ( Sung Hwan Kim ),양진모 ( Jin Mo Yang ) 대한간암학회 2017 대한간암학회지 Vol.17 No.2
The abscopal effect is a rare phenomenon that characterized by tumor regression of untreated metastatic lesions after a local radiotherapy. The mechanisms of abscopal effect are speculated to be associated with cytokine release and host immune system. In this case, we report a case of abscopal effect in a 64-year-old male with hepatocellular carcinoma with lung and bone metastasis, who had complete response in the lung after receiving radiation to the metastatic bone lesions. (J Liver Cancer 2017;17:168-173)
우황청심원 관련 최근 연구 동향 : 국내 논문에 대한 고찰
이제원,백경민,백영두,임은영,장우석,전우현,정인권,Lee, Je-Won,Baek, Kyung-Min,Baek, Young-Doo,Im, Eun-Young,Chang, Woo-Seok,Cheon, Woo-Hyun,Chung, In-Kwon 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.4
Objectives : Woohwangchungsim-won has been used for acute diseases such as cerebrovascular disease (stroke), heart disease. The aim of this study was to determine the effects, significance & necessity of Woohwangchungsim-won in acute stages of these disease by reviewing Korean articles about Woohwangchungsim-won. Methods : Article searches were performed on 8 major Korean web article search engine from January 1980 to August 2010. There were no restrictions on the types of publication, including grey articles. Results : Forty-three articles were included. Twenty one were efficacy tests, thirteen were comparative efficacy tests, eight were toxicity tests, and one was new method development. Eighteen articles were multicenter studies and twenty five were single center studies. Thirty two articles were animal testing, only ten articles were clinical articles. Thirty seven articles presented the composition and quantity of Woohwangchungsim-won, but six did not. Conclusions : The results of Korean articles about Woohwangchungsim-won can not strongly support the effects, significance & necessity of Woohwangchungsim-won. More rigorous studies are required for determination of the effects of Woohwangchungsim-won.
곽승기(Seung Ki Kwok),장우임(U Im Chang),이태규(Tae Kyu Lee),추교영(Kyo Young Choo),김진일(Jin Il Kim),박수헌(Soo Heon Park),한준열(Joon Yeol Han),김재광(Jae Kwang Kim),정규원(Kyu Won Chung),선희식(Hee Sik Sun) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.3
Tuberculosis of the abdominal wall is relatively uncommon and most cases were caused by a spread of the infection from tuberculous abdominal lymph nodes. Autopsy studies have shown abdominal wall involvement in less than 1% of patients who died of tuberculosis. We have experienced a case of the tuberculous abscess in the abdominal wall. A 21-year-old woman was admitted for the evaluation of a soft mass at the right upper abdomen. A 15×5×4 cm sized abscess in the abdominal wall was detected by ultrasonogram and CT. Abscess was drained by ultrasonogram-guided aspiration. The confirmed diagnosis of tuberculous abscess was made by means of polymerase chain reaction of the aspirated fluid from the mass. The patient was successfully treated with anti-tuberculosis therapy of four drug regimens. To our knowledge, this is the first report of tuberculous abscess developed in the abdominal wall in Korea. (Korean J Gastroenterol 2001;38:220-223)
포스터 전시 : 간 ; 우심부전과 유전성 구형적혈구증으로 발생한 심한 간비종대 1예
서석민 ( Seo Seog Min ),김창욱 ( Kim Chang Ug ),박찬권 ( Park Chan Gwon ),남순우 ( Nam Sun U ),장우임 ( Jang U Im ),최종영 ( Choe Jong Yeong ),윤승규 ( Yun Seung Gyu ),최상욱 ( Choe Sang Ug ),정규원 ( Jeong Gyu Won ),선희식 ( Seon 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<증례> 54세 여자가 내원 12시간 전부터 발생한 발열과 오한, 우상복부 동통을 주소로 응급실로 내원하였다. 과거력상 어려서부터 비장종대가 있었으나 특별한 검사 없이 지내다가 내원 2년전 호흡곤란으로 심장비대와 담석이 있다는 사실을 알고 약물치료 중 이었다. 내원당시 혈압은 120/80㎜Hg, 맥박은 분당 100회, 호흡은 분당 24회, 체온은 38.0℃였고, 창백하면서 황달이 있었다. 심음은 규칙적이었으나 강도 4정도의 수축기 잡음이 심첨과 흉골좌측