Reactions of trichloroethylideneacetophenone with hydrazines (I) synthesis of pyrazoline and pyridazinone derivatives

이윤영,이우영,장세희,Lee, Youn-Young,Lee, Woo-Young,Chang, Sae-Hee Korean Chemical Society 1970 대한화학회지 Vol.14 No.1

3-Phenyl-5-trichloromethyl-2-pyrazoline was synthesized from the reaction of trichloroethylideneacetophenone with hydrazine hydrate. Pyridazinone derivatives were synthesized from the reaction of trichloroethylideneacetophenone with phenylhydrazine or substituted phenylhydrazines. trichloroethylideneacetophenone과 hydrazine hydrate의 반응으로 3-phenyl-5-trichloromethyl-2-pyrazoline을 합성하였다. 또한 trichloroethylideneacetophenone과 phenylhydrazine 또는 치환된 phenylhydrazine의 반응으로 pyridazinone 유도체들을 합성하였다.

Trichloroethylideneacetone과 Hydrazine 들의 반응 (Ⅰ)

이윤영,이우영,장세희,Lee, Youn Young,Lee Woo Young,Chang Sae Hee Korean Chemical Society 1972 대한화학회지 Vol.16 No.4

2, 6-Disubstituted-3-pyridazinones were synthesized from the reaction of trichloroethylideneacetone with substituted phenylhydrazines. From the reaction of trichloroethylideneacetone with ο-nitrophenylhydrazine, pyridazinone derivative was not obtained, but ${\gamma},{\gamma}$-dichloro-${\gamma}$-(o-nitrophenylhydrazino)-ethylideneacetone was obtained in 24% yield.

박사르^®정 4 밀리그램(라시디핀 4 mg)에 대한 라니디엠^®정 4 밀리그램의 생물학적동등성

이윤영,김혜진,나숙희,조경희,장문선,박영준,이희주,Lee, Yun-Young,Kim, Hye-Jin,La, Sookie,Cho, Kyung-Hee,Jang, Moon-Sun,Park, Young-Joon,Lee, Hee-Joo 한국약제학회 2010 Journal of Pharmaceutical Investigation Vol.40 No.2

A bioequivalence study of LANIDIEM$^{(R)}$ tablet 4 mg (Samil. Co., Ltd.) to Vaxar$^{(R)}$ tablet 4 mg (GlaxoSmithKline Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Forty healthy male Korean volunteers were enrolled in the study and thirty six volunteers completed the study according to the protocol. Thirty six volunteers received each medicine at the lacidipine dose of 4 mg in a $2{\times}2$ crossover study. There was one week wash-out period between the doses. Plasma concentrations of lacidipine were monitored by a high performance liquid chromatography - tandem mass spectrometry (LC-MS/MS) for over a period of 24 hours after drug administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for LANIDIEM$^{(R)}$/Vaxar$^{(R)}$ were log 0.8102~log 1.0417 and log 0.8493~log 1.1439, respectively. These values were within the acceptable bioequivalence intervals of log 0.80~log 1.25. Thus, our study demonstrated the bioequivalence of LANIDIEM$^{(R)}$ tablet 4 mg and Vaxar$^{(R)}$ tablet 4 mg with respect to the rate and extent of absorption.

파목신 캅셀(아목시실린 500 mg)에 대한 곰실린 캅셀의 생물학적동등성

이윤영,최미희,이경률,이희주,Lee, Yun-Young,Choi, Mee-Hee,Lee, Kyung-Ryul,Lee, Hee-Joo 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4

A bioequivalence study of $Gomcillin^{TM}$ capsules (DAEWOONG Pharmaceutical Co., Korea) to $Famoxin^{TM}$ capsules (Dong Wha Pharm. Ind. Co., Korea) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the amoxicillin dose of 500 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of amoxicillin were monitored by a high-performance liquid chromatography for over a period of 8 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 8 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Gomcillin^{TM}/Famoxin^{TM}$ were $log0.91\;{\sim}\;log1.03$ and $;log0.93\;{\sim}\;log1.10$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80\;{\sim}\;log1.25$. Thus, our study demonstrated the bioequivalence of $Gomcillin^{TM}$ and $Famoxin^{TM}$ with respect to the rate and extent of absorption.

Reactions of $\gamma$,$\gamma$,$\gamma$-Trichloroethylidene-m-Nitroacetophenone with Hydrazines

이윤영,송석주,Youn Young Lee,Suk Zu Song Korean Chemical Society 1973 대한화학회지 Vol.17 No.1

$\gamma$,$\gamma$,$\gamma$-Trichloroethylidene-m-Nitroacetophenone과 phenylhydrazine및 치환된 phenylhydrazine들과의 반응으로 2,6-disubstituted-3-pyridazinone들을 합성하였으며 2,4-dinitrophenylhydrazine과의 반응에서는 hydrazone을 중간체로 분리하였다. hydrazinehydrate와의 반응에서는 3-(mnitrophenyl)-5-trichloromethyl-2-pyrazoline이 좋은 수득률로 얻어졌다. 또한$\gamma$,$\gamma$,$\gamma$-trichloroethylidene-m-nitroacetophenone과 치환된 phenylhydrazine과의 반응에서 phenyl기에 결합된 치환기의 효과를 검토하였다. 2,6-Disubstituted-3-pyridazinones were synthesized by the reactions of $\gamma$,$\gamma$,$\gamma$-trichloroethylidene-m-nitroacetophenone with phenylhydrazine and substituted phenylhydrazines, and hydrazone was isolated as an intermediate from the reaction with 2, 4-dinitrophenylhydrazine. From the reaction with hydrazine hydrate 3-(m-nitrophenyl)-5-trichloromethyl-2-pyrazoline was obtained in good yield. The effect of substituents on phenyl group in the reaction of $\gamma$,$\gamma$,$\gamma$-trichloroethylidene-m-nitroacetophenone with substituted phenylhydrazines was also discussed.

Synthesis Studies on Penems and Carbapenems (I). Improved Synthesis of 4(S)-Acetoxy-3(S)-phenylacetamidoazetidin-2-one

이윤영,왕한철,구양모,Youn Young Lee,Han Cheol Wang,Yang Mo Goo Korean Chemical Society 1986 대한화학회지 Vol.30 No.1

Fips : 파일 접근 유형을 고려한 동적 파일 선반입 기법

이윤영,김재열,서대화,Lee, Yoon-Young,Kim, Chei-Yol,Seo, Dae-Wha 한국정보과학회 2002 정보과학회논문지 : 시스템 및 이론 Vol.32 No.6

병렬 파일시스템은 클러스터 시스템에서 과도한 입출력 요청을 원활하게 지원하기 위해 사용되며, 특히 파일 선반입은 병렬 파일시스템의 성능을 개선하는데 유용하게 사용된다. 본 논문은 과학계산용 병렬 응용과 멀티미디어 서버 응용에서 효과적인 파일 접근 유형을 고려한 새로운 동적 파일 선반입기법인 Fips를 제안한다. 본 논문이 제안하는 동적 파일 선반입 기법인 Fips는 파일의 접근 유형을 고려하여 동적으로 선반입 할 데이타 블록을 예측하고, 다양한 접근 유형에서도 데이타 블록의 선반입을 효율을 높였다. 그리고 현재의 가용 대역폭을 고려하여 선반입 시기를 결정하므로 선반입이 시스템에 과부하로 작용하는 것을 방지하도록 하였다. 병렬 파일시스템에 Fips를 적용하여 실험한 결과 다양한 작업부하에서 제안한 선반입 기법은 우수한 성능을 보여주었다. A Parallel file system is normally used to support excessive file requests from parallel applications in a cluster system, whereas prefetching is useful for improving the file system performance. This paper proposes a new prefetching method, Fips(dynamic File Prefetching Scheme based on file access patterms), that is particularly suitable for parallel scientific applications and multimedia web services in a parallel file system. The proposed prefetching method introduces a dynamic prefetching scheme to predict data blocks precisely in run-time although the file access patterns are irregular. In addition, it includes an algorithm to determine whether and when the prefetching is performed using the current available I/O bandwidth. Experimental results confirmed that the use of the proposed prefetching policy in a parallel file system produced a higher file system performance.

SSL 프로토콜의 CipherSuite 설정 문제점과 해결 방안

이윤영,허순행,박상주,신동휘,원동호,김승주,Lee, Yun-Young,Hur, Soon-Haeng,Park, Sang-Joo,Shin, Dong-Hwi,Won, Dong-Ho,Kim, Seung-Joo 한국정보처리학회 2008 정보처리학회논문지 C : 정보통신,정보보안 Vol.15 No.5

인터넷과 정보통신기술의 사용이 일반화되면서 인터넷 상에서 중요한 데이터를 안전하게 전송해야 함에 따라 SSL 프로토콜의 사용은 필수요소가 되었다. SSL 프로토콜은 메시지 위/변조 공격과 같은 능동적인 공격에 안전하도록 설계가 되었지만 CipherSuite 설정 변경은 별다른 제약 없이 수정이 가능하다. 공격자가 Client의 시스템의 오작동을 유도하여 CipherSuite 설정을 키 길이가 낮은 대칭키 알고리즘으로 변경한다면 도청하여 데이터를 해독할 수 있다. 본 논문은 키 길이가 낮은 대칭키 알고리즘 설정에 대한 국내 웹사이트의 보안세션 생성 조사 및 CipherSuite 설정 문제점에 대한 해결책을 제시한다. As the use of Internet and information communication technology is being generalized, the SSL protocol is essential in Internet because the important data should be transferred securely. While the SSL protocol is designed to defend from active attack such as message forgery and message alteration, the cipher suite setting can be easily modified. If the attacker draw on a malfunction of the client system and modify the cipher suite setting to the symmetric key algorithm which has short key length, he should eavesdrop and cryptanalysis the encrypt data. In this paper, we examine the domestic web site whether they generate the security session through the symmetric key algorithm which has short key length and propose the solution of the cipher suite setting problem.

병렬 파일 시스템에서의 하이브리드 채널 모델

이윤영,황보준형,서대화,Lee, Yoon-Young,Hwangbo, Jun-Hyung,Seo, Dae-Wha 한국정보처리학회 2003 정보처리학회논문지 A Vol.10 No.1

병렬 파일 시스템은 고속의 네트웍으로 여러 대의 컴퓨터들을 서로 연결하여 컴퓨터들 간에 메시지를 주고받으면서 파일을 분산 저장하고 병렬로 읽어오는 방식으로 파일 입출력 장치의 병목현상을 해결한다. 그러나 대부분의 병렬 파일 시스템은 전달하려는 메시지의 특성을 고려하지 않은 프로토콜의 사용으로 성능저하의 문제를 가지고 있다. 이에 따라 본 논문에서 메시지 처리 방법으로 HCM(Hybrid Channel Model)을 제안한다. 본 논문에서 제안하는 HCM은 병렬 파일 시스템에서 전달되는 메시지를 그 특성에 따라 분리해서 별개의 프로토콜을 이용하여 제어 메시지와 파일 데이터 블록을 전송한다. 안정성이 검증된 TCP/IP를 이용하여 구현한 메시지 채널을 통해 제어 메시지를 고속의 데이터 전송이 가능한 VIA를 이용하여 구현한 데이터 채널을 통해 파일 데이터 블록을 각각 분리하여 처리하도록 하고 있다 HCM을 병렬 파일 시스템에 구현하고 실험해본 결과 본 논문에서 제안한 채널 모델이 상당한 성능향상을 보였다. Parallel file system solves I/O bottleneck to store a file distributedly and read it parallel exchanging messages among computers that is connected multiple computers with high speed networks. However, they do not consider the message characteristics and performances are decreased. Accordingly, the current study proposes the Hybrid Channel model (HCM) as a message-management method, whereby the messages of a parallel file system are classified by a message characteristic between control messages and file data blocks, and the communication channel is divided into a message channel and data channel. The message channel then transfers the control messages through TCP/IP with reliability, while the data channel that is implemented by Virtual Interface Architecture (VIA) transfers the file data blocks at high speed. In tests, the proposed parallel file system that is implemented by HCM exhibited a considerably improved performance.

Cycloaddition of Homophthalic Anhydrides to Azodicarboxylate and Alkylidenecarbamates

이윤영,김호현,구양모,Youn Young Lee,Ho Hyeon Kim,Yang Mo Goo Korean Chemical Society 1986 대한화학회지 Vol.30 No.2

호모프탈산 무수물(1또는 2)과 디에틸 아조디카르복시산 및 에틸 아릴메티리덴카르밤산과의 고리화첨가반응을 검토하였다. 전자의 반응에서는 2,3--디에톡시카르보닐-2,3-디히드로-1-히드록시프탈라진들(3 및 4)이 생성되었으며, 후자의 반응에서는 3-아릴-4카르복시-2-에톡시카르보닐-3,4-디히드로-1(2H)-이소퀴놀린온들(5~10)이 생성되었다. The cycloaddition between homophthalic anhydrides (1 or 2) and diethyl azodicarboxylate and ethyl arylmetbyldenecarbamates was investigated. The former led to 2,3-diethoxycarbonyl-2,3-dihydro-1-hydroxyphthalazines (3 and 4), while the latter gave 3-aryl-4-carboxy-2-ethoxycarbonyl-3,4-dihydro-1(2H) isoquinolinones (5∼10).