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이승규,김선웅,김태임,이형근,김응권,서경률.Seung Kyu Lee. M.D.. Sun Woong Kim. M.D.. Tae Im Kim. M.D.. Hyung Kuen Lee. M.D.. Eung Kweon Kim. M.D.. Kyoung Yul Seo. M.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.3
`Purpose: To compare short-term clinical results of LASEK and epi-LASIK. Methods: Fifteen subjects (30 eyes) underwent uncomplicated LASEK on one eye and uncomplicated epi- LASIK on the other eye by a single surgeon, and uncorrected visual acuity, refractive change, postoperative pain, and postoperative satisfaction were compared at postoperative week one, at one month, and at three months. Results: Postoperative uncorrected visual acuities were 0.68±0.20, 0.96±0.22, and 1.05±0.17 for LASEK and 0.75±0.21, 0.92±0.14, and 1.01±0.21 for epi-LASIK at one week, one month, and three months, respectively. Epi-LASIK showed faster improvement in visual acuity at one week, while LASEK showed faster improvement afterward. However, no statistical significance was found. Spherical equivalet of LASEK was -0.66±1.28D and that of epi-LASIK was -0.61±0.92D at postoperative week one, implying faster refractive recovery for epi-LASIK, but after one month, LASEK was faster in refractive recovery and all these changes were not statistically significant. Durations of postoperative pain were 3.13±1.25 days for LASEK and 3.02±1.32 days for epi-LASIK. Pain scores (0~10 point scale), however, were also lower for LASEK by 0.33 point, 0.57 point, and 0.45 point for postoperative day 1, 2, and 3, respectively. No statistical significance was noted in either pain duration or pain score. When asked for overall satisfaction, six subjects preferred LASIK, four subjects preferred epi-LASIK, and five subjects showed no preference. Conclusions: Both LASEK and epi-LASIK are effective for surgical correction of myopia, and no significant difference in visual recovery, refractive change or degree of postoperative pain was noted in this study.`
착륙장치용 Structural Fuse 파손확률 계산 및 개선 방안
이승규(Seunggyu Lee),김태욱(Tae-Uk Kim),황인희(In-Hee Hwang),이정선(Jeong-Sun Lee),조정준(Jeong Jun Jo),박총영(Chong-Yeong Park) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.11
The reason for crashworthy landing gear is to contribute to the overall aircraft design goals in the event of a crash. One of crashworthy landing gear design approaches is inclusion of structural fuse. Structural fuse is used to control the mode of failure of landing gear. If structural fuse doesn’t work at desired condition, other unexpected accidents can occur. In this paper, failure probability is calculated for landing gear structural fuse and improvement measure is introduced to improve failure probability of structural fuse.
복강경 담낭절제술에 있어 내시경적 역행성 담췌관 조영술의 역활에 대한 임상적 고찰
이선영(Sun Young Yi),이성구(Sung Koo Lee),김명환(Myung Hwan Kim),민영일(Young Il Min),이승규(Sung Kyu Lee) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.3
N/A 'A'idespread enthusiasm for laparoscopic cholecystectomy(LC) has raised new and inter- esting questions for the endoscopic retrograde cholangiopancraetography(ERCP) manage- ment of duct sotnes. Few laparoscopic surgeons currently explore the bile duct at cholecystectomy, which has focused attention on the role ERCP in the diagnosis and treatment of duct stones. We assessed the use of ERCP before and after LC at our hos- pital. Indications for ERCP depend on the likehood of duct patho)ogy,'clinical, biochemical and radiologic predictive factors are established. Prediction of duct stones and indication for ERCP before LC were 3 groups,'historic factors(recent jandice, cholangitis, pancreati- tis) 25%(29/116), abnormality of liver function tests 45%(53/116), and bile duct size<as measured at ultrasonography) 37%(43/116) in this study. ERCP is highly efficient in the management of patients with symptoms after LC in order to exclude, diagnose, and treat complications such as retained stones, cystic duct leaks, and strictures. Overall, ERCP technique are used in about 12.2% patients before and after LC of this study. The fundamental question is whether t.he combination(LC and endoscopic duct ex- ploration) is a better option for the patients than old fasioned operative intervention. Each surgical and endoscopic team will need to develop and test algorithms in the hope of minimizing the risk of unfortunate scenarios.(Korean J Gastroenterol 1994; 26: 541 548)
마이크로어레이 자료분석에서 모수적 방법을 이용한 유전자군의 유의성 검정
이선호,이승규,이광현,Lee, Sun-Ho,Lee, Seung-Kyu,Lee, Kwang-Hyun 한국통계학회 2009 Communications for statistical applications and me Vol.16 No.3
마이크로어레이 기술은 수만 개 유전자의 발현 패턴을 동시에 관찰하는 것을 가능하게 하였고, 이들을 하나씩 검정하여 찾아낸 특이발현 현상을 보이는 유전자를 중심으로 질병의 진단, 치료법 정립과 신약 개발을 위한 기본 정보를 확립하였다. 그러나 개별 유전자분석의 여러 문제점이 발견되면서 유전자들을 생물학적 대사경로나 염색체 위치가 같은 것끼리 묶은 집단을 분석하여 질병의 발생이나 생존에 영향을 미치는 집단을 찾는 방법이 제시되었다. 이러한 유전자 집단의 유의성에 대한 연구는 2002년에 MIT에서 비롯되어 GSEA, SAM-GS와 중심극한 정리의 개념을 이용한 모수적 방법인 PAGE 등이 사용되고 있다. 본 논문에서는 이들 통계량의 구조적 한계를 극복하고 계산이 간단한 새로운 모수적 방법을 제안하고 자료 분석을 통하여 효율성을 보였다. The development of microarray technology makes possible to analyse many thousands of genes simultaneously. While it is important to test each gene whether it shows changes in expression associated with a phenotype, human diseases are thought to occur through the interactions of multiple genes within a same functional cafe-gory. Recent research interests aims to directly test the behavior of sets of functionally related genes, instead of focusing on single genes. Gene set enrichment analysis(GSEA), significance analysis of microarray to gene-set analysis(SAM-GS) and parametric analysis of gene set enrichment(PAGE) have been applied widely as a tool for gene-set analyses. We describe their problems and propose an alternative method using a parametric analysis by adopting normal score transformation of gene expression values. Performance of the newly derived method is compared with previous methods on three real microarray datasets.
이선영(Sun Young Yi),이성구(Sung Koo Lee),이승규(Sung Kyu Lee),민영일(Young Il Min),김명환(Myung Hwan Kim),한동수(Dong Soo Han),김정원(Jung Won Kim) 대한내과학회 1994 대한내과학회지 Vol.47 No.3
N/A Objectives: Gallstone disease is the most common biliary disease, of which prevalence, composition, and location has different dermographic charateristics. Because there was difference in composition of gallstone between Korea and other countries, percentage of symptomatic stone, symptom in relation to size, number of gallstone and lucency of gallstone will have some difference. We carried out this study to determine the prevalence of gallstone and symptoms in related size, number and lucency among general health screening people. Method: 4,395 cases who visited general health screening center of Asan medical center during 9 mothperiod from June, 1990 to March, 1991 were surveyed by abdominal ultrasound. Gallstone disease group, which is defined by gallstone positive in ultrasonogram and postcholecystectomy du to gallstone. The number of stone was devided into 3 groups (1, 2-3, 4<) and size of stone was devided into 3 groups (<1cm, 1cm<@<3cm, 3cm<). And lucency of stone was evaluated by simple scout X-ray. We assessed the sex and age related prevlence, size, number, and lucency of stone related to symptom. Result: We experienced 160 cases of gallstone disease in 4,395 cases examined (133 case of gallstone, 27 cases of postcholecystectomy), Total age adjusted prevalence is 3.43%. And sex-adjusted prevalence 3.70% (95% CI 3. 14-4.26) of female is significantly higher than 2.08% (95% CI 3.14-4.26) of male. The prevalence of gallstone disease increased along with the increasing age with a significant linear trend. Asymptomatic gallstone cases were 104 case (2.37%) and lucent stone was 52 cases (66. 6%) of 78 cases who was examined by oral GB study. The patients who had biliary symptom increased along with increasing number of stone with a significant linear trend (p=0.044). In contrast, the size of stone was not related to symptom (p=0.668). But there was significant relation between size and number of stone, so the statistic correction of size and number was done. And then, the relation of number and symptom was not significant correlation (p=0.071). Also the lucency of stone was not related with symptom (p=0.539). Conclusion: Age adjusted prevalence of gallstone disease in general health screening people is speculated as 3.34% and increased along with the increasing age. The number and size of stone, and the lucency had no significant relation with symptom.
이정선(Jeong Sun Lee),강신현(Shin Hyun Kang),장우철(Woo Chul Jang),이승규(Seung Gyu Lee),오성환(Seong Hwan Oh) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.4
착륙장치 접개 작동기는 항공기 이착륙 시 착륙장치를 항공기 동체 내로 접어 올리거나 동체 밖으로 펼쳐 내려주는 역할을 한다. 접개 작동기 내부에는 착륙장치 펼침 상태에서 외란에 의해 착륙장치가 접히게 되는 것을 방지하기 위한 별도의 잠금장치가 장착된다. 이 잠금장치는 작동기 내부에 공급되는 유압을 통해 작동기 내부 구성품과 기계적으로 구속됨으로써 작동기 잠금 기능을 수행하게 된다. 착륙장치 접힘/펼침에 따라 잠금장치의 잠김/풀림이 반복되므로, 잠금장치는 항공기 운용 중 반복되는 동일 하중을 받게 되며, 이로 인한 피로 파괴의 가능성이 존재하게 된다. 본 논문에서는 잠금장치에 대한 피로해석 과정 및 결과를 제시하고, 피로시험을 통해 그 결과의 타당성을 검증하였다. The retract actuator make the landing gear retract or extend during landing and take-off of aircraft. To prevent folding of landing gear at the extended state by unexpected external disturbance, the internal locking device is applied to the retract actuator. The locking device is restrained with another internal component by oil pressure supplied to the retract actuator and this restraint make the locking of actuator possible. Because locking and unlocking is repeated as retraction and extension of landing gear, the locking device take repeated identical loads and the possibility of fatigue failure exist. In this study, the process and result of fatigue analysis for the locking device was presented and the appropriateness of analysis result was verified by result of fatigue test.
이정선(Jeong Sun Lee),강신현(Shin Hyun Kang),장우철(Woo Chul Jang),이승규(Seung Gyu Lee),오성환(Seong Hwan Oh) 대한기계학회 2012 大韓機械學會論文集A Vol.36 No.1
착륙장치 접개 작동기는 항공기 이착륙 시 착륙장치를 항공기 동체 내로 접어 올리거나 동체 밖으로 펼쳐 내려주는 역할을 한다. 접개 작동기 내부에는 착륙장치 펼침 상태에서 외란에 의해 착륙장치가 접히게 되는 것을 방지하기 위한 별도의 잠금장치가 장착된다. 이 잠금장치는 작동기 내부에 공급되는 유압을 통해 작동기 내부 구성품과 기계적으로 구속됨으로써 작동기 잠금 기능을 수행하게 된다. 착륙장치 접힘/펼침에 따라 잠금장치의 잠김/풀림이 반복되므로, 잠금장치는 항공기 운용 중 반복되는 동일 하중을 받게 되며, 이로 인한 피로 파괴의 가능성이 존재하게 된다. 본 논문에서는 잠금장치에 대한 피로해석 과정 및 결과를 제시하고, 피로시험을 통해 그 결과의 타당성을 검증하였다. The retract actuator makes the landing gear retract or extend during take-off and landing of an aircraft. To prevent folding of landing gear that has remained in the extended state because of an unexpected external disturbance, an internal locking device is applied to the retract actuator. The locking device is restrained with another internal component by oil pressure supplied to the retract actuator, and this restraint makes the locking of the actuator possible. Because locking and unlocking are repeated during retraction and extension of the landing gear, the locking device takes repeated identical loads, and the possibility of fatigue failure exists. In this study, the process and results of fatigue analysis for the locking device are presented, and the appropriateness of the analysis result is verified using a fatigue test.