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Cordyceps scarabaeicola 의 약리활성
원소영,정현주,구혜진,소지현,박은희 숙명여자대학교 약학연구소 2004 약학논문집-숙명여자대학교 Vol.20 No.-
Dongchunghacho (Dong-Chong-Xia-Cho in Chinese), one of folk medicines, is traditionally believed to be effective against various diseases. It includes many different genera such as Cordyceps, Paecilomyces, Torrubiella and Podonectria. Cordyceps scarabaeicola is one of well-known species. The 70% ethanolic extracts were prepared from two different sources pf C. scarabaeicola, fresh fruiting bodies (FFB) and mycelial cultured cells (MCC). Anti-angiogenic activity was determined by the chick embryo chorioallantoic membrane assay. Both FFB and MCC were found to contain strong anti-angiogenic activities. The extracts at the dose of 10 μg showed anti-angiogenic activity comparable to that of retinoic acid (dose, 1 μg) used as a control agent. Anti-angiogenic activities of FFB and MCC appeared to be concentration-dependent. No significant differences were found between the effects of FFB and MCC. These results might support the plausible anti-tumor activity of C. scarabaeicola. FFB also contains strong analgesic activity.
류마티스관절염에서 DAS28에 근거한 보험급여기준 적용시 항 TNF제제 대상 환자 예측
원소영 ( Soyoung Won ),성윤경 ( Yoon-Kyoung Sung ),조수경 ( Soo-Kyung Cho ),최찬범 ( Chan-Bum Choi ),고은미 ( Eun-Mi Koh ),김성규 ( Seong-Kyu Kim ),김진석 ( Jinseok Kim ),김태환 ( Tae-Hwan Kim ),김현아 ( Hyoun Ah Kim ),나성수 ( Se 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.2
Objective. The purpose of this study is to examine the difference between the numbers of patients in rheumatoid arthritis (RA) who are eligible to TNF inhibitors by the past Korean National Health Insurance reimbursement guideline and by the disease activity score with 28-joint assessment (DAS28) based criteria. Methods. Data were obtained from a multi-center registry for biologics users in Korean RA patients, BIOlogics Pharmacoepidemiologic StudY (BIOPSY). DAS28 was calculated based on either ESR or CRP, and DAS28 of more than 5.1 or between 3.2 and 5.1 with radiographic changes was defined as a cut-off point for the initiation of TNF inhibitors. For the maintenance criteria, we used both of improving in DAS28 score (>1.2) and low disease activity (DAS 28<3.2). Differences between the numbers in each step by two criteria were described with Chi-square test and Kappa agreement. Results. Of the 489 patients in BIOPSY, 299 were included in this study. Among them, 278 patients (93.0%) were eligible of TNF inhibitors when we applied the new initiation criteria with DAS28-ESR, and 244 patients (81.6%) were indicated for TNF inhibitors with DAS28-CRP. For the maintenance criteria, a low disease activity (DAS28<3.2) in 3 months after starting TNF inhibitors is too strict for achieving (33.6% with DAS28-ESR and 50.0% with DAS28-CRP). Instead, decreasing DAS28 by more than 1.2 is more reasonable as a tool for deciding early responsiveness of TNF inhibitors in RA patients (81.2% both with DAS28-ESR and DAS28-CRP). Conclusion. Our results show that the candidates for TNF inhibitors will be enormously changed according to a change in the reimbursement criteria. To define appropriate patients to receive TNF inhibitors, a further study with regard to the impact of changes in the reimbursement criteria on the outcomes of RA patients will be required.
전국 중, 고등학교 흡연실태 설문조사의 조사-재조사 신뢰도 평가
지선하,윤지은,원소영,김수정,서일 한국역학회 2003 Epidemiology and Health Vol.25 No.1
Purpose : Since 1988, the annual or biannual survey was conducted by Korean Association of Smoking and Health (KASH) to examine the smoking rate, knowledge and attitude on smoking of students attending middle and high school in Korea. The objective of this study was to investigate the test-retest reliability of self-administered smoking questionnaire for Korean middle and high school students. Methods : For the test-retest study, we sampled 30 school among 106 schools which participated in annual survey on June of 2002. Among 30 schools, 26 schools (86.7%) were responded for this study. Results : 1) For the subjects of 1st and 2nd surveys, there were no difference on smoking related variable including attitude, knowledge, perceived health status, father's smoking status, friend's smoking status, willingness to smoke, and readiness to quit smoking 2) For middle school students among male, current smoking rates were 3.5% for 1st survey and 3.0% for 2nd survey, which was statistically no significant. For high school students, however, current smoking rate of 1st survey was higher (21.1%) than that of 2nd (18.2%), although the rate was not significantly differed. 3) For middle school students among female, current smoking rates were 1.1% for 1st survey and 3.3% for 2nd survey, which was statistically no significant. Corresponding rate for high school students were 9.8% and 11.4%, respectively. Conclusion : The results indicated that smoking questionnaire has been conducted by KASH is reliable for use in estimation for prevalence of smoking for middle and high school students.
항 Tumor Necrosis Factor 제제 사용 전 잠복결핵 진단 전략에 따른 결핵 발생률
성윤경 ( Yoon Kyoung Sung ),조수경 ( Soo Kyung Cho ),원소영 ( Soyoung Won ),최찬범 ( Chan Bum Choi ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),유대현 ( Dae Hyun Yoo ),배상철 ( Sang Cheol Bae ) 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.4
Objective. To compare the incidence of tuberculosis (TB) in rheumatoid arthritis (RA) patients using tumor necrosis factor (TNF) inhibitors following two strategies for latent tuberculosis infection (LTBI) screening: Tuberculin skin test (TST) only vs. TST plus Qauntiferron-TB gold in tube (QFT-GIT). Methods. Data was extracted from a retrospective cohort of Korean RA patients who used biologic agents. Of the 406 RA patients who underwent TST before starting TNF inhibitor, we selected 355 patients who strictly followed LTBI screening and treatment strategies. Two hundred and twenty-two patients were classified as TST only group and the remaining 133 patients as TST plus QFT-GIT group. We calculated the standardized incidence ratio of TB in the entire sample and compared the TB incidence between groups. Results. Among the patients who received the TST only strategy (n=222, 538.6 person-year [PY]), two patients developed TB during anti-TNF therapy, while of those who followed the TST plus QFT-GIT strategy, none developed TB (n=133, 108.8 PY). The overall crude incidence of TB in RA patients using TNF inhibitors was 314 per 100,000 PY. Compared with the general population, the overall age standardized incidence of TB in TNF inhibitor users who followed management guideline for LTBI was 3.9. Conclusion. Despite following screening and management guidelines for LTBI, TB incidence for RA patients during anti-TNF therapy is higher than in the general population. Combining QFT-GIT with TST as a screening for LTBI might be reduce the risk of TB. (J Rheum Dis 2015;22:223- 230)