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Glucagon-Like Peptide-1 Based Therapies: A New Horizon in Obesity Management
손장원,임수 대한내분비학회 2024 Endocrinology and metabolism Vol.39 No.2
Obesity is a significant risk factor for health issues like type 2 diabetes and cardiovascular disease. It often proves resistant to traditional lifestyle interventions, prompting a need for more precise therapeutic strategies. This has led to a focus on signaling pathways and neuroendocrine mechanisms to develop targeted obesity treatments. Recent developments in obesity management have been revolutionized by introducing novel glucagon-like peptide-1 (GLP-1) based drugs, such as semaglutide and tirzepatide. These drugs are part of an emerging class of nutrient-stimulated hormone-based therapeutics, acting as incretin mimetics to target G-protein–coupled receptors like GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon. These receptors are vital in regulating body fat and energy balance. The development of multiagonists, including GLP-1–glucagon and GIP–GLP-1–glucagon receptor agonists, especially with the potential for glucagon receptor activation, marks a significant advancement in the field. This review covers the development and clinical efficacy of various GLP-1-based therapeutics, exploring the challenges and future directions in obesity management.
손장원,차동원,Sohn, Jang-Won,Cha, Dong-Won 한국디지털건축·인테리어학회 2005 한국디지털건축인테리어학회 논문집 Vol.5 No.1
In the study results, Incheon region, a classic house was consistently built in spite of having been the barrier which a foreign dwelling flowed into until 1960's. And met me in our dwelling habit and changed and used a house built by the Japanese. That is, the traditional dwelling format worked with a spindle accepting other dwelling culture and can do it. It was a too social change and was able to confirm the fact that it extended a room as necessary or it improved a classic house and used as West back various way whom it got cold, and exchanged it to a kitchen of a cause and effect life.
손장원,박정란,Sohn, Jang-Won,Park, Jung-Lan 한국디지털건축·인테리어학회 2005 한국디지털건축인테리어학회 논문집 Vol.5 No.2
It extended in the opening after simultaneous strong point flag and to Incheon the building where the designer whom the many modem time building comes to build but becomes known was not many so. The research against these people did not become accomplished and not to be the back author research which analyzes the work propensity which is the possibility of doing the possibility of becoming accomplished there was not a basic of architectural design. The research which it sees it led and khu lu thu the road khey keyl the back the depths data, it confronted compared to it secured does not become known during that time the multi architect who and the plan office and and and it searched the result of the back which it puts out well it put to the architects who become known and.
손장원,장혁재,이진경,정희정,송란영,김영진,Saurabh Datta,허란,신상훈,조인정,심지영,홍그루,정남식 한국심초음파학회 2013 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.21 No.2
Background: Accurate assessment of mitral regurgitation (MR) severity is crucial for clinical decision-making and optimizing patient outcomes. Recent advances in real-time three dimensional (3D) echocardiography provide the option of real-time full volume color Doppler echocardiography (FVCD) measurements. This makes it practical to quantify MR by subtracting aortic stroke volume from the volume of mitral inflow in an automated manner. Methods: Thirty-two patients with more than a moderate degree of MR assessed by transthoracic echocardiography (TTE)were consecutively enrolled during this study. MR volume was measured by 1) two dimensional (2D) Doppler TTE, using the proximal isovelocity surface area (PISA) and the volumetric quantification methods (VM). Then, 2) real time 3D-FVCD was subsequently obtained, and dedicated software was used to quantify the MR volume. MR volume was also measured using 3)phase contrast cardiac magnetic resonance imaging (PC-CMR). In each patient, all these measurements were obtained within the same day. Automated MR quantification was feasible in 30 of 32 patients. Results: The mean regurgitant volume quantified by 2D-PISA, 2D-VM, 3D-FVCD, and PC-CMR was 72.1 ± 27.7, 79.9 ±36.9, 69.9 ± 31.5, and 64.2 ± 30.7 mL, respectively (p = 0.304). There was an excellent correlation between the MR volume measured by PC-CMR and 3D-FVCD (r = 0.85, 95% CI 0.70-0.93, p < 0.001). Compared with PC-CMR, Bland-Altman analysis for 3D-FVCD showed a good agreement (2 standard deviations: 34.3 mL) than did 2D-PISA or 2D-VM (60.0 and 62.8mL, respectively). Conclusion: Automated quantification of MR with 3D-FVCD is feasible and accurate. It is a promising tool for the real-time 3D echocardiographic assessment of patients with MR.