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주용진,최성문,최영자,성호석 ( Yoing Jin Joo,Sung Moon Choi,Young Ja Choi,Ho Suk Sung ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5
A Case of Ehlers-Danlos syndrome Yoing Jin Joo, M.D., Sung Moon Choi, M.D., Young Ja Choi*, M.D., Ho Suk Sung, M.D. Department of Dermatology, Clooego of Medicine, Inje University, Pusan, Korea We presented a case of Ehlers-Danlos syndrome in a 25-year old female, who had hyperextensibility of skin, skin fragility, cigarette paper-like atrophic scar, joint hyperextensibility and skeletal abnormality of scoliosis since birth. There was no family history. Microscopic and electron microscopic examinations of the skin biopsy specimens from normal appearing skin on the forearm and the site of subcutaneous nodule was compatible with finding of Ehlers-Danlos syndrome. Although the manifestations of this case including marked extensibility of skin, joint, skin fraility and atrophic scar might be in accord with type Ⅰ(gravis) Ehlers-Danlos syndrome, skeletal abnormality of scoliosis did not correspond to this type, but to type Ⅳ(hydroxylysine deficient) Ehlers-Danlos syndrome. We consider this case as a type Ⅳ Ehlers-Danlos syndrome.
농가진의 원인균주 , 항생제 감수성 검사 및 치료에 대한 연구
박성욱(Sung Wook Park),왕한영(Han Young Wang),성호석(Ho Suk Sung) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.3
Background : It is traditiqnally considered that the non-bullous fonn of impetigo is primarily of streptococcal origin and the bullous form is of staphylococcal origin. However, recent reports have shown that Staphylococcus aureus (SA) has become the predominant cauative pathogen of non-bullous impetigo as well as of bullous impetigo. Objective. Our purpose was to evaluate the predominant causativi. pathogen, and to establish a therapeutic guideline for impetigo. Method : We described the characteristics of lesions and gerformed bacterial culture and susceptibility tests in patients with impetigo. Patients were treatecl by one of three frequently used antibiotics(erythromycin, cefuroxime, fusidic acid). Results : Of 77 patients, there were 47 cases of crusted type(61.9%), 18 cases of mixed type with crusted and bullous lesiona(23.3%), 7 cases of mixed type with crusted and pustular lesions(9.1%) and 5 cases of bullous type(6.6%). SA was grown from 90.1% af the cases, in 83.1% of cases it was the only organism to be foind and no gowth of streptococcus was faund even in mixed infections. An antimicrobial susceptibility test of 63 strains of SA demonstrated high susceptibility to vancomycin(98.4%), cefuroxime(97.1%), oxacillin(96.4%), cephalothin(95.2%), fusidic acid(91.7%) etc, and high resistance to penicillin(93.7%), gentamicin(90.5%), tobramycin(88.9%) and erythromicin(80.9%). Of 19 patients treated with erythrornycin, 12(63.1% ) showed treatment failure at a weeks, while no treatment failure occured in groups treated with cefuroxime and usidic acid. There were statistically significant differences iri therapeutic effect between cefuroxirne and erythromycin(P=0.005 by two tailedy test), and betweer fusidic acid and erythromycin(P=0.0040. But there was no significant difference between cefuroxime and fusidic acid. Collclusion : The predominant pathogen of non-bullous impetigo a well as bullous impetigo was SA which were highly resistant to erythromycin and highly sensitive to efuroxime and fusidic acid. In the clinical response, cefuroxinie and fusidic acid treatment were most effective and erythromycin was inadequate for treatment of impetigo. (Kor J Dermatol 1993; 31(3); 312-319)
박성욱(Sung Uk Park),이승희(Seung Hee Lee),왕한영(Han Young Wang),성호석(Ho Suk Sung) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.2
We report a case of nevus sebaceus associated with sebaceous epithelioma and basal cell epithelioma in a 48-year-old male patient. A 2.6 x 2.0cm orange-yellow erosive tumor and 1.5 x 1.0cm, l.0 x 0.8cm dark blue-yellow varigated nodules were intimately associated with a 4 x 3cm sized yellowish verrucous plaque on the parieto-occipital area of the scalp. Biopsy revealed sebaccous epithelioma, basal cell epithelioma and nevus sebaceus, respectively. (Kor J Dermatoi 1992;30(2): 225-228)
박필성(Pill Sung Park),주용진(Yoing Jin Joo),최영자(Young Ja Choi),성호석(Ho Suk Sung) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.6
We report a case of histiocytic cytophagic panniculitis in a 5-year-old male. The patient has complained of multiple erythematous indurated palques with tenderness on the lower abdomen, periocular areas, left forearm and both thighs associated with high fever for 45 days. Hepatosplenomegaly and enlarged lymph nodes were found. Laboratory data revealed pancytopenia, elevation of liver enzymes and prolon gation of PT and PTT. Histopathologic findings of subcutaneous plaque taken from the left forenrm showed lobular panniculitis with fat necrosis and some phagocytic histiocytes containing erythrocytes, leukocytes, lymphocytes and nuclear debris, that had the appearance of bean bag. There found no atypical histiocytic infiltrations or cellular pleomorphism.
강효준,왕한영,성호석 ( Hyo Jun Kang,Han Young Wang,Ho Suk Sung ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.3
Background: Pityriasis versicolor(PV) is a superficial mycosis, theoretically unusual in children. Epidemiologic and clinical data for children with PV under 14 years were collected. Objective . The purpose of this study was to evaluate the clinical features of PV in the young. Method: We included all cases of PV in patients under 14 years of age observed in our department from 1981 to 1995. All cases were diagnosed on the basis of clinical criteria and were confirmed by microscopic examination. Results : From 1981 to 1995 we encountered 32 cases of PV in children, compared with 637 cases in adults; thus children represented 4.7% of all cases. The ratio of male to female was l. 7:1. Among the age groups, the incidence was the highest in the 10-14 years(43%). The monthly prevalence was the highest in August. Distribution of the lesions were the face(40.9%), neck (25%), chest(13.6%), back(11.3%), extremities(6.8%) and abdomen(2.2%). The incidence of hypopigmented lesions was 70.4% and that of hyperpigmented lesions was 29.6%. Conclusion : This study confirms that the face is a predilectionl site for PV in children and all facial lesions are hypopigmented. Other clinical features are variable and similar to those of adults. (Kor J .Dermatol 1997;35(3): 431-434)
이드보라 ( Deborah Lee ),김상현 ( Sang Hyun Kim ),홍순권 ( Soon Kwon Hong ),서종근 ( Jong Keun Seo ),성호석 ( Ho Suk Sung ),황선욱 ( Seon Wook Hwang ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.8
Lyme borreliosis is a multi-systemic tick-borne infectious disease caused by the spirochaete, Borrelia burgdorferi. It has many non-specific symptoms affecting the skin, eye, musculoskeletal system, cardiovascular system, and central and peripheral nervous system. Typical cutaneous manifestations of lyme borreliosis include erythema chronicum migrans, borrelia lymphocytoma appearing a few weeks after the tick bite, and acrodermatitis chronica atrophicans developing a few years after. The diagnosis is based on clinical findings with detection of specific Ig M and Ig G antibodies to Borrelia burgdorferi. A 50-year old woman presented with an erythematous to violaceous annular patch with central scaly hyperpigmented patch on the right arm and an erythematous indurated patch on the right thigh for a month. She did not recall a deer tick bite. She had severe arthralgia on the right shoulder and myalgia on the right thigh at the first visit. Three months later, she complained of chest pain, and mild dyspnea on exertions. Serologic examinations revealed increased levels of Ig M and Ig G antibodies to borrelial antigen via ELISA, and Western blot test for Borrelia burgdorferi was positive. Her general symptoms as well as skin lesions subsided with an antibiotics (Doxycycline) and steroid therapy over 4 weeks. (Korean J Dermatol 2008;46(8):1112~1116)
Cartilage Shaver로 치료한 다발성 모평활근종
서종근 ( Jong Keun Seo ),황성환 ( Sung Hwan Hwang ),강정난 ( Jeong Nan Kang ),홍순권 ( Soon Kwon Hong ),이드보라 ( Deborah Lee ),성호석 ( Ho Suk Sung ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.9
Piloleiomyoma is a benign neoplasm arising from the erector pili muscle in the skin. It occurs as linear or dermatomal arrangements of firm, red to brown intradermal nodules, which are fixed to the skin but not to the deeper tissues. Although various treatments have been attempted, they have shown limited success and several complications remain. A 21-year-old male presented with 3-year history of multiple, erythematous, firm 4 mm to 3 cm sized nodules on the chest, The histopathological examination was compatible with piloleiomyoma, The lesions were removed using the dermal shaving method with a suction-assisted cartilage shaver, Each lesion were markedly flattened. This treatment was quicker and caused less subjective pain to the patient compared with those of classic surgical excision. No signs of adverse events or recurrence have been observed.
김효진 ( Hyojin Kim ),박인호 ( In Ho Park ),강정난 ( Jeong Nan Kang ),설정은 ( Jung Eun Seol ),성호석 ( Ho Suk Sung ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.4
Erythrokeratodermia variabilis is an autosomal-dominant inherited disease associated with a mutation in gap junctionbeta (GJB) 3 and 4. It shows two characteristic features: migratory and irregularly shaped erythematous lesionsusually accompanied by a burning sensation and fixed, symmetrically located hyperkeratotic plaques. A 6-year-oldboy had developed erythematous scaly patches with a geographic pattern on the entire body at age 1, and thelesions had migrated with an irregular pattern. Accompanying hyperkeratotic plaque developed on the trunk and bothlegs when he was 4 years old. As he grew older, the erythematous patches progressively disappeared and thehyperkeratotic plaque dominantly remained. His family history was unidentifiable because he was adopted at birth. Pathologic findings showed hyperkeratosis and superficial perivascular inflammation. Based on the clinical andpathologic features, we diagnosed erythrokeratodermia variabilis in this patient. Herein, we report a case of erythrokeratodermiavariabilis showing gradual disappearance of erythema.