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이드보라 ( Deborah Lee ),서종근 ( Jong Keun Seo ),황성환 ( Sung Hwan Hwang ),강정난 ( Jung Nan Kang ),김효진 ( Hyo Jin Kim ),이영석 ( Young Seok Lee ),성호석 ( Ho Suk Sung ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.8
50세 남자환자가 왼손의 첫 번째와 두 번째 손가락 사이에 발생한 홍반성의 반을 주소로 내원하였다. 피부병변은 내원 1년 전에 작은 홍반성 반점으로 발생하여 서서히 크기가 증가한다고 하였고, 내원 당시에는 왼손의 첫 번째와 두 번째 손가락 사이의 손바닥 쪽으로 약 2×2 cm 크기의 홍반성 반으로 관찰되었다(Fig. 1). 병변은 개인의원에서 4개월 간 국소 스테로이드제 및 항진균제 연고 등으로 치료하였으나 병변은 호전을 보이지 않았으며 그 외 가족 력 및 과거력 상 특이사항 없었다. 병변 부위에서 시행한KOH 검사에서는 음성 소견을 보였다. 피부조직검사에서는 이상 각화증, 극세포증과 함께 각질형성세포의 이형성 및 유사분열 소견과 비정상적인 각질형성세포가 표피 전층에 걸쳐 불규칙하게 배열되는 양상이 관찰되어 보웬병(Bowen disease)에 합당한 소견을 보였다(Fig. 2). 추가로 시행한 인간유두종 바이러스(human papilloma virus) 일반 항원검사 및 중합효소연쇄반응(polymerase chain reaction)에서는 음성소견을 보였다. 환자는 병변을 수술적으로 제거 받은 후 현재까지 1년 동안 특별한 재발 없이 경과 관찰 중이다.일반적으로 보웬병은 신체 어느 부위에나 발생할 수 있으나 두경부나 하지와 같은 노출부에 주로 호발한다. 간찰부에 발생한 보웬병의 경우 임상적으로 홍반성 혹은 과색소성의 반이나 판의 형태로 나타나며 삼출물을 동반하기도 한다. 이러한 병변 발생시 다른 급성 습진성 피부질환과 혼동되기 쉬운데 이와 유사한 임상양상을 보일 수 있는 피부진균감염증, 접촉피부염 및 간찰진을 감별해야 한다. 또한 본 증례와 같이 비노출부에 보웬병이 발생한 경우에는 관련된 유발인자에 대한 자세한 병력청취 및 진단적 검사가 필요하다1. 간찰부에 발생한 보웬병의 정확한 병태 생리는 현재까지 밝혀져 있지 않으나 간찰부에 발생한 다른 질환의 예와 마찬가지로 마찰이나 국소온도 등의 인자가 관여할 것으로 저자들은 추측하고 있다.2 현재까지 손샅에 발생한 보웬병은 총 3예가 보고되어 있으나 국내에서는 아직까지 보고된 바 없다3-5. 2예는 본 증례와 마찬가지로 첫째, 둘째 손가락 사이에 발생하였고 비교적 경계가 명확한 판의 형태를 보였으며, 삼출물 등은 동반되지 않았다. 이 중 한 증례는 통증이 동반되었으며, 다른 한 증례는 건선과 비슷한 임상양상을 보여 국소 스테로이드제 및 광선치료 등으로 수년간 치료하였으나 호전을 보이지 않아 조직검사 후 진단되었다. 3예 중 나머지 1예는 둘째와 셋째 손가락 사이에 병변이 발생한 증례였다. 저자들은 손바닥쪽 간찰부에 습진성 병변의 양상으로 발생한 보웬병을 경험하고 흥미로운 증례로 생각하여 보고한다.
이드보라 ( Deborah Lee ),서종근 ( Jong Keun Seo ),이현재 ( Hyun Jae Lee ),강주현 ( Ju Hyum Kang ),성호석 ( Ho Suck Sung ),황선욱 ( Seon Wook Hwang ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.5
Allergic reaction to different fruits and vegetables has frequently been described, but an allergic reaction to mango fruit, including its sap, pericarp, stems and leaves, has rarely reported in the literature. Mango dermatitis, although not common, is the term for allergic contact dermatitis caused by mango. The Mango plant is found worldwide, and the plant shares chemical compounds that are similar to other substances of the Anacardiaceae plant. The substances uroshiol and cardol cause the allergic contact dermatitis. Any case of allergic contact dermatitis with eating mango fruit has not been reported in the Korean dermatologic literature. Here we report the first case of mango contact dermatitis in a 20-years-old female and this happened when she drank mango juice. (Korean J Dermatol 2009; 47(5):612~614)
지루각화증과 유사한 양상으로 대퇴부에 발생한 Pinkus 섬유상피종 1예
이드보라 ( Deborah Lee ),전지승 ( Ji Sung Chun ),설정은 ( Jung Eun Seol ),최준희 ( Joon Hee Choi ),서종근 ( Jong Keun Seo ),황선욱 ( Seon Wook Hwang ),성호석 ( Ho Suk Sung ) 大韓皮膚科學會 2010 大韓皮膚科學會誌 Vol.48 No.1
Fibroepithelioma of Pinkus (FEP) is an uncommon variant of basal cell carcinoma and this typically appears as single or multiple nodular lesions on the lower back of the elderly. We report here on a case of a 59-year-old woman who presented with an asymptomatic erythematous sessile plaque on the lateral side of her right thigh, and she`d had this lesion for 8 years. Histologic examination showed anastomosing strands of basaloid cells extending from the overlying epidermis into the dermis. The tumor cells with large, oval nuclei and relatively little cytoplasms were grouped in a palisade pattern at the periphery of the tumor mass. The tumor was completely excised with a clear resection margin. The patient showed no recurrence for 10 months. For an elderly patient with a long-standing nodule found anywhere on the body, performing a skin biopsy should be considered to exclude malignancy, including FEP. (Korean J Dermatol 2010;48(1):69∼71)
이드보라 ( Deborah Lee ),설정은 ( Jung Eun Seol ),이현재 ( Hyun Jae Lee ),심현수 ( Hyun Soo Sim ),성호석 ( Ho Suk Sung ),서종근 ( Jong Keun Seo ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.5
Seborrheic keratosis is a common benign epidermal tumor. Although the etiology of seborrheic keratosis is unknown, a genetic predisposition, sun exposure and viral infection are possible factors. It also can be associated with auto-inoculation or chronic stimuli by friction. We experienced two cases of seborrheic keratosis with continuous arrangement along the frictional areas of the inguinal skin. Because there were no triggering factors, including sun exposure or human papilloma virus infection, we thought repetitive frictions or auto-inoculation might be related to these cases. Herein, we report on two cases of seborrheic keratosis that developed along the frictional areas of the inguinal skin. (Korean J Dermatol 2010;48(5):442~444)
지속성 발진성 반상 모세혈관 확장증의 임상 및 병리조직학적 고찰
이드보라 ( Deborah Lee ),조경종 ( Kyung Jong Cho ),김정욱 ( Jung Wook Kim ),강미선 ( Mi Seon Kang ),성호석 ( Ho Suk Sung ),황선욱 ( Seon Wook Hwang ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.10
Background: Telangiectasia macularis eruptiva perstans (TMEP) is a rare form of cutaneous mastocytosis, and this is characterized by multiple brownish-red confluent macules and telangiectasia. Although several cases of TMEP have been reported in the Korean literature, no clinicopathological studies have yet been reported. Objective: This study was undertaken to document the clinical features of TMEP, to examine the histopathological features of TMEP and to quantify the number of perivascular mast cell by using the `mast cells per vessel unit` method (MPV). Methods: The medical records of 16 patients with TMEP and who were seen at our institution from 1999 through 2006 were retrieved. We retrospectively reviewed the medical records, clinical photographs and histopathology slides of these patients. Furthermore, we quantified the number of perivascular mast cells, using the MPV method, on the slides of the TMEP patients, and then we compared this to the number of perivascular mast cells in normal skin (n=10) and urticaria pigmentosa skin (UP, n=10) as controls. Results: The ratio of male to female was 13:3 and the mean age of onset was 36.31±12.34 years. The most commonly involved sites were both the trunk and upper extremities (62.5%). 5 patients (31.3%) showed constitutional symptoms. A microscopic examination demonstrated scant perivascular infiltrate with mast cells. The average number of mast cells less than 55μm of vessel diameter in the TMEP, normal skin and UP was 3.32, 1.17 and 5.89, respectively and the average number of mast cells that were more than 55μm in the TMEP, normal skin and UP was 7.00, 2.08 and 21.00, respectively and these values showed statistical differences (p<.0001). The MPV that was of less than 55μm of vessel diameter in the patients with associated cutaneous or systemic symptoms was greater that that of the patients without associated symptoms and these values showed statistical differences (p<.005). Conclusion: This study suggested that TMEP can be associated various constitutional and cutaneous symptoms. The MPV method can be an effective method for differentiating the histopathologic findings of TMEP from those of normal skin or UP. (Korean J Dermatol 2008;46(10):1303∼1308)
이드보라 ( Deborah Lee ),김상현 ( Sang Hyun Kim ),홍순권 ( Soon Kwon Hong ),서종근 ( Jong Keun Seo ),성호석 ( Ho Suk Sung ),황선욱 ( Seon Wook Hwang ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.8
Lyme borreliosis is a multi-systemic tick-borne infectious disease caused by the spirochaete, Borrelia burgdorferi. It has many non-specific symptoms affecting the skin, eye, musculoskeletal system, cardiovascular system, and central and peripheral nervous system. Typical cutaneous manifestations of lyme borreliosis include erythema chronicum migrans, borrelia lymphocytoma appearing a few weeks after the tick bite, and acrodermatitis chronica atrophicans developing a few years after. The diagnosis is based on clinical findings with detection of specific Ig M and Ig G antibodies to Borrelia burgdorferi. A 50-year old woman presented with an erythematous to violaceous annular patch with central scaly hyperpigmented patch on the right arm and an erythematous indurated patch on the right thigh for a month. She did not recall a deer tick bite. She had severe arthralgia on the right shoulder and myalgia on the right thigh at the first visit. Three months later, she complained of chest pain, and mild dyspnea on exertions. Serologic examinations revealed increased levels of Ig M and Ig G antibodies to borrelial antigen via ELISA, and Western blot test for Borrelia burgdorferi was positive. Her general symptoms as well as skin lesions subsided with an antibiotics (Doxycycline) and steroid therapy over 4 weeks. (Korean J Dermatol 2008;46(8):1112~1116)
Vesosomal drug delivery for controlled and sustained release of multiple components
Jingyeong Yun(윤진경),Deborah Lee(이드보라),Seoyoon Song(송서윤),Suheon Kim(김수헌),Mina Lee(이민아),Eunsu Kim(김은수),Sunhee Yoon(윤선희),Han-Ul Kim(김한울),Sejin Son(손세진),Hyun Suk Jung(정현석),Yun Suk Huh(허윤석),Tae-Joon Jeon(전태 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.11