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한국인 위암의 Ras 암유전자군 점돌연변이 빈도와 의의
국상표(Sang Pyo Kook),현진해(Jin Hae Hyun) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.2
N/A Background/Aims: In the carcinogenic process, several markers have been defined as an evidence of genetic damage. The ras gene fami]y is one of these markers. Point mutation of a certain area of ras gene may represent the specific target of certain carcinogen. To elucidate the mechanism of ras gene activation in gastric carcinogenesis, we conducted this study. The goal of this study was to detect the frequency of K-ras, and H-ras point mutation in Korean gastric carcinoma patients. Methods: Experimental specimens were taken by gastrofiberscopic biopsy from 29 gastric cancer patients and DNA was extracted from the specimen. Intact genomic DNA was extracted from 17 cases and PCR was done with each pair of primers for K-ras 12th and 13th codon, 61st codon, H-ras 12th and 13th codon, 61st codon. These PCR products were selectively hybridized with detecting probes of various mutation. Results: One point mutation was found at K-ras 12th, 13th codon where glycine was substituted by aspartic acid. No other mutation was found at K-ras 6ist, H-ras 12th, 13th and H-ras 61st codon. The patient who showed mutation at K-ras codon 12 was confirmed as moderately differentiated adenocarcinoma. Conclusions: Point mutation of ras gene might be related in gastric carcinoma of the Koreans. In near future, studies for detection of ras gene mutation need to be done in a larger scale in precancerous lesions, and early, advanced and metastatic gastric cancers according to cell differentiation. (Korean J Gastroenterol 1996; 28:151 - 163)
현진해(Jin Hai Hyun),유호상(Ho Sang Ryu),이현구(Hyun Koo Lee),이상우(Sang Woo Lee),국상표(Sang Pyo Kook) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A The authors had diagnosed and treated on various intraabdominal diseases with peritoneoscope on 349 patients who had been visited to the Department of Internal Medicine, Korea University Hospital from May 1977 to August 1983 and the results are as followings. 1) Peritoneoscopic examination were performed in following conditions to evaluate and treat the diagnostic procedures in 258 cases, assessment procedures in 83 cases, and therapeutic procedures in 8 cases. 2) In the diagnostic procedures, the final diagnosis after peritoneoscopy were hepatobiliary carcinoma in 58 cases, macronodular cirrhosis in 40 cases and chronic active hepatitis in 25 cases of hepatobiliary diseases, tuberculous peritonitis in 20 cases, macronodular cirrhosis in 3 cases and carcinoma peritonei in 3 cases of undetermined ascites, mesenteric cyst in 3 cases, and pancreatic pseudocyst in 2 cases and tuberculoma in 2 cases of undetermined intraabdominal mass. 3) In the assessment procedures, stomach cancer in 61 cases, pancreatic cancer in 14 cases, colon cancer in 6 cases, malignant lymphoma in 1 case, and carcinoid tumor in 1 case were examined. To predict metastasis of intraabdominal malignancy, stomach cancer in 28 cases, pancreatic cancer in 8 cases, colon cancer in 5 cases, malignant lymphoma in 1 case, and carcinoid tumor in 1 case were metastasized. 4) Therapeutic peritoneoscopy were performed in ventriculoperitoneal shunt in 7 cases and removal of rubber drain in peritoneal cavity in 1 case. 5) The complications in peritoneoscopic examination were subcutaneous emphysema in 7 cases, leakage of ascites in 5 cases, massive hemorrhage of biopsy site in 4 cases, colonic perforation in 1 case, trauma of mesenteric vessel in 1 case, and leakage of liver abscess in 1 case.
이상우,현진해,유호상,국상표 대한소화기내시경학회 1984 Clinical Endoscopy Vol.4 No.1
The duodenal lipoma is infrequent and few reports deseribed its endoscopic features, We recently encountered one case of duodenal lipoma which was large polypoid one in the descending portion of the duodenum. The patient had been suffred from epigastric dull pain and bloating sensatio for 5 months. We did endoscopic polypectomy of the lipoma successfully.