담즙정체성 간염의 임상적 양상

최선택,은종렬,임상우,김봉준,이헌주,구미진,최준혁 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: Cholestatic hepatitis is failure of bile to reach the duodenum with hepatocellular damage and no demonstrable obstruction of the major bile ducts. The prognosis is usually good with recovery in less than 4 weeks after withdrawal of the offending drug. However, a prolonged course lasting over 3 months is possible and, in rare cases, progression to ductopenia with development of a vanishing bile duct syndrome occurs. A differential diagnosis with other causes of Chronic liver disease is needed. Materials and Methods: From January 1991 through Jaunary 2000, 14 patients diagnosed as cholestatic hepatitis by liver biopsy were inclouded. The possible causative drug, clinical features, laboatory findings, and progression of cholestatic hepatitis were evaluated. The semiquantitative study of liver lesions was performed by two independent observers. Results: Causes of cholestatic hepatitis are 5 cases of oriental medicine, 3 cases of anti-tuberculosis medication, 1 case of ticlopidine and antibiotics and 4 cases of unknown causes. The clinical features of cholestatic hepatitis were jaundice, itching, urine color change, and general weakness. During 6 to 30 months, LFT of 5 patients showed prolonged elevation. Elevated total cholesterol ≥250 mg/dL in 6 patients, pheripheral blood eosinophilia in 5 patients, auto-antibody positive in 6 patients were observed respectively. The biopsies showed intralobular bilirubinostasis with a mixed portal inflammatory infiltration. Conclusion: In cholestatic hepatitis. durations of abnormal LFT are variable regardless of causative drugs. If cholestatic hepatitis progresses toward chronic course, viral hepatitis, primary biliary cirrhosis, and autoimmune hepatitis should be differentially diagnosed and sequential liver biopsies are needed.

정형외과 영역에서의 골 이식술의 유용성

윤택림,정재윤,문은선,송은규,서형연 全南大醫大 2000 전남의대학술지 Vol.36 No.2

소아 대퇴 근위부 골절의 치료결과

정성택,이근배,윤택림,문은선,송은규 全南大醫大 2001 전남의대학술지 Vol.37 No.1

제지폐수처리용 생물고분자응집제를 생산하는 Bacillus sp. K-111의 배양특성조사

권기석,손용호,최선택,정석관,송숙희,김동걸 7개 국립대학교 환경연구 논문집 공동발행 위원회 2002 환경연구논문집 Vol.2 No.1

Flocculant-producing microorganisms were screened from obtained strains in the laboratory using a pulp-wastewater treatment as the flocculating agent. K-111 strain that had high flocculating activity among them was selected and identified as Bacillus sp. K-111 16s rDNA sequencing. The favorable medium for the production of flocculant was glucose 1.5%, NH_4NO_3 0.2%, tryptone 0.01%, K_2HPO_4 0.08%, KH_2PO_4 0.06%, CaCO_3 0.03%, MgSO_4·7H_2O 0.005%, MnSO_4 0.005% in 1 liter of D.W. at initial pH 7.0. The optimum culture temperature and pH were 30℃ and pH 7.0, respectively. the flocculating activity was observed most highly after 36 to 48 hr of cultivation at the optimum conditions. the flocculating activity of produced biopolymer on optimum conditions was about 2.5-fold higher than that of screening medium.

Session C : Cell Biology : Transport , Growth , and Differentiation : Introduction of negative charges in the begining of mature portion can suppress the export - defective signal sequence mutation

Taek Sun Song,Chan Kyu Park 생화학분자생물학회(구 한국생화학분자생물학회) 1993 추계학술대회집 Vol.- No.-

Compensatory Mutations in the Development of Rifampicin Resistance in M. tuberculosis (초)

Taek Sun Song,Yu Mi Park,Jong Seok Lee,John Walker,Whitney Barnes,Serge Batalov,Richard Glynne,Isdore Chola Shamputa,Laura E. Via,Clifton E. Barry 대한결핵 및 호흡기학회 2010 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.110 No.-

40세 이상의 연령에서 시행한 전방 십자 인대 재건술의 결과

송은규,문은선,윤택림,김종석,--,손일진 대한슬관절학회 2003 대한슬관절학회지 Vol.15 No.1

목적 : 40세 이상의 연령에서 전방 십자 인대 재건술을 시행받은 환자의 결과를 얻고, 결과에 영향을 미치는 인자에 대해 알아보고자 하였다. 대상 및 방법 : 1988년 8월부터 2002년 1월까지 관절경적 전방 십자 인대 재건술을 시행받은 수술 당시 연령이 40세 이상이었던 60명 60예와 40세 이하에서 표본 추출한 58명 58예의 임상적 결과와 스포츠 복귀, Telos기기를 이용한 스트레스 방사선 촬영을 이용하여 비교 연구하였다. 결과 : Lysholm Knee Score는 40세 이상군에서 54.0점에서 92.9점으로 호전되었으며, 40세 이하군에서는 56.2점에서 92.2점으로 호전되었다. 40세 이상군에서 임상적 결과가 우수 51예(85%), 양호 9예(15%)로 모두 만족스러운 결과를 얻었으며, 40세 이하군에서 우수 47예(81.0%), 양호 11예(19.0%)로 모두 만족스러운 결과를 얻었다. 스포츠로의 복귀는 40세 이상의 군에서 36예(60%), 40세 이하의 군에서 48%(82.8%)의 복귀율을 보였다. 40세 이하에서는 술 전 10.7 ㎜에서 술 후 2.9 ㎜의 차이를 보였다. 연령, 성별, 수술 방법, 동반 질환 유무, 수상 전 스포츠 활동으로 복귀 정도와 임상적 결과와의 인과 관계는 통계학적으로 의의가 없었다(p>0.05). 결론 : 전방 십자 인대 손상의 치료에 있어서 연령이 수술적 치료를 방해하는 요인으로 되지 않으며, 40세 이상의 연령에서도 전방 십자 인대 재건술을 시행하여 만족할 만한 결과를 얻을 수 있을 것으로 사료된다. Purpose: The purpose of the current study was to examine treatment outcome after anterior cruciate ligament (ACL) reconstruction in patients older than 40 years of age and determine the factors affecting the outcome. Subjects & Materials : Clinical results obtained from 60 cases from 60 patients older than 40 years of age at the time of surgery and 58 cases from 58 patients younger than 40 years of age who underwent ACL reconstruction between August 1988 to January 2002, return to sports activity, and stress radiographs using Telos instrument were compared. Result : The Lysholm knee score was improved from the preoperative score of 54.0 points the postoperative score of 92.9 in patients older than 40 years of age. Clinical outcome was excellent in 51 cases (85%) and good in 9 cases (15%) in patients older than years 40 years of age and was excellent in 47 cases (81.0%) and good in 11 cases (19.0%) in patients younger than 40 years of age. The rate of returning to preperative sports activity was high in 36 cases (60%) in patients older than 40 years of age and 48 cases (82.8%) in patients younger than 40 years of age. According to Telos stress rsdiography, the preoperative difference of 11.2 ㎜ was decrease to the postoperative difference of 3.1 ㎜ in patients older than 40 years of age and the preoperative difference of 10.7 ㎜ was decreased to the postoperative dufference of 2.9 ㎜ in patients younger than 40 years of age. Clinical outcome did not show significant correlation with age, gender, surgery method, the presence of additional injury, and the rate of return to sports activity before receiving injury(p>0.05). Conclusion : Age was not a factor interesting with the outcome of surgery for ACL injury, and satisfactory outcome could be obtained with ACL reconstruction even in patients older than 40 years of age.

Application of a Cold ECAP to Magnesium Alloy (AZ31) by a Combination of Extrusion Process

Song, Jae Wan,Lim, Hee Taek,Han, Jeong Whan,Kim, Mok Soon,Hwang, Sun Keun Trans Tech Publications, Ltd. 2005 Materials science forum Vol.486 No.-

<P>It is well known that magnesium alloys have difficulties in room temperature formability because of their HCP structure. As a basic approach to enhance a cold formability, a new combination process including an extrusion followed by a cold equal channel angular pressing (ECAP) was attempted. ECAP die has an inner die corner angle of 135 degree, the fillet angle of 45 degree and thickness of 5mm. A finite element analysis with a three-dimensional thermo-coupled elasto-plastic model was also carried out to understand the change of stress and strain during ECAP. Experiments showed that the AZ31 alloy, which is extruded at a ratio of 20 and is heat-treated at 350°C, was successful in a cold ECAP. From the simulated results, it was found that the effective strain gradually decreased from the inner die side (0.533) to the outer die side. This was confirmed by the analytical analysis via von Mises criterion. Furthermore, it also matched well with the experiments, which showed a uniform shear deformation band. It was also interesting to note that compressive yield strength was drastically increased, which is caused by the occurrence of numerous twins spread across the materials during a cold ECAP.</P>

MOCVD of GaN Films on Si Substrates Using a New Single Precursor

Song, Seon-Mi,Lee, Sun-Sook,Yu, Seung-Ho,Chung, Taek-Mo,Kim, Chang-Gyoun,Lee, Soon-Bo,Kim, Yun-Soo Korean Chemical Society 2003 Bulletin of the Korean Chemical Society Vol.24 No.7

Hexagonal GaN (h-GaN) films have been grown on Si(111) substrates by metal organic chemical vapor deposition using the azidodiethylgallium methylamine adduct, Et₂Ga(N₃)·NH₂Me, as a new single precursor. Deposition was carried out in the substrate temperature range 385-650 °C. The GaN films obtained were stoichiometric and did not contain any appreciable amounts of carbon impurities. It was also found that the GaN films deposited on Si(111) had the [0001] preferred orientation. The photoluminescence spectrum of a GaN film showed a band edge emission peak characteristic of h-GaN at 378 nm.

Raynaud 증후군을 위한 Reserpine, Procaine 의 동맥주사와 성상교감신경절 차단

송선옥,최규택,전재규,정정길 대한통증학회 1988 The Korean Journal of Pain Vol.1 No.1

Efforts from many different approaches have been made to cure Raynaud's phenomenon, auch as a dorsal sympathectomy, topical injection of nitroglycerin, phentolamin and procaine, and oral or parentral administration of various drugs. However, there has been no successful management proven yet. In recent years, it was reported that intra-arterial administration in normal subjects as well as patients with Raynaud's syndrome has demonstrated a significant rise in blood flow to the hands. We used intermittent stellate ganglion blocks in conjunction with intra-arterial injections of reserpine and procaine in 10 patients suffering from finger necrosis. The stellate ganglion block was performed in a paratracheal approach by injection of 1% lidocaine purposely mixed with adrenaline followed by the adminiatration of reserpine 1 mg and procaine 50 mg through a butterfly needle inserted in the radial or brachial artery. The administration of reserpine and procaine was done only twice at intervals of 1 week because of the development of suspected arteriosclerosia. The stellate ganglion block was carried out once a week for about 3 months, then once a month as needed for 6 to 12 months. As the procedure was carried out and the necrotic tissue sloughed off, oozing appeared and new granulation tiseue was observed. 5 out of 10 patients were healed completely and the rest improved considerably but were not followed to the end, We concluded that the intra-arterial administration of reserpine and procaine helped initiate and accelerate increasing blood flow to the hand and the stellate ganglion block continued to help revascularixation by dilating the peripheral beds.