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Objective: The purpose of the study was to evaluate the sensitivity and specificity of the TruScreen in the diagnosis of cervical intraepithelial neoplasia (CIN) and the benefit of an adjunct test to cervical cytology screening. Methods: Data were collected prospectively on 249 women who had undergone a loop electrosurgical excision procedure (LEEP) or hysterectomy at Kangnam St. Mary`s Hospital of Catholic University between March and December 2008. The TruScreen was performed on 249 patients and the sensitivity and specificity were determined. The accuracy of TruScreen and cervical cytology were also ascertained. Results: A remarkable improvement in the accuracy of the combined test for CIN 1 (sensitivity, 96.8%) and CIN2/3 (sensitivity, 92.4%) was noted. The sensitivity of TruScreen for CIN1 and CIN2/3 was 75.8% and 77.3%, respectively. The specificity of TruScreen for normal tissue was 85.1%. Conclusion: The present study suggests that the TruScreen is an excellent device as an adjunctive test for the detection of CIN. The instantaneous result of TruScreen in women with ASCUS or LSIL can provide rapid and reliable information.
Purpose: The aim of this study was to identify genegeneand gene-environmental factor on cervical carcinogenesisin Korean women.Materials and Methods: We evaluated 185 womenpatients who had cervical cancer with 345 normal controlhealthy women. The single nucleotide polymorphisms(SNPs) of the p53 codon 72, the p21 codon 31 and theIRF-1 intron 6 were evaluated from extracted DNA ofperipheral blood with an automatic DNA sequencer. Thedifference of each SNP, gene-gene and gene-environmentalinteraction between normal controls and patients,were evaluated in an adjusted environmental background.Results: With regard to environmental factors, thecervical cancer increased in the women with a lower levelof education, a younger age at first sexual intercourseand with the increased number of children borne. Thewomen who had p53 (Arg/Arg), IRF-1 (T/T) and an educationof less than 6 years showed a 14.7 fold increasedrisk of cervical cancer than those women who had p53(~Pro), IRF-1 (~C) and an education of more than 15years. The women who had p53 (Arg/Arg), p21 (Ser/Ser)and more than 3 children showed a 6.4 fold increased riskof cervical cancer than those women who had p53 (~Pro),p21 (~Arg) and had borne no child. The women who hadp53 (Arg/Arg), IRF-1 (T/T) and had experience of firstsexual intercourse before the age of 22-years showed a5.5 fold increased risk of cervical cancer than thosewomen who had p53 (~Pro), IRF-1 (~C) and hadexperience of first sexual intercourse after the age of26-years.Conclusion: We found that the level of education, theage at first intercourse, and the number of children borne,were independent risk factors in cervical carcinogenesis.The specific combination of p53, p21 and IRF-1 gene-geneand gene-environmental interactions were significantlynoted in the cervical carcinogenesis of Korean women.(Cancer Res Treat. 2002;34:357-364)
Natural killer cell-mediated cytotoxicity(NKMC), total, helper and suppressor T-cells were measured before and 4 weeks after treatment with 0.5-3.0 KE of OK-432 in the patients with trophoblastic disease which were divided into 2 subgroups of low risk (n=10) and high risk (n=11), and compared with those in normal control group (n=9). In the group of low risk trophoblastic disease no change was noted in any of all parameters after treatment. However, in the group of high risk trophoblastic disease, NKMC as well as total and helper T-cells before treatment were significantly lower while suppressor T-cells were higher than those in normal control. And all above data before treatment were definitely reversed after treatment except NKMC that remained unchanged. Considering above results OK-432 may play an important role in host defense mechanism through lymphokine or humoral immune response by increasing the ratio of helper to suppressor T-cells rather than increasing NKMC.
Trichomonas Vaginalis, first described by Donne, 1836, for many years has been associated with lesions of the female genital tract.
To detect the point mutation of c-k-ras in ovarian cancer, GGT of codon 12 was replaced by GAT, AGT, TGT and GTT, then we performed polymerase chain reaction and agarose gel electrophoresis and confirmed it using Southern blot hybrization with digoxygenin detection system. The frequency of c-k-ras point mutation was compared with the clinico-pathological characteristics of 37 ovarian cancer patients. The incidences of four-typed point mutations of K-ras oncogene in 37 ovarian cancers were 35.1%(13/37) and distribution were 32.4%(12/37), 2.7%(1/37), 0%(O/37) and 0%(O/37) in GGT to GAT, GGT to AGT, GGT to TGT, and GGT to GTT, respectively. The incidence of K-ras point mutations on codon 12 among 37 patients with ovarian cancer according to histological type was 35.5%(8/22) with serous cystadenocarcinomns, 28.6%(2/7) with mucinous cystadenocarcinomas. Comparing the positive rate of K-ras point mutations on code 12 among 37 patients with ovarian cancer in different clinical stages, point mutation was detected in 14.3%(1/7) with stage Ⅰ, 28.6%(2/7) with stage Ⅱ, and 43.5%(10/23) with stage Ⅲ/Ⅳ and there was statistically significant increasement of point mutations of K-ras oncogene with advance of the clinical stage of ovarian cancer (P<0.05). The incidence of K-ras point mutntions on codon 12 among 33 patients with ovarian cancer who were performed pelvic lymph node dissection was 52.4%(l1/21) of the patients with positive pelvic lymph node metastases and 16.7%(2/12) of the patients without pelvic lymph node metastasis and the difference was statistically significant (P<0.05). The activation of ras oncogene seems to be a major implication of the multistep process of ovarian carcinogenesis and tumor progression. Furthermore, the point mutation of c-K-ras gene could occur more frequently in the patients of ovarian cancer in far advance stage, and the those with pelvic lymph node metastases than in those without pelvic lymph node metastases, suggesting the role in tumor invasion and metastases.
오은경 ( Eun Kyung Oh ), ( Yong Seok Lee ), ( Keun Ho Lee ), ( Duck Yeong Ro ), ( Su Mi Bae ), ( Sun Young Kwak ), ( Sung Jae Shin ), ( Byung Don Han ), ( Joon Mo Lee ), ( Sung Eun Namkoong ), ( Woong Shick Ahn ) 대한산부인과학회 2006 대한산부인과학회 학술대회 Vol.92 No.-