한국인 폐확산능 정상예측식의 임상적 유용성과 정확성

나승원 ( Seung Won Ra ),박태선 ( Tai Sun Park ),홍윤기 ( Yoon Ki Hong ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2

연구배경: 폐확산능을 해석하는 데 필요한 정상예측식으로는 한국인을 대상으로 하여 박 등이 개발한 식(박 식)이 있으나 아직 외국 정상예측식을 많이 사용하고 있다. 이에 국내에서 많이 사용하는 외국 정상예측식인 Burrows 식과 박 식의 임상적 유용성과 정확성을 비교하고자 하였다. 방법: 1. 임상적 유용성 연구; 2006년 7월부터 12월까지 6개월간 폐확산능검사를 시행한 환자 중 두 식을 각각 정상예측식으로 적용하였을 때 폐확산능 해석이 다른 276명(대상군 A)을 대상으로 하였다. 대상군 A에게 두 식을 각각 적용하였을 때 폐확산능 해석과 임상적 판단과의 일치도를 비교하여 임상적 유용성을 평가하였다. 2. 간질성폐질환 진단의 정확성 비교; 2001년부터 2006년까지 폐조직검사를 시행하여 확진된 간질성폐질환군과 서울아산병원에서 모집한 정상군을 대상으로 하여 정상예측식으로 두 식을 각각 적용하였을 때 폐확산능 해석의 정확도를 비교하였고, 두 식이 차이가 나는지 맥니머의 카이스퀘어 검정을 하였다. 결과: 1. 임상적 판단과의 일치도 비교; 276명을 임상정보를 토대로 폐확산능을 예측하여 분류한 결과 정상 54명, 감소 220명, 불분명이 2명이었다. 예측식으로 박 식과 Burrows 식을 적용하였을 때 임상적 판단과 일치하는 환자는 각각 78%와 22%이었다(p<0.001). 2. 간질성폐질환 진단의 정확성 비교; 박 식은 민감도 90.1%, 특이도 100%이었고 Burrows 식은 민감도 64.2%, 특이도 100%로 민감도가 통계학적으로 유의하게 박 식이 높았다(p<0.001). 결론: 우리나라 정상예측식인 박 식이 외국 정상예측식인 Burrows 식을 정상예측식으로 적용하는 것보다 임상적 유용성이나 간질성폐질환 진단의 민감도에서 더 우월하였다. 향후 폐확산능검사의 정상예측식으로 박 식을 사용해야 할 것으로 사료된다. Background: Park et al. developed the Korean reference equation for the measurement of diffusing capacity in 1985. However, the equation has not been widely used in Korea and foreign reference equations have been popularly used. We intended to compare the clinical usefulness and the accuracy of the the Korean reference equation (Park`s equation) with that of the foreign equation (Burrows` equation) that is commonly used in Korea. Methods: 1. Evaluation of clinical usefulness; Among 1,584 patients who underwent diffusing capacity (DLCO) at the Asan Medical Center from July to December 2006, group A subjects included 276 patients who had different interpretations of DLCO in trials employing Burrows` equation and Park`s equation. Clinical assessment was decided by consensus of two respiratory physicians. In order to evaluate the clinical usefulness of Burrows` equation and Park`s equation, agreement of clinical assessment and DLCO interpretation were measured. 2. Evaluation of accuracy; Group B subjects were 81 patients with interstitial lung disease (ILD) and 39 normal subjects. The 81 ILD patients were diagnosed following a surgical lung biopsy. The accuracy of diagnosing ILD as well as sensitivity and specificity were evaluated according to the use of the reference equations (Burrows` equation and Park`s equation) for DLCO. Results: Agreement between clinical assessment and interpretation of DLCO was 22% for the use of Burrows` equation and 78% for the use of Park`s equation. The sensitivity and specificity of the Burrows` equation for diagnosing ILD were 64.2% and 100%. The sensitivity and specificity of the Park`s equation for diagnosing ILD were 90.1% and 100%. The sensitivity of the Park`s equation for diagnosing ILD was significantly higher than that of Burrows` equation (p<0.001). Conclusion: The Korean reference equation (Park`s equation) was more clinically useful and had higher sensitivity for diagnosing ILD than the foreign reference equation (Burrows` equation). (Tuberc Respir Dis 2008;64:80-86)

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

炭素纖維補强 매트릭스 複合體(CFRC)의 物理的 特性(Ⅰ)

박승범,권순욱 忠南大學校 産業技術硏究所 1988 산업기술연구논문집 Vol.3 No.2

In order to examine the physical properties of carbon fiber reinforced composites with the short random carbon fibers, experimental studies of fresh and hardened CFRC were carried out, The types of fiber used are pitch-based carbon fiber and high modulus PAN type carbon fiber. To examine the effects of the types, lengths, constents of CF and matrices, the following two types of CFRC were tested ; air cured CFRC and autoclaved CFRC. According to the test results, it can be concluded that the reinforcement of CF were considerably effective in improving tensile strength, flexural strength and toughness of cement matrices compared to conventional cement mortar.

鐵筋 콘크리트 "L" joint의 耐震應答 特性에 關한 硏究

朴承範 충남대학교 공업교육연구소 1981 論文集 Vol.4 No.2

最近 地震荷重 및 이와 類似한 震動荷重에 對한 鐵筋콘크리트 部材의 安全한 設計施工問題가 대두되어 이에 關한 여러 硏究가 進行되고 있으며, 보나 거어더가 柱, 壁體 등과 상호교차되는 個所의 脆性硏究 및 破壞問題에 對한 對策이 切實히 要望되고 있다. 이에 本 硏究에서는 鐵筋콘크리트 보와 柱로 이루어지는 "L"形 鐵筋콘크리트 joint部材의 模擬地震荷重 條件下에서의 動的 應答特性을 究明하고자 反復荷重에 따른 joint區域과 보 및 기둥의 破壞性狀을 考察하였다. 特히 耐震構造物 설계에 主要 要素인 延性(μ)이 0.5, 1.0, 3.0일 때 각각 3回씩 그리고 μ=5.0일 때 部材가 完全히 파괴될 때까지 반복하여 荷重을 作用시키면서 이 때의 部材의 極限强度 및 그 變形性能을 LVDT System을 사용하여 調査分析하였으며, 균열性狀은 勿論 配筋效果에 對하여도 이를 究明하고자 努力하였다. 本 硏究 結果 무엇보다도 部材의 伸縮彎曲, 剪斷變形 等의 變形性能의 改善 및 보의 휨破壞에 對한 補强, 그리고 joint 區域의 剪斷補强은 耐震構造物 設計를 爲하여 重要 事項임을 확인하였다.

외부 프리스트레스 도입에 의한 노후된 콘크리트 거더교의 보강성능평가

박승범,홍석주,이봉춘,장석호,권혁준 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

One of the promising methods to enhance the flexural strength of a externally prestressed girder is to place the tendons with large eccentricities. The analysis and design of composite girders prestressed by external tendons involve difficulties related mainly to the position of anchorages and the construction sequences. This study was conducted on the concrete bridges reinforced by the continuous girders and the external prestressing. The test results in this study showed that the external prestressing of a composite girder increased the range of the elastic behavior, reduced deflections, increased ultimate strength, and added to the redundancy by providing the multiple stress paths.

流動化 콘크리트의 物理的 特性에 關한 基礎的 硏究

朴承範,玄錫訓 忠南大學校 産業技術硏究所 1986 산업기술연구논문집 Vol.1 No.1

Superplasticizers(Melamine sulphonate, Naphthalene sulphonate) has been used to aid the placement of high quality, high strength concrete in other country. The purpose of this study was to examine the effect of superplasticizers in the manufacture of high quality concrete(especially durability). This paper describes the results of hydration, X-ray diffraction of cement paste and setting time, strength, drying shrinkage, freeze-thaw resistance of concretes by the use of admixtures(Melamine sulphonate, Naphthalene sulphonate, Lignosulphonate). As a result, superplasticizers(Naphthalene sulphonate, Melamine sulphonate) can be used at high dosage levels than Lignosulphonate without the problems of concrete.

CFRP 적층복합판의 충격 손상 예측 : PartⅡ: 실험 PartⅡ: Experiment

박승범,김문생 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.52 No.-

본 논문에서는 충격하중에 의하여 적층복합재의 내부에 발생하는 충격 손상의 발생과 진전에 대하여 연구하였다. 이를 위하여 강구에 의하여 횡방향 충격을 받는 CFRP 복합재료에 대하여 충격실험을 행하여, 초음파 탐조영상장치로 충격손상을 관찰하였다. 개발한 충격손상 유한해석에 의하여 예측된 결과와 비교 검토하였다. 충격에 의하여 발생하는 손상중 가장 큰 손상의 형태는 층간분리 손상으로서 충격이 계속 진행됨에 따라 경계면을 따라 진전되며, 길이방향은 경계면에 인접한 아래 단층의 섬유방향을 향한다. 충격을 가하는 외부 물체의 충격속도가 증가함에 따라 층간분리의 길이와 폭은 거의 선형적으로 증가하였다. 그리고 횡방향의 폭의 증가율 보다 종��향의 길이의 증가율이 더 크게 나타났으며, 층간분리의 진전은 주로 종방향인 길이방향으로 진행되었다. An investigation was performed to study the initiation and propagation of impact damages in laminated composites subjected to transversely impact of steel ball. For this purpose, transversely impact experiments for CFRP laminated composite plates were conducted, and impact damages were observed using the ultrasonic image scan system. As a results, interface delamination was a major impact damage mode and the longitudinal direction of the dilamination paralled to the fiber direction of the bottom layer below the interface. A linear relationship holds between impact velocity and the longiudinal length and transverse width of delmaination, and the ratio of growth in the longitudinal direction is high than in the transverse direction.

특성 길이를 이용한 평직 복합재 볼트 체결부의 강도 예측

박승범,변준형,안국찬 한국안전학회 2003 한국안전학회지 Vol.18 No.4

A study on predicting the joint strength of mechanically fastened woven glass/epoxy composite has been performed. An experimental and numerical study were carried out to determine the characteristic length and joint strength of composite joint. The characteristic lengths for tension and compression were determined from the tensile and compressive test with a hole respectively. The characteristic lengths were evaluated by applying the point stress failure criterion to a specimen containing a hole at the center subjected to tensile loading and a specimen containing a half circular notch at the center subjected to compressive load. The joint strength was evaluated by the Tsai-Wu and Yamada-Sun failure criterion on the characteristic curve. The predicted results of the joint strength were compared with experimental results.

유리纖維 補强 콘크리트 流動 特性에 관한 硏究

朴承範,任昌悳,尹義植 忠南大學校 産業技術硏究所 1989 산업기술연구논문집 Vol.4 No.1

Concrete is an excellent structural material, but it has many problems due to brittle behavior, weak resistance in tension, flexibility and toughness. In order to improve these problems, usually fiber reinforced concrete is used. But in the case of GFRC insufficient workability is caused by using glass fiber and there is lack of studying on it. This report of the following concrete of GFRC was experimented by the different W/C, S/A, glass fiber contents and maximum size of Aggregates. The results of this study is as follows; 1) Optimum S/A ratio is 0.6 at the glass fiber contents of from 0.25% to 0.75% in GFRC, but it cannot be obtained optimum S/A ratio at over 0.75. 2) Even though increasing the W/C ratio, we can get more slump, but slump is much more influenced by fiber contents in GFRC rather than increasing the W/C ratio. 3) Workability of GFRC is much more influenced by fiber contents than fiber length. 4) Workability of GFRC is a little improved by the bigger maximum size of aggregates.