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The relationship between maternal obesity in pre-pregnancy and preterm birth in Korean women
( Ayoung Song ),( Sung-eun Kim ),( Jae-young Sim ),( Eun-jin No ),( Ho Yeon Kim ),( Geum Joon Cho ),( Ki Hoon Ahn ),( Soon-cheol Hong ),( Hai-joong Kim ),( Min-jeong Oh ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: The prevalence of obesity and preterm birth steadily increased in Korea and obesity in early pregnancy has been known to be associated with maternal and perinatal complications. The aim of this study was to evaluate the effect of maternal pre-pregnancy obesity on the risk of preterm birth in Korean women. Methods: Primiparas who delivered a singleton between January 1, 2007 and December 31, 2015 and underwent a National Health Screening Examination within 1 year of pregnancy were eligible. The data of preterm birth was obtained by merging the data of the National Health Screening Program for Infants and Children database. Maternal obesity was defined as BMI ≥25kg/m2. Results: Among 237,062 women who delivered during the study period, 16,249 (6.85 %) women were obese. In the multivariable analysis, Women with obesity had an increased risk of preterm birth (<37 weeks of gestation) (OR, 1.14; 95% CI, 1.04, 1.23) compared with those without obesity. Women with obesity also had an increased risk of early preterm birth (<34 weeks of gestation) (OR, 1.44; 95% CI, 1.24, 1.69). Conclusion: Our study sustained actual relations between obesity in pre-pregnancy and the risk of preterm birth in Korea. Public health plan regarding obesity in prenatal counseling is needed to attend to optimal body weight gain before conception to mitigate the risk of poor perinatal outcomes.
Atf3 induction is a therapeutic target for obesity and metabolic diseases
Kim, Suji,Song, No-Joon,Bahn, Gahee,Chang, Seo-Hyuk,Yun, Ui Jeong,Ku, Jin-Mo,Jo, Dong-Gyu,Park, Kye Won Elsevier 2018 Biochemical and biophysical research communication Vol.504 No.4
<P><B>Abstract</B></P> <P>Activating transcription factor 3 (<I>Atf3</I>) has been previously demonstrated to impact obesity and metabolism. However, a metabolic role of Atf3 in mice remains debatable. We investigated the role of Atf3 in mice and further investigated Atf3 expression as a therapeutic target for obesity and metabolic diseases. Atf3 knockout (KO) mice fed with a high fat diet (HFD) aggravated weight gain and impaired glucose metabolism compared to littermate control wild type (WT) mice. Atf3 KO aged mice fed with a chow diet (CD) for longer than 10 months also displayed increased body weight and fat mass compared to WT aged mice. We also assessed requirements of Atf3 in a phytochemical mediated anti-obese effect. Effect of sulfuretin, a previously known phytochemical Atf3 inducer, in counteracting weight gain and improving glucose tolerance was almost completely abolished in the absence of Atf3, indicating that Atf3 induction can be a molecular target for preventing obesity and metabolic diseases. We further identified other Atf3 small molecule inducers that exhibit inhibitory effects on lipid accumulation in adipocytes. These data highlight the role of Atf3 in obesity and further suggest the use of chemical Atf3 inducers for prevention of obesity and metabolic diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Atf3 knockout mice increases body weight and impaired glucose tolerance in high fat diet fed mice. </LI> <LI> Atf3 knockout mice increases body weight in chow diet fed aged mice. </LI> <LI> Sulfuretin, a phytochemical Atf3 iducer, requires Atf3 expression to prevent obesity. </LI> </UL> </P>
( Yeon A No ),( Yonghee Lee ),( Yi Seop Song ),( Jaehyun Shim ),( Sun Young Choi ),( Kwang Ho Yoo ),( Hee Su Kim ),( Beom Joon Kim ),( Seong Jun Seo ),( Chang Kwon Hong ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Light-emitting diodes (LED) are considered to be effective in hair growth, skin rejuvenation and wound healing Objectives: We studied the effect of LED irradiation using 630 nm, 830 nm and combination of the two wavelengths on hair growth promotion in vitro and in vivo. Methods: In in vitro study, we investigated cell proliferation in human hair dermal papilla cells (hDPCs) by MTT assay and measured the expression levels of apoptosis, cell cycle-related factors and canonical signaling-related factors such as β-catenin, GSK-3β by Western blot analysis. In in vivo study, anagen induction by LED was evaluated using C57BL/6 mice model. Results: We performed three types of combined irradiation method: 1) 830 nm irradiation after 630 nm irradiation. 2) 630 nm irradiation after 830 nm irradiation. 3) Simultaneous- irradiation of 630 nm and 830 nm. Among combined irradiation types the 830 nm irradiation after 630 nm irradiation was most effective for hDPC proliferation. According to this result, when we irradiate 630 nm, 830 nm and 630 nm irradiation after 830 nm irradiation on hDPCs, 830 nm irradiation was most effective for increasing proliferation of hDPCs. In C57BL/6 mice model, irradiation of 830 nm was also most effective for anagen induction. Conclusion: Our results demonstrate the effect of 830 nm irradiation for anagen induction through apoptosis, cell cycle and canonical signaling pathways in hDPCs and C57BL/6 mice model.
Son, Kyung-No,Song, In-sung,Shin, Yong-Hyun,Pai, Tong-Kun,Chung, Dae-Kyun,Baek, Nam-In,Lee, Jung Joon,Kim, Jiyoung Korean Society for Molecular Biology 2005 Molecules and cells Vol.20 No.1
<P>Mannasantin B, a dilignan structurally related to manssantin A, is an inhibitor of NF-kappaB transactivation. In the present study, we found that it inhibited PMA-induced expression of IL-1beta, IL-1beta mRNA, and IL-1beta promoter activity in U937 cells with IC50 values of about 50 nM. It also inhibited NF-IL6- and NF-kappaB-induced activation of IL-1beta, with IC50 values of 78 nM and 1.6 microM, respectively, revealing a potent inhibitory effect on NF-IL6. Electrophoretic mobility shift assays showed that manassantin B had an inhibitory effect on DNA binding by NF-IL6, but not by NF-kappaB. Further analysis revealed that transactivation by NF-IL6 was also inhibited. Our results indicate that manassantin B suppresses expression of IL-1beta in promonocytic cells by inhibiting not only NF-kappaB but also NF-IL6 activity. Furthermore, our observations suggest that manassantin B may be clinically useful as a potent inhibitor of NF-IL6 activity.</P>