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Kyou Hoon Han,Cheorl Ho Kim,Dong Ho Choung,Kyu Hwan Park,Dae Sil Lee 생화학분자생물학회 1993 BMB Reports Vol.26 No.5
In order to determine the composition of a tetrasaccharide obtained from glycosylated barley β-amylase isozyme we applied two-dimensional (2-D) nmr (nuclear magnetic resonance) techniques. COSY (COrrelated SpectroscopY) and TOCSY (TOtally Correlated SpectroscopY) pulse sequences enabled us to achieve an unambiguous assignment of four monosaccharide units by allowing us to follow the shift-correlation map in each monomeric ring. After careful comparison to proton chemical shifts as well as the resonance patterns in literature we have found that there are α-D-G1cNAc, β-D-G1cNAc, α-D-Man and β-D-Man in the tetrasaccharide.
Kyou Hoon Han,Seung Moak Kim,Dong Ho Choung,Kyu Hwan Park,Tae Sung Moon,Dong Yeon Chae,Soo Kyung Kim,Hyun Jun Yoo 생화학분자생물학회 1994 BMB Reports Vol.27 No.4
A combination of the nuclear magnetic resonance (NMR) technique and the molecular modelling method has been successfully applied to determine high resolution solution conformations of a 17-residue oligopeptide LQARILAVERYLKDQQL (583-599) of gp41 from human immunodeficiency virus type I (HIV1), and its mutant with Ala→Thr at position 589. Vamous two-dimensional NMR methods such as NOESY (two-dimensional NOE SpectroscopY), ROESY (two-dimensional Rotating-frame nOE SpectroscopY), TOCSY (TOtal shift Correlation Spectroscopy), and COSY (shift Correlation Spectroscopy) have been used to obtain complete H-1 resonance assignments. Interproton distances obtained from NOE were input for a subsequent restrained molecular dynamics simulation. The overall shapes of both peptides are a-helical, except at the N- and C-termini. The threonyl side chain at position 589 in the mutant peptide protrudes outwards from the helical axis more than the alanyl side chain at the same position, which might account for differences in the antibody recognition patterns for the two peptides.
Han, Kyou-Hoon,Kim, Seung-Moak,Choung, Dong-Ho,Park, Kyu-Hwan,Moon, Tae-Sung,Chae, Dong-Yeon,Kim, Soo-Kyung,Yoo, Hyun-Ju 생화학분자생물학회 1994 한국생화학회지 Vol.27 No.4
A combination of the nuclear magnetic resonance (NMR) technique and the molecular modelling method has been successfully applied to determine high resolution solution conformations of a 17-residue oligopeptide LQARILAVERYLKDQQL (583-599) of gp41 from human immunodeficiency virus type I (HIV-1), and its mutant with Ala${\rightarrow}$Thr at position 589. Various two-dimensional NMR methods such as NOESY (two-dimensional NOE SpectroscopY), ROESY (two-dimensional Rotating-frame nOE SpectroscopY), TOCSY (TOtal shift Correlation SpectroscopY), and COSY (shift COrrelation SpectroscopY) have been used to obtain complete H-1 resonance assignments. Interproton distances obtained from NOE were input for a subsequent restrained molecular dynamics simulation. The overall shapes of both peptides are ${\alpha}$-helical, except at the N- and C-termini. The threonyl side chain at position 589 in the mutant peptide protrudes outwards from the helical axis more than the alanyl side chain at the same position, which might account for differences in the antibody recognition patterns for the two peptides.
Han, Kyou-Hoon,Kim, Cheorl-Ho,Choung, Dong-Ho,Park, Kyu-Hwan,Lee, Dae-Sil 생화학분자생물학회 1993 한국생화학회지 Vol.26 No.5
In order to determine the composition of a tetrasaccharide obtained from glycosylated barley ${\beta}-Amylase$ isozyme we applied two-dimensional (2-D) nmr (nuclear magnetic resonance) techniques. COSY (COrrelated SpectroscopY) and TOCSY (TOtally Correlated SpectroscopY) pulse sequences enabled us to achieve an unambiguous assignment of four monosaccharide units by allowing us to follow the shift-correlation map in each monomeric ring. After careful comparison to proton chemical shifts as well as the resonance patterns in literature we have found that there are ${\alpha}-D-GlcNAc$, ${\beta}-D-GlcNAc$, ${\alpha}-D-Man$ and ${\beta}-D-Man$ in the tetrasaccharide.
Injection-Acupuncture Combined by Conventional Treatment in Canine Demodicosis: Case Report
Hyung-kyou Jun,Ji-won Han,Hyun-wook Oh,Hyun-hwa Lee,Bae-kun Park,Seong-Jun Park,Sung-whan Cho,Duck-hwan Kim 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.3
Therapeutic effect by injection-AP with antibiotics plus conventional treatment was investigated to establisha new treatment method for canine demodicosis. Three patients diagnosed into canine demodicosis were used in thepresent study. Injection-AP with enrofloxacin (5 mg/kg, twice a week) was made into the acupoints such as Fei Shu(BL13), Wei Zhong (BL40), Da Zhui (GV14), Zu San Li (ST36), He Gu (LI04), Qu Chi (LI11) and Sang Yin jiao(SP06) for 5 weeks. Further, they were additionally received with conventional treatments including injection ofivermectin (0.5 mg/kg, twice a week, SC) and 0.05% amitraz rinse (twice a week) for 5 weeks. The clinical symptoms(pruritus, excoriation, erythema and alopecia) were much compared by those of pre-treatment. Case 1 became to normal after 4 weeks, Case 2 became to mild after 5 weeksand Case 3 became to normal after 5 weeks. Total WBC revealed decreasing tendency with treatment in all cases,however, N/L ratios didnt show regular pattern of change with treatment. Notable changes were not histopathogicallyfound in skin lesions of Case 1 and Case 3 except Case 2 with mild change after 5 weeks treatment, compared bythose of pre-treatment, respectively. In conclusion, the present patients were cases with canine demodicosis which
Cost Analysis of Iron-Related Complications in a Single Institute
( Ki Hwan Kim ),( Jin Won Kim ),( Ji Young Rhee ),( Min Kyung Kim ),( Byung Su Kim ),( In Ho Kim ),( Soo Mee Bang ),( Sung Soo Yoon ),( Jong Seok Lee ),( Kyou Sup Han ),( Seon Yang Park ),( Byoung Koo 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.1
Background/Aims: The financial burden of caring for iron-related complications (IRCs) is an emerging medical problem in Korea, as in Western countries. We produced a preliminary estimate of the costs of treating patients for IRCs. Methods: The medical records of patients who had received multiple transfusions were reviewed. Newly developed cardiomyopathy, heart failure, diabetes mellitus, liver cirrhosis, and liver cancer were defined as IRCs. The costs of laboratory studies, medication, oxygenation, intervention, and education were calculated using working criteria we defined. Costs that had a definite causal relationship with IRCs were included to produce as accurate an estimate as possible. Results: Between 2002 and 2006, 650 patients with hematologic diseases, including 358 with acute leukemia, 102 with lymphoma, 58 with myelodysplastic syndrome or myeloproliferative disease, 46 with multiple myeloma, and 31 with chronic leukemia, received more than 10 units of red blood cells. Nine patients developed IRCs. The primary diagnoses of eight patients were aplastic anemia and that of one patient was chronic lymphocytic leukemia. Two patients who had diabetes were excluded because one was treated at another hospital and the other was diagnosed as oxymetholone-induced diabetes. Of the seven patients included, liver cirrhosis developed in two, heart failure in four, and diabetes mellitus in three. Some of them had two diagnoses. The total cost attributed to IRCs for the seven patients was 47,388,241 KRW (approximately 50,000 USD). Conclusions: The medical costs of IRCs are considerable, and more effective iron-chelating therapy is necessary to save medical resources and improve patient care. More in the way of comprehensive health and economic studies of IRCs are needed to allow both clinicians and health-policy makers to make better decisions. (Korean J Intern Med 2009;24:33-36)