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Ji Ye Mok,Seung-Il Jeong,Seon Il Jang 한국콘텐츠학회 2009 ICCC International Digital Design Invitation Exhib Vol.2009 No.12
Oxidative stress is involved in many human diseases in the process of inflammation in various tissues including the skin. Therefore, the present study was undertaken to investigate the antioxidative and anti-inflammatory activities of the extracts of Spirodela polyrhiza in Human HaCaT Keratinocytes and NC/Nga mice. Exposure of human HaCaT keratinocytes to methanol extract of Spirodela polyrhiza (ESP) at 50 and 400 ㎍/㎖ showed significant protective effect against 500 ㎛ of hydrogen peroxide (H2O2). ESP not only protected cell survival from H2O2-induced toxicity, but also inhibited the H2O2-induced leakage of lactate dehydrogenase (LDH) enzyme release and DNA fragmentation significantly. It was also found that ESP showed scavenging activities of l,1-diphenyl-2-picrylhydrazyl (DPPH)-induced radicals and superoxide radicals in the xanthine/xanthine oxidase system, respectively. Interestingly, pretreatment with ESP significantly suppressed lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production through the inhibition of inducible NO synthase (iNOS) expression. Furthermore, topically applied ESP dose-dependently inhibited 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema in NC/Nga mice. Consistent with its antioxidative properties in vitro, our data suggest that the therapeutic potential of ESP for acute skin inflammation that may involve oxidative tissue damage.
Ji Ye Mok,Seung-Il Jeong,Jung-Keun Cho,Ji-Won Choi,Sang-Yun Nam,Won-Chil Chang,Byung-Eun Moon,Seon Il Jang 한국콘텐츠학회 2009 ICCC International Digital Design Invitation Exhib Vol.2009 No.12
Atopic dermatitis (AD) is a chronically relapsing prurtttc inflammatory skin disease. The effective microorganism fermentation extract (EM-X) is an antioxidant cocktail derived from the fermentation of plant material with effective microorganisms, it shows an anti-inflammatory, anticancer, and antioxidant effects. To find new anti¬inflammatory products for skin inflammatory disease such as AD and contact dermatitis, we produced the effective microorganism fermentation substance (EM-S) by fermentation of medicinal plants with effective microorganisms including photosynthetic bacteria, lactic acid bacteria and yeast, screened the effects of EM-S on mouse models of acute and chronic inflammatory responses. The effects of EM-S treatment inhibited 12-O-tetradecanoylphorbol 13-actate (TPA)-induced ear edema in Balb/c mice. Topically applied EM-S significantly reduced ear thickness, severity score and histological grade in AD-like NC/Nga mouse model by the house dust mite antigen (Dermatophagoides farinse extract) sensitization. In addition, the serum IgE and tissue Th2 chemokine levels were significantly reduced by EM-S. These results demonstrate that topical application of EM-S may be improve the AD-like skin lesion by suppressing IgE and Th2 chemokines.
Effect of Persimmon Leaf Extract on Phthalic Anhydride-induced Allergic Response in Mice
Mok, Ji-Ye,Jeon, In-Hwa,Cho, Jung-Keun,Park, Ji-Min,Kim, Hyeon-Soo,Kang, Hyun-Ju,Kim, Hyung-Soon,Jang, Seon-Il The Korean Society of Food Science and Nutrition 2012 Preventive Nutrition and Food Science Vol.17 No.1
The purpose of this study was to investigate the anti-allergy activities of persimmon leaf extract (PLE) on a phthalic anhydride (PA)-induced allergic mouse model. A human leukemic mast cell line (HMC-1) was used to examine the inhibitory activity of PLE on the histamine release by human leukemic mast cells. PLE inhibited histamine release from HMC-1 cells in response to cross-linkage of high-affinity IgE receptor-${\alpha}$ ($Fc{\varepsilon}RI{\alpha}$). Additionally, a PA-induced allergic mouse model was used to investigate the effects of PLE in vivo. Mice were orally administrated with or without PLE of single dose (250 mg/kg/day) for 31 days. Oral intake of PLE significantly inhibited passive cutaneous reactions. Oral administration of PLE to PA-induced allergic mice also led to a striking suppression of the development of contact dermatitis, ear swelling and lymph node weight. In addition, PA-specific IL-4 production of draining lymph node cells was markedly diminished by PLE oral administration, but not IFN-${\gamma}$. Furthermore, PLE treatment suppressed PA-induced thymus and activation-regulated chemokine (CCL17) and cutaneous T cell-attracting chemokine (CCL27) expressions in ear tissues. Based on these results, we suggest that PLE may have therapeutic potential as an effective material for management of irritant contact dermatitis or related inflammatory diseases.
Effect of Persimmon Leaf Extract on Phthalic Anhydride-induced Allergic Response in Mice
Ji Ye Mok,In Hwa Jeon,Jung-Keun Cho,Ji Min Park,Hyeon Soo Kim,Hyun Ju Kang,Hyung Soon Kim,Seon Il Jang 한국식품영양과학회 2012 Preventive Nutrition and Food Science Vol.17 No.1
The purpose of this study was to investigate the anti-allergy activities of persimmon leaf extract (PLE) on a phthalic anhydride (PA)-induced allergic mouse model. A human leukemic mast cell line (HMC-1) was used to examine the inhibitory activity of PLE on the histamine release by human leukemic mast cells. PLE inhibited histamine release from HMC-1 cells in response to cross-linkage of high-affinity IgE receptor-α (FcεRIα). Additionally, a PA-induced allergic mouse model was used to investigate the effects of PLE in vivo. Mice were orally administrated with or without PLE of single dose (250 ㎎/㎏/day) for 31 days. Oral intake of PLE significantly inhibited passive cutaneous reactions. Oral administration of PLE to PA-induced allergic mice also led to a striking suppression of the development of contact dermatitis, ear swelling and lymph node weight. In addition, PA-specific IL-4 production of draining lymph node cells was markedly diminished by PLE oral administration, but not IFN-γ. Furthermore, PLE treatment suppressed PA-induced thymus and activation-regulated chemokine (CCL17) and cutaneous T cell-attracting chemokine (CCL27) expressions in ear tissues. Based on these results, we suggest that PLE may have therapeutic potential as an effective material for management of irritant contact dermatitis or related inflammatory diseases.