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With the purpose of improving ginsenoside production in Korean wild ginseng (Panax ginseng Meyer) mutant adventitious root lines, a synthetic gene encoding squalene synthase (PgSS2) was placed under the control of 35S promoter and transferred to Panax ginseng. Embryogenic callus obtained from ginseng adventitious root lines were transformed by infection with A. tumefaciens strain EHA105 containing the PgSS2 gene. Ten phosphinothricin-resistant plants were generated on selection medium, and the transgene integration and expression in these plants were confirmed by PAT test strip, RT-PCR and Southern hybridization. Ginsenoside analysis by HPLC revealed that the total contents of the 8 ginsenoside types (Rg1, Re, Rf, Rh1, Rb1, Rc, Rb2, Rd) in transgenic adventitious root lines were about 1.6-fold higher than that of the mutant control line (MCL1). This transformation method may facilitate the improvement of Panax ginseng in terms of the accumulation levels of ginsenoside.
( Jun Hee Yim ), ( Duk Han Kim ), ( Ja Kyung Ku ), ( Yoon Sung Kang ), ( Mi Yeon Kim ), ( Hyung Ok Kim ), ( Myung Jun Chung ), ( Young Min Park ) 한국미생물 · 생명공학회 2006 Journal of microbiology and biotechnology Vol.16 No.11
( Jun Sung Park ), ( Ja Hye Myung ), ( Hun Sik Wang ), ( Ja Seong Koo ), ( Wonk Yung Cho ), ( Hee Jun Park ), ( Min Soo Kim ), ( Jeong Soo Kim ), ( Kwang Ho Cha ), ( Sung Joo Hwang ) 한국약제학회 2011 Journal of Pharmaceutical Investigation Vol.41 No.3
In this study simple and sensitive high performance liquid chromatographic method using a commercially available column, was developed and validated for the determination of zolpidem tartrate in human plasma. The developed method with suitable validation was applied to a bioequivalence study of two different kinds of zolpidem tartrate. Two different formulations containing 10 mg of zolpidem tartate (CAS: 99294-93-6) were compared in 24 healthy male volunteers in order to compare the bioavailability and prove the bioequivalence. The study was performed in an open, single dose randomized, 2-sequence, cross-over design in 24 healthy male volunteers with a one-week washout period. Blood samples for pharmacokinetic profiling were drawn at selected times during 12 h. The mean AUC0-12h, Cmax, Tmax and T1/2 were 676.6±223.4 ng·h·mL-1, 177.4±34.2 ng·mL-1, and 0.8±0.4 and 3.5±2.1, respectively, for the test formulations, and 640.7±186.6 ng·h·mL-1, 193.0±64.5 ng·mL-1, and 0.9±0.4 and 2.7±0.9, respectively, for the reference formulation. Both primary target parameters AUC0-12h and Cmax were log-transformed and tested parametrically by analysis of variance (ANOVA). 90% confidence intervals of AUC0-12h and Cmax were in the range of acceptable limits of bioequivalence (80- 125%). Based on these results, the two formulations of zolpidem tartate are considered to be bioequivalent.
( Jun Hee Yim ), ( Duk Han Kim ), ( Ja Kyung Ku ), ( Yoon Sung Kang ), ( Mi Yeon Kim ), ( Hyung Ok Kim ), ( Myung Jun Chung ), ( Young Min Park ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.2
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A Prospective, Randomized, Controlled Trial to Assess the Efficacy of a Multi-Disciplinary Screening, Brief Intervention and Referral to Treatment Program for Patients with Fractures of the Oral and Maxillofacial Region Because of Alcohol-Related Injuries in the Emergency Department
Purpose: We have implemented a multi-disciplinary Screening, Brief Intervention and Referral to Treatment (SBIRT) protocol to prevent individuals who sustained alcohol- related traumatic injuries. We therefore conducted this single-center, prospective, randomized, controlled trial (RCT) to assess its efficacy. Methods: All the enrolled patients (n=30) were randomized to either the SBIRT group or the control group. In the current RCT, the proportion of the patients who reduced the amount of alcohol consumption and those who received a specialized treatment served as primary outcome measures. Moreover, changes in a 3-item version of the Alcohol Use Disorders Identification Test Consumption (AUDIT-C), Severity of Dependence Scale (SDS) and Kessler Psychological Distress Scale (K-6) scores at 3 months from baseline served as secondary outcome measures. Results: At 3 months, the proportion of the patients who reduced the amount of alcohol consumption was significantly higher in the SBIRT group as compared with the control group (86.7% vs. 57.1%, p=0.02). Moreover, the proportion of the patients who received a specialized treatment was also significantly higher as compared with the control group (26.7% vs. 1.4%, p=0.01). Furthermore, there were significant differences in changes in the AUDIT, SDS and K-6 scores at 3 months from baseline between the two groups (p<0.05). Conclusions: In conclusion, our results indicate that the SBIRT is effective in reducing hazardous and harmful levels of drinking, the degree of alcohol dependence and that of psychological distress in at-risk drinkers.
Background/Aims: With the increasing incidence of cardiovascular disease, an-giocardiography using contrast-enhancing media has become an essential diagnostic and therapeutic tool, despite the risk of contrast-medium-induced acute kidney injury (CIAKI). CIAKI may be exacerbated by renin-angiotensin-system(RAS) blockers, which are also used in a variety of cardiovascular disorders. This study evaluated the effects of RAS blockade on CIAKI after coronary angiography. Methods: Patients who underwent coronary angiography in our hospital between May 2009 and July 2011 were reviewed. Serum creatinine levels before and after coronary angiography were recorded. CIAKI was diagnosed according to an increasein serum creatinine > 0.5 mg/dL or 25% above baseline. Results: A total of 1,472 subjects were included in this study. Patients taking RAS blockers were older, had a higher baseline creatinine level, lower estimated glomerular filtration rate (eGFR), and had received a greater volume of contrast medium. After propensity score matching, no difference was observed between the RAS (+) and RAS (-) groups. Multiple logistic regression identified RAS blockade, age, severe heart failure, contrast volume used, hemoglobin level, and eGFR as predictors of CIAKI. Multiple logistic regression after propensity matching showed that RAS blockade was associated with CIAKI (odds ratio, 1.552; p = 0.026). Conclusions: This study showed that the incidence of CIAKI was increased in patient streated with RAS blockers.
Background: Perirectal abscess could be caused by various causes such as intraabdominal disease or surgical complication. Without an early diagnosis and appropriate treatment, the mortality of this disease could be increased. Case Report: An 36-year-old man was transfered our hospital for the evaluation of the abdominal pain, fever, and yellowish discharge through the drain tube after laparoscopic appendectomy. Computed tomography(CT) of abdomen demonstrated the abscess at rectovesical fossa (3x4cm) and perirectal abscess was showed by endoscopic ultrasonography (EUS). EUS guided fi ne needle aspiration (FNA) was done and brownish pus was aspirated for about 18cc. And then, the stent(pig tail, 5cm, 7Fr) insertion was taken for abscess drainage. After 3days, we removed stent by endoscopic forcep due to stent migration through anus. CT of Abdomen was checked again and demonstrated that the size of abscess was decreased. Conclusion: We present here a case of perirectal abscess treated with EUS guided FNA and transrectal stent drainage.
The most common type of food-related foreign body in the esophagus is an impacted meat bolus. Acute esophageal obstruction upon eating poorly chewed meat has been called the "Steakhouse syndrome". A 69-year-old male patient visited the local medical center 2 years ago because of continuously aggravated anterior chest pain with solid and liquid dysphagia for 1 day. At that time, impacted meat like bolus was found in the distal esophagus through endoscopy. After removal of the meat with a polypectomy snare, neither stenosis nor mucosal lesion was noted. He experienced anterior chest pain and acid regurgitation for 2 months, after ceasing medication. The esophageal monometry and ambulatory 24 hr pH monitoring showed diffuse esophageal spasm. Herein, we report a case of diffuse esophageal spasm with a history of Steakhouse syndrome. (Kor J Neurogastroenterol Mot 2003;9151-154)