The Role of MCP 1 and IL 6 on the Progress of Crescentic Glomerulonephritis

( Hye Won Hahn ),( Eun Young Um ),( Il Soo Ha ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.4

Purpose: Growing data on the relationship between cytokine expression and the progression of renal diseases make these cytokines potential targets for therapeutic interventions. Weexamined the helper T1-cell- and macrophage-associated cytokines in anti-glomerular basement membrane (GBM) antibody-induced nephritis in mice and their temporal relationships with renal tissue fibrosis. Methods: Kidneys were harvested on days 1, 3, 7, 11, and 16 after glomerulonephritis was induced with anti-GBM antibody. The progression of renal fibrosis was serially monitored to quantitate the accumulation of cortical extracellular matrix, and various cytokines were measured simultaneously. Results: A single injection of anti-GBM antibody successfully produced severe crescentic glomerulonephritis. Proteinuria increased abruptly and both mesangial matrix expansion and interstitial fibrosis progressed rapidly. Cortical fibronectin and type III collagen increased continuously, reaching a peak on day 7, and the deposition of type III collagen followed the same pattern, in parallel with that of urinary transforming growth factor 1 (TGF-1) expression. Serial cytokine measurements revealed a sustained increase in interleukin (IL) 6 and monocyte chemoattractant protein 1 (MCP1) from day 3, but neither IL12, IL18, nor interferon changed significantly. Real-time polymerase chain reaction confirmed these features at the transcription level. Conclusion: MCP1 and IL6 correlated with the progression of renal fibrosis, with no increase in Th1-inducing cytokines. This confirms MCP1 and IL6 as attractive therapeutic targets for renal fibrosis in crescentic glomerulonephritis.

Renal Fibrosis : The Role of IL18 on the Progress of Crescentic Glomerulonephritis

( Hye Won Hahn ) 대한신장학회 2006 춘계학술대회 초록집 Vol.25 No.1

Genetics of kidney development: pathogenesis of renal anomalies

Hahn, Hye-Won The Korean Pediatric Society 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.7

Congenital anomalies of the kidney and urinary tract (CAKUT) account for more than 50% of abdominal masses found in neonates and involve about 0.5% of all pregnancies. CAKUT has a major role in renal failure, and increasing evidence suggests that certain abnormalities predispose to the development of hypertension and cardiovascular disease in adulthood. To understand the pathogenesis of human renal anomalies, understanding the development of kidney is important. Diverse anomalies of the kidney corresponding to defects at a particular stage of development have been documented recently; however, more research is required to understand the molecular networks underlying kidney development, and such an investigation will provide a clue to the therapeutic intervention for CAKUT.

소아에서 혈청 Cystatin C 의 정상 범위

한혜원(Hye Won Hahn),박경미(Kyung Mi Park),하일수(Il Soo Ha),정해일(Hae Il Cheong),송정한(Jeong Han Song),최용(Yong Choi) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.1

Cystatin C는, 모든 유핵 세포에서 생성되는 13.3KD 크기의 저분자량 단백질이다. 생성 속도가 일정하며, 사구체 기저막을 자유로이 통과한 후, 세뇨관 세포에서 재흡수 되고 분해되어 사구체 여과율만이 혈증 농도를 결정한다. 최근 cystatin C가 creatinine 보다 사구체 여과율과 연관성이 높으며, 특히 사구체 여과율이 낮은 환자에게서 연관성이 높다는 보고가 있어, 사구체 여과율의 지표로 cystatin C를 이용하고자 신질환이 없는 아동들에게서 그 정상 범위를 구하였다. 1999년 10월 서울대학교병원 어린이병원 외래를 방문한 환아들 중, 신 질환이 없는 102명의 환아(남아 47명, 여아 55명, 연령 중앙값 5.9세, 연령 분포 1세에서 15세까지 )를 대상으로 혈청 creatinine과 cystatin C값을 측정하였다. Creatinine은 통상적인 방법으로 측정하였으며, Cystatin C의 측정은 cystatin C에 대한 토끼의 항체를 이용한 immunonepheolometric assay로 시행하였다. 정상 범위(Reference interval, RI)는 2.5에서 97.5백분위수로 정하였다. 신 질환이 없는 아동에서 1세 이후 cystatin C값은 연령과 성별에 따른 차이가 없이 일정하였으며, 평균 0.72mg/L, 정상 범위 0.512-1.104mg/L였다. 이와 비교하여 creatinine은 연령에 따라 계속 증가하였다. Creatinine 과 비교하여 cystatin C값은 연령과 관계없이 일정하므로, 특히 소아 연령에서 사구체 여과율의 지표로 유용하게 이용될 수 있을 것으로 생각된다. Cystatin C is a non-glycated 13-kilodalton basic protein produced by all nucleated cells. It has received considerable attention over the last few years as a potential replacement for creatinine as a biochemical marker for glomerular filtration rate(GFR), Recently published studies have shown that cystatin C correlates more strongly than creatinine with GFR. The aim of this study was to define a reference in- terval for cystatin C concentrations in children. Cystatin C was measured by an immunonephelometric assay in sera obtained from 102 children(47 boys, 55 girls, range from 1 year to 15 years) without evi- dence of kidney disease. The reference interval was calculated non-parametrically using the 2.5 th and 97.5th percentiles. Cystatin C concentration was constant regardless of age and sex, with a reference in- terval of 0.512-1.104mg/L In contrast, serum creatinine concentration increased steadily with age until adulthood. Cystatin C offers easier recognition of renal function in childhood because its reference value is constant through all ages beyond 1 year.

만성신부전 : 신섬유화에서 조직 트랜스글루타미네이즈의 역할

한혜원 ( Hye Won Hahn ),최기항 ( Ki Hang Choi ),엄은영 ( Eun Young Um ),하일수 ( Il Soo Ha ) 대한신장학회 2008 춘계학술대회 초록집 Vol.28 No.1

양측 부신 거대종양의 형태를 보인 악성 임파종 2예

한지숙,정상수,정혜원,정재호,허갑범,이현철,임승길,김경래,송영득,남재현,안철우,김진석,김명수,한승혁,구영석 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.1

Adrenal gland is a common site of metastatic tumors such as breast cancer, lung cancer, and colon cancer. When adrenal mass is found incidentally, adenoma is the most common among single adrenal masses. But in the case of bilateral adrenal masses, infection, bilateral metastases and hemorrhage are common. Secondary involvement of the adrenal gland is found in 25% of autopsy cases of non-Hodgkin's lymphoma. However, adrenal insufficiency is rare because it becomes apparent only when approximately 90% of adrenal cortex is destructed. We exprienced two cases of malignant lymphoma which involved the adrenal glands bilaterally. One case in which adrenal insufficiency was suspicious, was accompanied by hypovolemic shock and sepsis at the initial presentation. He died of sepsis combined with DIC even though hydrocortisone, intravenous saline infusion, and antibiotics therapy were started immediately. The other one was found incidentally, in which adrenal infiltraion was confirmed by CT scan. Hormonal level was normal and adrenal masses disappeared after chemotherapy(J Kor Soc Endocrinol 15:121-127, 2000).

P148 : A clinical study of skin diseases on vulvar

( Hye Rim Ko ),( So Min Kim ),( Chae Young Won ),( Hyung Jin Hahn ),( Young Bok Lee ),( Jin Wou Kim ),( Dong Soo Yu ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Vulvar diseases are not rare in dermatology, however the clinical investigations of the vulvar lesions are insufficient. Objectives: The purpose of this study was to investigate the epidemiological aspects of the vulvar diseases, and to highlight the clinical features of dermatoses of the vulvar with the brief review of the common vulvar diseases. Methods: The retrospective clinical study was performed by reviewing charts, pathologic slide, and clinical photographs of 37 patients who had received skin biopsy for vulvar lesions at Uijeongbu St. Mary’s Hospital between February 2009 and September 2013. Results: The mean age was 47.3 years. The most frequent vulvar diseases were epidermal cyst, lichen sclerosus, lichen simplex chronicus, herpes simplex infection and condyloma accuminatum in the decreasing order of frequency. Except for the 11 asymptomatic patients, the rest of the patients complained of various symptoms such as a pain, prickling sensation, tenderness and pruritus. Of the 37 cases, 14 had patches or plaques, 11 had papules or nodules, 6 had erosions or ulcers and 6 had vulvar mass. Conclusion: We retrospectively studied 37 cases of vulvar diseases. The results of this study are similar to previousreports on the clinical features of vulvar diseases. This study suggests that various conditions can affect the vulvar. Further investigation with a larger group of patients is necessary to better understand the epidemiology of vulvar diseases.

Helicobacter pylori감염과 림프여포 출현과의 상관성: 절제위를 이용한 병리학적 재검토

이원애,한혜승,김우호,김용일 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.3

Lichen striatus following Blaschko lines

( Hye Rim Ko ),( Ji Won Yun ),( Hyung Jin Hahn ),( Young Bok Lee ),( Dong Soo Yu ),( Jin Wou Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Lichen striatus is an uncommon self-limiting dermatosis that occurs mostly in children and rarely in adults. It presents as linear, erythematous, lichenoid papules distributed along Blaschko lines usually on the extremities and rarely on the trunk and face. It is important to distinguish lichen striatus from many conditions following Blaschko lines, particularly the adult “blaschkitis” initially described as a distinct entity from lichen striatus. Blaschkitis is more common in adults, consists of papules and vesicles in multiple lines usually on the trunk, is more recurrent, and histologically shows a spongiotic rather than a lichenoid pattern. However, it is still not clear whether lichen striatus and blaschkitis are two distinct diseases or variations of the same entity. A 45-year-old male presented with pruritic, linear, brownish papules on the back for 1 month. The lesions showed the pattern of a v on the spine, suggesting the distribution along Blaschko lines. Histopathological findings showed minimal spongiosis and lichenoid lymphohistiocytic infiltrates in the upper dermis and around the sweat ducts in the deep dermis. After 6 months, the lesions improved with topical steroid preparations although pigmentation persisted. The clinical features and histologic findings suggested the diagnosis of lichen striatus. Herein, we report a case of lichen striatus distributed along Blaschko lines on a trunk in an adult patient.

Purification and Characterization of Recombinant Pea Cytoplasmic Fructose-1, 6-bisphosphatase

Hye-Kyung Jang,Sang-Won Lee,Tae-Ryong Hahn 한국토양비료학회 2001 한국토양비료학회 학술발표회 초록집 Vol.2001 No.5