자궁내 태아사망의 임상적 고찰

이권해,이정재,조현철,이석민,이임순,이해혁,김권대,이순곤,남계현 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Objective: This study was designed to evaluate diagnosis and complication, prognosis during clinical study of cases of intrauterine fetal death. Methods and materials: This is a clinical study of 56 cases of the intrauterine fetal death among 8064 deliveries at Seoul Sunchunhyang university hospital during 5 years from January, 1994 to December, 1998. Results: The incidence was 0.7%. The age distribution of mothers was 18 - 44 years and was highest in the 25 - 29 years range(46.4%). The parity was the most highest in the nulliparous group(51.8%). The most common gestational weeks was 20 - 28 weeks gestational period(46.4%), and most common presentation was cephalic(73.5%). The most common weights of the intrauterine fetal death was from 5,00gm to 1,000g(48.2%). The mode of the most common delivery was the induction of delivery(57.2%). The etiologic factors were: unknown(42.9%), preeclampsia(17.9%), chorioamnionitis(14.3%), congenital anomaly(12.5%), abruptio placenta(7.1%), cord complication(3.6%), placenta previa, death of one for twin. There were 2 cases of maternal complication(DIC, Uterine atony). Conclusion : Intrauterine fetal death should be diagnosised early and treated properly to reduce risk of the maternal complication.

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

인사정보시스템

李珣哲,李泳姬 홍익대학교 동북아연구소 2003 東北亞硏究 Vol.7 No.-

Many organizations have developed Human Resource Management Systems. However, with the rapid growth of the internet and the growing importance of knowledge management, different aspects of Human Resource Management Systems are required. Still most of these systems are in the initial stage of rather record keeping. But a few organizations successfully developed new systems which cut the amount of work required at same time effective manage human resources. In this study through an extensive analysis of case studies we identified the building blocks of information technology for Human Resource Systems and strategies for effective planning, hiring, deploying, developing human resources

서비스 기업의 고객

이순철 홍익대학교 경영연구소 1996 경영연구 Vol.21 No.-

서비스 기업의 고객은 서비스에 참여하고 있으므로 세가지 측면에서의 배려가 필요하다. 첫째, 서비스 기업의 고객에 대한 기대도를 만족시켜야 한다. 둘째, 고객이 언급하지는 않으나 갖고 있는 잠재적인 욕구를 개발하여 충족시켜야 한다. 셋째, 고객의 능력을 이용하는 서비스, 전달시스템, 직무방식을 디자인 할 수 있다.

肝吸蟲感染에 있어서의 免疫反應에 關한 硏究 : 白鼠脾藏 大好파이로 닌細胞數의 경시적 變動 Chronological Changes of Large Pyroninophilic Cell Count in the Spleen

李純炯,宋哲鏞 중앙대학교 의과대학 의과학연구소 1978 中央醫大誌 Vol.3 No.1

In order to know some aspects of immune response of albino rats by Clonorchis sinensis infections, the histopathological changes of the liver and the chronological changes of large pyroninophilic cell(LPC) count in the spleen were observed. Rats of 5 experimental groups (A series), each group consisted of 5 rats, were infected with 50 metacercariae of C. sinensis, and they were kept for 3 days (Group Ⅰ), 7 days (Group Ⅱ), 28 days (Group Ⅲ), 56 days (Group Ⅳ) and 84 days (Group Ⅴ). The same number of experimental groups(B series), each group of rats inoculated with 50 adult worms of C. sinensis intraperitoneally, were also kept as same as the above A series. Rats of each experimental groups were sacrificed immediately after the respective infection period, and then microscopic specimens of the liver and spleen were prepared by staining the paraffin sections of removed tissues with hematoxylin-eosin stain and methyl green-pyronin stain. Those materials from the experimental groups were examined in comparison with the materials obtained from non-infected control groups. The results obtained were as follows: 1. The counts of LPC in the periarterial lymphatic sheath of spleen were rapidly increased and reached at the maximum on the 3rd day (Group Ⅰ) in both A and B series of rats. Thereafter, the LPC counts were gradually decreased. 2. LPC counts of A series of experimental group were generally higher than those of B series throughout the whole infection period. 3. Histopathologically the liver failed to show any parasitic worm inside the intrahepatic biliary system in the rats of B series. However, various pathological changes of the liver, which seemed to be induced by the toxic metabolites of C. sinensis inhabiting in the abdominal cavity, were observed in B series of rats.

중추도파민신경활성에 미치는 뇌기능개선 후보약물의 행동약리학적 연구

이순철,유관희,山本經之 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-

The present study was undertaken to elucidate the behavioral characteristics of nootropic candidates, centrophenoxine, N-methyl-D-glucamine, piracetam and red ginseng saponin components on stereotyped sniffing behavior induced by apomorphine in rats. Apomorphine, a direct dopaminergic receptor agonist, induced stereotyped behaviors including sniffing, licking, gnowing and biting in a dose dependent manner, and that behaviors were completely inhibited when measured at 1 week after 6-hydroxydopamine(6-OHDA) treatment. Centrophenoxine, N-methyl-D-glucamine, red ginseng total sapomin (TS), panaxatriol (PT), and Rg_1 enhanced but panaxadiol (PD) inhibited, whereas priacetam and Rb1 were not effective of the stereotyped sniffing behavior induced by apomorphine (1 ㎎/㎏). The enhanced stereotyped behavior by centrophenoxine, N-methyl-D-glucamine, red ginseng total saponin, panaxatriol(PT), and Rg_1 was blocked by pretreatment of 6-OHDA. These results suggest that dopaminergic neuronal activity plays an important role in the action of some nootropic candidates. Red ginseng total saponin, panaxatriol and Rg_1 seems to have a similiarity to centrophenoxine, N-methyl-D-glucamate in modulating of dopaminergic neuronal activity and also may be useful for the nootropic candidates.

기억에 미치는 대뇌변연계의 기능적 역할 : 에탄올 급성 투여 흰쥐의 행동 및 신경화학적 변화 Behavioral and Neurochemical Alterations Following Acute Administration of Ethanol in Rats

이순철,유관희,김응배 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-

Behavioral and neurochemical effects of ethanol were assessed in rats after acute administration. Ethanol, 1-5g/㎏, inhibited the memory and rotarod performance, but significantly increased the spontaneous locomotor activity. Ethanol, 1-5g/㎏, did not affect the striatal dopaminergic neuronal activity and cortical noradrenergic neuronal activity. Ethanol, 1g/㎏, decreased the contents of DA(46.7%), DOPAC(66.7%) and HVA(79.2%) in frontal cortex, but increased the contents of DA(125%), DOPAC(116.7%) and HVA(l40%) in hippocampus. Ethanol, 2-5g/㎏, significantly increased the dopaminergic neuronal activity in frontal cortex, while it remarkably decreased the monoaminergic neuronal activity in hippocampus. These results suggest that the activity of cotical dopaminergic neuron play an important role in modulation of the motot activity induced by low does of ethanol, and that the activity of cotical and hippocampal catecholaminergic neurons could be responsible for the control of memory induced by higher does of ethanol.

표준화된 인삼추출물 G115의 중추도파민신경계에 대한 신경화학적 연구(Ⅱ)

이순철,유관희,김용호 충남대학교 약학대학 의약품개발연구소 1993 藥學論文集 Vol.9 No.-

Effects of the standardized ginseng extract (G115) on the central monoaminergic systems were investigated in comparison with that of haloperidol in rats. Immediately after sacrificed by decapitation, the striata and frontzl cortex were removed. Concentrations of the monoamines dopamine and serotonin and their metabolites were determined by HPLC-EC. G115 increased the concnetration of 5-HIAA and DOPAC/DA ratio in striatum. However, dopaminergic neuronal activities were not affected by G115 that decreased the concentrations of 5-HT and 5 HIAA in frontal cortex. G115 in combination with apomorphine significantly increased the concentration of DA and 5-HT but decreased the DOPAC/DA ratio and 5-HIAA/5-HT ratio only in frontal cortex. These results suggest that G115 like HPD inhibits the activity of nigrostriatal dopamine neuron in striatum. However, unlike HPD it activates central monoaminergic neuron activity in frontal cortex.

미래를 내다보는 경쟁 : 거래비용접근 Position Through Imagination

李珣哲 홍익대학교 경영연구소 1995 경영연구 Vol.20 No.-