평활근종으로 오인된 샘근육증에서 기원한 투명세포암

신유정 ( Yoo Jeong Shin ),조세은 ( Se Eun Cho ),성창옥 ( Chang Ohk Sung ),최철훈 ( Chel Hun Choi ),배덕수 ( Duk Soo Bae ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.9

The incidence of cancer from adenomyosis is rare. Previously, only two cases of clear cell adenocarcinoma (CCA) arising from adenomyosis have been reported in English literature. Here, we report a case of CCA arising from adenomyosis. A 52-year-old postmenopausal Korean woman presented with complaints of vaginal bleeding and back pain. Endometrial biopsy revealed endometrial polyp with atrophic change and transvaginal ultrasonography showed myomas with cystic change. Magnetic resonance imaging revealed a cystic degenerative mass consistent with leiomyoma in the posterior portion of uterus body. And the serum level of CA-125 was 17.7 U/mL. Hysterectomy revealed a yellow-ten solid mass in the myometrium that was diagnosed as CCA arising from adenomyosis, The tumor was mainly located in the myometrium and transition between adenomyosis and CCA along with endometrial stromal cell was identifi ed, Malignant tumor arising from adenomyosis could be considered as a differential diagnosis when the patient with adenomyosis and intact endometrial surface complained of vaginal bleeding.

만성 신부전증 환자의 중증 고혈당에 따른 의식변화 결핍에 대한 연구

박은주,강성귀,한상웅,김호중,이창범,임천규,박성광,윤경택,위형중,안유헌 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.6

In diabetic patients who were being treated with hemodialysis, coma and other neurological deficits did not occur in spite of extremely elevated serum glucose levels. In this report, we compared diabetic patients with renal failure in severe hyperglycemia with nonketotic hyperosmolar coma patients with normal renal function to know what affect mental changes. Mental changes were not present in diabetic patients with renal failure. These patients with renal failure showed more severe hyperglycemia, but corrected serum sodium concentration and calculated effective serum osmolality were low. So it is suggested that corrected serum sodium concentration and effective serum osmolality are more important factor affecting mental changes than high blood glucose levels in diabetic patients with renal failure, due to absence of osmotic diuresis.

抗癌丹을 投與한 胃癌 患者 105例에 對한 臨床報告

유화승,최우진,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

Clinical studies were carried out 105 cases of patients with stomach cancer treated by Hangamdan(抗癌丹) from January 1th 1998 to September 30th 2000. The results were summarized as follows; 1. Distribution of those attached by stomach cancer, by sex, showed that Male is more then Female, by age, showed that the number of forties, fifties, sixties are majority. 2. Distribution of diagnostic stage, in descending order; stage Ⅲ(45.1%, top), stage Ⅳ(40.2%). 3. The effects of maintenance and improvement in the symptoms with traditional oriental therapy(77.8%) and combined treatment of western and oriental therapy(92.3%) were observed. The effects of the symptoms were as follows; abdominal pain (16.3%), general body weakness(10.5%), nausea&vomiting (8.6%), diarrhea(6.7%) and etc, in orders. 4. Analysis of hematology attached by stomach cancer, maintenance and increasing of WBC(89.4%), RBC(63.6%), Hgb(62.3%), Platelet(95.6%) were observed. After taken Hangamdan, the safety of the liver and kidney were as follows; maintenance and decreasing of AST(85.3%), ALT(91.6%), BUN(84.8%), Creatinine(92.4%) were observed. 5. Analysis of IL-12 and IFN-γ attached by stomach cancer, increasing of IL-12(39.1%), IFN-γ(69.6%) were observed. 6. Analysis of QOL attached by stomach cancer, maintenance and improvement of combined treatment of western and oriental therapy(91%), traditional oriental therapy(85.2%) were observed. 7. Analysis of survival in patients with Ⅳ stage of stomach cancer, above 6 months(17.1%), 12 months(85.2%) were observed. 8. Analysis of antitumor effects, maintenance of traditional oriental therapy(81.5%) and maintenance and improvement of combined treatment of western and oriental therapy(89.7%) were observed. Analysis of tumor marker attached by stomach cancer, maintenance of CEA(85.7%) were observed. 9. Analysis of curative valuation, maintenance and improvement of traditional oriental therapy(77.7%), combined treatment of western and oriental therapy(82.1%) were observed. From the above results, it is suggested that Hangamdan has significant effects of antitumor and immune activity, also could be usefully applied for stomach cancer patients by combination with western therapy or alone.

VCM을 이용한 마이크로 조립용 6자유도 정밀 정렬 장치의 설계

유용환,이수훈,송준엽,이창우,하태호,김정재,이문구 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

This work will develop a 6-DOF precision aligner with small size and high resolution for assembling the micro parts for a mobile electronics. Here, VCM actuator that is precise and reliable will be applied to this aligner system. Arrangement of actuators will be a symmetrical based on kinematic design. This paper presents combining two modules of mechanism for the 6-DOF precision aligner. The first is a stage which can control XYθ_(z) motion, and the second can control Z motion, in other words, Z tilt motion. According to its specifications, it is expected to satisfy requirement of precision. Test of the first stage was presented to show the resolution and parasitic motion. For the test, PID algorithm was applied for feed-back control system.

혈청이 마우스 간 세포주 BNL CL.2의 Nitric Oxide 생성에 미치는 영향

유지창,정헌택,김유현,진효상,김신무,배현옥 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1999 Journal of biomedical laboratory sciences Vol.5 No.1

마우스 간 세포주인 BNL CL.2의 시험관내 배양에서 혈청과 IFN-γ가 세포주의 nitric oxide(NO) 생성과 세포 손상에 미치는 영향을 알아보기 위한 실험을 하였다. 혈청이 공급된 배양에서 IFN-γ에 의한 세포 생존율은 거의 변동이 없었으나, 혈청을 제거한 배양에서는 약 65%의 생존율이 유지되었으며, NO 생성 억제제인 N -monomethy-L-arginine (NMA)의 첨가는 농도 의존적으로 세포의 생존율을 감소시켰다. 혈청이 제거된 BNL CL.2세포주는 IFN-γ단독 처리에서도 NO 를 생성할 수 있었으며, IFN-γ와 lipopolysaccharide (LPS)의 복합 처리는 세포주의 NO 생성을 상승적으로 증가시켰다. 또한 protein tyrosine kinase (PTK) inhibitor인 herbimycin A와 genistein에 의해서 NO 생성이 억제되어 PTK의 활성이 혈청이 고갈된 BNL CL.2 세포에서 NO의 생성에 중요한 역할을 담당하고 있기 때문으로 판단된다. IFN-γ의 독성은 혈청을 제거시킬 때 NO 생성 억제제에 상승적으로 간 세포를 손상시키며, 이때 NO가 IFN-γ에 의해 유도된 손상을 어느 정도 억제시키는 것을 알 수 있었다. Nitric oxide (NO) plays an important role in immunologic defense, and influences upon the functioning of secretory tissues and cells. It also exhibits cytotoxic/cytostatic activity as one of major operating effectors of the cellular immunity system. We investigated the effects of serum on the cell damages and NO production in the mouse liver cell line BNL CL.2 to establish the role of NO. We observed that, when BNL CL.2 cells were cultured in serum-free medium, they were induced to cell damage by the stimulation of IFN-γalone or IFN-γplus LPS. Serumstarved cells showed large amount of nitrite accumulation and NO synthase (NOS) expression in response to IFN-γalone in dose-and time-dependent manners, but serum-supplied cells did not. The production of NO was blocked by protein tyrosine kinase (PTK) inhibitors, genistein and herbimycin. These results suggest that the deprivation of serum in the BNL CL.2 cell culture medium might primed with the cells to produce NO when the cells are triggered by IFN-γ and the involvement of PTK signal transduction pathway in the expression of NOS gene in murine hepatocytes.

마이크로 어셈블리용 6자유도 정렬기의 기구학적 분석 및 디자인

유용환,이문구,이수훈,홍민성,송준엽,이창우 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

This work will develop a 6-DOF precision aligner with small size and high resolution for assembling the micro parts for a mobile electronics. Here, Tiny PicomotorTM actuator that is small and reliable will be applied to this aligner system. The principle of this actuator is PZT that turns a precision thread and then the screw moves linearly. Arrangement of actuators will be a symmetrical based on kinematic design. This paper presents combining two modules of mechanism for the 6-DOF precision aligner. The first is a stage which can control XYθz motion, and the second can control Z motion, in other words, Z tilt motion. According to its specifications, it is expected to satisfy requirement of precision.

衛星通信에 관한 硏究 : Filter의 性能改善을 中心으로 Especially on the Improvement of Filter Performance

鄭憲相,宋鐵,劉炳守,朴暢均,白亨來,鄭鍾熙,李炅燮 조선대학교 동력자원연구소 1986 動力資源硏究所誌 Vol.8 No.2

There are two kinds of data transmission communication method, namely, Analog communication method and Digital communication method. The latter has many excellent characteristics as compared with the former. In order to design excellent Digital Filter, the window function is studied in this paper. The conventional time-domain windowing requires N/2 stored values of the data window and N multiplications. A class of windows, called binary windows, for the frequency-domain implementation of the Discrete Fourier Transform is proposed. They do not require multiplications or stored constants ; rather, they are replaced by shift and add operations. These windows offer excellent sidelobe behavior compared with the conventional windows.

스포츠 소비자의 스키용품 구매행동시 매체의존적 성향

이창민,최택진,김성훈,유재구 漢陽大學校 體育科學硏究所 2003 體育科學 Vol.23 No.23

For the purpose of reinforcing competitive power with foreign enterprises, this study was aimed at offering materials required to establish efficient marketing strategies by analyzing Korean ski consumers' consumptive behaviors. According to this, by using Convenience Sampling Method, 1 selected as the object of the survey 600 among skiers who visited J Skiing Ground and L Skiing Ground located in Gyunggi-do in the 2002-2003 season, distributed questionnaires to them, performed a survey by interview to them, and analyzed521 skiers' behaviors of purchasing goods for skiing, As the result, 1 could obtain the following conclusions. First, for the considerations when sports consumers purchased goods for skiing, there occurred statistically significant differences, in price, in sexes, ages, experiences and dates of using them, in design and color tone, in ages, experiences, dates of using them and skiing levels, in practicality and convenience, in ages, income levels, experiences and dates of using them, in manufacturers and their brands, in ages, income levels, experiences, dates of using them and skiing levels, and, in fashion, in ages, income levels, experiences, dates of using them and skiing levels. Secondly, for the final determinants when they purchased goods for skiing, asa whole, practicality and convenience were shown to be highest. There occurred statistically significant differences in all parts except sexes. Thirdly, for the places when they purchased goods for skiing, it was indicatedthat, as a whole, they purchased them most in an exclusive skiing shop. There occurred statistically significant differences in all parts.

急性 骨髓性 白血病 患者 1例에 對한 臨床報告

조정효,유화승,최우진,이용연,서상훈,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

AML is the most common type of leukemia in adults. AML(acute myeloid leukaemia) is characterised by a rapid accumulation of abnormal white blood cells in the blood and bone marrow, resulting in severe anemia, and possibly infection, and hemorrhage during the course of the disease. In general the prognosis of patient with relapsed AML is poor. At this time, however, the only potentially curative therapy for relapsed patients is allogeneic BMT(bone marrow transplantation). This clinical study were carried out 1 case of female patient aged 44 with relapsed AML treated by herb medicine. At the time of admission, she complained of mild fever, nausea, vomitting, abdominal pain, anorexia and no sign of bleeding. For the 10 days of admission, she was treated with Oriental-Western medicine and all the symptoms were disappeared. After that, the syptoms were aggravated because of secondary infection. Anyway, above result showed the possibility of Oriental therapy as Supportive Care in AML.

冬蟲夏草의 抗轉移와 免疫增進에 關한 硏究

최우진,유화승,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

This experimental study was carried out to evaluate the effects of Cordiceps sinensis on the antimetastasis and immune activity. In order to investigate the effect of Cordiceps sinensis, the followings were performed; Cytotoxicity, inhibition of MMP-2 & MMP-9 gene expression, fraction of CD4+, CD8+, CD19+ in splenic cell, the moprphological change of splenic cells, gene expression of IL-12(p35), IL-12(p40), IFN-?? and splenic cell proliferation by CS-E. The results were obtained as follows. 1. CS-E did not present cytotoxic effect on L+14, B16-F10 melanoma cells and HMCB. 2. CS-E inhibited MMP-2 and MMP-9 gene expression more effectively compared with control group. 3. CS-E inhibited invasion of B16-F10 melanoma cells more effectively compared with control group. 4. CS-E helped CD4+, CD8+, CD19+ expression more effectively compared with control group. 5. CS-E activated phagocytic cells in spleen more effectively compared with control group. 6. CS-E helped IL-12(p35), IL-12(p40), IFN-?? gene expression in splenic cell more effectively compared with control group. 7. CS-E activated splenic cell proliferation more effectively compared with control group. From above findings, it is suggested that CS-E is able to inhibit metastasis of cancer and activate immune response system.