Long-Term Effectiveness and Safety of Dutasteride versus Finasteride in Patients with Male Androgenic Alopecia in South Korea: A Multicentre Chart Review Study

최광성,심우영,강훈,허창훈,이양원,Sumitra Shantakumar,Yu-Fan Ho,Eun-Jeong Oh,Mei Sheng Duh,Wendy Y. Cheng,Priyanka Bobbili,Philippe Thompson-Leduc,Gary Ong 대한피부과학회 2022 Annals of Dermatology Vol.34 No.5

Background: Dutasteride improves hair growth compared with finasteride in maleandrogenic alopecia (AGA) and is well tolerated. However, real-world evidence for longtermdutasteride use in AGA is lacking. Objective: To describe baseline characteristics, treatment patterns and long-term safety andeffectiveness of dutasteride versus finasteride. Methods: This was a multicentre, retrospective medical chart review study conductedin South Korea. The index date was the first prescription of dutasteride or finasteride. Baseline characteristics were assessed 6 months prior to index. Safety and effectiveness(improvements in basic and specific [BASP] classification) data were collected from indexthroughout the observation period. Results: Overall, 600 male adult patients were included (dutasteride, n=295; finasteride,n=305). Dutasteride-treated patients were older (p<0.001) and more likely to have moderate/severe BASP classification at baseline (p=0.010) compared with finasteride-treated patients. Among patients treated with recommended, on-label dosing exclusively (n=535: dutasteride,n=250; finasteride, n=285), dutasteride-treated patients showed greater improvementin hair growth than finasteride-treated patients, as measured by the BASP basic M classification(adjusted incidence rate ratio [95% confidence interval]: 2.06 [1.08, 3.95]; p=0.029). Among this same subset, overall occurrence of adverse events (AEs) during the observationperiod were not statistically equivalent between groups (dutasteride 7.6%, finasteride 10.5%;p=0.201), although reports of AEs of special interest were equivalent (p<0.001). Conclusion: Dutasteride showed greater effectiveness than finasteride in improving BASP classificationin treating male AGA and had a similar or possibly lower occurrence of overall AEs. Dutasteride may provide an effective and safe treatment option for male patients with AGA.

Genetic aspects of alopecia areata(AA)

최광성 대한피부과학회 2011 초록집 Vol.49 No.20

교정시설 내 성폭력 치료프로그램이 고위험 성범죄자의 강간통념에 미치는 효과분석

최광성,변상해 아시아교정포럼 2020 교정담론 Vol.14 No.3

성범죄는 살인과 더불어 강력 범죄로 사람들을 분노케 하고 법적으로도 높은 형량을 선고하는 중범죄에 해당한다. 본 연구는 성폭력 치료프로그램이 교정시설에 수용 중인 고위 험군 성범죄자의 강간통념에 미치는 효과를 검증하는 데 있다. 본 연구의 대상은 서울 S교도소 고위험군 성범죄자 30명으로 실 험집단과 통제집단에 각 15명씩 배치하였다. 2019년 하반기에 성폭력 치료프로그램을 본 연구자가 직접 실시하였고, 실험집단 은 치료프로그램을 실시하였으며 통제집단에는 아무런 실험처치 를 하지 않았다. 성폭력 치료프로그램을 실시하기 전 실험집단과 통제집단에 대한 사전 동질성 검사를 실시하였으며, 프로그램이 종료한 후 강간통념의 변화 정도를 확인하기 위해 사전ㆍ사후 대응표본 t-test를 실시하였다. 자료의 분석은 SPSS 23. 통계프로그램을 활용하여 빈도분석 과 독립표본 t-test 및 사전ㆍ사후 대응표본 t-test를 실행하였다. 그 연구결과는 아래와 같다. 첫째, 실험집단의 사전검사와 사후검사 점수에서 사전검사 점수의 평균은 49.20이고 사후검사 점수의 평균은 31.46으로 성범 죄자의 강간통념에 유의미한 영향을 미치는 것으로 나타났다. 둘 째, 실험집단과 통제집단의 사후검사에서 실험집단의 평균은 31.46이고 통제집단의 평균은 47.53으로 두 집단의 차이는 유의 미한 영향을 미치는 것으로 나타났다. 셋째, 통제집단의 사전ㆍ 사후검사에서 사전검사 점수 평균은 45.73 이고 사후검사 점수 평균은 47.53으로 두 집단의 차이는 유의미한 영향이 미치지 않 는 것으로 나타났다. 본 연구결과는 성폭력 치료프로그램이 고위험군 성범죄자의 강간통념을 낮추는데 긍정적인 효과가 있었다. 본 연구는 교정시 설에서 성폭력 관련 치료프로그램에 방향성을 제시하고 교정현 장에서 치료프로그램을 진행하고 있는 임상심리사, 상담심리사 등 심리치료 전문가들에게 유용한 자료와 성범죄자의 재범방지 를 위한 제도적ㆍ정책적 개선안에 기여할 것으로 기대된다. Sex crimes are classified as violent crimes along with murder, and are serious crimes that make people angry, upset the media, and sentenced to high legal sentences. This study is aimed at verifying the effects of the sexual violence treatment program on the rape myths of high risk sex offenders being held in correctional facilities. In this study, 30 high-risk sex offenders at Seoul S prison were assigned 15 each as experimental and control groups. In the second half of 2019, The researchers conducted treatment program on the experimental group and did not conduct any treatment programs on the control group. Prior to the implementation of the sexual violence treatment program, prior homogeneity test was conducted on the experiment group and the control group. After the program was over, pre-post paired t-test was conducted to check the extent of changes in the rape myths of the high risk sex offenders. Frequency analysis and independent t-test and pre-post paired t-test was performed using the SPSS 23. statistical program for the data analysis. The results of the study are as follows. First, in difference analysis between pre-post test of experiment Group, the difference between mean(49.2000) of pre-test scores and mean(31.4667) of Post-Test scores is that the mean of post-test score is –17.7333 low. This difference had significant effects. Second, in the difference analysis of scores of post test between experiment group and control group, the difference between mean(31.4667) of experiment group and mean (47.5333) of control group is –16.0666. This difference had significant effects. Third, In the difference analysis of scores of pre-post test of control group, the significant result between mean(45.7333) of pre-test and mean(47.5333) of post-test did not produce a value. Therefore, the treatment program in this study turns out as having a positive effect on lowering the rape myths of high risk sex offenders. This study will provide direction to treatment programs related to sexual violence in correctional facilities, and it will be used as useful data for psychotherapy experts such as clinical psychologists and counseling psychologists who are conducting treatment programs at correctional field, and it is expected to help improve the system and policy to prevent sex offenders from committing crimes again.

여성형탈모증 환자의 삶의 질 조사

최광성,양보희,이원수,강훈,허창훈 대한피부과학회 2010 초록집 Vol.48 No.20

마이크로 LED용 전사 기술 개발 동향

최광성,Choe, Gwang-Seong 한국전기전자재료학회 2021 전기전자재료 Vol.34 No.2

한국인의 두피모발 특성과 남성형탈모증

최광성 대한의사협회 2013 대한의사협회지 Vol.56 No.1

The scalp hair is composed of one hundred thousand of hairs. Each hair goes through the three phases of the hair cycle, which causes the hair to turn from an anagen hair into a catagen hair,then into a telogen hair, and finally into a new anagen hair. The number of hairs is maintained at a relatively constant level because each hair has its own hair cycle. The hair of Koreans is relatively thicker than that of Caucasians and Africans but its growth rate and density are lower. There are various factors that influence hair growth such as hormones, nutritional status, and drugs. However,androgen is most important among these factors and, particularly, androgenetic alopecia is caused by androgen and genetic factors. Because excessive dihydrotestosterone produced by 5α-reductase is of the greatest importance in androgenetic alopecia, finasteride or dutasteride,which inhibits the action of 5α-reductase, is effective in treating androgenetic alopecia. Also,minoxidil is widely used as it promotes hair growth. Furthermore, there are various types of hair diseases and specialized examination is required for differential diagnosis.

4차 산업혁명의 숨은 혁신 기술: 전자 패키징 기술

최광성,문석환,배현철,장건수,엄용성,Choi, K.S.,Moon, S.H.,Bae, H.C.,Jang, K.S.,Eom, Y.S. 한국전자통신연구원 2017 전자통신동향분석 Vol.32 No.6

Electronic packaging technology is a technology that easily connects devices to the outside. The fourth industrial revolution is thought to be possible with the advancement of certain devices. The advancement of these devices must be accompanied by innovations in electronic packaging that connects the devices to the outside world, allowing their performances to be implemented at the system level. In this paper, the development trends of 2.5D/3D technology, heterogeneous integration technology, ultrafine interconnection technology, and heat dissipation technology will be examined, and the development direction of these technologies will be discussed.

제55차 추계학술대회 및 총회 : 심포지엄 5 ; 모발 : 반흔성 탈모증

최광성 대한피부과학회 2003 초록집 Vol.41 No.20

심포지엄 : 미용피부외과 ; 화학박피술

최광성 대한피부과학회 2009 대한피부과학회 학술발표대회집 Vol.61 No.1

제59차 추계학술대회 : 심포지엄3 ; 모발 : 다양한 탈모증 및 모간이상 ; 휴지기 탈모증

최광성 대한피부과학회 2007 초록집 Vol.45 No.20