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RISS 인기검색어
- 검색키워드
- 저자 : Sumitra Shantakumar (검색결과 3 건)
- 무료
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Choi Nam-Kyong,Shantakumar Sumitra,Kim Mi-Sook,Lee Chang-Hoon,Cheng Wendy Y,Bobbili Priyanka,Yang Bo Ram,Lee Joongyub,Hinds David,Duh Mei Sheng,Korves Caroline,Park Heung-Woo 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.2
Purpose: Although asthma treatment guidelines recommend regular inhaled medication, real-world treatment patterns and outcomes in South Korea have not been examined. We examined real-world treatment patterns and outcomes among patients treated for asthma in South Korea. Methods: This retrospective cohort study utilized data from the South Korean National Health Insurance database (2013–2016). Newly treated patients with asthma aged ≥18 years without history of chronic obstructive pulmonary disease were included. Initial and maintenance medication prescriptions were examined. Treatment discontinuation and switch were described. Asthma exacerbation rates, poor asthma control, and healthcare resource utilization (HRU) were compared between maintenance treatment groups (inhaled versus oral) using adjusted incidence rate ratios (aIRR) and hazard ratios (aHR). Results: Overall, 1,054,707 patients initiated any asthma medication; 37,868 patients initiated inhaled (n = 9,983, 26.4%) or oral (n = 27,885, 73.6%) maintenance medication. More patients initiating inhaled versus oral asthma medication discontinued treatment within 12 months (94.4% vs. 86.3%; P < 0.0001). Patients treated with inhaled and oral medication switched treatment (2.5% and 2.3%; P = 0.4160, respectively). Patients initiating inhaled medication had significantly lower rates of asthma exacerbation (aIRR, 0.52; 95% CI, 0.39–0.69), lack of asthma control (aHR, 0.55; 95% CI, 0.48–0.62; P < 0.0001), all-cause and asthma-related HRU versus oral medication. Conclusions: Despite current asthma guidelines, more patients in South Korea were prescribed oral than inhaled medications, resulting in suboptimal asthma management and increased HRU. This study highlights the need to reduce oral corticosteroid prescriptions for optimized treatment in asthma management.
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최광성,심우영,강훈,허창훈,이양원,Sumitra Shantakumar,Yu-Fan Ho,Eun-Jeong Oh,Mei Sheng Duh,Wendy Y. Cheng,Priyanka Bobbili,Philippe Thompson-Leduc,Gary Ong 대한피부과학회 2022 Annals of Dermatology Vol.34 No.5
Background: Dutasteride improves hair growth compared with finasteride in maleandrogenic alopecia (AGA) and is well tolerated. However, real-world evidence for longtermdutasteride use in AGA is lacking. Objective: To describe baseline characteristics, treatment patterns and long-term safety andeffectiveness of dutasteride versus finasteride. Methods: This was a multicentre, retrospective medical chart review study conductedin South Korea. The index date was the first prescription of dutasteride or finasteride. Baseline characteristics were assessed 6 months prior to index. Safety and effectiveness(improvements in basic and specific [BASP] classification) data were collected from indexthroughout the observation period. Results: Overall, 600 male adult patients were included (dutasteride, n=295; finasteride,n=305). Dutasteride-treated patients were older (p<0.001) and more likely to have moderate/severe BASP classification at baseline (p=0.010) compared with finasteride-treated patients. Among patients treated with recommended, on-label dosing exclusively (n=535: dutasteride,n=250; finasteride, n=285), dutasteride-treated patients showed greater improvementin hair growth than finasteride-treated patients, as measured by the BASP basic M classification(adjusted incidence rate ratio [95% confidence interval]: 2.06 [1.08, 3.95]; p=0.029). Among this same subset, overall occurrence of adverse events (AEs) during the observationperiod were not statistically equivalent between groups (dutasteride 7.6%, finasteride 10.5%;p=0.201), although reports of AEs of special interest were equivalent (p<0.001). Conclusion: Dutasteride showed greater effectiveness than finasteride in improving BASP classificationin treating male AGA and had a similar or possibly lower occurrence of overall AEs. Dutasteride may provide an effective and safe treatment option for male patients with AGA.
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( Gwang Seong Choi ),( Woo Young Sim ),( Hoon Kang ),( Chang Hun Huh ),( Yang Won Lee ),( Sumitra Shantakumar ),( Yu Fan Ho ),( Eun Jeong Oh ),( Mei Sheng Duh ),( Wendy Y. Cheng ),( Priyanka J. Bobbil 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: 5α-reductase inhibitors are commonly prescribed for treatment of male androgenic alopecia (AGA). Objectives: To evaluate the long-term effectiveness and occurrence of adverse events (AEs) in AGA patients receiving dutasteride or finasteride. Methods: A retrospective medical chart review study was conducted across 5 hospital-based dermatology clinics in South Korea between Jan 2010 and Dec 2018. Males aged ≥ 18 years at initiation of dutasteride or finasteride for the treatment of AGA (index date) with ≥ 3 years of available follow-up information were included. Results: 295 (49%) and 305 (51%) AGA patients were prescribed dutasteride and finasteride respectively. Dutasteride patients were older and had higher severity at index than finasteride patients. During follow-up, improvement in hair growth was more frequently observed in dutasteride patients, as measured by improvements in BASP for the basic M and specific V types (adjusted IRR = 1.84 [p=0.031] and 1.95 [p=0.019], respectively). Proportions of AEs were equivalent (equivalence margin ±5%) or sometimes lower among dutasteride patients, including AEs of special interest (e.g., decreased libido, erectile dysfunction and ejaculation disorder, proportion difference = 0.7%). Conclusion: Over an observation period of 3 years, dutasteride demonstrated greater effectiveness than finasteride among men with the most common type of AGA (M type) across severity levels. Similar AE frequencies were observed across both drugs.
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