CD99 Is Strongly Expressed in Basal Cells of the Normal Adult Epidermis and Some Subpopulations of Appendages: Comparison with Developing Fetal Skin

최가원,노진,박찬식 대한병리학회 2016 Journal of Pathology and Translational Medicine Vol.50 No.5

Background: CD99 is a cell surface transmembrane glycoprotein expressed in various tissues. CD99 is differentially expressed between subpopulations of each tissue and is highly expressed in certain hematopoietic and precursor cells. However, there has been no comprehensive study of CD99 expression in normal skin. We evaluated CD99 expression in normal human skin and developing fetal skin. Methods: Seventy-five adult skin samples containing normal skin and eight fetal skin samples of different gestational ages were collected. CD99 immunohistochemical staining was performed to evaluate expression pattern in adult and fetal skin samples. CD99 and CD34 expression were compared by double immunofluorescence. Results: In normal adult skin, CD99 was strongly expressed in the membrane of epidermal basal keratinocytes, hair follicle bulges and outer root sheaths, and inner secretory cells of eccrine sweat glands. In fetal skin, CD99 was not expressed on the periderm at 16 weeks of gestation but was expressed in basal cells of fetal skin at around 19 weeks of gestation. CD99 expression became comparable to that of the adult skin after 20 weeks of gestation. CD99 and CD34 were co-expressed in hair follicle outer root sheaths, as seen by double immunofluorescence study. Conclusions: This is the first study examining CD99 expression pattern in normal adult and fetal skin. CD99 tends to be expressed in the basal/precursor cells of epidermis and in hair follicles. These results provide a basis for future investigation on functions of CD99 in the skin and provide a novel potential target for the treatment of dermatologic lesions.

이후통(耳後痛)을 동반한 Bell's palsy 환자 30례에 대한 소장정격(小腸正格)과 체침(體鍼)의 임상적 비교연구

최가원,강재희,김영일,홍권의,이현,Choi, Ka-won,Kang, Jae-hui,Kim, Young-il,Hong, Kwon-eui,Lee, Hyun 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4

Objective : The study was designed to evaluate the effects of treatment of Bell's palsy patients with posterior ear pain by the Sa-Am acupuncture. Methods : From December 5th 2003 to May 22th 2004, the clinical comparison studies were carried out 30 cases of Bell's palsy patients with posterior ear pain treated by Sa-am acupuncture Sojangjeonggyeok(Group 1) & General acupuncture(Group 2), who had been treated in Dept. of acupuncture and moxibustion, Oriental Medical Hospital, Dae-Jeon University. Results : The result obtained as follows; 1. There was no significant difference between the two groups in the degree of improvement by H-B grade(p>0.05). 2. Group 1 is more effective than Group 2 in the VAS score after 5, 10 days of each treatment about mastoid pain($p{\leq}0.05$). Conclusion : In this study, although Sa-am acupuncture Sojangjeonggyeok was effective treatment of the posterior ear pain, there was no significant difference between the Group 1 and Group 2 in the degree of improvement of facial palsy. So further research is needed continuously.

款冬花藥鍼의 喘息抑制 및 免疫調節效果에 對한 實驗的 硏究

최가원,이현,홍권의 대한침구의학회 2007 대한침구의학회지 Vol.24 No.1

Objectives : The purpose of this study is to observe the suppressive effect of Asthma and Immune response improvement of FF(Farfarae Flos) Herbal-acupuncture into Joksamni(ST36) on ovalbumin-induced asthma in mice. Methods : C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks. Experimental group was treated with concentrations(1%) of FF-HA at Joksamni(ST36) for the later 8 weeks(3times/week). Results : 1. The weight and total cells in the mice lung treated with FF-HA decreased significantly compared with that of control group. 2. Total leukocytes and eosinophils in BALF of the mice group treated with FF-HA decreased remarkably compared with those of control group. 3. The sticking of collagen on histological analysis of lung sections, the mice group treated with FF-HA decreased significantly compared with those of Control group. 4. The concentrations of IgE, IL-4, IL-5 in BALF, and IL-4, IL-5, IL-13 in serum of the mice group treated with FF-HA decreased significantly compared with those of control group.5. The number of Gr-1+/CD11b+, CD11+ cells, CCR3+ cells, CD4+ cells, and CD3e+/CD69+ in the lungs of the mice group treated with FF-HA decreased significantly compared with those of control group. 6. The mRNA expression of TNF-α, IL-4, IL-5, IL-13 in the mice group treated with FF-HA with RT-PCR decreased remarkably compared with those of control group. Conclusion : These result suggests that Farfarae Flos Herbal-acupuncture at Joksamni(ST36) in C57BL/6mice may be an effective part to OVA-induced asthma in C57BL/6 mice.

영화 ‘아버지와 이토씨’에 나타난 가족갈등 분석을 통한 고령화 시대의 노인 부양에 관한 사례 연구

최가원,김민정 대한가정학회 2019 대한가정학회 춘계학술대회 자료집 Vol.2019 No.0

젊은 여성에게 발생한 자궁내막암종의 임상 및 병리학적 특징

최가원,강신광,김정원,김규래 대한병리학회 2009 Journal of Pathology and Translational Medicine Vol.43 No.5

Background : Despite an increased incidence of endometrial carcinomas in young Korean women, clinicopathologic characteristics and treatment outcomes have not been analyzed. Methods : We investigated clinicopathologic characteristics of endometrial carcinoma in 48 women who were under the age of 40 in order to determine treatment guideline. Results : According to the criteria of the Korean Society for Obesity, 70.8% of study patients were overweight or obese, with an average body mass index (BMI) of 26.0 kg/㎡. Twelve patients received progesterone treatment only, and 6 of them later had successful pregnancies. The histologic subtype was endometrioid adenocarcinoma in all patients. FIGO stages were 1A (41.7 %), 1B (47.1%), ⅡA (2.8%), ⅡB (2.8%), ⅢA (2.8%), and ⅢC (2.8%). FIGO grades were grade 1 (79%) or 2 (21%). The average depth of invasion, excluding stage 1A, was 4.6 ㎜ in the hysterectomy specimens. Two patients were given post-operative radiation treatment and 4 were treated with chemotherapy. All but one case had an uneventful postoperative course during follow-up. Conclusions : A majority of endometrial carcinomas in young Korean women were associated with an early FIGO stage, favorable histologic subtype and grades, and a good prognosis. Progesterone treatment with close observation was a successful treatment option in a selected group of young patients.

잇몸에 발생한 원발성 점막의 결합조직형성흑색종- 1예 보고 -

최가원,김정원,남순열,조경자 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.6

Desmoplastic melanoma (DM) is a rare malignant melanoma variant. Although DM mainly affects the skin chronically exposed to the sun, a small number of mucosal DM have been reported. Primary mucosal DM is difficult to diagnose because of its rarity and atypical histopathologic features. Here, we report a case of DM in a 52 year-old female who presented with a right cervical mass and upper gingival pigmentation. A CT scan revealed an ill-defined infiltrative mass 2 cm in size under the pigmented mucosa. She subsequently underwent a partial maxillectomy with neck dissection. Gross examination revealed that the mass exhibited a grayish white fibrotic cut surface and that the maxillary bone had been destroyed. Microscopically, the main mass was composed of cigar-shaped or wavy spindle cells with desmoplastic stroma under the melanoma in situ. The diagnosis of DM was confirmed immunohistochemically with S100 protein positivity and HMB45 negativity. The patient has survived for 29 months after the operation with a presumed metastatic focus. Desmoplastic melanoma (DM) is a rare malignant melanoma variant. Although DM mainly affects the skin chronically exposed to the sun, a small number of mucosal DM have been reported. Primary mucosal DM is difficult to diagnose because of its rarity and atypical histopathologic features. Here, we report a case of DM in a 52 year-old female who presented with a right cervical mass and upper gingival pigmentation. A CT scan revealed an ill-defined infiltrative mass 2 cm in size under the pigmented mucosa. She subsequently underwent a partial maxillectomy with neck dissection. Gross examination revealed that the mass exhibited a grayish white fibrotic cut surface and that the maxillary bone had been destroyed. Microscopically, the main mass was composed of cigar-shaped or wavy spindle cells with desmoplastic stroma under the melanoma in situ. The diagnosis of DM was confirmed immunohistochemically with S100 protein positivity and HMB45 negativity. The patient has survived for 29 months after the operation with a presumed metastatic focus.

만성 슬개대퇴통증 환자에 턱관절균형요법을 병용하여 증상 개선을 보인 치험 1례

최가원(Gawon Choe) 턱관절균형의학회 2023 턱관절균형의학회지 Vol.13 No.1

The purpose of this case report is to introduce a case of immediate results with TMJ balancing therapy (TBT) in the treatment of chronic patellofemoral pain (PFP). A 17-year-old female patient with 4-month-old chronic knee pain that was unresponsive to conventional treatment was treated with TBT for a total of 5 sessions. The primary outcomes were evaluated using the Numeric Rating Scale (NRS) and the Korean version of the Western Ontario and McMaster Universities Osteoarthritis Index (KWOMAC). Following the first treatment, the NRS decreased rapidly, and the KWOMAC improved after a total of five treatments. These findings suggest that TBT can be an effective pain management option for chronic PFP patients with temporomandibular joint malposition. However, as this study is a report of a single case, further research is necessary.

감정 인식과 음색 파라미터에 관한 연구

최가원(Ka-Won Choi),최정윤(Jeung-Yoon Choi) 한국통신학회 2008 한국통신학회 학술대회논문집 Vol.2008 No.11

거짓낭 제거술 후 췌두부에 발생한 외상신경종 - 짧은 증례 보고 -

김정원,최가원,황정은,강신광,한덕종,장세진 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.5

We describe here a case of traumatic neuroma that developed in the pancreas head as a rare complication of pancreatic surgery for pseudocyst. A 50-year-old man presented with septic shock. The patient was a heavy drinker with history of operation for pancreatic pseudocyst 28 years ago. On the radiologic examinations, a poorly defined mass-like lesion was found in the uncinate process of pancreas, and it had features of chronic pancreatitis and a stricture of the distal common bile duct. Whipple’s operation was performed due to the diagnosis of suspected pancreas head cancer. The pancreas revealed an ill-demarcated 4 cm sized firm mass with grayish white fibrotic cut surface in the head portion. On the microscopic examination, the mass was composed of haphazard proliferations of nerve fascicles in a fibrocollagenous matrix and this case was diagnosed as traumatic neuroma. Although traumatic neruoma is a rare cause of a pancreatic mass, it should be included as a differential diagnosis of pancreatic mass in patients with a history of pancreatic surgery.

急性 腰部 捻挫 환자 30例의 頭部 督脈經, 足太陽膀胱經 經穴 倒馬鍼法 치료효능에 대한 臨床的 考察

강민완,김성래,최가원,송형근,김정호,양기영,임윤경,김영일,홍권의,이현 대한침구의학회 2006 대한침구의학회지 Vol.23 No.3

Objectives : This study is designed in order to evaluate the therapeutic effect of Scalp Acupuncture and Do-ma Acupuncture related with Governer Vessel(Dok) and Bladder Meridian(Chok-taeyang) on acute low back pain Methods : We investigated 30 patients suffering from acute low back pain were admitted to Dunsan O.M.hospital from March. 1st 2005 to December. 30th 2005. We divided into two groups: one group was treated with Scalp acupunture, another group was treated with common acupuncture. 30 patients, were diagnosed only straightened curvature on lateral view of lumbar spine X-ray. Scalp acupunture related with Governer Vessel(Dok) and Bladder Meridian(Chok-taeyang) and Do-ma acupuncture. To estimate the efficacy of treatment that applied for two groups, we compared the visual analog scale(VAS), Oswestry disabiliby index(ODI) and Straight Leg Raising Test(SLRT) score of two groups statistically. Results : Both Scalp acupuncture related with Governer Vessel(Dok) and Bladder Meridian (Chok-taeyang) and Do-ma acupuncture therapy showed good effect on acute low back pain. It was proved by the difference between VAS, ODI and SLRT score checked before treatment and what checked after treatment on each groups. Conclusion : The therapeutic effect of Scalp Acupuncture and Do-ma Acupuncture on acute low back pain can be recommended as a useful therapy to treat acute low back pain.