COPD 조기 치료의 필요성

정지예 대한내과학회 2020 대한내과학회 추계학술대회 Vol.2020 No.1

Digital Healthcare for Airway Diseases from Personal Environmental Exposure

정지예,박영목,이찬호 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.-

Digital technologies have emerged in various dimensions of human life, ranging from education to professional services to wellbeing. In particular, health products and services have expanded by the use and development of artificial intelligence, mobile health applications, and wearable electronic devices. Such advancements have enabled accurate and updated tracking and modeling of health conditions. For instance, digital health technologies are capable of measuring environmental pollution and predicting its adverse health effects. Several health conditions, including chronic airway diseases such as asthma and chronic obstructive pulmonary disease, can be exacerbated by pollution. These diseases impose substantial health burdens with high morbidity and mortality. Recently, efforts have been made to develop digital technologies to alleviate such conditions. Moreover, the COVID-19 pandemic has facilitated the application of telemedicine and telemonitoring for patients with chronic airway diseases. This article reviews current trends and studies in digital technology utilization for investigating and managing environmental exposure andchronic airway diseases. First, we discussed the recent progression of digital technologies in general environmental healthcare. Then, we summarized the capacity of digital technologies in predicting exacerbation and self-management of airway diseases. Concluding these reviews, we provided suggestions to improve digital health technologies’ abilities to reduce the adverse effects of environmental exposure in chronic airway diseases, based on personal exposure-response modeling.

Association between Inhaled Corticosteroid Use and SARS-CoV-2 Infection: A Nationwide Population-Based Study in South Korea

정지예,Sang Chul Lee,Kang Ju Son,Seon Cheol Park,Chang Hoon Han 대한결핵및호흡기학회 2022 Tuberculosis and Respiratory Diseases Vol.85 No.1

Background: Although it is known that inhaled corticosteroid (ICS) use may increase the risk of respiratory infection,its influence on the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. Thus, the aim of this study was to investigate the association between ICS use and the positivity of SARS-CoV-2 infectionamong patients with chronic respiratory diseases. Methods: Nationwide data of 44,968 individuals with chronic respiratory diseases tested for SARS-CoV-2 until May 15,2021 were obtained from the Ministry of Health and Welfare and Health Insurance Review and Assessment Service inKorea. The positivity of SARS-CoV-2 infection was retrospectively analysed according to the prescription, type, and doseof ICS taken one year before SARS-CoV-2 test. Results: Among 44,968 individuals tested, 931 (2.1%) were positive for SARS-CoV-2. A total of 7,019 patients (15.6%)were prescribed ICS one year prior to being tested for SARS-CoV-2. Low, medium, and high doses of ICS were prescribedin 7.5%, 1.6%, and 6.5% of total cases, respectively. Among types of ICS, budesonide, fluticasone, beclomethasone, andciclesonide were prescribed in 3.7%, 8.9%, 2.3%, and 0.6% of total cases, respectively. A multivariate analysis showed nosignificant increase in infection with ICS use (odds ratio, 0.84; 95% confidence interval, 0.66–1.03). Moreover, there wereno associations between the positivity of infection and the dose or type of ICS prescribed. Conclusion: Prior ICS use did not increase the positivity for SARS-CoV-2 infection. Moreover, different doses or types ofICS did not affect this positivity.

만성폐쇄성폐질환

정지예 대한내과학회 2019 대한내과학회 추계학술대회 Vol.2019 No.2

국제표준화·시험인증 회의 참가보고 - Bluetooth SIG UnPlugFest #48(Bluetooth/Continua/NFC)

정지예,윤여훈,Jeong, Ji-Ye,Yun, Yeo-Hun 한국정보통신기술협회 2014 TTA저널 Vol.154 No.-

천식 환자에서 전반적 자기 평가와 한국 성인 천식 환자의 삶의 질 평가 설문과의 비교 분석

정지예,손지영,홍수정,이용원,신유섭,박중원,홍천수 대한알레르기학회 2008 천식 및 알레르기 Vol. No.

Background: The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA) is a valid and reproducible tool for evaluating and monitoring Korean adult asthmatics. However, the questionnaire is still burden to some patients, so we developed a simplified global self-assessment scoring. Objective: The goal of this study is to compare the patient’s global self-assessment scoring method with the QLQAKA and evaluate how it reflects quality of life (QOL) of asthmatics. Method: One hundred ninety-nine adult asthmatics were enrolled and asked to answer the QLQAKA composed of 17 items in 4 domains (activity, symptom, emotion and exposure to environmental stimuli) and one more global self-assessment question with a 5-point scale was added. According to the Global Initiative for Asthma (GINA) 2006 guide-lines, patients were divided into 3 groups: controlled, partly controlled and uncontrolled groups. Then, we analyzed the relationships between the QLQAKA scores, global self-assessment scores and various clinical parameters. Result: The mean QLQAKA score and global self-assessment score were statistically significantly different between the 3 groups. Pulmonary function tests were also statistically significantly different between the 5 QLQAKA score subgroups as well as 5 self-assessment score subgroups. Moreover, global self-assessment scores were well correlated with QLQAKA scores. Conclusion: In a busy outpatient clinic, we may estimate the QOL of asthma patients using a simplified patient’s global self-assessment scoring method.

Questionable Role of Interferon-γ Assays for Smear-negative Pulmonary TB in Immunocompromised Patients

정지예,임주은,이혜정,김영미,조상호,박병훈,박무석,김영삼,김세규,장준,강영애 대한결핵 및 호흡기학회 2011 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.112 No.-

Relationship of Vitamin D Binding Protein Polymorphisms and Lung Function in Korean Chronic Obstructive Pulmonary Disease

정지예,서일,최동필,원성호,이영,신주혜,김영삼,김세규,오연목,이상도 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.5

Purpose: Multiple genetic factors are associated with chronic obstructive pulmonarydisease (COPD). The association of gene encoding vitamin D binding protein (VDBP, GC) with COPD has been controversial. We sought to investigate the types of GC variants in the Korean population and determine the association of GC variants with COPD and lung function in the Korean population. Materials and Methods: The study cohort consisted of 203 COPD patients and 157 control subjects. GC variants were genotyped by the restriction fragment-length polymorphismmethod. Repeated measures of lung function data were analyzed using a linear mixed model including sex, age, height, and pack-years of smoking to investigatethe association of GC genetic factors and lung function. Results: GC1F variant was most frequently observed in COPD (46.1%) and controls (42.0%). GC1S variant (29.0% vs. 21.4%; p=0.020) and genotype 1S-1S (8.3% vs. 3.4%; p=0.047) were more commonly detected in control than COPD. According to linearmixed model analysis including controls and COPD, subjects with genotype 1S-1S had 0.427 L higher forced expiratory volume in 1 second (FEV1) than those with other genotypes (p=0.029). However, interaction between the genotype and smoking pack-year was found to be particularly significant among subjects with genotype 1S-1S; FEV1 decreased by 0.014 L per smoking pack-year (p=0.001). Conclusion: This study suggested that GC polymorphism might be associated with lung function and risk of COPD in Korean population. GC1S variant and genotype 1S-1S were more frequently observed in control than in COPD. Moreover,GC1S variant was more common in non-decliners than in rapid decliners among COPD.

Relationship of Vitamin D Binding Protein Polymorphisms to Lung Function Decline in Chronic Obstructive Pulmonary Disease

정지예,최동필,원성호,이영,김영삼,김세규,오연목,서일,이상도,( Kold Study Group ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Background: Multiple genetic factors are associated with the risk of developing COPD. One of the leading candidates is the gene encoding vitamin D binding protein (VDBP). We sought to investigate the types of VDBP variants in the Korean population and determine the association of VDBP variants with COPD and airflow deterioration. Methods: The study cohort consisted of 203 COPD patients and 157 control subjects. VDBP variants were genotyped by the RFLP method. All lung function data were analyzed using a linear mixed model. Results: GC1F variant was most frequently observed both in COPD (42.8%) and controls (38.6%). Genotype 1S-1S was more commonly detected in controls than in COPD (8.4% versus 3.4%, P=0.047). According to linear mixed model analysis, subjects with genotype 1S-1S had 0.427 L higher FEV1 than those with other genotypes (P=0.029). However, the genotype/smoking pack-year interaction was found to be particularly significant among subjects with genotype 1S-1S; FEV1 decreased by 0.014L per smoking pack-year (P=0.001). Conclusions: VDBP genotype 1S-1S was significantly associated with lung function decline in patients who smoke. Lung function decline in subjects with genotype 1S-1S was more prominent as the amount of pack-years increased compared to subjects with other genotypes (a grant of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare (A102065), a grant of the Korea Centers for Disease Control and Prevention (2006-E71011-00), and a Faculty Research Grant of Yonsei University College of Medicine for 2011 (6-2011-0192)).

F-86 Clinical implication of autoantibody against AIMP2 and AIMP2-DX2 in lung cancer

정지예,( Eun Young Kim ),( Arum Kim ),( Joon Chang ),( Nam Hoon Kwon ),( Sunghoon Kim ),( Yoon Soo Chang ) 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-

Introduction: Aminoacyl t-RNA synthetase-interacting multi-functional protein 2 (AIMP2) promotes cell death through activation of p53 and TNF-α signaling. Its alternative spliced form lacking exon 2 (AIMP2-DX2) competes with AIMP2 for binding to target proteins and compromises its tumor suppressive activity. We investigated clinical implication of autoantibodies against AIMP2-DX2 and AIMP2 in lung cancer. Methods: The diagnostic usefulness of autoantibody against AIMP2-DX2 and AIMP2 was investigated in 80 lung cancer and 80 control cases. Their clinical implication was analyzed in 165 lung cancer patients. Results: Diagnostic value of AIMP2-DX2, AIMP2, and AIMP2-DX2/AIMP2 in lung cancer was limited with low AUC of AIMP2-DX2, AIMP2, and AIMP2-DX2/AIMP2 ratio (0.416, 0.579 and 0.357). A total 165 lung cancer patients were classified into high and low AIMP2-DX2, AIMP2, and AIMP2/DX2 group, respectively, based on median value of each parameter. High AIMP2-DX2 group was older (66.8 vs. 63.8 yrs, P=0.040) and demonstrated more frequent larger tumor (>3cm)(26.9 vs. 12.7%, P=0.045) than low AIMP2-DX2 group. High AIMP2-DX2/AIMP2 group showed higher CYFRA-21 level (7.9 vs. 4.3ng/mL, P=0.020) and significant shorter overall survival (18.6 vs. 48.9 months, P=0.021) than low AIMP2-DX2/AIMP2. Conclusions: Autoantibodies against AIMP2-DX2 and AIMP2 exist at detectable level human blood. Increased AIMP2-DX2/ AIMP2 ratio is related to the poor clinical outcome of lung cancer patents, indicating those are warranted for further study for development as biomarkers in lung cancer.