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FBG Sensor Probes with Silver Epoxy for Tracing the Maximum Strain of Structures
임주은,김미현,최기선,황태경,권일범 한국비파괴검사학회 2013 한국비파괴검사학회지 Vol.33 No.5
Structures can be evaluated their health status by allowable loading criteria. These criteria can be determined by the maximum strain. Therefore, in order to detect this maximum strain of structures, fiber optic Bragg grating(FBG) sensor probes are newly designed and fabricated to perform the memorizing detection even if the sensor system is on-and-off. The probe is constructed with an FBG optical fiber embedded in silver epoxy. When the load is applied and removed on the structure, the residual strain remains in the silver epoxy to memorize the maximum strain effect. In this study, a commercial Al-foil bonded FBG sensor probe was tested to investigate the detection feasibility at first. FBG sensor probes with silver epoxy were fabricated as three different sizes. The detection feasibility of maximum strain was studied by doing the tensile tests of CFRP specimens bonded with these FBG sensor probes. It was investigated the sensitivity coefficient defined as the maximum strain divided by the residual strain. The highest sensitivity was 0.078 of the thin probe having the thickness of 2 mm.
임주은,박무석,김은영,정지예,강영애,김영삼,김세규,심효섭,조병철,장준 대한결핵및호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.4
Background: Plasminogen activator inhibitor type 1 (PAI-1), an important regulator of plasminogen activator system which controls degradation of extracellular membrane and progression of tumor cells, and PAI-1 gene polymorphic variants have been known as the prognostic biomarkers of non-small cell lung cancer patients. Recently, experimental in vitro study revealed that transforming growth factor-β1 initiated PAI-1 transcription through epithelial growth factor receptor (EGFR) signaling pathway. However, there is little clinical evidence on the association between PAI-1 A15T gene polymorphism and prognosis of Korean population with pulmonary adenocarcinoma and the influence of activating mutation of EGFR kinase domain. Methods: We retrospectively reviewed the medical records of 171 patients who were diagnosed with pulmonary adenocarcinoma and undergone EGFR mutation analysis from 1995 through 2009. Results: In all patients with pulmonary adenocarcinoma, there was no significant association between PAI-1 A15T polymorphic variants and prognosis for overall survival. However, further subgroup analysis showed that the group with AG/AA genotype had a shorter 3-year survival time than the group with GG genotype in patients with EGFR mutant-type pulmonary adenocarcinoma (mean survival time, 24.9 months vs. 32.5 months, respectively; p=0.015). In multivariate analysis of 3-year survival for patients with pulmonary adenocarcinoma harboring mutant-type EGFR, the AG/AA genotype carriers had poorer prognosis than the GG genotype carriers (hazard ratio, 7.729;95% confidence interval, 1.414−42.250; p=0.018). Conclusion: According to our study of Korean population with pulmonary adenocarcinoma, AG/AA genotype of PAI-1 A15T would be a significant predictor of poor short-term survival in patients with pulmonary adenocarcinoma harboring mutant-type EGFR.
하악의 교정용 미니 임플랜트 식립 부위에서의 피질골 두께와 치근간 거리 : 3차원으로 재구성한 CT 영상을 이용한 연구
임주은,임원희,전윤식 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.6
교정용 미니 임플랜트의 식립 부위에 대한 연구는 주로 구치부 치근사이 공간에 집중되어 왔다. 본 연구의 목적은 전치에서 구치에 이르는 치아간의 피질골 두께와 치근간 거리를 측정함으로써 교정용 미니 임플랜트 식립 시에 참고 할 수 있는 임상적 지침을 제공하는 것이다. 연구를 위해 성인 28명(남자 14명, 여자 14명)의 CT를 V-works 4.0 을 이용하여 3차원 영상으로 전환하였다. 중절치에서 제2대구치에 이르는 모든 치아 사이를 치간 접촉점을 지나면서 교합 평면에 수직이 되도록 잘라 90° 단면을 형성한 후 치조정으로부터 높이를 달리하여 0, 15, 30, 45° 의 각도를 주어 피질골의 두께를 측정하였다. 또한 치조정으로부터 2, 4, 6 mm 높이에서 교합 평면에 평행하게 잘라 90° 단면을 만든 후 치근간 거리를 측정하였다. 피질골의 두께는 전치부에서 구치부로 갈수록 두꺼워지는 경향을 보였으며, 5-6과 1-1 사이, 6-7과 1-1, 1-2, 2-3 사이에서는 유의한 차이를 보였다 (p < 0.05). 치조정으로부터 2 mm 높이를 제외한 대부분의 위치에서 각도가 증가함에 따라 피질골의 두께가 급격히 증가하는 경향을 보였고, 4 - 6 mm 높이에 식립시 30 - 45˚ 이상의 각도를 부여해야 피질골 보유량(engage 양)에 유의한 차이를 보였다. 치근간 거리 측정 결과 4-5, 5-6, 6-7 사이가 치근 손상 없이 미니 임플랜트를 식립하기에 적절한 위치라고 볼 수 있었고, 1-1과 1-2 사이는 미니 임플랜트 식립을 위한 충분한 치근간 거리를 제공하지 못하는 것으로 나타났다. 본 실험의 결과로 볼 때 피질골과 미니임플랜트의 접촉면을 증가시키기 위해서는 치조정에서 치근단부로 4와 6 mm 되는 부위에서 30˚ 또는 45˚ 로 식립하는 것이 유리할 것으로 보인다. The purpose of this study was to provide clinical guidelines to indicate the best location for mini-implants as it relates to the cortical bone thickness and root proximity. Methods: CT images from 14 men and 14 women were used to evaluate the buccal interradicular cortical bone thickness and root proximity from mesial to the central incisor to the 2nd molar. Cortical bone thickness was measured at 4 different angles including 0°, 15°, 30°, and 45°. Results: There was a statistically significant difference in cortical bone thickness between the second premolar/ first permanent molar site, central incisor/central incisor site, between the first/second permanent molar site and in the anterior region. A statistically significant difference in cortical bone thickness was also found when the angulation of placement was increased except for the 2 mm level from the alveolar crest. Interradicular spaces at the 1st/2nd premolar, 2nd premolar/1st permanent molar and 1st/2nd permanent molar sites are considered to be wide enough for mini-implant placement without root damage. Conclusions: Given the limits of this study, mini-implants for orthodontic anchorage may be well placed at the 4 and 6 mm level from the alveolar crest in the posterior region with a 30° and 45° angulation upon placement.