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최성관,전재복 ( Sung Koan Choi,Jae Bok Jun ) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.3
Clinical observations were made on 63 cases on nevus sebaceus of Jadasshon. 52 of 63 cases were diagnosed on the basis of clinical and histopathologic findings during a period of 19 years from January 1969 to July 1987 at the Department of Dermatology, Kyungpook National University Hospital, with the remaining 11 cases diagnosed at other skin clinics in Taegu. Histopathologic examinations were made on 51 selected cases of the 63. The results were as follows : Clinical observations 1) The percentage of patients with nevus sebaceus of Jadasshon of total new outpatients was 0.12%. Of the 63 cases, males numbered 38 and females, 25, with a sex r atio of 1.5: 1. 2) Patients when first seen were most commonly in the age group of 10~19. 3) The most favorate sites were the scalp(83.3%) and face(13.3%). 4) The average size of the lesions was 2.23cm * 3.24cm with no difference among the age groups. Histopathological observations 1) The apparent proliferation of sebaceous glands was observed in 32 of 51 cases(62.7%). The degree of proliferation markedly increased in the age group of l0~19 and slightly decreased beyond this age group. Apocrine glands were present. in 17(33.3%), with a higher number of glands seen in the age group of 10~19. Immature hair follicles were found in 38(74.5%), with no changes according to aging. 2) The epidermal changes such as acanthosis(86.3%), papillomatosis(70.6%), hyperkeratosis(78.2%) and hypergranulosis(78.2%) predominated in the age group of 10-19, and severe but more gradual changes were noted 20 years of age on. 3) Inflammatory cell infiltration of moderate to marked degree was noticeable in 27(53%). The older the patients were, the more pronounced dermal infiltration was. 4) Six of 51 cases were complicated with basal cell carcinoma(3) and syringocystadenoma papilliferum(4). The tumors, which occurred beyond 30 years of age, showed a marked inflammatory cell infiltration.
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장재원(Jae Won Jang),김도원(Do Won Kim),전재복(Jae Bok Jun),정상립(Sang Lip Chung) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.7
N/A Background: Systemic corticosteroids can arrest the progression of alopecia areata and lead to hair growth in a significant proportion of patients but may also cause unacceptable side effects. Objective: To minimize the side effects, we tried a new approach using minipulse therapy with betamethasone (CelestoneR). We performed a clinical observation of alopecia areata to understand its therapeutic responses. Method: Forty six patients with alopecia areata were given 3mg betamethasone as a single oral dose on 2 consecutive days per week. Therapeutic effects and side reactions were evaluated by dermatologists every month. Results: The extent of hair regrowth varied in different patients and even in different lesions in the same patient. Effective response, which shows vellus and/or terminal hair growth for more than 1 month, was achieved in 67.4% of the patients (31 cases). The side effects included acne in 14 patients, weight gain in 11 patients, gastrointestinal discomfort in 6 patients and facial flushing or edema in 5 patients; 19 patients had no side effects. Conclusions: Oral minipulse therapy with betamethasone seems to be an effective treatment modality to arrest the progression of alopecia areata and also induces hair regrowth. This modality of treatment had minimal and less severe side effects, compared with currently used pulse therapy with methylprednisolone. It deserves to be tried on a large scale to evaluate its advantages and disadvan-tages over the currently useful methods of treatment. (Korean J Dermatol 2001;39 (7) 775-781)
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김준영 ( Jun Young Kim ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ),김태훈 ( Tae Hoon Kim ),전재복 ( Jae Bok Jun ),김문범 ( Moon Bum Kim ),김병수 ( Byung Soo Kim ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.6
Background: Psoriasis is a chronic and intractable disease that drives patients to seek a complete cure. Recently, the patients who have failed with conventional medicine increasingly appear to be turning to complementary and alternative medicine (CAM), yet little is known of CAM`s prevalence of use, and its effectiveness and safety, and especially for treating psoriasis. Objective: The aim of this study was to qualify and quantify the usage of CAM for the treatment of psoriasis, and to offer valid information for dermatologists. Methods: A total of 158 patients suffering from psoriasis were interviewed and they filled out a face-to-face structured questionnaire. Results: Sixty-nine of 158 (43.7%) psoriasis patients reported the current or previous use of CAM. In the order of frequency, oriental medicine (49, 31.0%) was the most commonly used, followed by spa and bath therapy (31, 19.6%), health food supplements (28, 17.7%), topical applications (14, 8.9%) and dietary therapy (14, 8.9%). The majority of patients (60.9%) used CAM from the `Desire to try everything`. The subjective therapeutic effect and satisfaction with CAM were predominant with health food supplements (57.1% and 53.6%, respectively). After the use of CAM, the patients most frequently complained of `aggravation of psoriasis` as a side effect of CAM (14.0%). Conclusion: These results indicate that CAM is being widely used by patients with psoriasis. However, the use of CAM seems to not be very effective and it is not free of risks. Thus, the direct and indirect risks, and the merits and disadvantages of CAM should always be considered with prudence before using CAM in clinical practice. (Korean J Dermatol 2010;48(6):494∼502)
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경표피수분손실 및 Methyl Nicotinate 경피흡수에 의한 혈관 반응 측정을 이용한 피부 장벽 기능 검사
이정우,김도원,전재복,정상립 ( Jeong Woo Lee,Jae Bok Jun,Do Won Kim,Sang Lip Chung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6
Background: The measurement of transepidermal water loss(TEWL) is widely used in evaluating the stratum corneum barrier function. It is also possible to evaluate the penetration of substances into the skin as an adc'itional parameter of the straturn corneum barrier function. Objective : The purpose of the present study is to investigate ihe relat,ionship between TEWL and t,he percutaneous absorptic n of met,hyl nicotinate(MN) in the normal and acute perturbative state of the epidermal barrier. Method: Vascular response 10 MN penetration were rneasured by both laser Doppler flowmetry (LDF) and visual erythema oii the forearms of 30 healthy volunteers. Stratum corneum of the ar ea of 2*10cm on the volar for earm was removed by repeated tape stripping when TEWL reached 12-30g/rnh measured with Evaporimeter. The left forearm received no treatrnent as a control site. Each time the profile of the vascular response to MN penetration was analysed using the following parameters.the 1; g time between MN application and initial response(T0), the time between MN application and maximal response(Tmax), and the rnaximal response(LDF), the time between MN application and initial visual erythema(VT0), and the time between MN application and maxirnum visual erythema(VTmax). Results : The data showed a negative correlation between TEWL and T0(r=-12.89, p<0.001), TEWL and Tmax=(r=-14.87, p< 0.001), and TEWL and VT0>(r= -3.99, p<0.001), TEWL and VTmax(r = -9.29, p<0.001). And there was a positive correlation between VT0 and T0(r=1.19, p<0.001), and between VTmax and Tmax(r=1.05, p<0.001). However, there was no detectable correlation between TEWL and LDFmax(p>0.05). Conclusion : Vascular response to percutaneous absorption of MN measured by LDF as well as TEWL is a useful non-invasiv method for objective evaluation of the stratum corneum barrier function. In addition, visual erit,hema induced by t,opical vasodilators such as MN is also a good method for skin barrier function assessment. (Korean J Dermatol 1997;35(6): 1121 1129)
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Iontophoresis를 이용한 수장 족저 다한증의 치료
김영두(Young Doo Kim),전재복(Jae Bok Jun) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.6
In the present study, tap water iontophoresis as a method of treatment of palmoplantar hyperhidrosis was evaluated. Eighteen patients, twelve males and six females, with singnificant palmoplantar hyperhidrosis were treated on every weekday for 2 weeks. The hand and foot of the same side were randomly selected for the treatment by tap water iontophoresis according to the the method described by Levit. The selected hand and foot were immersed in a pair of pans containing tap water and exposed to 30V and 3 to 14mA of direct current for 20 minutes. The results obtained were as follows . Among 18 patients treated, 14(77.8%) accomplishei3 sufficient control of hyperhidrosis after 6 12(average 9.1) treatments. Two patients showed a moderate response and one weak response. One patient showed no response. Several patients experienced untoward effects such as mild itching, erythema, tingling sensation, exfoliation, compensatory hyperhidrosis, but the discomfort was not so severe as to stop the treatment (Kor J Dermatol 28(B):758 764, 1990)
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초음파가 Methyl nicotinate 경피흡수에 미치는 영향
황성주,정상립,김도원,전재복 ( Sung Joo Hwang,Sang Lip Chung,Do Won Kim,Jae Bok Jun ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.5
Background: The mechanism of enhancing effect of ultrasound on the percutaneous absorption of a drug is unclear. But thermal, chemical and mechanical effects are assumed to play a role in enhancing transdermal drug delivery. Objective : The aim of this study was to determine if ultrasound enhances percutaneous absorption of methyl nicotinate(MN) without raising the skins surface temperature. Methods . Treatment consisted of the application of ultrasound massage(1.0 MHz, 1.0 watt/cm, continuous output) or placebo massage(0 MHz) for 3 min to the forearms of the volunteers, followed by a standardized application of MN at intervals of 15 sec and 10 min postmassage. Percutaneous absorption of MN was monitored using laser doppler flowmetry. Results : 1. Data from the ultrasound treated sites after 15 sec showed significant decrease(p < 0.05, paired t-test) in the T(time between MN application and its initial response), T(time between MN application and maximuvi response) and increase in the LDF .(maximum cutaneous blood flow) compared to those of the control sites. 2. Data from the ultrasound treated sites after 10 min showed no difference in the T0 and T but significant increase in the LDF compared to those of the control sites. 3. Data from ultrasound trvated sites both after 15 sec and 10 min showed significant increase in basal cutaneous blood flow(LDF) compared to those of the control sites. 4. There was no difference between the ultrasound treated sites and the control sites in the skins surface temper ature. Conclusion : The results of this study suggest that ultrasound may affect the skin structure to provide skin penetration enharcement even without raising the skins surface temperature. (Korean J Dermatol 1997;35(5): 947 955)
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오수희,서순봉,김성화,전재복 ( Su Hee Oh,Soon Bong Suh,Sung Hwa Kim,Jae Bok Jun ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.5
N/A Contamination of Dermatophytes in the clothes of Patients with Tinea Cruris Su Hee Oh, M.D., Soon Bong Suh, M.D., Sung Hwa Kim, M.D., Jae Bok Jun, M.D.* Catholic Skin Disease Clinic, Taegu, Korea Department of Dermatology, Kyungpook National University School of Medicine*, Taegu, Korea Isolation of causative agents from clothes of patients with tinea cruris was carried out for 126 tinea cruris patients with Sabouradu’s cycloheximide-chlorampenicol agar petri dish. One hundred and thirteen strains were cultured from the panties.; They were Trichophyton rubrum in 108 strains and Epidermophyton floccosum in 5 strains. Seventy seven panties were contaminated over a moderate degree. The panties of patients infected by E. floccosum were more contaminated than by T.rubrum. The panties of females infected by T. rubrum were more contaminated than ones males. Briefs were more contaminated than boxer shorts. The panties worn for a longer period were more contaminated, but tests for causative agents were negative within two weeks following regular treatmen. Causative agents were isolated in 70.0~85.0% of the patients from the parts of the abdomen, thigh and lower leg of the patients’trousers, but the degree of contamination was much lower than that of patients’s panties. (Kor J Dermatol 9(5) : 610-615, 1991)
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