한의학의 미병 개념 및 변증과의 연관성에 대한 고찰

이재철,김상혁,이영섭,장은수,이시우,Lee, Jae-Chul,Kim, Sang-Hyuk,Lee, Young-Seop,Jang, Eun-Su,Lee, Si-Woo 대한예방한의학회 2012 대한예방한의학회지 Vol.16 No.2

Objectives : This work is aimed to reveal the relations between concepts of subhealth(mibyung) and Korean medicine patterns. Methods : We carried out a literature searching on Oasis, RISS, DBpia, Pubmed to summarize concepts of Mibyung. CNKI Searching also was performed with keyword related to mibyung(未病), subhealth(亞健康) and syndrome. Results : Korea, China and Japan have different concepts of mibyung. China's mibyung concept is relatively broader and wide which includes healthy, subhealth, development of disease and recurrence avoid. In contrast, Korea and Japan's mibyung concepts are focused on China's subhealth. Though Mibyung's patterns are varied widely depends on studies, China's studies of subhealth and TCM patterns showed that Deficiency patterns are diagnosed at high frequency in clinical study and literature study. Conclusions : This work could contribute to further study of subhealth(mibyung) and their relations to patterns, diagnostic methods and treatment efficacy.

전문가 진단을 통한 체질별 건강수준과 설문결과의 연관성 연구

이재철,이혜정,이유정,김근호,김상혁,이시우,장은수,김종열,Lee, Jae-Chul,Lee, Hae-Jung,Lee, Yu-Jung,Kim, Keun-Ho,Kim, Sang-Hyuk,Lee, Si-Woo,Jang, Eun-Su,Kim, Jong-Yeol 사상체질의학회 2011 사상체질의학회지 Vol.23 No.1

1. Objectives: We report the relation between the questionnaire and the health state on the Sasang Constitution. 2. Methods: We carried out a clinical test, in which 2 Oriental medical doctors participated to diagnose health state in each Sasang Constitution with 239 subjects. The subjects were divided into 3 subgroups, which are allocated to healthy group, poor health group and disease group. 3. Results: We extracted 4 questions for Taeeumin, 5 questions for Soyangin and 3 questions for Soeumin from the whole 98 questions respectively. Soyangin and Taeeumin share a same question that shows significant difference by health status. For the statistical analysis, we used a Chi-square test. As a result, we found out that Taeeumin showed different distributions of answers in direct/indirect characteristic, perspiration, frequent urination, regular defecation. According to the health status Soyangin showed the different distribution of the answers in color of urination, frequent urination, mouth dryness, abnormal perspiration, discomfort of head. Soeumin showed the different distribution of the answers in cold and chilly feel of abdomen, digestion status and cause of digestion problems when body condition gets worse. 4. Conclusions: This is the first work which reports the relatedness between Questionnaire and Health State in each Sasang Constitutions by an objective clinical test. We found out that several questions have different distributions by health status in each Sasang Constitution. These extracted questions are categorized not only by Wansilmoobyung(완실무병), but also by other symptoms and body status.

매선을 활용한 한의 안면 성형 임상 연구 설계 제안 -한의 안면 성형 임상연구 동향 분석을 바탕으로-

이재철,임창규,김정원,박선희,윤정호,Lee, Jae-Chul,Lim, Chang-Gyu,Kim, Jung-Won,Park, Sun-Hee,Yoon, Jeong-Ho 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.2

Objectives : This work aimed to review clinical trial trend of Korean medicine's face rejuvenation and suggest future trial using embedded needle(Maesun) based on Evidence-based medicine's PICO Model. Methods : 46 papers were searched from Oasis and DBPia, then 8 papers were engaged in review of clinical trial trend. Based on PICO model, clinical trial's patient, intervention, and outcome measurement were suggested. Results : Evidence level of clinical trials is relatively low, because their study designs are almost case report or case series. No study have comparison groups. Outcome measurement is varied, however, 3D face scanner were used to measure before-after changes of face. Based on review, we suggested that necessity of intervention standardization, measuring of normal control group and 2D/3D combined outcome measurement of face. Conclusions : There are many demands for revealing efficacy and safety of Korean medicine's intervention, also for face rejuvenation using embedded needle. For meeting the level of demands, more rigorous works are needed.

광양만 북동부 해역의 해류관측

이재철,김정창,박명원,Lee, Jae-Chul,Kim, Jeong-Chang,Park, Myug-Won 한국해양학회 2006 바다 Vol.11 No.4

난치성 결핵 환자의 단핵구에서 IFN-$\gamma$ 활성화 효과 및 IFN-$\gamma$ 수용체의 숫적 변화에 대한 연구

이재철,유철규,이춘택,김영환,한성구,심영수,Lee, Jae-Cheol,Yoo, Chul-Gyu,Lee, Choon-Taek,Kim, Young-Whan,Han, Sung-Koo,Shim, Young-Soo 대한결핵및호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.47 No.3

연구배경: 결핵에 대한 면역 반응은 T-림프구와 단핵 식세포를 주축으로 하는 세포성 면역 반응이 주률 이루는데 여기에 IFN-$\gamma$와 TNF-$\alpha$등의 cytokine 이 관여하고 있다. IFN-$\gamma$는 주로 T-림프구에서 분비되어 활성화된 단핵구에서의 TNF-$\alpha$생성을 증가시키는 기전을 통해 결핵균 증식을 억제하고 치유에 이르는 과정을 매개하는 것으로 알려져 있다. 효과적인 화학요법에도 불구하고 난치성 결핵으로 이행하는 기전에 IFN-$\gamma$가 관여하는지 규명하고자 본 연구를 시행하였다. 대상 및 방법: 정상 대조군과 최근 결핵으로 진단받아 치료를 시작한 환자, 난치성 결핵 환자에서 혈액을 채취하여 단핵구를 분리하고 아무런 자극을 하지 않은 경우, 12시간 LPS($l{\mu}g/ml$)만으로 자극을 한 경우, IFN-$\gamma$($2{\mu}g/ml$)로 2시간 전처치한 후 12 시간 LPS 자극한 경우로 니누어 TNF-$\alpha$의 농도를 측정, IFN-$\gamma$ 활성화 효과에 변화가 있는지를 살펴보았고 IFN-$\gamma$ 수용체 항제를 이용, IFN-$\gamma$ 활성화 효과의 변화가 IFN-$\gamma$ 수용체의 숫적 변화와 관련이 있는지를 확인하였다. 결과: IFN-$\gamma$ 활성화 효과를 알아보기 위해 LPS 만으로 지극한 경우와 IFN-$\gamma$ 전처치 후 LPS로 자극한 경우에 생성된 TNF-$\alpha$의 비를 구하여 보았을 때 정상 대조군 $13.5{\pm}7.6$, 최근 결핵환자로 진단받은 군 $10.8{\pm}6.4$, 난치성 결핵 환자군 $6.7{\pm}3.9$의 결과를 보였다. 난치성 결핵환자군의 경우 정상대조군에 비해 IFN-$\gamma$의 활성화 효과가 통계적으로 유의하게 감소되어 있음을 알 수 있었다 (p=0.002). IFN-$\gamma$ 수용체수의 감소는 대상 환자 중 난치성 결핵 환자 1명에서 관찰되었다. 결론: 난치성 결핵으로의 이행에 있어 단핵구에서의 IFN-$\gamma$ 활성화 효과의 감소가 중요한 역할을 할 것으로 생각되며 IFN-$\gamma$ 활성화 효과의 감소는 일부 환자의 경우, IFN-$\gamma$ 수용체의 감소와 관련되어 생기는 것으로 판단된다. Background: IFN-$\gamma$ plays an important role in host response to intracellular organisms such as mycobacterium. Human infection with mycobacterium leads to a wide variety of outcomes, ranging from asymptomatic infection to widespread and rapidly fatal disease. Recent reports suggest that alteration of the function of IFN-$\gamma$ caused by a defective IFN-$\gamma$ receptor gene can explain different host response to mycobacterium. In this study, we investigated the role of IFN-$\gamma$ in the development of chronic refractory tuberculosis. Methods: The LPS-induced TNF-$\alpha$ production with or without IFN-$\gamma$ priming was compared by using monocytes taken from recently diagnosed tuberculosis, chronic refractory tuberculosis patients and controls. And the IFN-$\gamma$ receptor was measured by indirect fluorescent antibody technique to know whether change in the priming effect of IFN-$\gamma$ is related to IFN-$\gamma$ receptor deficiency or not. Results: The ratio of TNF-$\alpha$ produced in response to stimulation with INF-$\gamma$ and LPS to LPS alone was $13.5{\pm}7.6$ in controls, $10.8{\pm}6.4$ in recently diagnosed tuberculosis patients and $6.7{\pm}3.9$ in chronic refractory tuberculosis patients. The priming effect of IFN-$\gamma$ significantly decreased in chronic refractory tuberculosis patients compared with that in controls(p=0.002). However, IFN-$\gamma$ receptor deficiency was detected in one of chronic refractory tuberculosis patients. Conclusion: The decrease of the priming effect of IFN-$\gamma$ may play an important role in the development of chronic refractory tuberculosis, and in some patients, this may be related to the IFN-$\gamma$ receptor deficiency.

2006년 봄철 광양만 해류의 구조와 변동

이재철,김정창,Lee, Jae-Chul,Kim, Jeong-Chang 한국해양학회 2007 바다 Vol.12 No.3

광양만의 순환을 이해하기 위하여 2006년 봄철에 수심이 가장 깊은 두 지점을 선정하여 ADCP가 장착된 모니터링 부표 2대를 이용하여 유속관측을 하였다. 두 지점에서 공통적으로 북향류가 지배적인데, 이는 서쪽의 남향류를 동반하는 반시계 방향의 순환 이 있음을 뒷받침 하고 있다. 남쪽에서는 14 m 수심에서 유향이 반전되는 2층 구조가 뚜렷하며 저층의 북향류는 바닥에 가까운 36 m 수심까지 증가한다. 북쪽 지점에서는 북향류가 더욱 강해져서 북쪽의 단면적 감소에 따른 해류의 가속 효과가 있으며 상층부에서도 북향류가 우세하다. EOF 분석을 통한 연직구조에 있어서 첫 번째 모드는 북쪽 부표에서 전체 분산의 74%인데 비하여 남쪽 부표에서는 67%로 감소하고 상대적으로 2층 구조의 비중이 크다. 반시계 방향의 순환과 관련된 북향류의 전형적인 유속은 약 10 cm/s이다. 여기에 중첩되는 변동성으로서 국지적인 바람의 영향은 거의 받지 않는 반면에 동-서 방향의 바람에 의한 외해의 에크만 수송과 관련된 비국지적 영향은 주로 풍속이 강할 경우에 나타난다. Two monitoring buoys equipped with ADCP were deployed at the deepest positions along the trough of the central Gwangyang Bay in spring 2006 in order to study the circulation in the bay. Northward velocity is commonly dominant at both stations located in the eastern part of the channel, which supports the cyclonic circulation accompanied by the southward flow in the western part. The southern station has a distinct two-layer structure with current reversal at 14 m depth and increasing northward velocity in the lower layer to 36 m depth close to the bottom. At the northern station the northward flow becomes accelerated due to the decrease in the cross-sectional area and this northward current is dominant even in the upper layer. In the modal structure from the EOF analysis, the first mode has 74% of total variance at the northern station whereas it is 67% but the baroclinic portion increases at the southern station. The typical northward velocity is about 10 cm/s which is associated with the cyclonic circulation. Subtidal variability due to the local wind effect is negligible, but the nonlocal response associated with offshore Ekman flux by the zonal wind is found during strong wind events.

하상장애물에 의한 흐름특성 변화에 관한 실험연구

이재철,이희영,Lee Jae-chul,Lee Hee-young 한국관개배수위원회 1999 한국관개배수논문집 Vol.6 No.2

In this paper, the variation of flow characteristics by obstacles in urban streams is studied with laboratory experiments. Experiments to measure the depths and velocities affected by rectangular shape obstacles which are general in the field were perform

반응고 성형기술의 연구개발 동향

이재철,이호인 ( Jae Chul Lee,Ho In Lee ) 대한금속재료학회 1997 大韓金屬學會會報 Vol.10 No.2

Structure of Upwelling off the Southease Coast of Korea

이재철,나정열,Lee, Jae-Chul,Na, Jung-Yul The Korean Society of Oceanography 1985 韓國海洋學會誌 Vol.20 No.3

Hydrographic data and daily time series of longshore wind, sea level and sea surface temperature were used in order to explain why the upwelling effect in SST is especially prominent near Ulgi-Gampo although the sea level records along the whole southeast coast show a nearly uniform upwelling-downwelling response to wind. Regional difference in intensity of the wind-induced upwelling represented by the SST decrease is attributed to the combined influence of two factors; one is the baroclinic tilting of isotherms due to the East Korea Warm Current (EKWC) near the Ulgi-Gampo coast, the other is the topographic effects around the southeast coast. Baroclinic tilting effect of EKWC which is generally strongest near the coast of Ulgi to Gampo results in both of the shoaling of cold water and the westward trapping of the coldest bottom water over the shallower shelf rather than the deepest troough region off that coast regardless of the season. Therefore, becacse of the cold water ready for upwelling at the subsurface layer, SST responds very rapidly to the upwelling-favorable winds of summer only off the Ulgi-Gampo coast. Spreading isobaths from Pusan to Gempo can reinforce the upwelling of the cold bottom water and its westward trapping.

夏季 韓國 南東海域에서 湧昇과 關聯된 바람, 海水面 및 表層水溫의 變化 TEVARIATIONS OF SEA LEVEL AND SEA SURFACE TEPERATURE ASSOCIATED WITH WIND -INDUCED UPWELLING IN THE SOUTH

이재철,Lee, Jae Chul 한국해양학회 1983 韓國海洋學會誌 Vol.18 No.2

Extensive wind, sea level and sea surface temperature (SST) data collected along the east coast of Korea in 1973-1979 were used to ascribe the variations of sea level and SST associated with wind forcing during summer. Alongshore components of wind were dominant but the offshore components were little significance in the southeast coast in summer. The variations in SST and sea level adjusted barometricallyagreed with the upwelling-downwelling processes and showed a rapid response to wind.Appearance of cold water to the surface in the upwelling region concurred well with te periods of positive y-component wind when the tangential line at Ulgi was takem as the y-axis. In general, SST at Ulgi and Gampo as well as the adjusted sea level at Pohang, Ulsan and Busan decreased significantly when strong winds favorable for upwelling persisted for more then three days whereas they increased during the relaxation or unfavorable periods. The period of an upwelling event, on the average, was about 10 days and the mean speed of alongshore sind was 4.0m/sec.