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인터뷰 - 첨단 물류기기 표준화의 선구자 '생수이동랙 개발'
이홍기,Lee, Hong-Gi 한국파렛트컨테이너협회 2009 파렛트 뉴스 Vol.53 No.-
본 인터뷰 기사는 지난 2008년 12월 30일 월간 굿뉴스피플에 실린 내용으로 최근생수물류과정에 문제를 제기하여 '생수이동랙 개발 에 힘을 실어온 (주)골드라인의 이홍기 회장의 인터뷰 내용이다.
Formulation of a Extended Release Tablet Containing Dexibuprofen
이홍기,지문혁,김용일,박은석,우종수 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.12
Dexibuprofen, or S(+)-ibuprofen, is the pharmacologically effective enantiomer of racemic ibuprofen. Since dexibuprofen has a low melting point, the amorphous form having a high melting point was prepared with the fused solid dispersion method. With the fused solid dispersion of dexibuprofen, immediate release tablets, extended release tablets, and dual release tablets were compressed and their dissolution profiles compared. The dissolution profiles of the extended release and the dual release tablet depended on the amount of used release modulators (PEO 5,000,000). The release profiles of extended release tablets and extended release part of dual release tablets were well fitted to zero-order release model. The correlation coefficient ranged from 0.982 to 0.995. A pharmacokinetic evaluation where healthy volunteers took tablets of DRT-1 (300 mg) once and the reference drug, two tablets of conventional immediate release tablet (Daxfen, 300 mg), with a 6-h interval between them was studied. The 90% confidence interval for the ratio of the logarithmically transformed AUC (0-24 h), Cmax (0-6 h), and Cmax (6-24 h) values of the dual release tablet compared to those of the conventional immediate release tablet were calculated to be between 0.9176 and 1.0007, 0.9240 and 1.1968, and 0.8713 and 1.1414, respectively. When the immediate release tablet was taken two times with a six hour interval between doses it showed a bioequivalent effect to taking the dual release tablet once within 12 h. The Cmax was reached due to the rapid absorption of the immediate release portion of the dual release tablet and the AUC was maintained due to continuous absorption of the extended release portion.
라니 니켈 촉매에 대한 알칼리형 연료전지용 수소극의 전극특성
이홍기,이주성 ( Hong Ki Lee,Ju Seong Lee ) 한국공업화학회 1992 공업화학 Vol.3 No.3
Raney nickel 촉매를 이용하여 알칼리형 연료전지의 수소극을 제작하였다. 700℃에서 소결한 Raney nickel로 제작한 수소극의 경우 가장 좋은 전극성능을 갖는 450mA/㎠의 전류밀도를 나타댔으며 이때의 평균촉매입자 크기는 90Å이었다. CO-chemisorption 측정 및 분극곡선과 Tafel slope를 통하여 PTFE의 첨가량에 대한 전극의 전기화학적 성능을 고찰하였다. CO-chemisorption 측정 결과 5wt%의 PTFE가 첨가되었을 메 최고값을 갖는 것이 확인되었으나 전극에서의 전류밀도와 Tafel slope를 비교한 결과 10wt%의 PTFE를 첨가하는 경우가 가장 적당함을 알았다. Raney nickel제조시 nickel과 aluminum의 함량비는 60:40의 경우에 가장 좋은 전극 특성을 나타내었으며 담지량은 0.25g/㎠ 의 경우가 적당하였다. 전극제조시 촉매층의 press압 및 촉매층과 기체확산층과의 접합시의 press압에 대한 영향도 검토하였다. 또한 촉매의 표면 구조를 SEM으로 관찰하였으며 활성화시간 및 열처리 온도 등 여러가지 조건에 대한 전극의 영향도 고찰하였다. Raney nickel was used as catalyst in the hydrogen electrode for an alkaline fuel cell. The hydrogen electrode manufactured with the Raney nickel catalyst which was sintered at 700℃ was found to have the highest electrode performance. Using the Raney nickel powder of average particle size 90Å for the electrode, the current density which had been measured was 450mA/㎠ at 80 ℃ using 6N KOH solution as an electrolyte. The effects of PTFE addition were investigated with CO-chemisorption, polarization curves and Tafel slope. CO-chemisorption had shown the optimum value when the Raney nickel was mixed with 5wt% of PTFE, but from the current density and Tafel slope at porous Raney nickel electrode, the appropriate value of PTFE addition was 10wt% . Recommendable Ni and Al portion for Raney nickel was 60 : 40 and loading amount was 0.25g/㎠. Also the influence of pressing pressure for manufacturing catalytic layer and for junction with gas diffusion layer was examined. The morphology of catalysts surface was investigated with SEM. The influence of reactivation time and heat-treatment temperature were also studied.