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젊은 성인 남자 근로자들에 있어서 음주, 흡연, 비만도와 혈중 지질과의 관련성에 관한 조사 연구
이지호,조병만,이수일,김돈균,Lee, Ji-Ho,Cho, Byung-Mann,Lee, Soo-Ill,Kim, Don-Kyoun 대한예방의학회 1992 예방의학회지 Vol.25 No.4
In order to study the relationship between life-style and serum lipids level in young adults, the author measured the concentration of serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) and investigated age, relative weight, weekly alcohol intake and daily cigarette smoking through questionnaire in 310 male workers aged 20 to 39, in Ulsan area. The results obtained were as follows: 1. In the factors being able to influence serum lipids level there was negative correlation between age and alcohol intake, and the positive correlation between age and relative weight, alcohol intake and relative weight, alcohol intake and smoking with the strongest correlation between alcohol intake and smoking. 2. In univariate analysis, mean total cholesterol concentration were significantly different according to age, smoking and relative weight: mean triglyceride concentration were significantly different according to relative weight only; mean HCL-C concentration were significantly different according to alcohol intake alone. 3. In non-drinkers, HDL-C concentration of smokers were significantly lower than that of non-smokers but triglyceride concentration of smokers were significant higher. And in drinkers, total cholesterol concentration of smokers was significantly higher than that of non-smokers. 4. In multiple regression analysis, significant independent variables were relative weight, age and smoking in the total cholesterol concentration, and relative weight, age and alcohol intake in the triglyceride concentration, and alcohol intake, relative weight and smoking in the HDL-C concentration. By these independent variables, total variation in each dependent variable was explained 7.9%, 17.6% and 7.4% respectively.
Factors Associated with Adherence to Allergen Specific Subcutaneous Immunotherapy
이지호,이소희,반가영,예영민,남동호,박해심,신유섭 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.6
Purpose: Allergen-specific immunotherapy (AIT) is known to be the only therapeutic modality to alter the natural course of allergicdiseases. However, at least 3 years of treatment is recommended for achieving long-term disease modifying effect. This studyaimed to investigate factors associated with immunotherapy non-adherence in real practice. Materials and Methods: We retrospectively reviewed medical records of patients who were diagnosed with allergic rhinitis, asthma,or atopic dermatitis, and received AIT to common allergens such as house dust mite and/or pollens from January 2007 toAugust 2014. In this study, non-adherence was defined as not completing 3 years of AIT. Results: Among 1162 patients enrolled, 228 (19.6%) failed to complete 3 years of AIT. In multivariate analysis, age less than 20years [odds ratio (OR) 3.11, 95% confidence interval (CI) 1.70–5.69] and 20 to 40 years (OR 2.01, 95% CI 1.17–3.43), cluster buildup(OR 1.78, 95% CI 1.05–3.02) and ultra-rush build-up schedules (OR 5.46, 95% CI 2.40–12.43), and absence of visit to other departmentsin the same hospital (OR 1.87, 95% CI 1.05–3.32) were independently associated with immunotherapy non-adherence. Disease duration of 5–10 years was negatively associated with non-adherence compared to shorter disease duration of less than 5years (OR 0.61, 95% CI 0.40–0.94). Although male sex and commercial product of AIT, Tyrosine S®, compared to Novo-Helisen®were non-adherent factors in univariate analysis, no statistical significances were identified in multivariate analysis. Conclusion: Various factors are associated with immunotherapy adherence affecting the utility of immunotherapy. Cliniciansshould be aware of factors associated with adherence to maximize the utility of allergen-specific subcutaneous immunotherapy.