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Balb/c 마우스에서 Local Lymph Node Assay(LLNA)를 01용한 피부 감작성 시험 대체시험법 연구
이종권,황인창,박재현,김형수,정승태,엄준호,오혜영 한국독성학회 2002 Toxicological Research Vol.18 No.2
Allergic contact dermatitis (skin sensitization) may be caused by a wide variety of chemicals. A murine local lymph node assay (LLNA) has been developed as an alternative to guinea pig models for assessing the contact sensitization potential of chemical. This study was carried out to evaluate the skin sensitization potential for chemicals in Balb/c mice by LLNA. Contact allergen, dinitrochlorobenzene (DNCB), respiratory allergen, toluene diisocyanate (TDI) and a weak allergen, $\alpha$-hexlycinnamaldehyde (HCA) were wed as positive chemicals and irritant, sodium lauryl sulfate(SLS) also wed as a reference chemical in this study. The weights of lymph node in the mice treated with DNCB, TDI, and HCA were increased compared to vehicle control. There was a significant increase in lymph node weight of mice treated with high concentration of SLS compared to vehicle control. The stimulation index (SI) of Lymph node cell in the mice treated with DNCB, TDI, and HCA revealed over three-fold increase compared to vehicle control by $3^H$-thymidine uptake. All allergens correctly identified in this LLNA study wing Balb/c mice. These results suggest that LLNA wing Balb/c mice could be a useful method for screening the allergenic potential of chemicals. The expression of IL-2 mRNA was slightly increased in draining auricular lymph node cell of the mice treated with TDI and HCA by RT-PCR. However the IL-2 levels in DNCB and SLS of treated animals were not significantly changed.
철근콘크리트 깊은 보의 전단 내력에 대한 개구부 보강 효과
이종권,최윤철,이용택,Lee, Jong-Kweon,Choi, Yun-Cheul,Lee, Yong-Taeg 한국전산구조공학회 2007 한국전산구조공학회논문집 Vol.20 No.6
일반적으로 깊은 보의 개구부 보강을 할 경우 개구부 주변의 부족한 내력에 대해 수직, 수평, 대각, 혹은 혼합된 배근 형태를 사용하게 되는데, 경제성과 구조적 안전성을 고려하기 위해서는 각 배근 형태 및 방법에 따른 깊은 보의 거론 평가와 적절한 조합에 관한 연구가 절실히 필요하다. 이에 본 연구에서는 개구부 보강방법을 변수로 한 simulation 모델을 통해 수직, 수평 보강의 효과에 대해 해석적으로 검증을 한 후, 각 규준에서 제시하고 있는 개구부가 있는 깊은 보의 전단 내력식을 분석하고 해당 식을 보완하여 단순지지 1경간 및 연속 경간에 적용 가능한 전단 내력 산정식을 제안하고자 한다. Reinforced concrete deep beams are general structural members used as transfer-girder, pile cap, foundation wall and so on. They have a complex stess formation. Generally, failure mechanisms differ from either continuous deep beams or simple supported deep beams. In continuous deep beams, a negative moment is occurred over intermediate support and the location of maximum moment coincide with high shear force. Therefore, failure usually occurs at this region. While on the other hand, in simple supported deep beam, the region of high shear coincides with the region of low moment. The web opening of deep beams for accepting a facility makes shear behaviors of deep beams more complex and gives rise to an expansion of crack around the opening and a decline of shear capacity of deep beams. Therefore, Engineers must determine a delicate reinforcement method to control a crack and increase a shear capacity. The purpose of this report is a computation of an effective reinforcement method through non-linear finite element method by means of adopting various reinforcement method as variables and a computation of shear capacity formula taking an effectiveness of reinforcement into consideration.
Balb/c 마우스에서 Local Lymph Node Assay(LLNA)를 이용한 피부 감작성 시험 대체시험법 연구
이종권,황인창,박재현,김형수,정승태,엄준호,오혜영 한국독성학회 2002 Toxicological Research Vol.18 No.2
Allergic contact dermatitis (skin sensitization) may be caused by a wide variety of chemicals. A murine local lymph node assay (LLNA) has been developed as an alternative to guinea pig models for assessing the contact sensitization potential of chemical. This study was carried out to evaluate the skin sensitization potential for chemicals in Balb/c mice by LLNA. Contact allergen, dinitrochlorobenzene (DNCB), respiratory allergen, toluene diisocyanate(TDI) and a weak allergen, α-hexylcinnamaldehyde (HCA) were used as positive chemicals and irritant, sodium lauryl sulfate(SLS) also used as a reference chemical in this study. The weights of lymph node in the mice treated with DNCB, TDI, and HCA were increased compared to vehicle control. There was a significant increase in lymph node weight of mice treated with high concentration of SLS compared to vehicle control. The stimulation index (SI) of lymph node cell in the mice treated with DNCB, TDI, and HCA revealed over three-fold increase compared to vehicle control by ³H-thymidine uptake. All allergens correctly indentified in this LLNA study using Balb/c mice. These results suggest that LLNA using Balb/c mice could be a useful method for screening the allergenic potential of chemicals. The expression of IL-2 mRNA was slightly increased in draining auricular lymph node cell of the mice treated with TDI and HCA by RT-PCR. However, the IL-2 levels in DNCB and SLS of treated animals were not significantly changed.
이종권,박지환,송통환,류근걸,이윤배 한국산학기술학회 2003 한국산학기술학회논문지 Vol.4 No.1
태양전지에 소모되는 비용중의 30% 이상이 silicon 기판의 가공 및 silicon자체의 비용이다. 본 연구에서는 이러한 비용을 절감하기 위해 silicon기판대신 STS 304를 사용하고자 한다. STS 304를 태양전지용 기판으로 사용하기 위해서는 고도로 연마된 표면을 필수조건으로 하기 때문에 STS 304에 전해연마를 실시하여 AFM으로 표변의 거칠기를 살펴보았다. 또한, 표면 조도의 향상을 위해 최적의 연마조건에서 leveller를 첨가하였다. 인산(H₃PO₄)을 기본으로 한 전해연마액에 2A의 전류와 극간거리 0.7 ㎝의 조건하에서 STS 304의 최적 전해연마조건을 찾기 위해 전해액의 온도는 80℃~120℃, 연마시간은 3~20분간 천해연마를 실시하였다. 그 결과 2N㎠, 80℃, 10분에서 27.9 ㎚의 표변조도를 보였으며, leveller로 사용된 glycerine, ethylene glycol, propylcne glycol의 영향을 연구하였다. Leveller 중에서는 ethylene glycol을 0.4 g/l 첨가하였을 때 표면조도가 약 l5㎚로서 그 효과가 가장 좋았다. The cost of material and slicing of silicon wafer occupied more than 30% of solar cell manufacturing cost. The substitution of silicon wafer into STS 304 stainless steel could be the promising solution to decrease the material cost Moreover the stainless steel solar cell could have the advantage of low weight and durability. However, the highly polished surface is required to meet the characteristic of solar cell. The electropolishing process in phosphoric acid based solution was used to get the surface quality. The obtained result was 28 ㎚ obtained in current density of 2 Amp/㎠ at 80℃. The leveller effect of glycerine, ethylene glycol and propylen glycol was studied, When the 0.4 g/l of ethylene glycol was added to the electrolyte, the surface roughness was best, 15 ㎚.