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Immunohistochemical Classification of Primary and Secondary Glioblastomas
이규상,남경한,서안나,윤수미,김경주,조화진,박성혜,최기영 대한병리학회 2013 Journal of Pathology and Translational Medicine Vol.47 No.6
Background: Glioblastomas may develop de novo (primary glioblastomas, P-GBLs) or through progression from lower-grade astrocytomas (secondary glioblastomas, S-GBLs). The aim of this study was to compare the immunohistochemical classification of glioblastomas with clinically determined P-GBLs and S-GBLs to identify the best combination of antibodies for immunohistochemical classification. Methods: We evaluated the immunohistochemical expression of epidermal growth factor receptor (EGFR), p53, and isocitrate dehydrogenase 1 (IDH-1) in 150 glioblastoma cases. Results: According to clinical history, the glioblastomas analyzed in this study consisted of 146 P-GBLs and 4 S-GBLs. Immunohistochemical expression of EGFR, p53, and IDH-1 was observed in 62.6%, 49.3%, and 11.1%, respectively. Immunohistochemical profiles of EGFR(+)/ p53(–), IDH-1(–)/EGFR(+)/p53(–), and EGFR(–)/p53(+) were noted in 41.3%, 40.2%, and 28.7%, respectively. Expression of IDH-1 and EGFR(–)/p53(+) was positively correlated with young age. The typical immunohistochemical features of S-GBLs comprised IDH-1(+)/EGFR(–)/p53(+), and were noted in 3.6% of clinically P-GBLs. The combination of IDH-1(–) or EGFR(+) was the best set of immunohistochemical stains for identifying P-GBLs, whereas the combination of IDH-1(+) and EGFR(–) was best for identifying S-GBLs. Conclusions: We recommend a combination of IDH-1 and EGFR for immunohistochemical classification of glioblastomas. We expect our results to be useful for determining treatment strategies for glioblastoma patients.
이규상,길원평 한국물리학회 2017 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.71 No.9
The dynamic properties, such as the crossing time and time-dependence of the relative density of the four-state haploid coupled discrete-time mutation-selection model, were calculated with the assumption that ¹ij = ¹ji, where ¹ij denotes the mutation rate between the sequence elements, i and j. The crossing time for s = 0 and r23 = r42 = 1 in the four-state model became saturated at a large ¯tness parameter when r12 > 1, was scaled as a power law in the ¯tness parameter when r12 = 1, and diverged when the ¯tness parameter approached the critical ¯tness parameter when r12 < 1, where rij = ¹ij=¹14.
이규상 한국사회경제학회 2008 사회경제평론 Vol.- No.31
The present paper aims to provide a summary of the background of (the rise of) new economic methodology and also to offer a portrayal of its defining features. To this end, the paper starts with a discussion of Thomas Kuhn's work, the one diametrically opposed to traditional philosophy of science which had provided traditional methodology of economics with a philosophical foundation. Sociology of scientific knowledge, of which the establishment was very much indebted to Kuhn's work, played such a significant role in shaping new economic methodology that an account of it is provided. An explanation of economics of scientific knowledge follows which has emerged in a reaction to sociology of scientific knowledge. The concept of performativity, which has recently garnered widespread attention among new economic methodologists, and a controversy centering around it are to be discussed next. And a discussion of the implication of the rise of new economic methodology for the metatheoretical investigation of economics and its sister disciplines concludes the paper. 본 논문의 목적은 최근에 등장한 새경제학방법론의 배경과 핵심을 정리하고 그 주요 흐름을 소개하는 데에 있다. 이를 위해 우선 전통적 경제학방법론에 철학적 기초를 제공하던 전통적 과학철학의 쇠락에 기여한 토마스 쿤의 작업을 논의한다. 쿤의 연구로부터 큰 영향을 받은 과학지식 사회학은 새경제학방법의 형성에 중요한 역할을 했으므로 그에 대한 설명이 이어지며, 과학지식 사회학에 대한 대응으로서 등장한 과학지식 경제학에 대한 소개와 예시가 이루어진다. 뒤이어, 가장 최근 새경제학방법론에서 중요한 주제로 떠오른 수행성에 대한 설명 그리고 이 새로운 개념을 둘러싼 논쟁들 중 하나에 대한 소개를 한다. 마지막으론 새경제학방법론의 대두가 경제학과 관련된 메타이론적 분석에 갖는 함의를 간략히 논의한다.
이규상 목원대학교 사회과학연구소 2007 社會科學硏究 Vol.- No.7
연구소에서 스핀오프된 벤처기업의 창업과정과 기업가 정신을 정리하였다. 대전지역의 연구소에서 파생된 IT BT RT 분야 6개 벤처기업을 방문하여 창업이전 준비과정 창업과정시제품개발 그리고 기업가정신에 대하여 사례연구 방법으로 면담하고 이를 요약 정리하였다.