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B16/F10 흑색종양세포에서 삼내자 메탄올 추출물의 멜라닌 생성에 미치는 억제효과
윤정원,한정민,윤화정,고우신,Yoon, Jung-Won,Han, Jung-Min,Yoon, Hwa-Jung,Ko, Woo-Shin 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.1
Objective: Recently the demands for the effective and safe depigmentative and anti-aging agents of the skin have increased due to the medical, pharmaceutical and cosmetic reasons. The purpose of this study is to investigate the MKG(Methanol Extract of Kaempferia galanga) and their dermal bioactivity properties related to cosmeceuticals such as depigmentation. Methods: We assessed inhibitory effects of MKG on melanin production in B16/F10 melanoma cells, on mushroom tyrosinase activity, effects of MKG on the expression tyrosinase, TRP-1, TRP-2, GSK-$3{\beta}$, CREB, MITF in B16/F10 melanoma cells without cytotoxicity range. Cell viability was measured by MTT assay and tyrosinase activity was assessed using by DOPA staining, western-blot analysis. We measured inhibition of melanin synthesis and tyrosinase activity by down-regulation of melanogenic enzyme expressions in ${\alpha}$-MSH induced melanogenesis B16/F10 melanoma cells. Results: MKG inhibited tyrosinase-activity, total melanin contents and dendrite out-growth. MKG inhibited melanogenesis by down-regulation of tyorsinase, TRP-1, TRP-2, CREB, and MITF in B16/F10 cells. The treatment with MKG at the 12.5, $25{\mu}g/ml$ level significantly inhibited the melanin synthesis induced ${\alpha}$-MSH in B16/F10 melanoma cells compared with untreated control. Conclusion: These results suggest that MKG inhibit melanin biosynthesis which is involved in hyper-pigmentation. So MKG is considered to be used as a whitening components reducing cytotoxicity.
BALB/c 마우스에서 동종 지방유래 기질세포가 창상치유에 미치는 영향
윤정원,임진수,김정남,유결,Yoon, Jeong-Won,Lim, Jin-Soo,Kim, Jung-Nam,Yoo, Gyeol 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.4
Purpose: Adipose-derived stromal cells (ADSCs) are multipotent cells that have been found to promote wound healing through the process of angiogenesis and reepithelialization. Generally, it is well known that the antigenicity of ADSCs doesn't affect stem cell therapy. In this study, we investigated the effect of allogeneic ADSCs in the wound healing process by applying allogeneic ADSCs on the wound healing splint model of mice. Methods: Adipose tissue was harvested from the epididymal fat pads of BALB/c and C57BL/6 mice. Twenty four mice BALB/c were divided into three groups; control, isogeneic, and allogeneic groups. Two full thickness defects with 6 mm diameters were created on the back of BALB/c mice. $1{\times}10^6$ ADSCs from BALB/c mice were applied on the isogeneic group. In the allogeneic group, ADSCs from the C57BL/6 mice were applied. No cells were applied to the control group. The sizes of the wounds were evaluated in 3, 5, 7, 10, and 14 days after the wounds were applied, and tissues were harvested in 7 and 14 days for histological analysis. Results: Wound healing rates had showed significant increase in 10, and 14 days when the isogeneic group was compared to the control group, but the allogeneic group showed significantly decrease compared to the isogeneic group (p<0.05). Histological scores in the isogeneic group were significantly high, but significantly lower in the allogeneic group when compared to the isogeneic group in 2 weeks (p<0.05). In the isogeneic group, thick inflammatory cell infiltration with abundant capillaries were observed in 1 week, and thick epithelium with many large capillaries were observed in 2 weeks. Conclusion: When isogeneic ADSCs were applied to wounds, they presented a faster wound healing rate compared to controls and the allogeneic group. Unlike general stem cell therapy, these findings suggest that cell therapy targeted at enhancing wound healing may benefit from the use of ADSCs with identical antigenicity, as opposed to allogeneic or xenogenic ADSCs.
윤정원,방정환,고용호,유세훈,김준기,이창우,Yoon, Jeong-Won,Bang, Jung-Hwan,Ko, Yong-Ho,Yoo, Se-Hoon,Kim, Jun-Ki,Lee, Chang-Woo 한국마이크로전자및패키징학회 2014 마이크로전자 및 패키징학회지 Vol.21 No.4
The paper gives an overview of the concepts, basic requirements, and trends regarding packaging technologies of power modules in hybrid (HEV) and electric vehicles (EV). Power electronics is gaining more and more importance in the automotive sector due to the slow but steady progress of introducing partially or even fully electric powered vehicles. The demands for power electronic devices and systems are manifold, and concerns besides aspects such as energy efficiency, cooling and costs especially robustness and lifetime issues. Higher operation temperatures and the current density increase of new IGBT (Insulated Gate Bipolar Transistor) generations make it more and more complicated to meet the quality requirements for power electronic modules. Especially the increasing heat dissipation inside the silicon (Si) leads to maximum operation temperatures of nearly $200^{\circ}C$. As a result new packaging technologies are needed to face the demands of power modules in the future. Wide-band gap (WBG) semiconductors such as silicon carbide (SiC) or gallium nitride (GaN) have the potential to considerably enhance the energy efficiency and to reduce the weight of power electronic systems in EVs due to their improved electrical and thermal properties in comparison to Si based solutions. In this paper, we will introduce various package materials, advanced packaging technologies, heat dissipation and thermal management of advanced power modules with extended reliability for EV applications. In addition, SiC and GaN based WBG power modules will be introduced.
윤정원 ( Jung Won Yoon ) 한국외국어대학교 언어연구소 2012 언어와 언어학 Vol.0 No.55
In this paper, we analyzed the quotative clauses within the framework of grammatical function analysis. This paper aims for the new classification of the quotative clauses, reviewing of the embedded clause system of Korean. We extend the range of the quotative clauses on the basis of the definition of the quotative clauses. And we examine the syntactic characters of the quotative clauses. We find out that the quotative clauses don’t need the morphological element to change their grammatical category. The conclusion is that the direct quotative clause should not be included in the embedded clause system of Korean, and that the indirect quotative clause is exceptional noun clause.
論文(논문) : 항공안전인증을 고려한 소형제트항공기 플랩 재설계
윤정원 ( Jung Won Yoon ),이효진 ( Hyo Jin Lee ),이재우 ( Jae Woo Lee ),김상호 ( Sang Ho Kim ),변영환 ( Yung Hwan Byun ),김임권 ( Im Gun Kim ) 한국항공운항학회 2011 한국항공운항학회지 Vol.19 No.3
In this paper, a conceptual design process for Very Light Jet aircraft has been proposed incorporating aircraft safety certification. During the proposed design process, satisfaction of the airworthiness certification for an intermediate resulting aircraft configuration is evaluated and then redesigns are carried out if necessary and until the designed aircraft configuration satisfies the airworthiness requirements. Certification database has been developed using FAR 23, AC 23, KAS 23, and CS 23 as the airworthiness certification. Based on the developed certification database Design Certifcation Related Table has been produced to use the airworthiness requirements as design constraints in the propsed design process. Using Quality Function Deployment the design variables for a redesign are carefully selected and a design optimization is performed. To demonstrate the feasibility and effectiveness of rapid aircraft conceptual design using the proposed approach, a Very Light Jet design optimization including a redesign of wing flap has been performed and the design results have been presented.
윤정원(Jung-Won Yoon) 한국HCI학회 2016 한국HCI학회 학술대회 Vol.2016 No.1
모바일 미디어는 시공간성에 큰 변화를 불러오고 있다. 예를 들어, 스마트폰의 LBS, GPS 는 물리적으로 길을 찾는 과정없이도 공간을 경험하게 했으며, 하이퍼미디어를 통한 이동 또한 우리의 공간 인식을 변화시켰다. 그렇다면, 모바일이 우리의 시간성에는 어떠한 변화를 가져왔을까? 모바일 미디어에서는 ‘과거’로의 접근과 현재성(Now-ness)을 강화시키는 타임라인 양식이 지배적인 인터페이스 형식으로 자리잡았지만, 예측불가능한 미래를 표현하는 인터페이스는 통용되는 양식이 없어, 모바일 캘린더는 전통적인 양식을 그대로 사용하고 있다. 한편, 모바일은 개인의 시간 주도권을 회복시켰고, 개인화된 시간을 만든다. 그러나 이는 협업시, 개인화된 시간을 사회적 시간과 동기화하거나 일정을 맞추는 것을 더욱 어렵게 만들었다. 그러므로, 개인이 주도권을 갖는 시간에서 사회적 시간성을 증가시킬 수 있는 대안이 필요하다. 본 연구는 모바일에서 ‘미래’를 나타낼 수 있는 양식과 일정의 사회성을 관리하는 방안을 모색하고자, 모바일 캘린더의 사용 행태를 알아볼 것이다. 이를 위해, 사용하는 캘린더를 수집하여, 사람들의 일정 관리 및 사회성 관리 전략을 도출하고자 한다. Mobile media brings about a great change to spatio-temporal. In the situation that LBS and GPS in Smartphone caused the change about our ‘spatial perception’, how did Smartphone cause ‘temporal perception’? In mobile media, the timeline style that strengthens the approach to the past and ‘now-ness’ settled as a dominant interface type. However, since the interface that represents the unpredictable future does not have current form in mobile calendar, it could not help using traditional form until now. In the case of Smartphone, while it recovered the initiative for individual time management, it made people harder about synchronizing personalized and socializing time. So, mobile calendar needs an alternative that can increase socializing time. Thus, in this study, we will collect various occupied mobile calendars and derive the scheduling strategy, in order to seek the style that represents the future and how to manage the sociality of schedule.