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      • KCI등재후보

        개가시나무 가지로부터 항산화성분의 규명

        문미연 ( Mi Youn Moon ),백종석 ( Jong Seok Baik ),김상숙 ( Sang Suk Kim ),장원정 ( Won Jung Jang ),김미선 ( Mi Sun Kim ),이남호 ( Nam Ho Lee ) 대한화장품학회 2009 대한화장품학회지 Vol.35 No.3

        개가시나무 가지의 에탄올 추출물에서 항산화활성을 관찰하였으며, 활성성분을 규명하기 위한 연구를 진행하였다. 그 결과, 4종류의 화합물을 분리하여 동정하였다. 분리 동정된 성분은 catechin(1), epi-catechin(2), tyrosol(3) 및 tiliroside(4)이다. 분리 성분의 항산화활성은 DPPH 라디칼 및 superoxide 음이온 라디칼 소거활성을 이용하여 측정하였다. 화합물 1, 2, 3, 4는 100 μL/mL 농도에서 각각 94.2 %, 93.4 %, 33.6 %, 11.2 %의 DPPH 라디칼 저해활성을 나타내었다. 또한, 화합물 1, 2, 3, 4는 200 μL/mL 농도에서 각각 60.2 %, 35.1 %, 20.6%, 4.5 %의 superoxide 음이온 라디칼 저해활성을 나타내었다. 화합물 1 ∼ 4는 개가시나무에서는 처음으로 분리된 물질이다. Investigation of antioxidative constituents from the ethanol extract of Quercus gilva branches led to the identification of four compounds; catechin (1), epi-catechin (2), tyrosol (3) and tiliroside (4). The antioxidative activity was examined using DPPH radical and superoxide anion radical scavenging method. The isolated compounds 1, 2, 3 and 4 exhibited 94.2 %, 93.4 %, 33.6 % and 11.2 % scavenging activities respectively against DPPH radicals at the concentration of 100 μL/mL. As well, the compounds 1 ∼ 4 showed respectively 60.2 %, 35.1 %, 20.6 %, 4.5 % inhibition activities against superoxide anion radicals at 200 μL/mL. Interestingly, the compounds 1 ∼ 4 were isolated for the first time from Quercus gilva Blume.

      • Clinical utility of combined ctDNA and CTC assays in the diagnosis of primary lung cancer

        성미,이경종,정병호,김경희,김홍관,김진국,이혜선,정윤규,정미,김성민,미연,배진식,권혁중,김지호,이민섭,이성훈,엄상원 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

        Objectives: Liquid biopsy is a promising non-invasive test for the detection of malignancy. The purpose of this prospective study was to evaluate diagnostic performance of each and combined assays of circulating tumor DNA (ctDNA) and circulating tumor cell (CTC) compared with traditional tumor markers including CEA, cyfra 21-1 and NSE. Methods: From March 15, 2018 through July 9, 2018, a total of 44 subjects who had suspicious lesions for primary lung cancer were enrolled. After excluding 8 subjects diagnosed with other tumors or inconclusive results, 32 subjects with primary lung cancer and 4 subjects with benign pulmonary disease were analyzed. For ctDNA analysis, single nucleotide variants and copy number alterations were evaluated in the platform of next-generation sequencing. For the detection of CTC, EpCAM and cytokeratin were used for the markers. Results: The diagnostic sensitivity and specificity of ctDNA and CTC were 75% and 50% vs. 78% and 75%, respectively. The combination of ctDNA and CTC showed the diagnostic sensitivity and specificity of 100% and 50%, respectively. The positive predictive value, negative predictive value and overall accuracy of the combined two assays were 94%, 100% and 94%, respectively. Combined diagnostic sensitivity and specificity of tumor markers (CEA, cyfra 21-1 and NSE) were 53% and 75%, respectively. Conclusion: The combination of ctDNA and CTC assays can enhance the diagnostic sensitivity for the diagnosis of the primary lung cancer (ClinicalTrials.gov number, NCT03479099).

      • KCI등재후보

        손바닥선인장 종자로부터 항산화와 미백 활성 성분 규명

        문미연(Mi-Yeon Moon),이하연(Ha-Yeon Lee),장문식(Moon-Sik Chang),차준석(Joon-Seok Cha) 한국화장품미용학회 2018 한국화장품미용학회지 Vol.8 No.1

        We identified active components from the methanol extract of Opuntia ficus-indica seeds. Five compounds were identified: 9‘-O-methyl isoamericanol A (1), americanol A (2), 3,3‘-bisdemethylpinoresinol (3), isoamericanin A (4) and adenosine (5). We evaluated the antioxidant, anti-inflammatory and melanogenesis inhibitory effects of these compounds. In antioxidant test, compounds 2, 3, 4 and 5 showed 12-47% of ROS generation inhibition at the concentration of 100 μg/mL. In NO assay, compounds 2 and 3 are similar with the positive control, quercetin by displaying IC<SUB>50</SUB> of 57.80, 57.27, and 51.44 μg/mL, respectively. Furthermore, melanogenesis inhibitory effects of compounds 2, 3, and 4 were 3 to 5 times higher than arbutin, a well-known skin whightening agent. These results indicate that Opuntia ficus-indica seed can be an effective natural cosmetic ingredient.

      • KCI등재

        학교관리자의 지원에 대한 영양(교)사의 인식과 직무만족도

        문미연 ( Mi-yeon Moon ),김명희 ( Myung-hee Kim ),장기효 ( Ki-hyo Jang ),이제혁 ( Je-hyuk Lee ) 한국식생활문화학회 2016 韓國食生活文化學會誌 Vol.31 No.5

        The purpose of this study was to determine the association between school administrator support as perceived by nutrition teachers (dietitians) and job satisfaction in order to provide data concerning efficient job performance of nutrition teachers, to determine effects of school administrator support on job satisfaction in nutrition teachers, and to provide basic data that could help improve school meals. Major supporters of nutrition teachers (dietitians) were chief administrators (55.3%), principals (27.2%), assistant principals (15.0%), and managers in charge (2.4%). Nutrition teachers (dietitians) scored 3.38 for perception of school administrator support, 3.66 for emotional support, 3.27 for informational support, 3.22 for instrumental support, and 3.11 for evaluation support. Support of nutrition teachers (dietitians) by school managers included emotional support (3.66)>informational support (3.27)>instrumental support (3.22)>evaluative support (3.11). Nutrition teachers (dietitians) scored 3.37 for job satisfaction, as follows: work performance (4.19)>interpersonal relationships (3.39)>job satisfaction in general (3.37)>job itself (3.29)>job environment (3.07)>performance rating and benefits system (2.70). Statistically significant correlation was observed between perception of school administrator support and job satisfaction (r= .771, p< .01). Therefore, school administrators are necessary to provide evaluative supports to nutrition teachers (dietitians), performance assessment, employee benefit packages, and improvement of school meal plans and quality.

      • KCI등재후보

        마삭줄로부터 멜라닌 생성 저해 활성 성분 규명

        문미연(Mi-Yeon Moon),이하연(Ha-Yeon Lee),장문식(Moon-Sik Chang),차준석(Joon-Seok Cha) 한국화장품미용학회 2018 한국화장품미용학회지 Vol.8 No.1

        The extracts of Trachelospermum asiaticum were examined for the inhibitory effect on the melanin synthesis in B16/F10 mouse melanoma cells, to evaluate as a functional ingredient for cosmetics. Similar to the effect of arbutin at 50 μg/mL (38%), 70% ethanol extracts, chloroform and ethyl acetate layers showed 34%, 52% and 45% of inhibition at 100 μg/mL. Investigation of constituents from the ethanol extracts of T. asiaticum led to the identification of six compounds; arctigenin (1), matairesinol (2), arctiin(3), luteolin 7-O-glucoside (4), quercitrin (5), luteolin 4`-O-glucoside (6). The compound (5) was isolated from T. asiaticum for the first time, and more interestingly, compounds 1∼3 showed 58%, 84% and 14% inhibitory effect of melanin synthesis. Based on these resutls, we can propose T. asiaticum is a natural cosmeceutical ingredient with skin brightening effect.

      • KCI등재

        코로나 19 상황이 미용 전공 대학생의 취업준비행동과 취업스트레스에 미치는 영향

        미연(Mi-Yeon Lim),소희(So-Hee Moon),이재숙(Jae-Sook Lee) 한국인체미용예술학회 2021 한국인체미용예술학회지 Vol.22 No.4

        In addition to the global economic difficulties caused by the radio waves of Covid-19, the employment stress of college students has become a social problem due to the recent difficulty in finding employment. In this study, by analyzing the effects of the stagnation of the employment market on the employment preparation behavior and employment stress of university students due to the spread of Covid-19, we learned about the employment-related psychology of university students and became uneasy about employment preparation in the situation of Covid-19. I wanted to find a way to reassure my life. Research results It was found that the correlation between cosmetology college student s corona 19 recognition, employment preparation behavior, and employment stress is + at the p <.01 level except for some. Corona 19 As a result of testing the relationship between the influence of influence on employment preparation behavior and employment stress, the employment advice t=3.802 (p=.000), and employment anxiety psychology t=35.709 (p=.000) and came to know the fact that the influence of Covid-19 has a significant influence on the employment preparation behavior and employment stress of beauty major college students. Covid-19 As a result of testing the relationship between the effects of fear psychology on employment preparation behavior and employment stress, the employment information collection t=2.622(p=.009), employment advice t=2.697(p.=.008), employment anxiety psychology is that the t=9.243(p=.000), and we know the fact that Covid-19 fear psychology has a significant effect on employment preparation behavior and employment stress of beauty major university students.

      • KCI등재

        미용 전공 대학생의 비대면 수업경험이 학습무기력 및 자기효능감에 미치는 영향

        미연(Mi-Yeon Lim),소희(So-Hee Moon) 한국문화융합학회 2023 문화와 융합 Vol.45 No.10

        In the field of education, there has been a general change in the learning situation with non-face-to-face classes, as well as phenomena related to adaptation to university life. However, non-face-to-face classes have more side effects than traditional face-to-face classes, and research on the experience of non-face-to-face classes, learning apathy, and self-efficacy among cosmetology majors is incomplete. Therefore, as a result of analyzing this study, we analyzed the influence of non-face-to-face class experience on learning apathy among college students majoring in cosmetology, and found that there was a statistically significant effect on learning apathy(β=-.621, p<.001) and an analysis of the effect on self-efficacy revealed that social efficacy(β=.632, p<.001) and self-regulatory efficacy(β=.340, p <.001)was shown to have a statistically significant effect on failure anxiety and efficacy(β =.124, p<.001) The results of this study revealed that the experience of non-face-to-face classes had a significant impact on learning apathy and self-efficacy among cosmetology majors. Through this study, we hope to stimulate discussion about the non-face-to-face class experiences, learning apathy, and sense of self-efficacy among cosmetology majors. 최근 교육분야에서는 전염병 상황에 따른 대학생들의 비대면 수업이라는 학습상황의 전면적 변화와 더불어 대학생활 적응에서 나타나는 현상이 비대면 수업에 유기적으로 연결되어 작용하고 있다. 하지만비대면 수업은 기존 대면 수업보다 여러 가지 부작용이 나타나고 있으며, 미용전공 대학생의 비대면 수업경험, 학습무기력, 자기효능감에 대한 연구는 미비한 실정이다. 이에 미용을 전공한 대학생의 비대면수업경험이 학습무기력에 미치는 영향을 분석한 결과 학습무기력(β=-.621, p<.001)에 유의미한 부(-)의영향을 미치는 것으로 나타났으며, 자기효능감에 미치는 영향을 분석한 결과 사회적효능감(β=.632, p<.001), 자기조절효능감(β=.340, p<.001), 실패불안효능감(β=.124, p<.001)에 유의미한 영향을 미치는것으로 나타났다. 연구결과 미용을 전공한 대학생의 비대면으로 수업한 경험이 학습무기력 및 자기효능감에 유의미한 영향을 미친다는 것을 알 수 있었다. 본 연구를 통해 미용을 전공한 대학생의 비대면수업경험과 학습무기력, 자기효능감에 대한 논의가 활발히 이루어지기를 기대한다.

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