사라 맥라클란의 보컬 플립 기법 활용 양상 연구

송미연 대중음악콘텐츠학회 2018 대중음악콘텐츠 Vol.2 No.2

이중으로 Q-스위치된 Nd:YAG 레이저 및 내부 공진기 주파수 배가된 레이저의 출력특성

송미연,추한태,최진혁 한국물리학회 2022 새물리 Vol.72 No.3

808 nm 레이저 다이오드로 단면 펌프하고 음향 광학 (acousto-optic, AO) 소자와 Cr4+:YAG 포화흡수체를 이용하여 이중으로 Q-스위치된 1064 nm Nd:YAG 레이저와 비선형 결정인 LBO (Lithium Triborate, LiB3O5)를 이용하여 내부 공진기 주파수 배가(frequency doubling)된 532 nm 레이저의출력 특성을 조사하였다. 입사 펌프 파워가 8 W이고, Q-스위치 펄스 반복률이 1 kHz인 경우, AO Q스위치소자만 사용한 경우와 포화흡수체를 사용하여 이중으로 Q-스위치시킨 경우에 대한 평균 출력 및펄스폭은 각각 1.37 W과 0.55 W 및 159 ns와 52 ns로 측정되었고, 그때의 첨두 파워는 각각 8.6 kW 및10.6 kW이었다. 따라서 이중으로 Q-스위치된 경우가 더 펄스폭이 좁아지고, 피크 파워도 증가하여 출력특성 향상에 효과적임을 확인하였다. 한편 Q-스위치 펄스 반복률 및 입사 펌프 파워가 각각 1 kHz 및 8 W 일 때, 이중으로 Q-스위치되고, 내부 공진기 주파수 배가된 532 nm 레이저의 평균 출력 및 펄스폭은각각 0.27 W 및 50 ns로 측정되어, 5.5 kW의 피크 파워와 50%의 광 변환 효율을 얻을 수 있었다.

중심망막정맥폐쇄의 장기 결과와 황반부종 소실과 연관된 인자

송미연,김종우,김철구,김재휘 대한안과학회 2022 대한안과학회지 Vol.63 No.8

목적: 중심망막정맥폐쇄에 동반된 황반부종 환자의 장기 결과를 보고하고 치료 과정 중 황반부종이 소실되는 빈도와 이에 관련된 인자를분석하고자 한다. 대상과 방법: 중심망막정맥폐쇄에 동반된 황반부종으로 진단된 환자를 대상으로 후향적 연구를 시행하였다. 진단 시 시력과 최종 추적관찰 시 시력을 서로 비교하였다. 치료 과정 중 황반부종이 소실되는 빈도와 시기를 분석하였으며, 황반부종이 소실된 경우와 그렇지않은 경우 사이에 시력 결과를 서로 비교하였다. 추가적으로 황반부종의 소실을 예측할 수 있는 인자를 분석하였다. 결과: 전체 79명을 대상으로 결과를 분석하였으며, 평균 추적 관찰 기간은 50.1 ± 14.3개월이었다. LogMAR (logarithm of minimal angle of resolution) 시력은 진단 시 평균 0.94 ± 0.75, 최종 추적 관찰 시 평균 1.00 ± 0.84였으며(p=1.000), 28명(35.4%)에서logMAR 0.3 이상의 시력 악화가 나타났다. 추적 관찰 기간 중 40명(50.6%)에서 평균 16.9 ± 17.4개월에 황반부종의 소실이 나타났는데, 황반부종 소실군에서는 비소실군에 비해 더 큰 폭의 시력 호전이 나타났다(p<0.001). 60세 미만의 연령(p=0.039)과 진단 시 망막하액이 관찰되지 않은 경우(p<0.001) 황반부종의 소실 빈도가 높게 나타났다. 결론: 중심망막정맥폐쇄에 동반된 황반부종에서 고령의 환자와 진단 시 망막하액이 관찰된 경우 장기간 황반부종이 지속적으로 재발할가능성이 높으므로 보다 면밀한 추적 관찰과 적극적인 치료가 필요할 것이다.

분홍색 통성 메탄올 자화세균이 생산하는 Poly-β-Hydroxybutyrate

송미연,이호재,이용현 한국산업미생물학회 1990 한국미생물·생명공학회지 Vol.18 No.3

PHB 생산을 위하여 메탄올을 기질로 한 선별배지에서 토양, 하천수, 퇴비 등으로부터 분홍색 색소를 가지는 PHB 축적 facultative methylotroph를 분리하여, 균주의 특성을 검토하였다. 분리균주의 최적 생육조건과 PHB 축적을 위한 최적 배양조건을 조사한 결과 균체의 생육은 메탄올 농도 1.0%(v/v), 질소원인 NH_4Cl 농도 1.0g/l, 즉 C/N ratio 13.2일 때 그리고 pH 7.0과 30℃에서 가장 좋았으며, PHB는 C/N ratio가 50.8, 즉 메탄올 농도 1.0%(v/v), NH_4Cl 0.26g/l일 때, 그리고 pH 6.0일 때 건조중량의 약 40%까지 축적되었다. 고농도 메탄올에 의한 생육저해를 극복하기 위하여 기질을 간헐적으로 계속 공급해주는 fed-batch 배양을 시도한 결과 균체량은 14g/l, PHB 축적량은 5.5g/l까지 증가시킬 수 있었다. 생산된 PHB를 분리·정제하여 IR과 ^1H-NMR로 구조를 분석한 결과 3-hydroxybutyric acid의 homopolymer임이 확인되었다. 또한 균주의 pinkpigment를 추출하여 absorption spectrum를 조사하여 그 특성을 규명하였다. For poly-β-hydroxybutyrate(PHB) production, a pink-pigmented facultative methylotrophic bacterium(PPFM) P-10 was newly isolated from soils through methanol-enrichment culture. The optimal medium composition for cell growth was 1.0%(v/v) of methanol as carbon source and 1.0g/l of NH_4Cl, equivalent to C/N ratio of 13.2 at pH 7.0 and 30℃. To investigate the optimal condition for PHB accumulation, two-stage culture technique was adopted; first stage for cell growth and second stage for accumulation of PHB providing unbalanced growth conditions. The optimal PHB accumulation was 1.0%(v/v) of methanol and 0.26g/l of NH_4Cl, C/N of 50.8 at pH 6.0. To overcome methanol inhibition on cell growth, intermittent feeding fed-batch culture technique was employed, and the cell concentration as high as 14g/l with 40% of PHB was achieved. The purified PHB was identified using IR and ^1H NMR as homopolymer of 3-hydroxybutyric acid. The absorption spectrum of extracted pink colored microbial pigment was also investigated.

Aucubin Promotes Differentiation of Neural Precursor Cells into GABAergic Neurons

송미연,김효민,박수진,권혁만,정인실,김윤희 한국뇌신경과학회 2018 Experimental Neurobiology Vol.27 No.2

Aucubin is a small compound naturally found in traditional medicinal herbs with primarily anti-inflammatory and protective effects. In the nervous system, aucubin is reported to be neuroprotective by enhancing neuronal survival and inhibiting apoptotic cell death in cultures and disease models. Our previous data, however, suggest that aucubin facilitates neurite elongation in cultured hippocampal neurons and axonal regrowth in regenerating sciatic nerves. Here, we investigated whether aucubin facilitates the differentiation of neural precursor cells (NPCs) into specific types of neurons. In NPCs cultured primarily from the rat embryonic hippocampus, aucubin significantly elevated the number of GAD65/67 immunoreactive cells and the expression of GAD65/67 proteins was upregulated dramatically by more than three-fold at relatively low concentrations of aucubin (0.01 µM to 10 µM). The expression of both NeuN and vGluT1 of NPCs, the markers for neurons and glutamatergic cells, respectively, and the number of vGluT1 immunoreactive cells also increased with higher concentrations of aucubin (1 µM and 10 µM), but the ratio of the increases was largely lower than GAD expression and GAD immunoreactive cells. The GABAergic differentiation of pax6-expressing late NPCs into GABA-producing cells was further supported in cortical NPCs primarily cultured from transgenic mouse brains, which express recombinant GFP under the control of pax6 promoter. The results suggest that aucubin can be developed as a therapeutic candidate for neurodegenerative disorders caused by the loss of inhibitory GABAergic neurons.

자동색인방법(自動索引方法)과 자동색인(自動索引) 시스템 성능(性能)

송미연,Song, Mi-Yeon 한국과학기술정보연구원 과학기술정보센터 1984 Journal of Information Science Theory and Practice Vol.17 No.3

「관계 지향형 수업」의 사례 연구 ―대학의 일본어 작문 수업을 중심으로―

송미연(宋美娟) 한국일본문화학회 2023 日本文化學報 Vol.- No.96

In this study, relationship-oriented classes refer to classes aimed at forming a friendly relationship between teachers and learners at all stages of class design, execution, and evaluation. The case of the researchers relationship-oriented class was introduced, and the students evaluation was summarized. This study also summarized what is needed to lead the relationship-oriented class to success. First, the teacher must express their knowledge, experience, emotions, and thoughts before asking the learners about their knowledge and emotions. According to the survey, learners feel receptive toward the teachers active self-expression, and actively participate in class activities. Moreover, teachers should recognize learners ashavingequivalentcommunicationcapabilitiestothem . Based on this perception, teachers and learners should continue to communicate with each other. Then, the learner will be able to communicate independently. Finally, the purpose of communication in class should be changed from the delivery of class contents to communication that creates a relationship between humans. Through this communication, both learners and teachers can grow humanely.

Combined Phototherapeutic Keratectomy and Peripheral Anterior Stromal Puncture for the Treatment of Recurrent Corneal Erosion Syndrome

송미연,정재림,김국영,황규연,Young A Kwon,Sang Wroul Song,김병엽,Kyungmin Koh 대한안과학회 2020 Korean Journal of Ophthalmology Vol.34 No.4

Purpose: To investigate the efficacy of the combined phototherapeutic keratectomy (PTK) and peripheral anterior stromalpuncture (ASP) compared with that of PTK alone in patients with recurrent corneal erosion syndrome (RCES). Methods: The medical records of 25 patients (25 eyes) who underwent combined treatment of PTK and peripheral ASP forRCES from March 2016 to May 2017 were retrospectively reviewed. Twenty-three patients (23 eyes) treated with PTK alonefrom March 2015 to February 2016 served as a control group. All surgeries were performed by a single surgeon. This retrospectiveclinical study comprised 48 patients (48 eyes) who were followed up for more than 18 months. Clinical records ofage, sex, laterality, etiology of RCES, and history of recurrence after treatment were evaluated. Results: Twenty-five eyes were treated with combined PTK and ASP, and 23 eyes were treated with PTK only. The meanfollow-up period was 19.63 ± 2.97 and 19.75 ± 6.83 months, respectively. There were no differences in baseline parametersbetween the groups. In the combined treatment group, one patient experienced recurrence 6 months after the surgery. Inthe single treatment group, five patients showed recurrence at 4, 7, 8, 11, and 13 months after the surgery, respectively. Compared to the single treatment group, the combined treatment group showed significantly lower recurrence rate (p < 0.05). All recurred patients required no additional treatment except temporary therapeutic contact lenses and topical lubricants. Conclusions: Our findings suggest that combined treatment of PTK and peripheral ASP is effective in alleviation of symptomsand prevention of recurrence in refractory RCES compared with treatment using PTK alone.

타 인종에 있어 체질과 체성분의 상관성에 관한 연구

송미연,김재희,지상은,Song, Mi-Yeon,Gallagher, Dympna,Kim, Jae-Hee,Chi, Sang-Eun 사상체질의학회 2003 사상체질의학회지 Vol.15 No.2

Background: Sasang Constitutional Medicine (SCM) is a component of Korean traditional medicine that classifies humans into four categories, according to their constitution (Taeyangin, Taeumin, Soyangin and Soeumin). We are unaware of previous assessments of SCM in non-Asian race groups. Objectives: To quantify body composition components in three race groups and to determine whether SCM has an independent effect on body composition components. Design: A cross-sectional evaluation of 76 adults (28 Caucasian, 21 African-American, 27 Asian). Body composition was estimated using dual energy x-ray absorptiometry. Results: SCM component had a significant effect on weight, fat, and lean mass regardless of race group (p <0.001).

체질따른 식이요법이 최상

송미연,Song, Mi-Yeon 한국과학기술단체총연합회 2003 과학과 기술 Vol.36 No.9