http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
곰팡이에서 분리한 Helicobacter pylori 항균물질의 분리 및 구조규명
남궁준,연승우,백남수,김태한,김영호,김창진,김기원 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-
Helicobacter pylori is a Gram-negative bacterium which causes chronic gastritis and is associated with gastric ulcer, duodenal ulcer and gastric carcinoma. In the process of screening of antibacterial activities against H. pylori from soil microorgani는, fungus No. 60686 was isolated. After fementaion of No. 60686, the antibacterial compound was isolated, purified and followed by extraction of mycelium with orgainic solvents, acetone and ethyl acetate, through silica gel chromatography, LH-20 gel chromatography and HPLC. As a result of the structural analyses of the compound by IR, ^1H- and ^13C-NMR, FAB/Mass spectrophotomer, the compound having the antimicrobial activity was idenfitied as chaetoglobosin A (C_32H_36N_2O_5), a cytochalasan derivative. The antimicrobial activity of chaetoglobosin A was tested against Gram-positive and negative bacteria by paper disk method. Among the test strains of 9 Gram-positive bacteria and 18 Gram-negative bacteria containing 4 H. pylori strains, the growth of 4 H. pylori strains and 3 S. aureus strains (SG 511, 285 and 503) was only inhibited by chaetoglobosin A. Also it was shown that its growth inhibition against H. pylori strains was stronger than that against S. aureus strains at the treatment of the same concentration. Therefore it was concluded that chaetoglobosin A has a specific growth inhibition against H. pylori of the tested bacteria.
남궁준,백운하,윤주경 한국응용곤충학회 1971 한국응용곤충학회지 Vol.10 No.1
The only record of spider's from Cholla Namdo was made by T. Kambe in 1953. They were collected from Mokpo area which is located south-west coast of Cholla Namdo and included 24 species belonging to 8 families. In this paper are given for the first time a iist of spiders from Kwangju City, inland of Cholla Namdo. wis located at the center of Cholla Namdo. More than 5,000 individual spiders were collected by one of the junior author, J.K. Yoon during autumn in 1570. In spite ef rather large number of spiders were collected, collecting season and the locality are restricted, number of species was reiatit·ely small and many young spiders were undeterminable, A total of 50 species belong to 15 families, including 5 unrecorded species from Korea, were identified. Unrecorded species were as follows: Uloborus yesoensis Pirate piraticus Stemmops sp. Trochosa ruricola Erigone koshiensis , 1960
남궁준,이승철,이승훈,이현경,정재용,김홍주,박원도 인제대학교 2000 仁濟醫學 Vol.21 No.1
In this case report we described the case of an unexplainable newsy developed ascites following renal allograft transplantation in the patient who was free of ascites during a period of peritoneal dialysis. This case suggests that ascites in the patients with end-stage renal failure is not limited to the period of maintenance dialysis and that renal transplantation may paradoxically followed by development of ascites. There has been no previous reported in Korea, so we report this case along with the brief review of the literature.
남궁준,유영진,김성록 인제대학교 1999 仁濟醫學 Vol.20 No.1
5-Fluorouracil은 투여 방법에 따라 효과가 달라지는 항암약제로서 지난 수년간 5-Fluorouracil의 치료효과를 향상시키기 위한 많은 연구가 있었다. 저자들은 치료효과를 높이기 위한 예비실험으로서 5-Fluorouracil 불응성 위장관 암 환자를 대상으로 저용량의 leucovorin과 5-Fluorouracil의 급속 및 지속주입을 병합한 방법으로 제2상 실험을 한 후 그 효과 및 독성을 관찰하였다. Object: To determine the efficacy and toxicity of low dose leucovorin and hybrid regimen of bolus and contunuous infusion of 5-fluorouracil for the refractory gastrointestinal tract cancers. Material and Method: 13 patients with advanced gastrointestinal cancer refractory to 5-FU containing chemotherapy entered on this study between July 1987 to September 1998. Among 13 patients, there were 2 patients with stomach cancer, 3 colon cancer, 6 rectal cancer, 1 pancreatic cancer and 1 bile duct cancer. 9 patients are presently evaluable for response; 4 patients were lost to follow up before evaluation. The chemotherapy regimen consisted of leucovorin 20mg/m2 IV bolus followed by 5-FU 400mg/m2 IV over 15 minutes and continuous 5-FU 800mg/m2 IV for 18hours daily for 4 days. The treatment was repeated every 3 weeks. Results: This regimen resulted in no objective response out of 9 evaluable patients; Six of 9(67%) had stable disease and 3(33%) had progressive disease. Overall survival of evauable patients were 7+∼48+ weeks(median : 28 weeks) and time to progression were 5+∼23+weeks(median: 14 weeks). Toxicities were moderate but tolerable. No one was hospitalized due to toxicity. The most common and dose limiting toxicity was stomatitis (53.8%). Conclusion: This regimen with low dose leucovorin and hybrid regimen of bolus and continuous infusion of 5-FU was tolerable and failed to show good effect on the patients with gastrointestinal tract cancer refractory to 5-FU containing chemotherapy. As 6/9 patients were in stable disease, the comparative study on the standard chemotherapy and this regimen is warranted.