Minor alleles in the FTO SNPs contributed to the increased risk of obesity among Korean adults: meta-analysis from nationwide big data-based studies

김오연,Park Jihyun,Lee Jounghee,Sohn Cheongmin,Yoon Mi Ock,이명숙 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.1

BACKGROUND/OBJECTIVES: Many studies have revealed an association between fat mass and the obesity-related gene (FTO) and obesity. On the other hand, no meta-analysis was conducted with data from only Koreans. Therefore, this study performed a meta-analysis using Korean data to provide evidence for the association between FTO single nucleotide polymorphisms (SNPs) and the risk of obesity among Korean adults. SUBJECT/METHODS: Meta-analysis was finally conducted with data extracted from seven datasets of four studies performed on Korean adults after the screening passed. Five kinds of FTO SNPs (rs9939609, rs7193144, rs9940128, rs8050136, and rs9926289) were included, and the relationship between FTO SNPs and body mass index (BMI) was investigated using linear regression with an additive model adjusted for covariants, such as age, sex, and area. RESULTS: The minor alleles of FTO SNPs were associated with increased BMI (odds ratio [OR], 1.31; 95% confidence interval [CI], 1.21–1.42). In sub-group analysis, FTO rs9939609 T>A was significantly associated with BMI (OR, 1.23; 95% CI, 1.06–1.42). The other FTO SNPs together were significantly associated with BMI (OR, 1.37; 95% CI, 1.25–1.49). The publication bias was not observed based on Egger’s test. CONCLUSIONS: This meta-analysis showed that minor alleles in the FTO SNPs were significantly associated with an increased BMI among Korean adults. This meta-analysis is the first to demonstrate that minor alleles in the FTO SNPs contribute significantly to the increased risk of obesity among Korean adults using data from a Korean population.

소비자대상 직접 (DTC) 비만유전자 기반 정밀영양 (PNH)의 국내 현황

김오연,이명숙,이정희,손정민,윤미옥 한국영양학회 2022 Journal of Nutrition and Health Vol.55 No.6

In the era of the fourth industrial revolution technology, the inclusion of personalized nutrition for healthcare (PNH), when establishing a healthcare platform to prevent chronic diseases such as obesity, diabetes, cerebrovascular and cardiovascular disease, pulmonary disease, and inflammatory diseases, enhances the national competitiveness of global healthcare markets. Furthermore, since the government experienced COVID-19 and the population dead cross in 2020, as well as numerous health problems due to an increasing super-aged Korean society, there is an urgent need to secure, develop, and utilize PNH-related technologies. Three conditions are essential for the development of PNH technologies. These include the establishment of causality between obesity genome (genotype) and prevalence (phenotype) in Koreans, validation of clinical intervention research, and securing PNH-utilization technology (i.e., algorithm development, artificial intelligence-based platform, direct-to-customer [DTC]-based PNH, etc.). Therefore, a national control tower is required to establish appropriate PNH infrastructure (basic and clinical research, cultivation of PNH-related experts, etc.). The post-corona era will be aggressive in sharing data knowledge and developing related technologies, and Korea needs to actively participate in the large-scale global healthcare markets. This review provides the importance of scientific evidence based on a huge dataset, which is the primary prerequisite for the DTC obesity gene-based PNH technologies to be competitive in the healthcare market. Furthermore, based on comparing domestic and internationally approved DTC obese genes and the current status of Korean obesity genome-based PNH research, we intend to provide a direction to PNH planners (individuals and industries) for establishing scientific PNH guidelines for the prevention of obesity.

A narrative review on the application of doubly labeled water method for estimating energy requirement for Koreans

김오연,박종훈,김은경 한국영양학회 2022 Nutrition Research and Practice Vol.16 No.3

Research articles were reviewed to validate the estimated energy requirements (EERs) equations developed by the Institute of Medicine of the National Academies (IOM). These equations are based on total energy expenditure (TEE) measured by the doubly labeled water (DLW) method. We subsequently aimed to provide the basis for the suitability to apply the IOM equations as EER equations for Koreans, and develop relevant equations for EER in the Dietary Reference Intake for Koreans (KDRI). Additionally, besides the EER(IOM) equations, other equations were examined for EER estimation. Research papers demonstrating the validation of the EER(IOM) equations based on TEE(DLW) were searched through PubMed (up to September 2019). Of the 637 potentially relevant articles identified, duplicates and unsuitable titles and abstracts were excluded. Furthermore, papers with irrelevant subject and inappropriate study design were also excluded. Finally, 11 papers were included in the review. Among the reviewed papers, 8 papers validated the application of the EER(IOM) equations for EER based on TEE(DLW). These included 3 studies for children (USA 1, Korea 2), 1 for adolescents (Portugal), 2 for adults (Korean), and 2 for the elderly (Korea, USA). EER(IOM) equations were found to be generally acceptable for determining EER by using the DLW method, except for Korean boys at 9–11 yrs (overestimated) and female athletes at 19–24 yrs (underestimated). Additionally, 5 papers include the validation of other EER equations, beside EER(IOM) for EER based on TEE(DLW). In Japanese dietary reference intake and recommended dietary allowance, EER equations are acceptable for determining EER based on TEE(DLW). The EER(IOM) equations is generally acceptable for determining EER using the DLW method in Koreans as well as several populations, although certain defined groups were found to be unfit for the estimation. Additionally, the concept of healthy body mass index of Koreans and physical activity levels need to be considered, thereby providing the basis for developing relevant equations of EER in KDRI.

Poster Presentation: Differences in Body Fat Distribution and Postprandial Lipemia in Men with or without Hypertriglyceridemia

유하정,김오연,채지숙,박현영,이종호,장양수 한국지질동맥경화학회 2002 韓國脂質學會誌 Vol.12 No.1

식물재배가 스마트폰 의존도에 미치는 영향

김승주,김오연,이주영 한국환경과학회 2019 한국환경과학회 학술발표회 발표논문집 Vol.2019 No.11

창의성 증진 교육방법의 개선방안

임효희,김오연,신경훈,유혜원,백윤수 한국공학교육학회 2009 공학교육연구 Vol.12 No.4

This study aimed to investigate the perception of students for the general creativity education in order to suggest the practical education for the improvement of their creativity. Most students chose 'discussion and projects' which indicates students preferred the class where they can mainly participate with a help of professors. 본 연구는 대학생들의 창의성 향상과 관련하여 대학에서 실용적인 교육환경 제시를 위해 전반적인 창의성 교육환경에 대한 대학생들의 인식조사를 목적으로 하였으며, 서울시내 대학에서 공학을 전공하는 2, 3, 4학년을 대상으로 실시하였다. 대학수업 중 창의성 관련 전공과목 수강과 관련하여, 약 28%의 학생이 수강하였다고 응답하였고, 이중 3, 4학년의 비율이 높았으며, 창의성 향상에 도움이 되었다고 응답한 경우가 60%이상이 되었다. 창의성 관련 수업은 교수와 학생이 모두 참여하는 토론식 방식이 약 39%, 학생발표와 교수논평 방식이 약 29%를 차지한다고 답하였으나, 현재 대학에서 진행되고 있는 수업방식은 교수위주의 이론 주입방식이 대다수를 차지(79%) 한다고 답하였다. 창의성 증진에 영향을 줄 수 있는 수업방식에 대한 질문에, 2, 3, 4학년 모두 토론 및 프로젝트 수업방식을 선택하여 대부분의 학생들은 교수가 조력자로서의 역할을 가지고 함께 참여하는 수업방식을 선호하는 것으로 나타났다.

비만한 중년 남성에서 열량제한과 운동을 통한 체중 감소의 효과

박현영,장양수,김오연,유하정,채지숙,이종호 대한비만학회 1999 The Korean journal of obesity Vol.8 No.2

$quot;Background: With abdominal obesity being recognized as an important risk factor of metabolic disease and atherosclerosis, it is important to determine the optimal weight loss program for decreasing this risk. The goal of this study was to determine beneficial health effects of modest weight loss with low calorie diet and exercise in middle-aged overweight Korean men. Method: Sixteen overweight men aged 40-49 years participated in a 3-month weight- management program. The diet and exercise program reduced daily energy intake by 300-400 kcal from daily energy need and expended about 100 kcal in walking and other light exercise. Compliance with the diet and exercise protocol was monitored through 7-day records of diet and physical activity maintained by subjects monthly. Adipose tissue and muscle areas were calculated from computerized tomography scans at 3 body levels, Ll, IA and mid portion of thigh before and after weight loss. Anthropometries, serum levels of lipids and hormones and response areas of glucose, C-peptide, insulin and free fatty acid during oral glucose tolerance test (OGTT) were determined. Result: After 3 months of diet and exercise, body weight fell an average of 4.9 kg (6.3%) and waist circumference reduced an average of Scm. Modest weight loss appeared to decrease blood pressure in overweight males. Although weight loss did not show any significant differences in thigh muscle and femoral subcutaneous fat areas, there was about 20% reduction in visceral, subcutaneous and total fat areas of Ll and L4 levels after weight loss. Mean values of serum total cholesterol, even though within normal range before weight loss, decreased significantly after weight loss. Serum triglyceride concentration fell from 192 to 143 mg/dL in association the loss of weight. Modest weight loss showed a 30% decrease in fasting insulin and response areas of insulin during OGTT. There was a 16% but not significant decrease in the response area of free fatty acid during OGTT after weight reduction. Conclusion: The result suggests that modest weight reduction with diet and exercise can show a rapid decrease in abdominal fat without muscle loss, compared with in femoral fat. Modest weight loss about 6% of initial weight can be viable apprach to help decrease serum lipids and hyperinsulinemia and improve insulin responsiveness to glucose challenge.

Short-term Effects of Eating Behavior Modification on Metabolic Syndrome-Related Risks in Overweight and Obese Korean Adults

김현영,윤은주,김오연,김은미 대한비만학회 2022 The Korean journal of obesity Vol.31 No.1

Background: We investigated whether eating behavior modification improves metabolic syndrome (MetS)-related risks in overweight/obese Korean adults, and identified dietary factors that improve metabolic status. Methods: Among 159 volunteers, 71 with a body mass index ≥23 kg/m2 and without other chronic diseases participated in the 8-week intervention, among which 54 participants who completed the intervention were included in the analyses. At baseline, patients were categorized either metabolically healthy obese (MHO; <3 MetS risk factors, n=42) or metabolically unhealthy obese (MUHO; ≥3 MetS risk factors, n=12), and then educated regarding how to choose healthy foods and meals. Results: Lipid profiles and anthropometric and glycemic parameters were significantly improved among all participants after the intervention. Changes in waist circumference (P= 0.025), and glycemic parameters (glucose, P=0.046, insulin, P=0.005, C-peptide, P=0.041) were positively correlated with changes in calorie intake from snacks. Changes in visceral fat area were negatively correlated with changes in total calorie intake (P=0.046), and positively correlated with those in calorie intake from dietary fats (P=0.039). In addition, changes in insulin (P=0.013) and C-peptide (P=0.008) concentrations were negatively correlated with changes in dietary fiber intake at dinner. After the intervention, 83.3% of initially MUHO participants became MHO and 16.7% of MHO participants became MUHO. Conclusion: Eating behavior modification may be an important strategy to improve metabolic factors in overweight/obese people.

출생시 체중에 따른 지방증 반등 시기의 변화 및 영향요인

고은경,전효정,김오연,윤소라 한국아동학회 2018 한국아동학회 학술발표논문집 Vol.2018 No.11

Effect of Breakfast Consumption and Meal Time Regularity on Nutrient Intake and Cardiometabolic Health in Korean Adults

윤소라,최미옥,김오연 한국지질동맥경화학회 2021 지질·동맥경화학회지 Vol.10 No.2

Objective: Dietary factors are important contributors to obesity and related metabolic disorders. Few studies have evaluated the impact of dietary habits (e.g., breakfast consumption frequency and meal regularity) on metabolic health. We investigated the effects of breakfast consumption frequency and meal time regularity on nutrient intake and cardiometabolic status in Korean adults. Methods: Participants without diagnosed diseases (n=217) were examined for anthropometric and biochemical parameters, lifestyle, dietary habits, and nutrient intake. They were categorized into 4 groups by breakfast consumption frequency (≥6 or <6 times/week) and meal time regularity (regular or irregular): breakfast ≥6 times/week and regular eating (HBRE), breakfast ≥6 times/week and irregular eating (HBIE), breakfast <6 times/week and regular eating (LBRE) and breakfast <6 times/week and irregular eating (LBIE). Results: Participants in the LBIE group were the youngest, had higher waist circumference, body mass index, triglyceride levels, and inflammation, and consumed the highest daily total caloric intake (TCI), the highest proportion of fats, and the lowest proportion of carbohydrates. The LBIE group also had the lowest proportion of energy intake at breakfast and the highest proportion at dinner. The LBIE group consumed the lowest amounts of fiber, beta-carotene, vitamin K, folate, calcium and iron, and had the highest prevalence of inadequate nutrient intake for TCI, protein, vitamins A, C, B6, and B12, folate, calcium, iron, zinc, and copper. Conclusion: Regular breakfast consumption and meal times are related to healthy lifestyle habits and adequate nutrient intake, which affect metabolic health, thereby helping prevent obesity and related metabolic disorders.