심근경색의 위험인자로서 Thrombomodulin유전자변이의 의의

박현영,김영미,권혁문,지선하,조승연,정남식,심원흠,장양수 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

3교대 근로자에서 교대근무기간과 혈압 및 심박수 변동성

하미나,김재용,박정선,정호근 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

목적 : 교대근무가 심혈관계에 미치는 만성적인 영향을 살펴보기 위하여 본 연구를 수행하였다. 방법 : 4조 3교대의 빠른 순환주기의 교대근무를 하는 1개 제조업체 남성근로자 134명을 대상으로 교대근무마다 혈압 및 심박수 변동성을 측정하였다. 교란변수로서 Karasek의 직무긴장도 모델에 의거한 49항목의 직무스트레스설문지를 이용하여 직무스트레스를 측정하였고, 수면유형과 흡연, 음주력 및 과거병력 등의 사항에 관한 설문조사를 실시하였다. 반복측정 자료의 분석을 위해 mixed model을 이용한 다변량 회귀분석을 수행하여, 교대근무기간과 혈압 및 심박수 변동성과의 관련성을 살펴보았다. 결과 : 대상 근로자의 평균연령은 29 세였다(범위 25∼44). 이들 중 77.9 % 는 현재도 흡연을 하고 있었고, 50 % 는 직무긴장도 모형에서 수동형이었다. 평균 총 교대근무기간은 5.21 년(범위 5.4 개월∼10년)이었다. 수면유형검사에서는, 극단적인 아침형이나 극단적인 저녁형은 없었다. 연령, 직무스트레스, 수면유형 및 흡연을 보정한 다변량 분석에서, 혈압은 총 교대근무기간이 증가함에 따라 통계학적으로 유의하게 증가하는 소견을 보였다(p(0.05). 심박수 변동성은 저주파 및 고주파 영역 모두에서 총 교대근무기간이 증가함에 따라 유의한 감소양상을 나타냈다(p<0.05) . 결론 : 본 연구의 결과는 교대근무가 혈압을 상승시키고 심박수 변동성을 감소시키는 것으로써 심혈관계 기능에 영향을 미침을 보여주었다. Objectives : This study was performed to investigate the chronic health effect of shift-work on cardiovascular system. Methods : We checked blood pressure(BP) and heart rate variability (HRV) at every shift on 134 male workers whose shift type was 8-hour and short rotating of 3 days shift interval. As confoundings, job stress was measured by Karasek's JCQ 49 items questionnaire and circardian type was assessed by morningness-eveningness questionnaire. Smoking and alcohol drinking habit, marital status and past medical history were also acquired. We used the method of repeated measured data analysis with mixed model to show the association between shiftwork duration and BP or HRV. Results : Average age of workers was 29 years olds(range 25∼44). Among them, 77.9 % were current smokers, 50 % were the passive type of job strain in Karasek's model. Mean shiftwork duration was 5.21 years(range 5.4 months∼10 years). In circadian type, no one was definitely morning type or definitely evening type. In multivariate analyses adjusted by age, job strain, shift, circadian rhythm and smoking, blood pressure were showed significantly increasing trends according to shiftwork duration in both systolic and diastolic (p(0.05) . Heart rate variability were also showed significantly decreasing trends according to shiftwork duration in both parasympathetic and sympathetic functions (p(0.05) . Conclusions : The results of this studs suggests the chronic negative health effect of shiftwork on cardiovascular system.

겨우살이 첨가 김치의 발효양상과 항돌연변이 및 암세포성장저해효과

최선미,길정하,전영수,박건영 부산대학교 김치연구소 2003 김치의 과학과 기술 Vol.9 No.-

Fermentation characteristics, and antimutagenic and anticancer effects of mistletoe added kimchi were studied. The changes in pH, acidity and the value of prevalence test of the mistletoe added kimchi during the fermentation were determined. Ames antimutagenicity test against aflatoxin B_(1) (AFB_(1)) and N-methyl-N'nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100, and MTT assay using HT-29 human colon carcinoma cells and AGS human gastric adenocarcinoma cells were employed to test the chemopreventive effect of the kimchis. Mistletoe added kimchis were fermented at 15℃ for 1 days and then ripened at 5℃ to reach optimum pH of 4.3. Mistletoe added kimchis fermented slowly compared to the control kimchi when the changes of pH and acidity of the kimchis were compared. Sour flavor of mistletoe in the kimchis was decreased during the fermentation. Mistletoe added kimchis exhibited higher inhibitory effect against the mutagenicities induced by AFB_(1) and MNNG in the Ames test than the control kimchi. Especially, 2% mistletoe added kimchi showed the highest inhibitory effect (75%, 68%) in the Ames test (p<0.05), Two % mistletoe added kimchi showed the highest anticancer effect against HT-29 human colon cells (p<0.05). Mistletoe added kimchis exhibited significantly higher anticancer effect than the control kimchi in AGS cells, too, however, there was no significant different effect among the different levels of mistletoe (0.5∼2.0%) addition (p<0.05). It can be concluded that addition of mistletoe in kimchi increased preservation period of the kimchi and enhanced antimutagenic and anticancer effects of the kimchi.

겨우살이 첨가 김치의 발효양상과 항돌연변이 및 암세포성장저해효과

최선미,길정하,전영수,박건영 대한암예방학회 2003 Journal of cancer prevention Vol.8 No.2

자궁 경부의 편평상피 화생, 이형성과 콘딜롬에서 p53, Ki-67 및 HPV의 발현 양상

윤성웅,오미혜,양승하,김의한 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

To observe the expression of p53, Ki-67 and HPV type in the uterine cervical lesions, such as 11 cases of squamous metaplasia, 6 cases of CIN Ⅱ and 14 cases of condyloma accuminatum and to evaluate the correlationship between the results, the author has been carried out immunohiostochemical staining for monoclonal antibodies to p53, Ki-67 and in situ hybridizatiion of HPV nucleic acid. So, following results are obtained. 1. The HPV type 6 and 11 are negative in all cases of suamous metaplasia and CIN Ⅱ. 2. In condyloma accuminatum, the HPV type 16 and 18 are negative in all cases, but HPV 6 and 11 are positive in 9 cases out of 14 (65%). 3. The stain patterns of p53 in squamous metaplasia and CIN Ⅱ show similar findings but the areas of basal and reserve cell layers show more strong stain. 4. The stain pattern of Ki-67 in squamous metaplasia and CIN Ⅱ show high prolliferatlion. 5. In condyloma accuminatum, the expresseion of p53 show weakly reaction in general, but in cases of present nuclear enlargement and atypia, the stain degree show more stronger than only koilocyte presence. 6. The Ki-67 in condyloma accuminatum show high proliferation in all cases.

당귀잎김치 및 당귀잎첨가 배추김치의 암예방 효과

최선미,길정하,문숙희,박건영 대한암예방학회 2003 Journal of cancer prevention Vol.8 No.3

천식치료의 현황과 대책

유광하,김미진,김순종 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-

Asthma is disease with affect in the almost every coner in the world and it is estimated worldwide we have 300 million people with this disease. The distribution of this disease varying from place to place such that in English speaking country such as USA, Canada, Australia and some part of South America, the prevalence of clinical asthma is more than ten percent. In Asia pacific area, the prevalence is about 2.5%. Several surveys have been done in the last 5 years starting with the AIA so called Asthma In America, followed ALA data, the AIRE data, AIRIAP data, AIJ data was done. The purpose of this survey were to see how well the disease is being controlled. According to the surveys asthma is possessed big burden on health care budget in worldwide. About 25% of patients in Europe, 47% of patients in Japan had urgent visit to local clinics and 10% in Europe and 23% in USA had an emergency room visit in the past year. The percentage of hospitalization ranged form 7% in Europe to 19% in Central and East Europe. Only 5% have what we called good control of asthma according to the GINA criteria. As a result, asthma impact significantly one's life. The goal of asthma treatment is to achieve every asthmatic should feel normal and be free to live their life. For achieving this, practical strategies have to be developed for well understanding about asthma, perception of asthma as a chronic disease, which needs persistent asthma management.

불소함유 지문방지제 합성

차미선,범정철,하종욱,박인준,소원욱,이수복 한국공업화학회 2004 응용화학 Vol.8 No.2

The anti-fingerprint coating agents, consist of a fluorinated macromer(F-macromer) were prepared by marcromonomer technique and hydrosilation reaction. The products were characterized by ¹H-NMR, differential scanning calorimetry. The surface properties of the anti-fingerprint coating agents were investigated by the contact and sliding angle measurement. The modified surface with the anti-fingerprint coating agents showed the extremely low surface free energy of a 10.09 dyn/cm and the sliding angle was smaller than that of commercial products. That is, The synthesised coating agents can be the good candidate for the water and oil repellent, soil release and anti -fingerprint application coating agent.

일부 여대생의 스트레스와 철분 영양상태에 관한 연구

승정자,하보경,김미현,최선혜 숙명여자대학교 건강. 생활과학연구소 1999 生活科學硏究誌 Vol.14 No.1

The purpose of this study was to evaluate the iron status of 39 female adult who divided into five groups according to the stress condition. The iron status was evaluated based on dietary intake and blood analysis. The average age of the subjects was 23.10years, and the average score of BMI was 20.06kg/m2. The proportion of subjects in each stress condition was : 2.56%(1) in A1type(the group who easily get disease associated with stress), 64.10%(25) in A2type(condition susceptible to the disease associated with stress), 30.77%(12) in ABtype(middle type of A and B), 2.56%(1) in B2type(appropriate stressed condition) and 0%(0) in B1type(risk free to the disease associated with stress). The average daily intake of energy in study subjects was 2,399kcal, ti caloric ratio of carbohydrate, protein, fat was 59.90 : 14.39 : 25.71, respectively. There was no significant difference in anthropometric measurements, dietary intake status, hematologic indices of iron status between high stress group(A1type and A2type) and low stress group(ABtype and B2type). To compare the iron stores between high stress group and low stress group, subjects in each group were devided into iron 0 mg, 250 mg, 500 mg group. Stress level did not affect iron stores although in both groups, number of subjects in iron 0 mg group were higher than those of iron 250 mg and 500mg groups. Correlation coefficients between anthropometric measurements, nutrient intake status, hematologic indices of iron status and stress score of subjects did not reveal any significance. Therefore, the results suggest that psychological stress did not affect the iron status in normal female adult. However, be more systematic study on stress and the iron status is required in the future.

간암 환자에 합병된 Citrobacter braakii 패혈증 1례 보고

이해미,배성하,이수남,이정우,신아영,류시영,이수연,윤문희,한선영,한남익,이영석,유진홍 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Citrobacter species is a gram-negative bacilli that can cause opportunistic infections in immunocompromised hosts. Citrobacter braakii refers to the genomospecies 6 of the Citrobacter freundii complex. There are no detailed studies on infections caused by this newly identified specific genetic species in Korea. We herein report a case of a patient with hepatocellular carcinoma who, after undergoing transcatheter arterial chemoembolization, developed biloma which later progressed to C.braakii sepsis and did not respond to treatment. To our knowledge, this is the first reported case in Korea on C. braakii infection resulting in septic shock in a patient with malignancy in Korea.