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( Joong Rock Hong ),( Su Jin Seok ),( Du Shin Jeong ),( Sang Gon Lee ),( Hyo Wook Gil ),( Jong Oh Yang ),( Eun Young Lee ),( Sae Yong Hong ) 대한내과학회 2010 The Korean Journal of Internal Medicine Vol.25 No.4
Background/Aims: Many patients with acute paraquat (PQ) intoxication die even at low PQ concentrations, whereas others with similar concentrations recover. Therefore, it is possible that individual differences in antioxidant capacity are responsible for the variable clinical outcome in patients with acute PQ intoxication. Methods: We investigated whether there was a relationship between the genetic polymorphisms of SOD (V16A), catalase (C262T), and GPX1 (C593T) in 62 patients with acute PQ intoxication and the clinical outcomes of these patients. Results: The frequency of the Mn-SOD V/V, V/A, and A/A genotypes were 56.3, 43.5, and 0% in survivors and 86.9, 13.1, and 0% in non-survivors (p > 0.05). The GPX1 C/C, C/T, and T/T genotypes were present in 100, 0, and 0% of all subjects. The catalase C/C, C/T, and T/T genotypes were present in 100, 0, and 0% of survivors, and in 82.6, 17.4, and 0% of non-survivors. Neither erythrocyte SOD activity nor catalase activity were significantly different between survivors and non-survivors. Conclusions: No association was found between clinical outcome of acute PQ intoxication and the genetic polymorphism of GPX1 (C593T) or the genetic polymorphisms or enzyme activity of superoxide dismutase (V16A) or catalase (C262T). (Korean J Intern Med 2010;25:422-428)
Benzene and toluene concentrations in a hemodialysis room in a medium sized South Korean city
( Moon Soo Kang ),( Joong Rock Hong ),( Hyo Wook Gil ),( Jong Oh Yang ),( Eun Young Lee ),( Sae Yong Hong ),( Yong Taek Jun ),( Bu Soon Son ) 대한내과학회 2008 The Korean Journal of Internal Medicine Vol.23 No.3
Background/Aims: The current study was designed to determine whether the indoor air pollution in a hemodialysis room (HD) was different from that of other comparable areas in a hospital. Methods: Five air monitor samplers were hung on the ceiling and placed on the table in both the HD and general ward nursing stations, respectively. In addition, five samplers were placed in the nurse`s breathing zone of the HD and the general ward, respectively. Ten air monitor samplers were also placed on the edge of the bed in the HD, which represented the patient`s breathing zone. The levels of benzene and toluene were analyzed by GC/MS. Results: In the general ward, the toluene concentration was significantly higher in the nurse breathing zone than that for the ceiling or table samples (p=0.001). The benzene concentration was also significantly higher in the general ward nurse breathing zone than that in the HD (p=0.006). In addition, the benzene concentrations on the table were higher at the general ward as compared to the HD (p=0.028), but there was no significant difference between the ceiling, general ward station and HD. Conclusions: Both the benzene and toluene concentrations in the HD appear to be more affected by the outdoor atmospheric conditions than by any potential indoor internal sources.
Seok, Su-Jin,Park, Jae-Seok,Hong, Joong-Rock,Gil, Hyo-Wook,Yang, Jong-Oh,Lee, Eun-Young,Song, Ho-Yeon,Hong, Sae-Yong Informa Healthcare 2011 Clinical toxicology Vol.49 No.10
<P><I>Background:</I> Glyphosate, one of the most commonly used herbicides worldwide, has been considered as minimally toxic to humans. However, clinical toxicologists occasionally encounter cases of severe systemic toxicity. The purpose of this study was to determine the effect of glyphosate-surfactants (“glyphosate-surfactant toxicity”) in patients with acute glyphosate intoxication. <I>Methods:</I> In all, 107 patients (69 men and 38 women, aged 52.3 ± 15.5 years) with acute glyphosate intoxication were enrolled in this study. From their medical records, we identified the formulation of ingested glyphosate products and derived clinical parameters, which focused on clinical outcome, admission days, duration in the intensive care unit, development of respiratory failure, cardiovascular deterioration, renal failure, altered mental status, and convulsions. The effect of surfactants on clinical complications was also assessed. <I>Results:</I> For surfactant ingestion volumes of 8 mL, the incidence of clinical complications was (in rank order) as follows: hypotension, 47.1%; mental deterioration, 38.6%; respiratory failure, 30.0%; acute kidney injury, 17.1%; and arrhythmia, 10.0%. These complications were influenced by the volume of surfactant and not the type of surfactant-ingredient in the herbicide product. Two patients died of refractory shock, metabolic acidosis, and respiratory failure. However, the final clinical outcomes of the surviving patients were benign, and cardiovascular, respiratory, kidney, and mental functions were fully restored to normal levels. <I>Conclusions:</I> Our results indicate that treatment of patients with acute glyphosate herbicide intoxication should take into account the volume and not the type of surfactants in herbicide formulations.</P>
다구찌법을 이용한 컨테이너화물 안전수송장치 ConTracer의 성능향상에 관한 연구
최형림(Hyung Rim Choi),김재중(Jae Joong Kim),강무홍(Moo Hong Kang),손정락(Rock Jung Shon),신중조(Joong Jo Shin),이호인(He-in Lee),김광필(Gwang Pil Kim),김채수(Chae Soo Kim) 한국산업정보학회 2009 한국산업정보학회논문지 Vol.14 No.2
미국에서 발생한 9.11 테러 이후 물류보안(Supply Chain Security)에 대한 패러다임이 발생하였으며, 국외의 관련 기업과 기관들은 물류보안을 위하여 다양한 연구들을 진행하였다. 하지만 국내의 경우 물류보안이라는 용어 자체가 생소할 뿐만 아니라 보안에 관한 패러다임이 물류부분까지 확산되지가 않아서 관련 연구가 부족한 실정이었으나, 최근에 물류보안 기술 중의 하나로서 RFID 기반 컨테이너 화불 안전수송 장비인 ConTracer(Container Tracer)를 개발하는 등 관련 연구가 활성화되기 시작하였다. 현재 개발되고 있는 컨테이너 화물 안전수송 장비들의 주요 이슈는 높은 인식률과 충분한 인식거리가 확보되는 것이며, 본 연구에서는 이러한 목적을 달성하기 위하여 다구찌 방법론을 활용하여 ConTracer(433㎒ 타입, 2.4㎓ 타입)의 인식률 향상을 위한 다양한 실험을 하였다. 실험결과 433㎒ 주파수에서는 리더기의 방향을 전방우측으로 향하는 것이 다소 유리하고, 2.4㎓ 주파수에서는 크게 영향을 미치지는 못하는 것으로 나타났으며, 안테나의 위치는 예상했던 대로 두 주파수 모두 외부에 설치하는 것이 인식률 향상에 유리한 것으로 분석되었다. Since 9.11 terrorist attacks against the USA, the new paradigm for “supply chain security” has been established. And at the same time a lot of researches are being made on supply chain security by many foreign companies or research institutes. However, domestically the terms “supply chain security” themselves are not yet familiar, and the paradigm of security are not being used in the logistics, while little researches are being made on them. But recently along with development of “ConTracer,” a supply chain security technology, which is to be used as the equipment for container cargo transportation safety based on RFID technology, related researches have begun to be activated. The key issues for the development of equipment for container transportation safety are to obtain both a high recognition rate and enough recognition distance. To this end, this study has tested the ConTracer (433 ㎒ type and 2.4 ㎓ type) by using Taguchi Method. According to our test results, in the case of 433 ㎒ type, it is a little more effective that the reader faces to the front-right side, and in the case of 2.4 ㎓, reader direction does not make difference in the view of sensitivity. The test also has proved that it is better that antenna location, as expected, is to be installed on the outside for both types alike.