드부룬의 라텍스분리풍선카테타법에 의한 경동맥해면정맥동루 및 내경동맥 동맥류의 치료

장기현,한만청,김주완,한대희,최길수,심보성 대한신경외과학회 1984 Journal of Korean neurosurgical society Vol.13 No.1

The two cases, one carotid-cavernous fistula and one giant aneurysm of internal carotid artery, treated with Debrun's latex detachable balloon catheter technique are reported. Case 1 was a 50-year-old man who had proptosis, chemosis and 3rd nerve palsy in his right eye. His cerebral angiography showed typical traumatic carotid-cavernous fistula. Following complete radiologic and neurologic examination, the fistulous opening was successfully occluded with preservation of the internal carotid artery using latex detachable balloon. Immediately after occlusion of the fistula the clinical symptoms were markedly improved. Only transient facial pain occured as a complication. Case 2 was a 21-year-old woman who had a dizziness and left facial nerve palsy. The cerebral angiography showed a giant aneurysm at the petrous portion of left internal carotid artery. The patient tolerated occlusion of the left carotid artery. The left internal carotid artery was completely occluded with 3 detachable balloons. The patient had no complications during 9 days follow-up. The procedures and complications of detachable balloon catheter technique will be described and discussed.

Review : The lymphatic vascular system in liver diseases; its role in ascites formation

( Chu Han Chung ),( Yasuko Iwakiri ) 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.2

The lymphatic system is part of the circulatory system and plays a key role in normal vascular function. Its failure plays a crucial role in the development and maintenance of various diseases including liver diseases. Lymphangiogenesis (the growth of lymphatic vessels) and changes in the properties of lymphatic vessels are associated with pathogenesis of tumor metastases, ascites formation, liver fibrosis/cirrhosis and portal hypertension. Despite its significant role in liver diseases and its importance as a potential therapeutic target for those diseases, the lymphatic vascular system of the liver is poorly understood. Therefore, how the lymphatic vascular system in general and lymphangiogenesis in particular are mechanistically related the pathogenesis and maintenance of liver diseases are largely unknown. This article summarizes: 1) the lymphatic vascular system; 2) its role in liver tumors, liver fibrosis/cirrhosis and portal hypertension; and 3) its role in ascites formation.

Effects of Processed Barley on Growth Performance and Ileal Digestibility of Growing Pigs

Chu, K.S.,Kim, J.H.,Chae, B.J.,Chung, Y.K.,Han, In K. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.3

Two experiments were conducted to evaluate the effects of processing of barley on the growth performance and ileal and fecal digestibility of growing pigs. In Exp. 1, a total of 20 cannulated pigs (10.80 kg BW) were allotted to four treatments. Treatments were coarse ground barley as a control (CON), finely ground barley (FINE), extruded barley (EXT) and enzyme supplemented coarse ground barley (ENZ). In Exp. 2, a total of 100 growing pigs (36.50 kg BW) were allocated to the same treatments in completely randomized block design based on sex and body weight. In the first trial, pigs fed extruded barley showed significantly higher crude protein digestibility over pigs fed finely ground barley (p < 0.05). Pigs fed finely ground barley generally showed lower nutrients digestibility. Extrusion and ${\beta}$-glucanase supplementation showed a trend to improve nutrients digestibility. However, fine grinding rather reduced nutrients digestibility. The similar trend was found in the digestibility of essential amino acids. Fine grinding of barley significantly reduced amino acids digestibility. Extrusion and enzyme supplementation were found to improve amino acids digestibility of barley in growing pigs. In the growth trial, pigs fed extruded barley grew significantly faster than any other processed barley fed pigs. And extrusion of barley significantly improved feed/gain of pigs (p < 0.05). Fine grinding of barley and enzyme supplementation did not improve growth performance of pigs. In conclusion, fine grinding and enzyme supplementation does not appear to be an economical feed processing for growing pigs when barley is employed in the diets, while extrusion can be recommended as an effective feed processing technique for barley.

Association Between Genetic Polymorphisms of the Cytochromes P-450 (1A1, 2D6, and 2E1) and the Susceptibility to Pancreatic Cancer

( Han Chu Lee ),( Yong Bum Yoon ),( Chung Yong Kim ) 대한내과학회 1997 The Korean Journal of Internal Medicine Vol.12 No.2

Cytochrome P-4501Al(CYP1A1)의 유전적 다형성이 췌장암 발생에 미치는 영향

이한주,윤용범,김정룡 大韓消化器病學會 1997 大韓消化器病學會誌 Vol.29 No.4

Tissue Plasminogen Activator in Chronic Subdural Hematoma & Its Relationship with CT Findings

Chung, Yong Gu,Kim, Han Kyeoum,Park, Young-Kwan,Kim, Bong Ryung,Chung, Heung Seob,Lee, Hoon Kap,Lee, Ki Chan,Chu, Jung Wha 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.1

저자는 고려대학교 병원에 입원하여 수술치료를 받았던 17례의 만성경막하 혈종의 환자에서 immunoperoxidase assay를 이용하여 tissue plasminogen activator의 존재유무와 출현정도, 그리고 CT 영상소견과의 연관관계를 추적하였다. t-PA 면역염색은 경막하혈종의 외막 혈관벽(모세혈관과 정맥)에 국한되어 나타났다. CT상 5례에서 mixed density소견을 보였으며 이중 3례는 최근에 출혈이 발생되었다는 중거가 되는 층형태(layering type) 소견이었으며, 이 층형태의 CT소견을 보이는 경우에 t-PA 면역염색의 정도가 뚜렷이 나타났다. t-PA 면역염색이 진하고 뚜렷이 보이는 6례 중 4례에서 CT 영상소견에서 막의 대조강화(enhancement)가 뚜렷이 보인 반면, 면역염색이 약하게 나타난 10례중 3례에서 CT 영상소견상 막의 강화소견을 보였다. CT소견상 종괴효과는 t-PA면역염색이 진하고 넓게 보이는 예에서(4/6) 연하고 국한되게 나타나는 예보다(3/11) 뚜렷이 나타났다. 만성경막하혈종의 혈액양은 t-PA의 염색정도에 따라 비교하여 보면, 염색이 가장 약하고 국한되게 나타난 경우에서 평균 26cc, 중간정도로 염색되는 경우에서 평균 35cc, 가장 진하고 넓게 되는 경우에 평균 61cc로 나타났으나, 임상례의 숫자가 적어 조금더 연구가 필요할 것으로 사료되나, t-PA가 혈종의 증대에 중요한 역할을 하는 요소중의 하나가 될것이라는 추측을 가능하게 한다고 사료된다.

3D Part Similarity Comparison based on Levels of Detail in Negative Feature Decomposition Using Artificial Neural Network

Cheng, Han-Chung,Chu, Chih-Hsing,Wang, Eric,Kim, Yong-Se CAD Solutions, LLC 2007 Computer-aided design and applications Vol.4 No.5

소 간세포암의 전산화단층촬영 소견 - 조영제 증강 전후 소견의 비교검토 -

김정룡(Chung Yong Kim),이효석(Hyo Suk Lee),최병인(Byung Ihn Choi),한만청(Man Chung Han),김수태(soo Tae Kim),김주완(Chu Wan Kim),김용일(Yong Il Kim),이건욱(Kuhn Uk Lee) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3

N/A Sixty-seven lesions of small hepatocellular carcinoma in 50 patients under 5cm in diameter detected by computed tomography (CT) were reviewed to characterize the CT feature. All 50 patients were studied with a CT-9800 scanner. CT scans were obtained both before and after administration of contrast medium given by bolus injection of 120 ml of meglumine iohatlamate. CT density of the tumor was classified as hypodense, isodense, and hyperdense on the basis of the difference in density between the lesion and the surrounding liver parenchyma. Detectability of small hepatocellular carcinoma on CT scans was divided into three categioies; Good: tumor is noted, and extent of tumor is clearly defined; Fair: tumor is noted, but extent of tumor is not defined; Poor: tumor is not noted. On nonenhanced CT scans, 40 cases (60%) showed hypodense masses and 27 cases (40%) showed isodense masses whereas all cases showed hypodense masses on contrast-enhanced CT scans. On nonenhanced CT scans, 27 cases (40%) were categorized as good, 13 cases (20%) as fair, and 27 cases (40%) as poor while 65 cases (97%) were categorized as good, and 2 cases (3%) as fair on contrast-enhanced CT scans. Additional CT characteristics of small hepatocellular carcinoma were well defined margin (99%), and peripheral hyperdense rim (44%). These results suggest that contrast-enhanced CT scans are better than nonenhanced CT scans in detecting and defining the tumor, and CT might be useful for characterization of small hepatocellular carcinoma.

간세포암의 자연경과와 여러 치료방법에 따른 생존률에 관한 연구 - 과거 20 년간의 경험을 토대로 -

김정룡(Chung Yong Kim),이준성(June Sung Lee),이한주(Han Chu Lee),이효석(Hyo Suk Lee),윤용범(Yong Bum Yoon),송인성(In Sung Song),박재형(Jae Hyung Park),김수태(Soo Tae Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.2

N/A Background: Hepatocellular carcinoma (HCC) is the most common form of primary hepatic carcinoma and is a pressing sociomedical problem in Korea. Of the various solid cancers, HCC is perhaps the most diffcult to treat because of the frequently associated cirrhosis and advanced stage of tumor. In recent years, diagnostic procedures, surgical techniques and various therapeutic modalities other than surgery have been developed and improved. So, the prognosis of these patients may have changed from what it was in the past and it is necessary to establish the criteria for selection of therapeutic modality in indivisual patient with HCC. The purpose of this study was to elucidate the natural history of HCC and the survival rate of patients with HCC in relation to various therapeutic modalities in different stage of chronic liver disease. Method: A total of 1149 patients with HCC seen during the last 20 years were analyzed retropectively. The effects of treatment on survival were analyzed with regard to Child's grading and UICC stage of HCC. Results: In the 265 patients who received no specific treatment, the cumulative survival rates of 6 month and 1 year were 37.5%, 16.6% and the median survival time was 4 months. Survival rates of the surgically treated patients were better than that of other patients groups in comparable Child's grade and UICC stage, Especially, among patients with Child's A or B the actuarial survival rate for surgery was significantly better than that for transarterial chemoembolization. Transarterial chemoembolization gave a significantly better survival rate compared with systemic chemotherapy and no specific treatment in all child's grade and UICC stage. Systemic chemotherapy improved survival as compared with no specific treatment in Child's A or B patients and with UICC stage IV and Child's C with stage IV, patients. The major causes of death were hepatic failure and gastrointestinal bleeding irrespective of treatment modality. Conclusion: Adequate therapeutic modalities according to the severity of liver cirrhosis and tumor stage could improve the prognosis of HCC patients.

Cytochrome P-4501A1 ( CYP1A1 ) 의 유전적다형성이 췌장암 발생에 미치는 영향

이한주(Han Chu Lee),윤용범(Young Bum Yoon),김정룡(Chung Yong Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.4

N/A Rackground/Aims: Cigarette smoking is the best-established risk factor for pancreatic cancer. Metabolic activation is a prerequisite for the carcinogenic effect of many carcinogens, and the CYP1A1 activates polycyclic aromatic hydrocarbons in smoke. Genetic polymorphisms of the CYP1AI have been shown to be related to inter-individual variation in metabolic activation of carcinogens and to increased susceptibilitv to lung cancer. The aim of this study was to clarify the association between genetic polymorphisms of the CYP1Al and tbe susceptibility to pancreatic cancer, another smoking-related cancer. Methods: We analyzed 45 samples from patients with pancreatic cancer (28 males, 17 females) and 53 samples from controls. DNA was isolated from blood samples and the CYP1A1 gene was amplified by PCR. Analyzing the genotypes of the CYP1A1 by allele-specific PCR or RFLP analysis, we assessed the mutant allele frequencies of the CYP1Al among cases and controls. Results: (1) The allele frequencies for mutation in the 3-flanking region of the CYP1A1 (ml) among cases and controls were 0.31 and 0.36, respectively. (2) The allele frequencies for exon 7 mutation of the CYP1A1 (m2) were 0.16 and 0,235, respectively, with no statistical significance. (3) There was no difference iin the mutant allele frequencies of the CYP1A1 among smokers and non-smokers in patients with pancreatic cancer. Conclusions: No association was found between genetic polytnorphisms of the CYP1A1 and the susceptibility to pancreatic cancer. (Korean J Gastroenterol 1997; 29:522-529)