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- 저자 : Zhifang Guo (검색결과 3 건)
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Rui Yan,Jianbo Song,Zhifang Wu,Min Guo,Jianzhong Liu,Jianguo Li,Xinzhong Hao,Sijin Li 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.4
To determine the efficacy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the detection of radiation-induced myocardial damage in beagles by comparing two pre-scan preparation protocols as well as to determine the correlation between abnormal myocardial FDG uptake and pathological findings. The anterior myocardium of 12 beagles received radiotherapy locally with a single X-ray dose of 20 Gy. 18F-FDG cardiac PET/CT was performed at baseline and 3 months after radiation. Twelve beagles underwent two protocols before PET/CT: 12 hours of fasting (12H-F), 12H-F followed by a high-fat diet (F-HFD). Regions of interest were drawn on the irradiation and the non-irradiation fields to obtain their maximal standardized uptake values (SUVmax). Then the ratio of the SUV of the irradiation to the non-irradiation fields (INR) was computed. Histopathological changes were identified by light and electron microscopy. Using the 12H-F protocol, the average INRs were 1.18 ± 0.10 and 1.41 ± 0.18 before and after irradiation, respectively (p = 0.021). Using the F-HFD protocol, the average INRs were 0.99 ± 0.15 and 2.54 ± 0.43, respectively (p < 0.001). High FDG uptake in irradiation field was detected in 33.3% (4/12) of 12H-F protocol and 83.3% (10/12) of F-HFD protocol in visual analysis, respectively (p = 0.031). The pathology of the irradiated myocardium showed obvious perivascular fibrosis and changes in mitochondrial vacuoles. High FDG uptake in an irradiated field may be related with radiation-induced myocardial damage resulting from microvascular damage and mitochondrial injury. An F-HFD preparation protocol used before obtaining PET/CT can improve the sensitivity of the detection of cardiotoxicity associated with radiotherapy.
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The NAC transcription factor OsSWN1 regulates secondary cell wall development in Oryza sativa
Maofeng Chai,Maria Bellizzi,Caixia Wan,Zhifang Cui,Yebo Li,Guo-Liang Wang 한국식물학회 2015 Journal of Plant Biology Vol.58 No.1
Rice, as a major crop in the world, produces huge agronomic biomass residues besides food, which consist of cellulose, hemicelluloses and lignin. Many master regulators of secondary wall synthesis were identified in the model plant Arabidopsis. In this study, we investigated the function of a NAC (NAM, ATAF, and CUC2) transcription factor related to secondary cell wall biosynthesis, which is highly expressed in rice sclerenchyma tissue and is named OsSWN1. Our results showed that engineering of OsSWN1 could exhibit multiple features regulated to agronomic traits and bioenergy research. Over-expression of OsSWN1 caused an erect-leaf and enclosed-flower phenotype. Secondary cell wall-related genes were actively expressed in transgenic plants with obvious ectopic lignin deposition in the leaf collar, while increased lignin content and decreased the sugar yield correspondingly. In addition, down-regulation of OsSWN1 expression levels decreased lignin content and increased the sugar yield in transgenic plants. Bioinformatics analysis revealed that OsSWN1-like genes are highly conserved in switchgrass and sorghum, suggesting a possibility of manipulating the expression level of the OsSWN1 orthologs in the bioenergy crops for biofuel production.
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Anterior Gradient 3 Promotes Breast Cancer Development and Chemotherapy Response
Qiao Xu,Ying Shao,Jinman Zhang,Huikun Zhang,Yawen Zhao,Xiaoli Liu,Zhifang Guo,Wei Chong,Feng Gu,Yongjie Ma 대한암학회 2020 Cancer Research and Treatment Vol.52 No.1
Purpose Anterior gradient 3 (AGR3) belongs to human anterior gradient (AGR) family. The function of AGR3 on cancer remains unknown. This research aimed to investigate if AGR3 had prognostic values in invasive ductal carcinoma (IDC) of breast cancer and could promote tumor progression. Materials and Methods AGR3 expression was detected in breast benign lesions, ductal carcinoma in situ and IDC by immunohistochemistry analysis. AGR3’s correlations with clinicopathological features and prognosis of IDC patients were analyzed. By cell function experiments, collagen gel droplet-embedded culture drug sensitivity test and cytotoxic analysis, AGR3’s impacts on proliferation, invasion ability, and chemotherapeutic drug sensitivity of breast cancer cells were also detected. Results AGR3 was up-regulated in luminal subtype of histological grade I-II of IDC patients and positively correlated with high risks of recurrence and distant metastasis. AGR3 high expression could lead to bone or liver metastasis and predict poor prognosis of luminal B. In cell lines, AGR3 could promote proliferation and invasion ability of breast cancer cells which were consistent with clinical analysis. Besides, AGR3 could indicate poor prognosis of breast cancer patients treated with taxane but a favorable prognosis with 5-fluoropyrimidines. And breast cancer cells with AGR3 high expression were resistant to taxane but sensitive to 5-fluoropyrimidines. Conclusion AGR3 might be a potential prognostic indicator in luminal B subtype of IDC patients of histological grade I-II. And patients with AGR3 high expression should be treated with chemotherapy regimens consisting of 5-fluoropyrimidines but no taxane.
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