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Eddy current and coupled landscapes for nonadiabatic and nonequilibrium complex system dynamics
Zhang, Kun,Sasai, Masaki,Wang, Jin National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.37
<P>Physical and biological systems are often involved with coupled processes of different time scales. In the system with electronic and atomic motions, for example, the interplay between the atomic motion along the same energy landscape and the electronic hopping between different landscapes is critical: the system behavior largely depends on whether the intralandscape motion is slower (adiabatic) or faster (nonadiabatic) than the interlandscape hopping. For general nonequilibrium dynamics where Hamiltonian or energy function is unknown a priori, the challenge is how to extend the concepts of the intra- and interlandscape dynamics. In this paper we establish a theoretical framework for describing global nonequilibrium and nonadiabatic complex system dynamics by transforming the coupled landscapes into a single landscape but with additional dimensions. On this single landscape, dynamics is driven by gradient of the potential landscape, which is closely related to the steady-state probability distribution of the enlarged dimensions, and the probability flux, which has a curl nature. Through an example of a self-regulating gene circuit, we show that the curl flux has dramatic effects on gene regulatory dynamics. The curl flux and landscape framework developed here are easy to visualize and can be used to guide further investigation of physical and biological nonequilibrium systems.</P>
Zhang Weifeng,Li Gaocai,Luo Rongjin,Lei Jie,Song Yu,Wang Bingjin,Ma Liang,Liao Zhiwei,Ke Wencan,Liu Hui,Hua Wenbin,Zhao Kangcheng,Feng Xiaobo,Wu Xinghuo,Zhang Yukun,Wang Kun,Yang Cao 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of an inflammatory microenvironment in NP tissue. Excessively accumulated cytosolic DNA acts as a damage-associated molecular pattern (DAMP) that is monitored by the cGAS-STING axis to trigger the immune response in many degenerative diseases. NLRP3 inflammasome-dependent pyroptosis is a type of inflammatory programmed death that promotes a chronic inflammatory response and tissue degeneration. However, the relationship between the cGAS-STING axis and NLRP3 inflammasome-induced pyroptosis in the pathogenesis of IVD degeneration remains unclear. Here, we used magnetic resonance imaging (MRI) and histopathology to demonstrate that cGAS, STING, and NLRP3 are associated with the degree of IVD degeneration. Oxidative stress induced cGAS-STING axis activation and NLRP3 inflammasome-mediated pyroptosis in a STING-dependent manner in human NP cells. Interestingly, the canonical morphological and functional characteristics of mitochondrial permeability transition pore (mPTP) opening with the cytosolic escape of mitochondrial DNA (mtDNA) were observed in human NP cells under oxidative stress. Furthermore, the administration of a specific pharmacological inhibitor of mPTP and self-mtDNA cytosolic leakage effectively reduced NLRP3 inflammasome-mediated pyroptotic NP cell death and microenvironmental inflammation in vitro and degenerative progression in a rat disc needle puncture model. Collectively, these data highlight the critical roles of the cGAS-STING-NLRP3 axis and pyroptosis in the progression of IVD degeneration and provide promising therapeutic approaches for discogenic LBP.
A New Method of Point-Clouds Accurate Measurement and Reconstruction
Kun Zhang,Weihong Bi,Xinghu Fu 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.6
With the reverse engineering development, the accuracy of system is more important in reconstruction, especially in non-contacting measurement. This paper provides a new method measuring the accuracy the point clouds, define a image probability and the point probability according to uncertainty data. The quantity of the uncertain point data is important to measuring the result of reconstruction. The prior data can be catch from the last measurement process, especially the edge data or characteristic points. Referring to prior data, basing on the Bayesian theory the more accuracy posterior data can be computed in this paper. We divided the point cloud into different areas, and organized the data with hierarchical tree-structure. According to the probability of one tree node, we adjust the area corresponding to the node. At last, by using the existing experimental equipment, we verify the measurement of point cloud accuracy algorithm. The depth data was obtained by a laser scanner---SICK LMS100. The depth data can be computed as point data with uncertainty. The result of the reconstruction deeply relies on the quality of prior data.
Zhang Pei-Pei,Liang Su-Xia,Wang Hua-Lun,Yang Kun,Nie Shao-Chen,Zhang Tong-Mei,Tian Yuan-Yuan,Xu Zhao-Yuan,Chen Wei,Yan Ying-Bin 한국통합생물학회 2021 Animal cells and systems Vol.25 No.5
The aim of this study was to compare the functional characteristics of mesenchymal stromal cells (MSCs) from a sheep model of traumatic temporomandibular joint (TMJ) fibrous and bony ankylosis. A sheep model of bilateral TMJ trauma-induced fibrous ankylosis on one side and bony ankylosis on the contralateral side was used. MSCs from fibrous ankylosed callus (FAMSCs) or bony ankylosed callus (BA-MSCs) at weeks 1, 2, 4, and 8 after surgery were isolated and cultured. MSCs derived from the bone marrow of the mandibular condyle (BM-MSCs) were used as controls. The MSCs from the different sources were characterized morphologically, phenotypically, and functionally. Adherence and trilineage differentiation potential were presented in the ovine MSCs. These cell populations highly positively expressed MSC-associated specific markers, namely CD29, CD44, and CD166, but lacked CD31 and CD45 expressions. The BA-MSCs had higher clonogenic and proliferative potentials than the FA-MSCs. The BA-MSCs also showed higher osteogenic and chondrogenic potentials, but lower adipogenic capacity than the FA-MSCs. In addition, the BA-MSCs demonstrated higher chondrogenic, but lower osteogenic capacity than the BM-MSCs. Our study suggests that inhibition of the osteogenic and chondrogenic differentiations of MSCs might be a promising strategy for preventing bony ankylosis in the future.
A New Kmeans Clustering Algorithm for Point Cloud
Kun Zhang,Weihong Bi,Xiaoming Zhang,Xinghu Fu,Li Zhu,Kunpeng Zhou 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.9
With development of 3D scanner, it becomes more convenient to access point data. However, for processing the large-scale point cloud, it raised a new challenge for computer graphics. This paper places an emphasis on the point data own characteristics, and then the point data have been divided into certain point sets by clustering algorithm, that is will be divided into different clusters. In order to suit for the point data organization or space division, the clustering algorithm would be improved. This paper provided a new Kmeans algorithm with density constraints. Before processing the point cloud by Kmeans algorithm with density constraints, the density of the point cloud have been defined in this paper, the density of the point cloud can be used for quantification of the convergence. Finally, the Kmeans algorithm with density constraints is verified by the experiment results. Our experiment showed that the improved Kmeans can reduce the processing time, especially, As the increase of the value of K, that is number of cluster, the calculating time of the clustering algorithm can be decreased greatly. In addition, with the increases of the the scale of data size, the stability of the improved Kmeans algorithm has been verified.
An Overview on the Integration of Informatization and Industrialization (IOII)
Kun Zhang,Zhenji Zhang 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.9
The integration of informatization and industrialization (IOII) is a policy guidelines proposed by the Chinese Government to promote the production upgrade and the transformation of economic development mode, which is given increasingly attention by academic circles. In this paper, a brief introduction to IOII is presented. The research collections of IOII required to study the concept, development and process are surveyed as well as the application evaluation. By summarizing the development, relationship and the existing concept of IOII, a new concept of IOII is put forward. Then by studying comparatively the process and the application evaluation of IOII, suggestions for future empirical investigation is offered.
Low Microsomal Epoxide Hydrolase Expression is Associated with Bladder Carcinogenesis and Recurrence
Zhang, Zhe,Yu, Xiu-Yue,Zhang, Guo-Jun,Guo, Kun-Feng,Kong, Chui-Ze Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
Microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics and is associated with several forms of cancer. Here, we investigated the role of mEH expression in bladder carcinogenesis, subsequent progression and recurrence. The expression of mEH was analyzed by Western blot in 50 bladder urothelial carcinoma and 20 normal epithelial tissues. There was a significantly higher mEH expression in the normal epithelium (P<0.05) and mEH expression was lower in high stage than in low stage tumors (P<0.05). Further, immunohistochmistry in 106 bladder urothelial carcinoma demonstrated mEH expression to be negatively correlated with histological grade, pT stage and recurrence (P<0.05). These findings suggest the important role of mEH in bladder carcinogenesis, cancer development and recurrence, providing support for efforts to develop mEH-based gene therapy.
Kun Wen,Li Han,Zhi-ting Zhou,Zhen-nan Fan,Yong Liao,Jun Wang,Zhang Sun,Bing Yao,Bide Zhang 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.3
To obtain more precise and rational calculation details of the loss and heat of a damper winding in a tubular hydro-generator, this study develops a three-dimensional, fi nite-element, electromagnetic-temperature fi eld close-coupling model of the damper winding. On the basis of multi-physical fi eld coupled theory, the model fully considers the temperature eff ects of the damper winding resistivities and heat conductivities, and the eddy current loss in the end region of the damper winding. The model was verifi ed by direct tests of the damper winding temperature. Unlike the conventional weak-coupling model, the proposed close-coupling model fully captures the interaction between the electromagnetic and temperature fi elds. Therefore, of the model more accurately and reasonably calculates the loss and heat of the damper winding than the conventional model. The proposed calculation model can properly assess the loss and heat of damper windings in large hydro-generators, which is helpful for improving the design standards of hydro-generators.