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RISS 인기검색어
- 검색키워드
- 저자 : Zhang Pei-Pei (검색결과 212 건)
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Possible Epithelial Ovarian Cancer Association with HPV18 or HPV33 Infection
Zhang, Pei-Pei,Zhou, Lei,Cao, Jia-Shi,Li, Yi-Ping,Zeng, Zhi,Sun, Ni,Shen, Li,Zhu, Hao-Yue,Ruan, Yang,Zha, Wen-Ting,Wang, Xin-Yu,Zhang, Ke-Qiang,Zhang, Ran Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
The present study was conducted to investigate the prevalence of HPV infection in epithelial ovarian cancer (EOC) in Hunan province. DNA samples were collected from paraffin embedded ovarian tissue from 322 patients with EOC, 99 with ovarian benign tumors and 199 normal persons. The polymerase chain reaction and direct sequencing were used to identify the HPV types in the samples. The relationship between the infection of human papillomavirus (HPV) and the epithelial ovarian carcinoma (EOC) was investigated combined with clinical data. The prevalence of HPV18 and HPV33 in EOC group and benign group was higher than in the normal group. HPV18 and HPV33 may play a role in the development of both EOC and ovarian benign tumor and may participate in the development of EOC with traditional risk factors, family history and abortion, possibly exerting synergistic effects.
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Zhang, Qiang,Geng, Pei-Liang,Yin, Pei,Wang, Xiao-Lin,Jia, Jin-Peng,Yao, Jie Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Objective: To investigate the expression level of TUG1 and one of its transcript variants (n377360) in osteosarcoma cells and assess the role of TUG1 in proliferation and apoptosis in the U2OS cell line. Methods: TUG1 and n377360 expression levels in patients with osteosarcomas and the U2OS human osteosarcoma cell line were evaluated using real-time quantitative PCR. U2OS cells were transected with TUG1 and n377360 siRNA or non-targeting siRNA. MTS was performed to assess the cell proliferation and flow cytometry was applied to analyze apoptosis. Results: We found significantly higher TUG1 and n377360 expression levels in osteosarcoma tissues compared with matched non-tumorous tissues. In line with this, suppression of TUG1 and n377360 expression by siRNA significantly impaired the cell proliferation potential of osteosarcoma cells. Furthermore, inhibition of TUG1 expression significantly promoted osteosarcoma cell apoptosis. Conclusions: The overexpression of TUG1 and n377360 in osteosarcoma specimens and the functional role of TUG1 and n377360 regarding cell proliferation and apoptosis in an osteosarcoma cell line provided evidence that the use of TUG1 or n377360 may be a viable but an as yet unexplored therapeutic strategy in tumors that over express these factors.
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Zhang, Shao-Kai,Guo, Lan-Wei,Chen, Qiong,Zhang, Meng,Liu, Shu-Zheng,Quan, Pei-Liang,Lu, Jian-Bang,Sun, Xi-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background and Aim: No firm evidence of HPV infection in esophageal cancer has been established to date. The aim of this meta-analysis was to investigate the prevalence of HPV 16 in esophageal cancer in China, which had a high burden of the disease. Materials and Methods: Studies on HPV infection and esophageal cancer were identified and a random-effects model was used to pool the summary prevalence and corresponding 95% confidence intervals (CIs). Results: A total of 3,429 esophageal cancer cases were evaluated from 26 eligible studies in this meta-analysis. The summary estimate for HPV16 prevalence was 0.381 (95% CI: 0.283, 0.479). The prevalence varied by geographical areas of the study, publication year, HPV detection method and types of specimen. In sensitivity analysis, HPV 16 prevalence ranged from 0.368 (95% CI: 0.276, 0.460) to 0.397 (95% CI: 0.286, 0.508). Conclusions: The results indicate a relatively high level of HPV 16 prevalence in esophageal cancer among Chinese population, although there was variation between different variables. Further studies are needed to elucidate the role of HPV in esophageal carcinogenesis with careful consideration of study design and laboratory detection method, providing more accurate assessment of the HPV status in esophageal cancer.
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Zhang Pei-Pei,Liang Su-Xia,Wang Hua-Lun,Yang Kun,Nie Shao-Chen,Zhang Tong-Mei,Tian Yuan-Yuan,Xu Zhao-Yuan,Chen Wei,Yan Ying-Bin 한국통합생물학회 2021 Animal cells and systems Vol.25 No.5
The aim of this study was to compare the functional characteristics of mesenchymal stromal cells (MSCs) from a sheep model of traumatic temporomandibular joint (TMJ) fibrous and bony ankylosis. A sheep model of bilateral TMJ trauma-induced fibrous ankylosis on one side and bony ankylosis on the contralateral side was used. MSCs from fibrous ankylosed callus (FAMSCs) or bony ankylosed callus (BA-MSCs) at weeks 1, 2, 4, and 8 after surgery were isolated and cultured. MSCs derived from the bone marrow of the mandibular condyle (BM-MSCs) were used as controls. The MSCs from the different sources were characterized morphologically, phenotypically, and functionally. Adherence and trilineage differentiation potential were presented in the ovine MSCs. These cell populations highly positively expressed MSC-associated specific markers, namely CD29, CD44, and CD166, but lacked CD31 and CD45 expressions. The BA-MSCs had higher clonogenic and proliferative potentials than the FA-MSCs. The BA-MSCs also showed higher osteogenic and chondrogenic potentials, but lower adipogenic capacity than the FA-MSCs. In addition, the BA-MSCs demonstrated higher chondrogenic, but lower osteogenic capacity than the BM-MSCs. Our study suggests that inhibition of the osteogenic and chondrogenic differentiations of MSCs might be a promising strategy for preventing bony ankylosis in the future.
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Zhang, Pei-Yun,김옥규,최현 한국건축시공학회 2019 한국건축시공학회지 Vol.19 No.6
Recently, research has been carried out into the use of carbon fiber reinforced polymer (CFRP), which has goodtensile strength and corrosion resistance, as an alternative to rebar. But as of yet, the research into fatigue failure ofCFRP is insufficient. In this paper, an analysis was performed of the mechanical behavior and failure patterns of CFRPreinforced concrete beams according to static and cyclic loads, in order to evaluate the safety and validity of CFRPrebar as an alternative material for rebar. The cyclic load ranged from 10 % to 70% of the ultimate load, and wasloaded at a speed of 3Hz using a sine wave in the form of a three-point loading method. Through the static load test,the maximum load or stiffness of the beam was found to increase remarkably with the increase of the reinforcement,but the fatigue test showed that the number of repetitions decreased and the amount of deflection increased with theincrease of the reinforcement. 최근 철근의 대체재로서 인장강도나 내부식성이 좋은CFRP(carbon fiber reinforced polymer)를 이용한 연구가 활발히 진행되고 있다. 그러나 현재 피로 파괴에 대한연구는 미비한 상태이다. 따라서 본 연구에서는 CFRP보강 콘크리트 보를 제작하여 정적 및 반복 하중에 따른 역학적 거동과 파괴형태를 분석하고 철근의 대체 재료로서 CFRP 보강근 사용에 대한 안전성과 타당성을 평가하도록 하였다. 반복하중의 범위는 극한하중의 10~70%를 취하고 3점 재하방식으로 sine파를 이용한 3Hz의 속도로 재하 하였다. 정적 실험결과 보강량의 증가에 따라 보의 최대하중이나 강성은 현저하게 증가하였지만 피로 실험결과 보강량의 증가에 따라 반복 횟수는 감소하고 처짐량은 증가하여 안전성은 다소 감소됨을 알 수 있었다.
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Pei Shengxiang,Niu Siwen,Xie Fuquan,Wang Wenjing,Zhang Shuang,Zhang Gaiyun 한국미생물학회 2021 The journal of microbiology Vol.59 No.10
During a study of the marine actinobacterial biodiversity, a large number of Brevibacterium strains were isolated. Of these, five that have relatively low 16S rRNA gene similarity (98.5– 99.3%) with validly published Brevibacterium species, were chosen to determine taxonomic positions. On the basis of 16S rRNA gene sequence analysis and BOX-PCR fingerprinting, strains o2T, YB235T, and WO024T were selected as representative strains. Genomic analyses, including average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH), clearly differentiated the three strains from each other and from their closest relatives, with values ranging from 82.8% to 91.5% for ANI and from 26.7% to 46.5% for dDDH that below the threshold for species delineation. Strains YB235T, WO024T, and o2T all exhibited strong and efficient decolorization activity in congo red (CR) dyes, moderate decolorization activity in toluidine blue (TB) dyes and poor decolorization in reactive blue (RB) dyes. Genes coding for peroxidases and laccases were identified and accounted for these strains’ ability to effectively oxidize a variety of dyes with different chemical structures. Mining of the whole genome for secondary metabolite biosynthesis gene clusters revealed the presence of gene clusters encoding for bacteriocin, ectoine, NRPS, siderophore, T3PKS, terpene, and thiopeptide. Based on the phylogenetic, genotypic and phenotypic data, strains o2T, YB235T and WO024T clearly represent three novel taxa within the genus Brevibacterium, for which the names Brevibacterium limosum sp. nov. (type strain o2T = JCM 33844T = MCCC 1A09961T), Brevibacterium pigmenatum sp. nov. (type strain YB235T = JCM 33843T = MCCC 1A09842T) and Brevibacterium atlanticum sp. nov. (type strain WO024T = JCM 33846T = MCCC 1A16743T) are proposed.
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Zhang, Pei-Zhen,Chong, Le,Zhao, Ye,Gu, Jing,Tian, Jin-Hui,Yang, Ke-Hu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Background: We performed this meta-analysis to assess the effectiveness and safety of axillary dissection in old women. Methods: The Cochrane Library, PubMed, EMBASE and Chinese Biomedical Literature Database were searched and all randomized controlled trials of axillary dissection in old women (at least 60 years old) were considered. Meta-analyses were completed using RevMan5.1. Results: Three eligible randomized controlled trials (RCTs) including 5,337 patients were considered. There was weak evidence in favour of axillary dissection (AD) in old women. The meta-analysis showed that the overall survival (OS) after 1, 3, 5 and 7 years and the disease free survival (DFS) after 1, 3 and 5 year were not statistically significantly different between AD and no AD groups. However, there was a difference in the 7 year DFS. Conclusions: Axillary dissection did not provide survival benefit to the old women with breast cancer analysed. Therefore, axillary dissection is not well-indicated in old women with breast cancer.
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Involvement of GRP78 in the Resistance of Ovarian Carcinoma Cells to Paclitaxel
Zhang, Li-Ying,Li, Pei-Ling,Xu, Aili,Zhang, Xin-Chen Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: Glucose regulated protein 78 (GRP78) is a type of molecular chaperone. It is a possible candidate protein that contributes to development of drug resistance. We first examined the involvement of GRP78 in chemotherapy-resistance in human ovarian cancer cell. Materials and Methods: The expression of GRP78 mRNA and protein were examined by RT-PCR and western blotting, respectively, in human ovarian cancer cells line (HO-8910). Sensitivity of HO-8910 to paclitaxel was determined with methyl thiazolyl tetrazolium (MTT). Suppression of GRP78 expression was performed using specific small-interfering RNA (siRNA) in HO-8910 cells, and cell apoptosis was assessed by flow cytometry. Statistical analysis was performed using the SPSS 15.0 statistical package. Results: HO-8910 cells, with high basal levels of GRP78, exhibited low sensitivity to paclitaxel. The mRNA and protein levels of GRP78 were dramatically decreased at 24h, 48h and 72h after transfection and the sensitivity to paclitaxel was increased when the GRP78 gene was disturbed by specific siRNA transfection. Conclusions: The results suggested that high GRP78 expression might be one of the molecular mechanisms causing resistance to paclitaxel, and therefore siRNA of GRP78 may be useful in tumor-specific gene therapy for ovarian cancer.
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ICI problem and compensation in MIMO SC‐FDMA system with SC‐SFBC scheme
Zhang, Xiu Pei,Ryu, Heung‐,Gyoon John Wiley Sons, Ltd. 2010 International Journal of Communication Systems Vol.23 No.12
<P><B>Abstract</B></P><P>In this paper, we address the ICI (intercarrier interference) problem and compensation in MIMO (multiple input multiple output) SC‐FDMA (single carrier frequency division multiple access) system that exploits SC‐SFBC (single carrier‐space frequency block coding) scheme. Recently, SC‐FDMA technique has received more attention due to the low PAPR (peak to average power ratio) property. However, SC‐FDMA system is sensitive to phase noise and CFO (carrier frequency offset) which is unavoidable in wireless communication systems. Phase noise and CFO introduce CPE (common phase error) as well as ICI into the received signal and seriously degrade the system performance. Therefore, analysis and suppression of these interferences are of great importance. In this paper, we analyze the interferences in MIMO SC‐FDMA system with SC‐SFBC. Then a new ICI estimation and suppression method is proposed to suppress the interferences. Instead of directly estimating the CFO and phase noise, which is pretty difficult and complex, this algorithm exploits block‐type pilots, which is a common pilot pattern in wireless communication systems, such as LTE standard, to estimate the interferences. After that the interferences are suppressed by the inverse matrix method. Simulation results show that the system performance is significantly improved. Copyright © 2010 John Wiley & Sons, Ltd.</P>
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