Enhancing the static behavior of laminated composite plates using a porous layer

Yuan Yuan,Ke Zhao,Kuo Xu 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.72 No.6

The main aim of this paper is enhancing design of traditional laminated composite plates subjected to static loads. In this regard, this paper suggests embedding a lightweight porous layer in the middle of laminated composite as the core layer of the resulted sandwich plate. The static responses of the suggested structures with uniform, symmetric and non-symmetric porosity distributions are compared to optimize their design. Using the first order shear deformation theories, the static governing equations of the suggested laminated composite plates with a porous layer (LCPPL) rested on two-parameter foundation are obtained. A finite element method is also utilized to solve the governing equations of LCPPLs. Effects of laminated composite and porosity characteristics as well as geometry dimension, edges’ boundary conditions and foundation coefficients on the static deflection and stress distribution of the suggested composite plates have been investigated. The results reveal that the use of core between the layers of laminated composites leads to a sharp reduction in the static deflections of LCPPLs. Furthermore, in compare with perfect cores, the use of porous core between the layers of laminated composite plates can offer a considerable reduction in structural weight without a significant difference in their static responses.

The Loading–Unloading Model of Contact Between Fractal Rough Surfaces

Yuan Yuan,Kuo Xu,Ke Zhao 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.6

A loading–unloading elastic–plastic model of contact between three dimensional fractal rough surfaces has been presented in this paper. During loading process, the mechanical properties of a single asperity follow Hertzian theory. During unloading process, the load-area relationships of a single asperity are obtained by EK model. The truncation size distribution functions for diff erent levels of asperities are deduced. And total true contact area and total contact load are obtained during a loading–unloading process. The results show as the rough surface is in elastic deformation, the load-area relationships during loading and unloading process are identical. As the rough surface is in inelastic deformation, the total true contact area during unloading process is greater than that during loading process. An experiment is designed to verify the validity of the present model.

Synthesis and characterization of monodisperse yttrium aluminum garnet (YAG) micro-crystals with rhombic dodecahedron

Xu, Tao,Yuan, Rui,Xu, Peng-Cheng,Pan, Dong-Jie,Yang, Woochul,Guo, Hai-Bo,Shen, Yu-Fang,Hu, Jian-Feng,Zhang, Zhi-Jun,Zhao, Jing-Tai Elsevier 2018 Journal of alloys and compounds Vol.762 No.-

<P><B>Abstract</B></P> <P>Uniform, monodisperse yttrium aluminum garnet (YAG) rhombic dodecahedron micro-crystals were synthesized using coprecipitation and hydrothermal methods. The Na<SUB>2</SUB>SO<SUB>4</SUB> as a surfactant was helpful in improving the dispersity of the crystallites and forming well-faceted, micro-sized dodecahedral YAG crystallites. The effect of the reaction time and the solvent has also been studied. The crystal growth mechanism called dissolution/crystallization was determined by analyzing the experimental and simulated results. And the specific well-developed crystal facets in the {110} family have been demonstrated by the theoretical calculation. A higher integrated emission intensity can be achieved for the YAG:Ce crystallites by improving the phase purity, morphology with better developed dodecahedrons, and dispersion. Furthermore, a rather high luminous efficacy (LE = 104.14 lm/W) for the white LED fabricated using the YAG:Ce<SUP>3+</SUP> phosphor prepared in this work was realized. The correlation between the crystal growth, morphology and luminescence properties of YAG crystallites has been established, which exhibits a great importance for the synthesis and application of mono-dispersed YAG crystallites.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Uniform and monodisperse YAG rhombic dodecahedron micro-crystals were synthesized. </LI> <LI> The growth mechanism of YAG rhombic dodecahedron was studied through experimental and computational simulation. </LI> <LI> The correlation between the crystal growth, morphology and luminescence of YAG crystallites was established. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

8q24 rs4242382 Polymorphism is a Risk Factor for Prostate Cancer among Multi-Ethnic Populations: Evidence from Clinical Detection in China and a Meta-analysis

Zhao, Cheng-Xiao,Liu, Ming,Xu, Yong,Yang, Kuo,Wei, Dong,Shi, Xiao-Hong,Yang, Fan,Zhang, Yao-Guang,Wang, Xin,Liang, Si-Ying,Zhao, Fan,Zhang, Yu-Rong,Wang, Na-Na,Chen, Xin,Sun, Liang,Zhu, Xiao-Quan,Yuan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: Evidence supporting an association between the 8q24 rs4242382-A polymorphism and prostate cancer (PCa) risk has been reported in North American and Europe populations, though data from Asian populations remain limited. We therefore investigated this association by clinical detection in China, and meta-analysis in Asian, Caucasian and African-American populations. Materials and Methods: Blood samples and clinical information were collected from ethnically Chinese men from Northern China with histologically-confirmed PCa (n=335) and from age-matched normal controls (n=347). The 8q24 (rs4242382) gene polymorphism was genotyped by polymerase chain reaction-high-resolution melting analysis. We initially analyzed the associations between the risk allele and PCa and clinical covariates. A meta-analysis was then performed using genotyping data from a total of 1,793 PCa cases and 1,864 controls from our study and previously published studies in American and European populations, to determine the association between PCa and risk genotype. Results: The incidence of the risk allele was higher in PCa cases than controls (0.222 vs 0.140, $P=7.3{\times}10^{-5}$), suggesting that the 8q24 rs4242382-A polymorphism was associated with PCa risk in Chinese men. The genotypes in subjects were in accordance with a dominant genetic model (ORadj=2.03, 95%CI: 1.42-2.91, $Padj=1.1{\times}10^{-4}$). Presence of the risk allele rs4242382-A at 8q24 was also associated with clinical covariates including age at diagnosis ${\geq}65$ years, prostate specific antigen >10 ng/ml, Gleason score <8, tumor stage and aggressive PCa, compared with the non-risk genotype ($P=4.6{\times}10^{-5}-3.0{\times}10^{-2}$). Meta-analysis confirmed the association between 8q24 rs4242382-A polymorphism and PCa risk (OR=1.62, 95%CI: 1.39-1.88, $P=1.0{\times}10^{-5}$) across Asian, Caucasian and African American populations. Conclusions: The replicated data suggest that the 8q24 rs4242382-A variation might be associated with increased PCa susceptibility in Asian, Caucasian and African American populations. These results imply that this polymorphism may be a useful risk biomarker for PCa in multi-ethnic populations.

Long non-coding RNA H19X promotes tumorigenesis and metastasis of colorectal cancer through regulating the miR-503-5p/KANK1 axis

Yuan Zihan,Zhao Haizhou,Zhi Qiaoming,Wang Sentai,Liu Chao,Han Ye,Xu Zhihua,Liu Fei,Liu Xingyi,Zan Xinquan,Wang Qiang,Wan Daiwei 한국유전학회 2022 Genes & Genomics Vol.44 No.12

Background: It has been well established that the long non-coding RNAs (lncRNAs) plays a critical role in tumor progression. However, the function of these transcripts and mechanisms responsible for their deregulation in colorectal cancer (CRC) remain to be investigated. Objective: To explore the potential effect and regulation mechanism of lncRNA H19X in colorectal cancer. Methods: We predicted and validated long non-coding RNA H19X from microarray data of colorectal cancer tissues. In addition, the biological behaviors of H19X and miR-503-5p on CRC were examined in vitro and in vivo, including MTT, colony formation assay, Hoechst33342 and transwell assay. The mRNA and protein levels of KN Motif and Ankyrin Repeat Domains 1 (KANK1) were analyzed by Quantitative real-time PCR (qRT-PCR), western blotting (WB) assay. Moreover, bioinformatics tools and dual-luciferase reporter assay were applied to demonstrate the relationship between KANK1 and miR-503-5p. Results: H19X was remarkably up-regulated in CRC tissues. Its expression related to tumor size (p = 0.041), lymph node metastasis (p = 0.037), distal metastasis (p = 0.028), advanced TNM stage (p = 0.034) and poor survival in CRC. H19X acted as an oncogenic lncRNA that induced CRC cell proliferation, invasion and metastasis. Through a number of functional studies, we found that H19X silencing inhibited the malignance phenotype of cancer cells through loss of miR-503-5p. Further studies demonstrated that miR-503-5p was involved in the progression of CRC by directly regulating the downstream target KANK1. Conclusion: Collectively, the findings of the present study indicate H19X/miR-503-5p/KANK1 axis has critical role in the progression of colorectal cancer, providing an effective prognostic indicator and promising target in treatment of colorectal cancer.

Novel fuzzy direct torque control based on constructed functional transformed grey model

Zhao, Wei,Li, Zhizhong,Xu, Jiheng,Zhang, Haitao,Yuan, Yuan The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.6

To reduce the ripple of the magnetic flux and torque of motors and the reduce the hysteresis in motor speed control, an improved grey model predictive fuzzy direct torque control (DTC) method based on function transformation is proposed. First, a function transformation is used to transform the sampled sequences to nonnegative values. This overcomes the disadvantages caused by fluctuant and random sampling of the motor torque and stator flux linkage. Second, an equal dimensional new information model is used to keep the dimensions unchanged, which reduces the time to predict the motor parameters through the model. Moreover, the voltage space vector plane is divided into six sectors, which simplifies the fuzzy control system rules. Simulation results show that the proposed fuzzy direct torque control based on the improved grey model method reduces the influence of hysteresis on the control system, decreases the motor flux chain and torque ripple, improves the response speed of the torque and rotational speed, reduces overshoot, achieves good effects in terms of anti-interference capability and dynamic response, and improves the real-time performance and accuracy of the fuzzy control system.

An LMI Approach to Consensus in Second-Order Multi-Agent Systems

Huanyu Zhao,Shengyuan Xu,Deming Yuan 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.6

This paper deals with the consensus problem of the second-order multi-agent systems based on linear system theory. By a system transformation, the consensus problem is converted to the stability problem of a linear system. The second-order systems considered include the systems with both the fixed topology and the Markov switching topology. Necessary and sufficient conditions of consensus or mean square consensus are obtained. The results are extended to the cases of the uncertain transition probability rates and time-delay, respectively. Finally, a simulation example is given to show the effectiveness of the presented results.

Low‑capacitance cascaded H‑bridge STATCOM for full power operation

Yalei Yuan,Juan Zhou,Yonglei Zhang,Xiangkun Zhao,Gaoxiang Xu 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.2

A cascaded H-bridge STATCOM requires large DC filter capacitors to suppress the low-frequency voltage fluctuation in each of the H-bridge cells. Keeping the voltage stress of power device unchanged, increasing the fluctuation of the DC-link voltage is a possible method to significantly reduce the required capacitance for a STATCOM. However, excessive voltage fluctuation greatly degrades the operating range of the inductive conditions. This paper proposes a universal capacitance design method that can significantly reduce the required capacitance when compared with the traditional design method. First, the inductance is constrained in the form normalized by the system impedance. Then a new analysis method between the DC-link capacitance and the operating range is introduced. Experiment results obtained on a low-power 5-level cascaded H-bridge STATCOM prototype are presented to validate the correctness of the proposed design method.

Blind Source Separation of Instantaneous Mixture of Delayed Sources Using High-Order Taylor Approximation

Wei Zhao,Zhi-Gang Yuan,Yue-hong Shen,Yufan Cao,Yimin Wei,Pengcheng Xu,Wei Jian 한국전자통신연구원 2015 ETRI Journal Vol.37 No.4

This paper deals with the problem of blind source separation (BSS), where observed signals are a mixture of delayed sources. In reference to a previous work, when the delay time is small such that the first-order Taylor approximation holds, delayed observations are transformed into an instantaneous mixture of original sources and their derivatives, for which an extended second-order blind identification (SOBI) approach is used to recover sources. Inspired by the results of this previous work, we propose to generalize its first-order Taylor approximation to suit higher-order approximations in the case of a large delay time based on a similar version of its extended SOBI. Compared to SOBI and its extended version for a first-order Taylor approximation, our method is more efficient in terms of separation quality when the delay time is large. Simulation results verify the performance of our approach under different time delays and signal-to-noise ratio conditions, respectively.

Multifunctional nanozyme‑reinforced copper‑coordination polymer nanoparticles for drug‑resistance bacteria extinction and diabetic wound healing

Jiahui Zhao,Tengfei Xu,Jichao Sun,Haitao Yuan,Mengyun Hou,Zhijie Li,Jigang Wang,Zhen Liang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Drug-resistant bacterial infections in chronic wounds are a persistent issue, as they are resistant to antibiotics and can cause excessive inflammation due to generation of reactive oxygen species (ROS). An effective solution would be to not only combat bacterial infections but also scavenge ROS to relieve inflammation at the wound site. Scaffolds with antioxidant properties are attractive for their ability to scavenge ROS, and there is medical demand in developing antioxidant enzyme-mimicking nanomaterials for wound healing. Methods In this study, we fabricated copper-coordination polymer nanoparticles (Cu-CPNs) through a self-assembly process. Furthermore, ε-polylysine (EPL), an antibacterial and cationic polymer, was integrated into the Cu-CPNs structure through a simple one-pot self-assembly process without sacrificing the glutathione peroxidase (GPx) and superoxide dismutase (SOD)-mimicking activity of Cu-CPNs. Results The resulting Cu-CPNs exhibit excellent antioxidant propertiesin mimicking the activity of glutathione peroxidase and superoxide dismutase and allowing them to effectively scavenge harmful ROS produced in wound sites. The in vitro experiments showed that the resulting Cu-CPNs@EPL complex have superior antioxidant properties and antibacterial effects. Bacterial metabolic analysis revealed that the complex mainly affects the cell membrane integrity and nucleic acid synthesis that leads to bacterial death. Conclusions The Cu-CPNs@EPL complex has impressive antioxidant properties and antibacterial effects, making it a promising solution for treating drug-resistant bacterial infections in chronic wounds. The complex’s ability to neutralize multiple ROS and reduce ROS-induced inflammation can help relieve inflammation at the wound site.