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RISS 인기검색어
- 검색키워드
- 저자 : Zarnani, Saman (검색결과 5 건)
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Comparison of numerical and analytical solutions for reinforced soil wall shaking table tests
Zarnani, Saman,El-Emam, Magdi M.,Bathurst, Richard J. Techno-Press 2011 Geomechanics & engineering Vol.3 No.4
The paper describes a simple numerical FLAC model that was developed to simulate the dynamic response of two instrumented reduced-scale model reinforced soil walls constructed on a 1-g shaking table. The models were 1 m high by 1.4 m wide by 2.4 m long and were constructed with a uniform size sand backfill, a polymeric geogrid reinforcement material with appropriately scaled stiffness, and a structural full-height rigid panel facing. The wall toe was constructed to simulate a perfectly hinged toe (i.e. toe allowed to rotate only) in one model and an idealized sliding toe (i.e. toe allowed to rotate and slide horizontally) in the other. Physical and numerical models were subjected to the same stepped amplitude sinusoidal base acceleration record. The material properties of the component materials (e.g. backfill and reinforcement) were determined from independent laboratory testing (reinforcement) and by back-fitting results of a numerical FLAC model for direct shear box testing to the corresponding physical test results. A simple elastic-plastic model with Mohr-Coulomb failure criterion for the sand was judged to give satisfactory agreement with measured wall results. The numerical results are also compared to closed-form solutions for reinforcement loads. In most cases predicted and closed-form solutions fall within the accuracy of measured loads based on ${\pm}1$ standard deviation applied to physical measurements. The paper summarizes important lessons learned and implications to the seismic design and performance of geosynthetic reinforced soil walls.
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Amir-Hassan Zarnani,Monireh Torabi-Rahvar,Mahmood Bozorgmehr,Mehri Zareie,Nazanin Mojtabavi 대한암학회 2015 Cancer Research and Treatment Vol.47 No.3
Purpose Targeted immunotherapy using dendritic cells (DCs) has been employed in numerous investigations aiming at combating neoplasms. We previously showed that copulsing of an antigen with a helper protein could considerably enhance antigen presenting capacity of ex vivo–generated DCs. In this study, we attempted to administer an effective treatment in a murine model of colon cancer with DCs pulsed with the mixture of a tumor-specific gp70-derived peptide (AH1) and a helper protein, ovalbumin (OVA). Materials and Methods First, the presence of gp70 in CT26 tumor cells and tumor tissues was verified using immunofluorescence and Western blot analyses. Next, DCs were purified from normal mice, loaded ex vivowith AH1 and OVA (DC-Pep-OVA), and injected into tumor-bearing mice. Tumor volume, in vitro antigen (Ag)-specific proliferation of splenic cells, and survival rate were measured to determine the efficacy of DC-Pep-OVA. As the control groups, tumor-bearing mice were vaccinated with DC-Pep, unpulsed DC, and DCs loaded with a mixture of OVA and an irrelevant peptide (P15), or were not vaccinated at all. Results DC-Pep-OVA showed superior efficacy over other groups, as indicated by smaller tumor volume, higher Ag-specific proliferation rate of splenic cells, and prolonged survival. Conclusion Overall, in the present study we showed for the first time that DCs copulsed with AH1 (tumor Ag) and OVA (helper molecule) could be considered as potentially robust weapons for use in future antitumor immunotherapies.
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Ramin Ghahremanzadeh,Zahra Rashid,Amir-Hassan Zarnani,Hossein Naeimi 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.6
A simple, efficient and rapid method has been developed for synthesis of 6,6-dimethyl-4-phenyl-6,7-dihydro-1H-spiro[furo[3,4-b]quinoline-9,30-indoline]1,20,8(3H,4H,5H)-trione derivatives. These heterocycleswere prepared through domino one-pot and multicomponent condensation reactions of isatins,dimedone, and anilinolactones in the presence of alum (15 mol%) as an inexpensive, nontoxic,convenient, and available Lewis acid catalyst under microwave irradiation. The corresponding productshave been obtained in excellent isolated yields between 78% and 90%, with high purity, in short reactiontimes about 10–12 min and easy work up.
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Madjd, Zahra,Akbari, Mohammad Esmaeil,Zarnani, Amir Hassan,Khayamzadeh, Maryam,Kalantari, Elham,Mojtabavi, Nazanin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
Background: The EMSY gene encodes a BRCA2-binding partner protein that represses the DNA repair function of BRCA2 in non-hereditary breast cancer. Although amplification of EMSY gene has been proposed to have prognostic value in breast cancer, no data have been available concerning EMSY tissue expression patterns and its associations with clinicopathological features. Materials and Methods: In the current study, we examined the expression and localization pattern of EMSY protein by immunohistochemistry and assessed its prognostic value in a well-characterized series of 116 unselected breast carcinomas with a mean follow up of 47 months using tissue microarray technique. Results: Immunohistochemical expression of EMSY protein was detected in 76% of primary breast tumors, localized in nuclear (18%), cytoplasmic (35%) or both cytoplasmic and nuclear sites (23%). Univariate analysis revealed a significant positive association between EMSY expression and lymph node metastasis (p value=0.045) and larger tumor size (p value=0.027), as well as a non-significant relation with increased risk of recurrence (p value=0.088), whereas no association with patients' survival (log rank test, p value=0.482), tumor grade or type was observed. Conclusions: Herein, we demonstrated for the first time the immunostaining pattern of EMSY protein in breast tumors. Our data imply that EMSY protein may have impact on clinicipathological parameters and could be considered as a potential target for breast cancer treatment.
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Saeed Farzamfar,Majid Salehi,Arian Ehterami,Mahdi Naseri-Nosar,Ahmad Vaez,Amir-Hassan Zarnani,Hamed Sahrapeyma,Mohammad Reza Shokri,Mehdi Aleahmad 대한의용생체공학회 2018 Biomedical Engineering Letters (BMEL) Vol.8 No.4
This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation viadecellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM wasseeded with MenSCs at the density of 3 9 104 cells/cm2 and implanted onto a rat’s 1.50 9 1.50 cm2 full-thicknessexcisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSCseededDAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicatedthat the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
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