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RISS 인기검색어
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- 저자 : Ramin Ghahremanzadeh (검색결과 2 건)
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Ramin Ghahremanzadeh,Zahra Rashid,Amir-Hassan Zarnani,Hossein Naeimi 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.6
A simple, efficient and rapid method has been developed for synthesis of 6,6-dimethyl-4-phenyl-6,7-dihydro-1H-spiro[furo[3,4-b]quinoline-9,30-indoline]1,20,8(3H,4H,5H)-trione derivatives. These heterocycleswere prepared through domino one-pot and multicomponent condensation reactions of isatins,dimedone, and anilinolactones in the presence of alum (15 mol%) as an inexpensive, nontoxic,convenient, and available Lewis acid catalyst under microwave irradiation. The corresponding productshave been obtained in excellent isolated yields between 78% and 90%, with high purity, in short reactiontimes about 10–12 min and easy work up.
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Reduced graphene oxide coated alginate scaffolds: potential for cardiac patch application
Nafseh Baheiraei,Mehdi Razavi,Ramin Ghahremanzadeh 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Cardiovascular diseases, particularly myocardial infarction (MI), are the leading cause of death worldwide and a major contributor to disability. Cardiac tissue engineering is a promising approach for preventing functional damage or improving cardiac function after MI. We aimed to introduce a novel electroactive cardiac patch based on reduced graphene oxide-coated alginate scaffolds due to the promising functional behavior of electroactive biomaterials to regulate cell proliferation, biocompatibility, and signal transition. Methods The fabrication of novel electroactive cardiac patches based on alginate (ALG) coated with different concentrations of reduced graphene oxide (rGO) using sodium hydrosulfite is described here. The prepared scaffolds were thoroughly tested for their physicochemical properties and cytocompatibility. ALG-rGO scaffolds were also tested for their antimicrobial and antioxidant properties. Subcutaneous implantation in mice was used to evaluate the scaffolds’ ability to induce angiogenesis. Results The Young modulus of the scaffolds was increased by increasing the rGO concentration from 92 ± 4.51 kPa for ALG to 431 ± 4.89 kPa for ALG-rGO-4 (ALG coated with 0.3% w/v rGO). The scaffolds’ tensile strength trended similarly. The electrical conductivity of coated scaffolds was calculated in the semi-conductive range (~ 10− 4 S/m). Furthermore, when compared to ALG scaffolds, human umbilical vein endothelial cells (HUVECs) cultured on ALG-rGO scaffolds demonstrated improved cell viability and adhesion. Upregulation of VEGFR2 expression at both the mRNA and protein levels confirmed that rGO coating significantly boosted the angiogenic capability of ALG against HUVECs. OD620 assay and FE-SEM observation demonstrated the antibacterial properties of electroactive scaffolds against Escherichia coli, Staphylococcus aureus, and Streptococcus pyogenes. We also showed that the prepared samples possessed antioxidant activity using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and UV–vis spectroscopy. Histological evaluations confirmed the enhanced vascularization properties of coated samples after subcutaneous implantation. Conclusion Our findings suggest that ALG-rGO is a promising scaffold for accelerating the repair of damaged heart tissue.
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