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Saeed Farzamfar,Majid Salehi,Arian Ehterami,Mahdi Naseri-Nosar,Ahmad Vaez,Amir-Hassan Zarnani,Hamed Sahrapeyma,Mohammad Reza Shokri,Mehdi Aleahmad 대한의용생체공학회 2018 Biomedical Engineering Letters (BMEL) Vol.8 No.4
This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation viadecellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM wasseeded with MenSCs at the density of 3 9 104 cells/cm2 and implanted onto a rat’s 1.50 9 1.50 cm2 full-thicknessexcisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSCseededDAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicatedthat the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
Arian Ehterami,Majid Salehi,Saeed Farzamfar,Hadi Samadian,Ahmad Vaez,Hamed Sahrapeyma,Sadegh Ghorbani 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.2
In the present study, we fabricated vitamin D 3 -loaded alginate hydrogel and assessed its wound healing capability in the animalmodel. The various concentrations of vitamin D3 were added to the pre-dissolved sodium alginate in deionized water andcross-linked by calcium carbonate in combination with D -glucono-δ-lactone. The microstructure, swelling behavior, weightloss, hemo- and cytocompatibility of the fabricated hydrogels were evaluated. In the last stage, the therapeutic effi cacy ofthe prepared hydrogels was evaluated in the full-thickness dermal wound model. The scanning electron microscopy imagesshowed that the prepared hydrogel was highly porous with the porosity of 89.2 ± 12.5% and contained the interconnectedpores. Weight loss assessment showed that the prepared hydrogel is biodegradable with the weight loss percentage of about89% in 14 days. The results showed that the prepared hydrogels were hemo- and cytocompatible. The animal study resultsimplied that alginate hydrogel/3000 IU vitamin D 3 group exhibited the highest wound closure present which was statisticallysignifi cant than the control group ( p < 0.05). Moreover, the histological examinations revealed that hydrogel containing3000 IU vitamin D3 had the best performance and induced the highest re-epithelialization and granular tissue formation. Allin all, this study suggests that alginate hydrogels with 3000 IU vitamin D 3 can be exploited as a potential wound dressingin skin tissue engineering.
Majid Salehi,Arian Ehtrami,Farshid Bastami,Saeed Farzamfar,Sepanta Hosseinpour,Hamid Vahedi,Ahmad Vaez,Mostafa Rahvar,Arash Goodarzi 한국섬유공학회 2019 Fibers and polymers Vol.20 No.3
Peripheral nerve injury is a serious challenge which influences 2.8 percent of trauma patients. Tissue engineeringof peripheral nerves mainly focuses on axonal regeneration via various nerve guides. The aim of this study is to evaluate a novel polyurethane (PU)/gelatin nanofibers (GNFs) conduit’s potential combination with resveratrol (RVT) for sciatic nerve regeneration in the rat. Platelet-rich plasma (PRP) was used as a carrier for RVT. Different tests like contact angle, tensile strength etc. was used to evaluate properties of PU/GNFs conduits. In addition, the electron microscopy, MTT assay, and DAPI staining revealed its compatibility with Schwann cells. 24 male Wistar rats were allocated into four groups (n=6) (1) PU/GNF/PRP/Schwann cell, 2) PU/GNF/Schwann cell/PRP/RVT, 3) Positive control, and 4) Negative control in order to assess sciatic functional index (SFI), hot plate latency, electromyographical (EMG), the percentage of wet weight-loss of gastrocnemius muscle and histopathological studies using hematoxylin-eosin staining. The results represented sciatic functional index (SFI), hot plate latency, electromyographical improved significantly in group 1 and 2 compared to the negative control group. Histopathological findings showed remarkable improvements in myelin sheath regeneration and fibers condition in group 1 and 2 compared to the negative control group. Group 2 showed more resemblance to the normal sciatic nerve, with well-arranged fibers and an intact myelin sheath. This study successfully applied PU/GNFs/PRP/RVT conduits as a potential biocompatible nerve guide with proper mechanical properties, biocompatibility, and biodegradability that enhanced injured sciatic nerve’s recovery rate.
Majid Salehi,Ahmad Vaez,Mahdi Naseri-Nosar,Saeed Farzamfar,Arman Ai,Jafar Ai,Shima Tavakol,Mehrdad Khakbiz,Somayeh Ebrahimi-Barough 한국섬유공학회 2018 Fibers and polymers Vol.19 No.1
In the present study, naringin, a flavonoid isolated from the grape and citrus fruit species, was incorporated with poly(ε-caprolactone)/gelatin composite mats in order to develop a potential wound dressing. The composite mats were prepared by electrospinning of poly(ε-caprolactone)/gelatin (1:1 (w/w)) solution incorporated with 1.50 %, 3 % and 6 % (w/w) of naringin. The electrospun mats were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile properties, drug release, cellular response and in vivo wound healing activity. The study showed that after 2 weeks, the full-thickness excisional wounds of Wistar rats treated with the naringin-loaded dressings achieved a wound closure of higher than 94 % and the dressing containing 6 % (w/w) naringin had almost 100 %wound closure. The sterile gauze, as the control group, showed nearly 86 % of wound closure after this period of time. Our results provided evidence that supports the possible applicability of naringin-loaded wound dressing for successful wound treatment.
Majid Salehi,Keyvan Shahporzadeh,Arian Ehterami,Hodays Yeganehfard,Heliya Ziaei,Mohammad Moein Azizi,Saeed Farzamfar,Amirreza Tahersoltani,Arash Goodarzi,Jafar Ai,Akbar Ahmadi 한국섬유공학회 2020 Fibers and polymers Vol.21 No.8
In the current study, selenium particles were loaded into poly(ε-caprolactone)/gelatin nanofibrous matrices in orderto fabricate a potential wound dressing. The mats were produced by electrospinning of poly(ε-caprolactone)/Gelatin (1:1(w/w)) solution supplemented with 1 and 10 % (w/v) of selenium particles. Prepared wound dressings were investigatedregarding their morphology, mechanical properties, surface wettability, water-uptake capacity, water vapor permeability,porosity, blood compatibility, microbial penetration test and cellular response. Dressings containing 1 % and 10 % seleniumand selenium free mats were chosen to treat the full-thickness excisional wounds in Wistar rats. The study revealed that after14 days, the wound closure of the mat containing 1 % selenium was about 95.5±6.38 % while wound closure of the negativecontrol group was about 48.83±4.03 %. Our results showed the capability of nanofibrous containing selenium for successfulwound treatment.