모반세포성 모반과 악성 흑색종의 CD44 발현에 관한 면역조직화학적 연구

김정수,김영조,최규철,정병수 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

모반세포성 모반과 악성 흑색종의 CD44 발현에 관한 면역조직화학적 연구

김정수,김영조,최규철,정병수 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

CD44 is the major human cell surface receptor for hyaluronate and mediate cellmatrix and cell-cell interactions involved in the mechanisms of tumor invasion and metastasis. Typical acquired melanocytic nevi appear to follow a life cycle characterized by active growth, maturation, and progressive involution, In contrast, congenital melanocytic nevi have a different course and prognosis with potential for development of melanoma, and metastatic spread is very common in malignant melanoma. We investigated the expression of CD44 in acquired and congenital melanocytic nevi, and malignant melanoma by immunohistochemical technique. Formalin-fixed and paraffin-embeded tissue from 5 compound nevi, 6 intradermal nevi, 5 congenital melanocytic nevi, and 5 malignant melanoma were immunolabeled with monoclonal antibodies directed against CD44. All acquired melanocytic nevi showed negative or weak staining for CD44. However, all congenital melanocytic nevi exhibited positive staining for CD44 with minimal irregularities according to location. In malignant melanoma, there was variable intensity of staining for CD44 in different areas of the tumor. These findings suggest that the different expression of CD44 in melanocytic nevi may contribute to different biological behavior between acquired and congenital meanocytic nevi. and CD44 seems to be related to metastasis and tumorigenesis of the malignant melanoma.

심실중격결손증-치험 1예-

조광현,우종수,황윤호,이양행,박철호,김종성,김철호,이경순,조영일,박태인 인제대학교 1985 仁濟醫學 Vol.6 No.4

A successful treatment of infants and children with congenital heart defects depends upon several factors: diagnosis must be accurate, the operative technique, including techniques of perfusion and myocardial preservation, must be suited to the needs of patients and intensive cares, including accurate anesthesia, must be applied through all stages of investigation and treatment, i.e. before, during and after the operation. Recently we performed a open heart surgery successfully for a six-years old girl who had suffered from frequent upper respiratory tract infection and mild to moderate exertional dyspnea with congenital heart defects (ventricular septal defect, Kirklin type II, with patent foramen ovale). The operation and postoperative course were very smooth. And now we report this with review of literatures.

상악 절치부-토크에 의한 치아 이동과 응력 분포에 관한 유한요소법적 연구

윤현주,임용규,이동렬,조영수 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.2

본 연구는 상악 절치부에 active 토크가 가해졌을 경우, 교정력을 직접 받은 치아와 인접 치아의 반응을 알아보고자 상악 치아 및 치조골의 유한요소 모델을 제작하고, stainless steel, NiTi, TMA 세 종류의 각형 호선을 육면체 요소로 모델링하여 유한요소 모델을 완성하였다. 호선이 브라켓에 삽입되었을 때 브라켓에 발생하는 반력과 모멘트를 구하였고, 이것을 유한 요소 모델에 적용하여 각 치아의 변위와 응력 분포를 측정하였다. 브라켓에 발생하는 반력은 근원심 방향과 협설 방향으로의 힘은 0에 가까우며, 중절치, 측절치, 견치의 브라켓 근심측에서는 정출력이 원심측에서는 압하력이 발생하였다. 힘과 모멘트의 크기는 측절치에서 최대였고, 중절치, 견치 순으로 감소하였고, 소구치 부위와 대구치 부위에서는 급격히 감소하였다. 중절치와 측절치는 치관 협측, 원심 경사 이동과 압하를 보였으며, 견치는 치관 설측 원심 경사와 정출을 보였고, 제1소구치는 치관 설측 경사이동을 보였다. .019×.025 SS을 사용하여 상악 절치부에 토크를 부여하는 경우에는 측절치에 과도한 힘이 집중되므로, 임상에서 토크를 조절할 경우에는 NiTi나 TMA 호선을 사용하는 것이 바람직하리라고 생각된다. The purpose of this study was to investifate the stress distribtion in the periodontal tissue and the displacement of teeth when active torque was applied to the maxillary incisors by three-dimen-sional finite element analysis. A three- dimensional finite element model consisted of the maxillary teeth and surrounding periodontal membrane, .022×.028 Roth prescription bracket and stainless steel. NiTi and TMA rectangular ideal arch wires which were modeled by hexahedron elements. Applied active torques were 2, 5 and 10 degrees. The findings of this study showed that the reaction force acting on the bracket was the extrusion force on the mesial side of the incisors and canine and the intrusion force on the distal side of the incisors and canine.The amount of force and moment was greatest at the lateral incisor. When active anterior labial crown torque was applied, labial crown and distal tipping and intrusion of the incisors took place, and lingual crown distal tipping and extrusion of the canin occured. An excessive force was concentrated on the lateral incisor, when the stainless steel wire was used. NiTi or TMA wire os desirable for torque control.

脂體不自由兒의 特殊學校의 再活訓練 基本模型

鄭載權,金東淵,裵晟洙,姜渭榮,元英祚,安秉輯 大邱大學校 特殊敎育總合硏究所 1983 特殊敎育硏究 Vol.10 No.-

The increasing stress on the need for standardized rehabilitation programs for the crippled has faced the workers in the field with the problems of finding out an ideal model of rehabilitation programs which can most facilitate maximum development of the children in various educational aspects. As part of the basic research, the study has been conducted to analyze the data on the present status of the six schools for the crippled in the country, together with other related survey on the available literature. Most of the data on the present situation of the schools and the status of the workers were obtained through questionnaires. The findings derived from the analysis of those data are as follows: 1. The Present Status of the Rehabilitation Training The survey revealed only forty-nine percent(381) of the entire subjects of 784students had been put to the training, that classroom lesson comprised 50% and 43% of the curricula in primary and secondary courses respectively, and that in the rehabilitation programs, physical therapy accounted for 50%, occupational therapy 31% and speech therapy 19%. As for the qualification of rehabilitation workers, twenty of the twenty-five who are presently serving at the six schools are license holders, averaging three physical therapists, 0ne occupational therapist and 0.2 speech therapist at each school. Ninety-six percent are junior college graduates and fifty-six percent are aged 20∼25,forty percent 26∼30. Eighty percent fall into the monthly pay range of 140,000 to 210,000 won, leaving the others below or above the scale. The study also showed that the cause or motivation of their becoming the workers was out of a sense of duty; seventy-six percent replied that they volunteered to help the crippled. Principals, the workers and special teachers showed in that order their enthusiasm about their enthusiasm about the rehabilitation prgrams. It was also found in the study that the authorities concerned have held a special guidance session once a year, achieving their annual goal only 50% and that most of the schools (82%) organized their own rehabilitation programs. The tools and other materials used in the programs were mostly(67%) domestic products. Four schools (67%) prepared thir own evaluation devices for the achievements of the trainees. 2. Facilities and Equipment for Rehabitition Training In all, thirty-four kinds of equipment and tools are currently provided at the six schools to help the chidren maintain or develop their residual function in the deficient limb. Of them only eighteen kinds were owned by each school, aberaging more than one; they were mats, walkers, parallel bars, mirrors, puzzle patches, stairs, shoulder wheels, tilt tables, walking aids, safety aids safety walking belts restorators, over head pulleys, knee exercise units, rotary wrist macihnes, holdings and gloves. The rest of the tools or apparatus averaged less than one among the schools. Nine kinds of electro therapeutic apparatus were owned by them, but only electrostimulation test machined lamps aberaged more than one. As for the hydro therapeutic apparatus, eight kinds were provided among the schools. Each school had more than one set of these three devices: hydor collator, whirl pool and hydro collator pack, with hydro collator pack averaging 17.33. They maintained thirteen kinds of occupational therapy appraratus, of which only three were owned by every school. Most of the apparatus were meant to deal with metallic works. Eleven sorts of speech therapy devices were found; only breathing exercise apparatus averaged more than one. The rehabilitation facilities and equipment at the schools are far below sufficient both in number and kind to meet the need. 3. Teacher' Attitude and Morale Toward the Rehabilitation Programs The schools for the crippled generally try to put equal emphasis on every field needed to rehabiletate the children but it was found that they were, intentionally or unintentionally, putting varying degrees of stresses on indivdual parts. The findings allowed making a list arranged in order of their priority: physical therapy, occupational therapy, speech therapy, motor development training and play therapy. The teachers responded that facilities, equipments, materials, parental cooperation, administravtive support and the ability of the rehabilitation workers were not sufficient enough to meet expectations. When asked to list the priority of the urgent fields, approximately percent put physical therapy at the top, twenty-one percent human relationships. The study showed teachers thought that the sense of duty (35%), ability and qualifications(21%), training skill(15%), academic career(13%) should be considered as the objective determinants in selecting a teacher, and 34% opined that a worker should have “ardent desire and sense of service”. Others expressed their opinion that understanding children's psychology(20%), having good knowledge of basic theory of the rehabilitation(19%) should be prerequisite to the service. Seventy-five percent of the teachers responded that rehabilitation training should be greatly improved and that they positively cooperated with the workers in the programs. It was inferred that the school administrators were generally affirmative towards the programs. The work-load of the rehabilitation workers was regarded as almost the same as that of special teachers(37%). The public and the education authorities assessed the ability of the workers "fair"(52%). Seventy-six percent of those who replied opined the financial support”, was "not sufficient", and seventy-one percent insisted the Ministry of Education should ear-mark special fund for the rehabilitation programs. As part of promotion measures, the majority of the replied(52%) reommended that authorization of more courses and expansion of the existing courses for the workers should be made, and the great majority(71%) advocated raising the special allowances, which was found to be the first in the order of priority, followed by the government's administrative and legislative support(26%) and development and development and supply of materials and equipment for the rehabilitation(22%). The analysis of the above data helped deduct a reasonable rehabilitation practice pattern in which the rehabilitation programs are adopted with the same weight as other parts of the curriculum such as classroom lessons or extra curricula activities, and the programs should cover, with an equal emphasis on every field physical therapy(functional training), occupational therapy (vocational training), speech therapy, sensory training(perception-motor training) and psychological training. Shown in IV-B are the tentatively listed basic sets of facilities and apparat believed indespensable in the rehabilitation programs. 4. Suggestions The following are the suggestion based on the results of the comprehensive study on the present rehabilitation practice in the country. (1) The rehabilitation programs which is to facilitate maximum motor-skill development should compulsorily be included in the curriculum of the school for the crippled. (2) The present training course of the rehabilitation workers should be reorganized to produce highly skilled rehabilition experts who will satisfactorily meet the need on the part of the children. Also desirable is the change of the present title of the workers "rehabilitation attendant" to "rehabilitation training teacher". In parallel with the intensification on training and requirement of the teachers, an increase in emolument to or level of the other special teachers should be made. (3) It is recommended that the programs be extended to other fields of special education, in view of the fact that the rehabilitation programs are basically meant to maintain, improve or eliminate any human defects.

Cost-Effective, Green, and Sustainable Solvent Process Engineering for the Commercialization of Sulfide-Based All-Solid-State Batteries

Yung-Soo Jo,Junyoung Heo,Junghwan Sung,Heetack Park,Jun-Ho Park,You-Jin Lee,Yoon-cheol Ha,Doohun Kim,Jun-Woo park 한국표면공학회 2023 한국표면공학회 학술발표회 초록집 Vol.2023 No.11-1

Expression profiles of HERV-K Env protein in normal and cancerous tissues

Jo, Jin-Ok,Kang, Yun-Jeong,Ock, Mee Sun,Song, Kyoung Seob,Jeong, Moon-Jin,Jeong, Soon-Jeong,Choi, Yung Hyun,Ko, Eun-Ji,Leem, Sun-Hee,Kim, Suhkmann,Kim, Heui-Soo,Cha, Hee-Jae Springer-Verlag 2016 Genes & Genomics Vol.38 No.1

<P>Human endogenous retroviruses (HERVs) have been proposed as etiological cofactors in chronic diseases such as cancer, autoimmunity and neurological disease. HERV RNA expression is also increased in several autoimmune diseases and cancers. However, only a few studies have analyzed the expression levels of HERV-derived proteins in normal and diseased tissues. Here, we investigated the expression profiles of HERV-K Env protein, which is the most well-known pathogen, from normal and cancer tissue microarray. Normal and cancer tissue microarray slides containing 59 normal or 60 tumor surgical specimens, respectively were immunostained with mouse monoclonal antibody to HERV-K and staining intensity was scored. The expression of HERV-K Env protein is generally low in normal tissues but high in specific tissues including bronchus submucosal gland, salivary gland acini, pancreas acini, testis seminiferous tubule, uterine cervix epithelium, ovary stroma, skin epidermis, and heart. The expression of HERV-K Env protein in tumors was usually higher than normal tissues and specifically high in breast, liver, stomach, prostate, and ovarian cancer. This study provides protein expression profiles of HERV-K Env protein in human normal and cancer tissues and provides a good reference for further studies on the expression patterns and roles of HERV-K Env protein in normal organs and various cancers. Further studies with specific organs or cancers and a statistically significant numbers of samples are necessary.</P>

小兒期의 成人型 慢性顆粒性白血症 1例

曺義鉉,盧鎭英,朴秀夏,申相滿 金原出版 1975 小兒科 Vol.16 No.11

데이터마이닝 기법을 이용한 지능형 학회 관리 시스템 설계 및 구현

조영기(Yung Ki Jo),백성욱(Sung Wook Baik),김상수(Sang Soo Kim),조주상(Ju Sang Cho),장인엽(In Yeob Jang),장철호(Chul Ho Chang) 한국정보과학회 2004 한국정보과학회 학술발표논문집 Vol.31 No.2Ⅱ

본 논문에서는 학회사이트의 중요 정보들을 효율적으로 관리하기 위해 구축된 지능형 학회관리 시스템의 설계 및 구현사례를 제시한다. 시스템 운영을 지원 하기위해 회원정보, 기업정보, 논문분야 정보 및 논문 정보등의 데이터를 기반으로 데이터마이닝을 수행했으며 데이터마이닝 과정에서 나타난 여러 유용한 규칙들을 제시했다. 분석된 정보를 이용해 회원 위주의 학회 사이트 운영정책과 동작 인터페이스를 제공하기 위한 웹 사이트의 개인화 계획을 제시하였다.

최소침습수술을 위한 복강경 매니퓰레이터 제어

김수현(Soo-Hyun Kim),김광기(Kwang-Gi Kim),조영호(Yung Ho Jo) 제어로봇시스템학회 2011 제어·로봇·시스템학회 논문지 Vol.17 No.7

An efficient laparoscope manipulator robot was designed to automatically control the position of laparoscope via a passive joint on end-effector position. The end position of the manipulator is controlled to have corresponding velocity defined in the global coordinate space using laparoscopic visual information. Desired spatial position of laparoscope was derived from detected positions of surgical instrument tips, then the clinical viewing plane was moved by visual servoing task. The laparoscope manipulator is advantageous for automatically maintaining clinically important views in the laparoscopic image without any additional operator. A laparoscope is mounted to a holder which is linked to four degree of freedom manipulator via universal joint-type passive rings connection. No change in the design of laparoscope or manipulator is necessary for its application to surgery assistant robot system. Expanded working space and surgical efficiency were accomplished by implementing slant linking structure between laparoscope and manipulator. To ensure reliable positioning accuracy and controllability, the motion of laparoscope in an abdominal space through trocar was inspected using geometrical analysis. A designed laparoscope manipulating robot system can be easily set up and controlled in an operation room since it has a few subsidiary devices such as a laparoscope light source regulator, a control PC, and a power supply.