Procalcitonin and C-Reactive Protein in the Diagnosis and Prediction of Spontaneous Bacterial Peritonitis Associated With Chronic Severe Hepatitis B

Le-Yong Yuan,Zun-Qiong Ke,Ming Wang,Yan Li 대한진단검사의학회 2013 Annals of Laboratory Medicine Vol.33 No.6

Background: Procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBCs) are inflammatory markers used to diagnose severe bacterial infections. We evaluated the diagnostic role of these markers and compared their accuracy for spontaneous bacterial peritonitis (SBP) associated with chronic severe hepatitis B (CSHB). Methods: PCT and CRP concentrations, WBC count, and other hematological parameters were measured in serum from 84 well-characterized patients with CSHB, of whom 42 had SBP. Receiver operating characteristics (ROC) curve analysis was performed to assess the diagnostic accuracy. Results: PCT and CRP concentrations were significantly higher in the CSHB patients with SBP (n=42) than CSHB patients without SBP (n=42). PCT and CRP concentrations were more accurate than WBC count for the diagnosis of CSHB-associated SBP. The optimal cutoff value of PCT was 0.48 ng/mL. The PCT concentration was significantly correlated with the CRP concentration and WBC count. Conclusions: Serum PCT and CRP seems to be better markers than WBC for the diagnosis of CSHB patients with SBP.

Effect of fiber type and content on properties of high-strength fiber reinforced self-consolidating concrete

Bui Le Anh Tuan,Mewael Gebregirogis Tesfamariam,Chao-Lung Hwang,Chun-Tsun Chen,Yuan-Yuan Chen,Kae-Long Lin 사단법인 한국계산역학회 2014 Computers and Concrete, An International Journal Vol.14 No.3

Effects of polypropylene (PP) fibers, steel fibers (SF) and hybrid on the properties of high-strength fiber reinforced self-consolidating concrete (HSFR-SCC) under different volume contents are investigated in this study. Comprehensive laboratory tests were conducted in order to evaluate both fresh and hardened properties of HSFR-SCC. Test results indicated that the fiber types and fiber contents greatly influenced concrete workability but it is possible to achieve self consolidating properties while adding the fiber types in concrete mixtures. Compressive strength, dynamic modulus of elasticity, and rigidity of concrete were affected by the addition as well as volume fraction of PP fibers. However, the properties of concrete were improved by the incorporation of SF. Splitting tensile and flexural strengths of concrete became increasingly less influenced by the inclusion of PP fibers and increasingly more influenced by the addition of SF. Besides, the inclusion of PP fibers resulted in the better efficiency in the improvement of toughness than SF. Furthermore, the inclusion of fibers did not have significant effect on the durability of the concrete. Results of electrical resistivity, chloride ion penetration and ultrasonic pulse velocity tests confirmed that HSFR-SCC had enough endurance against deterioration, lower chloride ion penetrability and minimum reinforcement corrosion rate.

金融市场开放对金融服务贸易竞争力影响的实证分析

Yuan Tao,문철주(Mun Cheilju),Tang Le 영남대학교 중국연구센터 2020 중국과 중국학 Vol.- No.39

서비스 무역은 전 세계 경제 발전의 새로운 원동력이 되었으며, 그 중에서도 금융서비스 무역은 고도성장을 이루었다. 금융서비스무역의 경쟁률 높이는 것은 각국의 관심사가 되었다. 따라서 본 연구는 세계 43개 국가와 지역의 2000년∼2017년의 패널 데이터를 사용하여 금융개방이 금융서비스 무역경쟁력에 미치는 영향요인을 실증분석 연구를 통해서 밝히고자 한다. 연구결과를 보면 전체적인 수치에서나 선진국가과 개발도상국가 및 지역의 패널 데이터에서 보면 금융개방이 금융서비스 무역경쟁력과 현저히 관련이 있음을 알 수 있다. 또한 선진경제권의 금융서비스무역경쟁력 제고는 금융개방에 따른 충격을 견딜 수 있고, 금융개방과 금융서비스 경쟁력제고는 정의 상관관계를 나타났다. 그러나 일부 학자들은 개발도상국가의 경제충격에 대한 제한으로 금융개방과 금융서비스무역 경쟁력 제고 간의 꼭 정의 상관관계가 아닐 수 있다는 견해도 있다. 그러나 본 연구에서는 개발도상국의 금융개방과 금융서비스경쟁력과 현저히 정의 상관관계가 있는 것으로 나타났다. 이는 중국 등 개발도상국의 금융개방의 귀감이 될 수 있다. Service trade has now become a new driving force for economic development around the world, in which financial services trade has achieved rapid growth, and improving the competitiveness of financial services trade has also become a concern of all countries. This thesis uses panel data of 43 countries and regions from 2000 to 2017 to conduct empirical research on the impact of financial liberalization on the competitiveness of financial services trade. Both the empirical results of overall data and the panel data of developed and developing countries and regions show that financial liberalization has a significant positive influence on the competitiveness of financial services trade. Some scholars believe that the financial services trade of developed economies is highly competitive and can withstand the impact of financial openness, so financial openness of developed economies is significantly positively related to the competitiveness of financial services trade, but the ability of developing countries to withstand shocks is limited, and the relationship between service trade competitiveness and financial openness of developing countries is not necessarily positively. The research in this paper shows that there is significant positive correlation between the financial opening of developing countries and the competitiveness of financial services trade, which is of reference for the financial opening of developing countries such as China.

글로벌 스포츠브랜드 기업의 고객지향성이 중국소비자의 충성도에 미치는 영향에 관한 연구

장러쵸 ( Zhang Le Qiao ),무사원 ( Wu Shi Yuan ) 한국유통경영학회(구 한국유통정보학회) 2018 유통경영학회지 Vol.21 No.3

본 논문의 연구목적은 글로벌 스포츠브랜드 기업의 고객지향성이 중국소비자의 충성도에 미치는 영향을 검증하고, 고객지향성과 고객충성도의 관계에서 매개변수인 고객지각가치, 기업가이미지, 고객만족도의 인과관계를 검증하고자 한다. 연구결과를 요약하면 첫째, 고객지향성과 고객지각가치에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 둘째, 고객지향성은 기업이미지에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 셋째, 고객지각가치는 고객만족도에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 넷째, 고객지각가치는 고객만족도에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 다섯째, 기업이미지는 고객만족도에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 여섯째, 고객지각가치는 고객충성도에 유의한 영향을 미치지 않는 것으로 나타났다. 일곱 번째, 기업이미지는 고객충성도에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 마지막으로, 고객만족도는 고객충성도에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 연구결과는 다음과 같은 시사점을 제시 한다. 첫째, 고객지향성과 고객충성도의 관계는 고객지각가치, 기업이미지, 고객만족도를 거쳐 간접적으로 고객충성도에 영향을 미치는 것이 확인 되면서 고객지향성이 고객충성도의 관계를 새롭게 접근할 수 있는 실증적인 기여를 이루었다. 둘째, 다국적기업이 중국시장에서의 국제경영활동에서 중국고객의 고객충성도를 향상하기 위해서는 고객지향적인 행위를 더욱 많이 진행시켜 고객지각가치, 기업이미지, 고객만족도를 향상시켜야 한다는 것을 시사한다. The purpose of this paper is to verify the impact of global sports brand business's customer-oriented appeal on Chinese consumers ' loyalty, to satisfy the customer perception values and the entrepreneurial relationship, which are parameters in relation to customer loyalty. In summary, the study results showed that the first is the influence of positive comments on customer-oriented and customer perception values. Second, customer-oriented characteristics are found to affect positive aspects of corporate image. Third, it has been shown that the perception value of customers affects the degree of client satisfaction (+). Fourth, the perceived value of the client was found to have a positive effect on the customer satisfaction level. Fifth, the corporate image was found to affect the degree of client satisfaction with positive comments. Sixth, it turns out that the perception value of clients does not significantly affect customer loyalty. Seventh, corporate image has a positive effect on customer loyalty. Finally, it has been shown that customer satisfaction has a positive effect on customer loyalty. The results of the study give the following suggestions. First, the relationship between customer-oriented and consumer-oriented customers has been confirmed to affect customer loyalty indirectly through the customer perception values, corporate images and customer satisfaction, creating a new customer oriented loyalty relationship. Second, in order to improve customer loyalty in China's international business activities in the Chinese market, multinational corporations should develop more customer-oriented behaviors to enhance customer perception values, corporate image and customer satisfaction.

The Effects of Engineered Extracellular Vehicles Rich in Let-7i-5p MicroRNA on Counteracting the Adverse Effects of Endotoxin in Mice

( Van Long Le ),( Chun-jen Huang ),( Chao-yuan Chang ),( Van Minh Nguyen ) 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0

Wavelet PWM Technique for Single-Phase Three-Level Inverters

Zheng, Chun-Fang,Zhang, Bo,Qiu, Dong-Yuan,Zhang, Xiao-Hui,Xiao, Le-Ming The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.6

The wavelet PWM (WPWM) technique has been applied in two-level inverters successfully, but directly applying the WPWM technique to three-level inverters is impossible. This paper proposes a WPWM technique suitable for a single-phase three-level inverter. The work analyzes the control strategy with the WPWM and obtains the design of its parameters. Compared with the SPWM technique for a single-phase three-level inverter under the same conditions, the WPWM can obtain high magnitudes of the output fundamental frequency component, low total harmonic distortion, and simpler digital implementation. The feasibility experiment is given to verify of the proposed WPWM technique.

Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF- κB/AQP8 pathway

Gang Wang,Peng-yu Duan,Yuan Ma,Xi-na Li,Feng-zhi Qu,Liang Ji,Xiao-yu Guo,Wang-jun Zhang,Fan Xiao,Le Li,Ji-sheng Hu,Bei Sun 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

Currently, preliminary results have confirmed the existence of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL)-dependent necroptosis of pancreatic acinar cells during early acute pancreatitis (AP), which might be a potential target for the effective regulation of necroinflammatory injury. However, the exact effect of receptor-interacting protein kinase 1 (RIPK1)-dependent regulated acinar cell necrosis on AP is still uncertain. In our study, we first explored the changes in the degree of local and systemic inflammation in AP rats when the activation of acinar cell RIPK1 was inhibited. The RIPK1 inhibitor Nec-1 was used to treat rats, and the levels of related inflammatory markers, necrosis indicators and apoptotic indicators were measured. Changes in pancreatic nuclear factor κB (NF-κB) and aquaporin 8 (AQP8) expression were noted. Next, the expression of AQP8 in AR42J cells was inhibited, and the degree of cell necrosis and inflammatory damage was found to be significantly reduced. Most importantly, we demonstrated that the RIPK1/NF-ĸB/AQP8 axis might be a potential regulatory pathway mediating RIPK1-dependent regulated acinar cell necrosis in early AP. Finally, we used the NF-κB inhibitor PDTC and Nec-1 to treat rats in different groups and measured the degree of pathological pancreatic injury, the activation of RIPK1, and the expression of NF-κB and AQP8. In summary, we hypothesized that there might be a RIPK1/NF-ĸB/AQP8 pathway controlling RIPK1-dependent regulated necrosis of acinar cells in AP, which might be a promising therapeutic target against AP-related injury.

SOF System; A New Nomenclature System for the Surgical Techniques of Cervical Spine Deformity

홍재택,Heiko Koller,Kuniyoshi Abumi,Wen Yuan,Asdrubal Falavigna,이호진,이종범,Jean-Charles Le Huec,박종혁,김일섭 대한척추신경외과학회 2020 Neurospine Vol.17 No.3

Although cervical spinal deformity (CSD) can have a profoundly negative impact on an individual’s quality of life and there have been many advances in surgical treatment of CSD in recent years, there exists no comprehensive classification system of surgical treatment that categorizes anterior and posterior surgery separately according to the grade of surgery. The objective of this study is to introduce the new classification system of various surgical treatments for CSD. We developed a new classification system (SOF system) for CSD surgery that describes the sequence of surgical approach (S), the grade of osteotomy (O), and the information of fixation (F) using alphanumeric codes. This new classification system can provide a consistent description of the various osteotomies performed in CSD surgery. Especially, regarding research, there has been a clear benefit to this classification. Having a standardized classification that allows for common frame for cervical deformity correction surgery, communication between surgeons and the evaluation of the CSD surgeries make it possible to conduct global comparative research about surgical outcome.

Establishing a Nomogram for Stage IA-IIB Cervical Cancer Patients after Complete Resection

Zhou, Hang,Li, Xiong,Zhang, Yuan,Jia, Yao,Hu, Ting,Yang, Ru,Huang, Ke-Cheng,Chen, Zhi-Lan,Wang, Shao-Shuai,Tang, Fang-Xu,Zhou, Jin,Chen, Yi-Le,Wu, Li,Han, Xiao-Bing,Lin, Zhong-Qiu,Lu, Xiao-Mei,Xing, H Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

Background: This study aimed to establish a nomogram by combining clinicopathologic factors with overall survival of stage IA-IIB cervical cancer patients after complete resection with pelvic lymphadenectomy. Materials and Methods: This nomogram was based on a retrospective study on 1,563 stage IA-IIB cervical cancer patients who underwent complete resection and lymphadenectomy from 2002 to 2008. The nomogram was constructed based on multivariate analysis using Cox proportional hazard regression. The accuracy and discriminative ability of the nomogram were measured by concordance index (C-index) and calibration curve. Results: Multivariate analysis identified lymph node metastasis (LNM), lymph-vascular space invasion (LVSI), stromal invasion, parametrial invasion, tumor diameter and histology as independent prognostic factors associated with cervical cancer survival. These factors were selected for construction of the nomogram. The C-index of the nomogram was 0.71 (95% CI, 0.65 to 0.77), and calibration of the nomogram showed good agreement between the 5-year predicted survival and the actual observation. Conclusions: We developed a nomogram predicting 5-year overall survival of surgically treated stage IA-IIB cervical cancer patients. More comprehensive information that is provided by this nomogram could provide further insight into personalized therapy selection.

Separation of Nattokinase from Bacillus subtilis Fermentation Broth by Expanded Bed Adsorption with Mixed-mode Adsorbent

Lu Miao-Hua,Lin Dong-Qiang,Wu Yuan-Chun,Yun Jun-Xian,Mei Le-He,Yao Shan-Jing The Korean Society for Biotechnology and Bioengine 2005 Biotechnology and Bioprocess Engineering Vol.10 No.2

Mixed-mode hydrophobic/ionic matrices exhibit a salt-tolerant property for adsorbing target protein from high-ionic strength feedstock, which allows the application of undiluted feedstock via an expanded bed process. In the present work, a new type of mixed-mode adsorbent designed for expanded bed adsorption, Fastline $PRO^{\circledR}$, was challenged for the capture of nattokinase from the high ionic fermentation broth of Bacillus subtilis. Two important factors, pH and ion concentration, were investigated with regard to the performance of nattokinase ad-sorption. Under initial fermentation broth conditions (pH 6.6 and conductivity of 10 mS/cm) the adsorption capacity of nattokinase with Fastline PRO was high, with a maximum capacity of 5,350 U/mL adsorbent. The elution behaviors were investigated using packed bed adsorption experiments, which demonstrated that the effective desorption of nattokinase could be achieved by effecting a pH of 9.5. The biomass pulse response experiments were carried out in order to evaluate the biomass/adsorbent interactions between Bacillus subtilis cells and Fastline PRO, and to demonstrate a stable expanded bed in the feedstock containing Bacillus subtilis cells. Finally, an EBA process, utilizing mixed-mode Fastline PRO adsorbent, was optimized to capture nattokinase directly from the fermentation broth. The purification factor reached 12.3, thereby demonstrating the advantages of the mixed-mode EBA in enzyme separation.