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Lee, Siyoung,Kim, Eunsom,Jhun, Hyunjhung,Hong, Jaewoo,Kwak, Areum,Jo, Seunghyun,Bae, Suyoung,Lee, Jongho,Kim, Busun,Lee, Jungmin,Youn, Sulah,Kim, Somi,Kim, Miyeon,Kim, Hyunwoo,Lee, Youngmin,Choi, Dong American Society for Biochemistry and Molecular Bi 2016 The Journal of biological chemistry Vol.291 No.28
<P>Although it has been established that diabetes increases susceptibility to infections, the role of insulin (INS) in the immune response is unknown. Here, we investigated the immunological function of INS. Proinsulin dimer (pINSd) was a potent immune stimulus that induced inflammatory cytokines, but mature INS was unable to induce an immune response. An affinity-purified rabbit polyclonal antibody raised against mature IL-1α recognized IL-1α and pINS but failed to detect mature INS and IL-1β. Analysis of the pINS sequence revealed the existence of an INS/IL-1α motif in the C-peptide of pINS. Surprisingly, the INS/IL-1α motif was recognized by monoclonal antibody raised against IL-1α. Deleting the INS/IL-1α motif in pINSd and IL-1α changed their activities. To investigate the pINSd receptor, the reconstitution of IL-1 receptor 1 (IL-1R1) in Wish cells restored pINSd activity that was reversed by an IL-1R antagonist. These data suggested that pINSd needs IL-1R1 for inflammatory cytokine induction. Mouse embryo fibroblast cells of IL-1R1-deficient mice further confirmed that pINSd promotes immune responses through IL-1R1.</P>
입자상 물질 수량 규제 대응을 위한 디젤 승용자동차의 국내연구기관간 입자상 물질 배출 상관성 시험 및 평가
이형민(Hyungmin Lee),권상일(Sangil Kwon),이상민(Sangmin Lee),전종익(Jongik Jun),우영민(Youngmin Woo),이민호(Minho Lee),명차리(Cha-Lee Myung),박심수(Simsoo Park) 한국자동차공학회 2009 한국자동차공학회 부문종합 학술대회 Vol.2009 No.4
In early 2008, the ILCE (Inter-Laboratory Correlation Exercise) was performed by the Korea Particle Measurement Program (KPMP) with a domestic diesel passenger vehicle equipped with a catalyzed DPF between three certification laboratories and the research center of an automotive manufacturer to meet EURO 5 and EURO 6 of particle number concentration for light-duty vehicles. This paper focused on measuring the particle number and mass levels from a representative light-duty diesel passenger vehicle during new European driving cycle (NEDC) mode to analyze the repeatability and reproducibility between laboratories in Korea. In addition, particle size distribution characteristics from ILCE test vehicle were compared with LPG, gasoline, and non-DPF diesel vehicles. From the ILCE test results in Korea, the mean total particle number concentration levels ranged from 5.43E+10 #/㎞ to 1.58E+11 #/㎞ and 0.0003 g/㎞ to 0.0036 g/㎞ for particle mass. Repeatability between participating laboratories ranged from 32% to 66% for particle number, 11% to 70% for particle mass; the reproducibility level was 46% for particle number, and 66% for particle mass emission.
MinSoo Byun,Dahyun Yi,JunHo Lee,YoungMin Choe,BoKyung Sohn,JunYoung Lee,HyoJung Choi,Hyewon Baek,YuKyeong Kim,YunSang Lee,ChulHo Sohn,Inhee MookJung,Murim Choi,YuJin Lee,DongWoo Lee,SeungHo Ryu,ShinGy 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6
Objective-The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s disease (KBASE) aimed to recruit 650 individuals, aged from 20 to 90 years, to search for new biomarkers of Alzheimer’s disease (AD) and to investigate how multi-faceted lifetime experiences and bodily changes contribute to the brain changes or brain pathologies related to the AD process. Methods-All participants received comprehensive clinical and neuropsychological evaluations, multi-modal brain imaging, including magnetic resonance imaging, magnetic resonance angiography, [11C]Pittsburgh compound B-positron emission tomography (PET), and [18F]fluorodeoxyglucose-PET, blood and genetic marker analyses at baseline, and a subset of participants underwent actigraph monitoring and completed a sleep diary. Participants are to be followed annually with clinical and neuropsychological assessments, and biannually with the full KBASE assessment, including neuroimaging and laboratory tests. Results-As of March 2017, in total, 758 individuals had volunteered for this study. Among them, in total, 591 participants-291 cognitively normal (CN) old-aged individuals, 74 CN young- and middle-aged individuals, 139 individuals with mild cognitive impairment (MCI), and 87 individuals with AD dementia (ADD)-were enrolled at baseline, after excluding 162 individuals. A subset of participants (n=275) underwent actigraph monitoring. Conclusion-The KBASE cohort is a prospective, longitudinal cohort study that recruited participants with a wide age range and a wide distribution of cognitive status (CN, MCI, and ADD) and it has several strengths in its design and methodologies. Details of the recruitment, study methodology, and baseline sample characteristics are described in this paper.
Room-Temperature Ferromagnetic Ultrathin α-MoO<sub>3</sub>:Te Nanoflakes
Lee, Dong Jin,Lee, Youngmin,Kwon, Young H.,Choi, Soo Ho,Yang, Woochul,Kim, Deuk Young,Lee, Sejoon American Chemical Society 2019 ACS NANO Vol.13 No.8
<P>We materialized room-temperature ferromagnetism in ultrathin α-MoO<SUB>3</SUB>:Te nanoflakes. The α-MoO<SUB>3</SUB>:Te nanoflakes, which had been grown by vapor-phase epitaxy, clearly exhibited an A<SUB>g</SUB> Raman band from symmetric stretching of υ(Mo-O<SUB>3</SUB>-Mo) in the 2D-like ultrathin α-MoO<SUB>3</SUB>:Te layer. Due to the intentional incorporation of smaller Te ions into bigger Mo sites, the pentacoordinated Mo<SUP>5+</SUP> bonds were created inside the orthorhombic α-MoO<SUB>3</SUB>:Te lattice system. Since Mo<SUP>5+</SUP> ions have magnetic moments from unpaired electron spins, a large number of overlapped bound magnetic polarons could be formed <I>via</I> ferromagnetic coupling with charged oxygen vacancies that are inevitably generated at pentacoordinated [Mo<SUP>5+</SUP>O<SUB>5</SUB>] centers. This gives rise to the increase in long-range ferromagnetic ordering and leads to room-temperature ferromagnetism in the entire α-MoO<SUB>3</SUB>:Te solid-state system. The results may move a step closer to the demonstration of spin functionalities in the wide bandgap semiconductor α-MoO<SUB>3</SUB>:Te.</P> [FIG OMISSION]</BR>
Lee, Sejoon,Lee, Youngmin,Kim, Deuk Young,Panin, Gennady N. Elsevier 2019 APPLIED SURFACE SCIENCE - Vol.470 No.-
<P><B>Abstract</B></P> <P>The low voltage-operational thin-film type of the high-quality nanoporous ZnMnO (Mn: ∼18 at.%) green phosphor was fabricated by grain boundary engineering <I>via</I> the thermal nucleation of the well-crystallized columnar ZnMnO thin film. Vertically-aligned nanopores were observed to be formed throughout the whole area of the ZnMnO phosphor film; and the impact excitation of Mn<SUP>2+</SUP> centers and the defect-mediated optical transition in nanoporous ZnMnO significantly enhanced green light emission in the nanoporous cavity. The results suggest nanoporous ZnMnO to hold promise for the next-generation color-field panels as a new type of the thin-film phosphor. The material characteristics, including the structural, electrical, and optical properties, are meticulously examined, and the formation mechanism of nanoporous ZnMnO and the origin of its low-voltage strong-green-cathodoluminescence are described.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nanoporous ZnMnO was fabricated by thermal nucleation using a columnar ZnMnO film. </LI> <LI> Nanoporous ZnMnO showed a low-voltage cathodoluminescence of strong green emission. </LI> <LI> Green emission originates from both Mn<SUP>2+</SUP>- and V<SUB>O</SUB>-related optical transitions. </LI> <LI> Nanocavities in nanoporous ZnMnO significantly enhances the light emission intensity. </LI> <LI> Nanoporous ZnMnO holds great potential as a low voltage-operational green phosphor. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Eun-Mee,Shin, Sangsu,Cha, Hwa Jun,Yoon, Youngmin,Bae, Seunghee,Jung, Jin Hyuk,Lee, Sun-Mi,Lee, Su-Jae,Park, In-Chul,Jin, Young-Woo,An, Sungkwan D.A. Spandidos 2009 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.24 No.1
<P>Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase inhibitor (HDACI) with antitumor effects that is being explored as a therapeutic drug. However, it has been reported that non-small cell lung cancer (NSCLC) is resistant to HDACIs. MicroRNAs (miRNAs) are a key class of small, non-coding RNA molecules that modulate post-transcriptional regulation of gene expression in multi-cellular organisms. miRNA expression patterns are involved in deregulation of gene expression in human lung cancer. Here we identified miRNA expression profile changes in response to SAHA treatment in the human lung carcinoma cell line A549. We also examined potential mRNA targets of SAHA-responsive miRNAs by using a target prediction program. Using microarray analysis, we found 64 miRNAs with >2-fold expression changes in SAHA-treated A549 cells. Among them, two unique miRNAs were altered in 2.5 microM SAHA-treated cells, 31 unique miRNAs were altered in 5.0 microM SAHA-treated cells and 31 miRNAs were altered with both doses. These miRNAs are predicted to have several target genes related to angiogenesis, apoptosis, chromatin modification, cell proliferation and differentiation. In conclusion, we have identified a unique set of miRNAs and their expression profiles that are influenced significantly by SAHA in the A549 NSCLC cell line model, which might provide useful information for understanding the anticancer mechanism of SAHA.</P>
Suggestions for the Estimation of the Methane Emission from a Landfill Site
Lee, Kyungho,Jeon, Eunjeong,Lee, Youngmin,Park, Junghyun Urban Science Institute 2020 도시과학 Vol.9 No.1
Sudokwon landfill("Sudokwon" means regions of Seoul, Kyunggi and Incheon metropolitan cities in Korea), the world's largest sanitary landfill, has been systematically managing statistics on the incoming and dumping wastes and satisfactorily controlling pollutants including leachate and LFG. According to our long time experience of LFG field monitoring, the emission of GHG from landfill estimated by the IPCC Guideline showed much difference with our results. C&D waste has high concentration of sulfate compared to other wastes. Increased C&D waste of dumping waste had changed the COD/sulfate ratio in the landfill, which caused the increase of H<sub>2</sub>S gas and the decrease of CH<sub>4</sub> gas. But the IPCC estimation method does not consider the effects of sulfate. In addition to that, the oxidation factor of the cover soil is set to the default values of 0.1 but the measured values by the field monitoring, are showing much higher than that, especially in the closed landfill.
Lee, Daehee,Wu, Mihye,Kim, Dong-Hyun,Chae, Changju,Cho, Min Kyung,Kim, Ji-Young,Lee, Sun Sook,Choi, Sungho,Choi, Youngmin,Shin, Tae Joo,Chung, Kyung Yoon,Jeong, Sunho,Moon, Jooho American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.26
<P>The initial reversible capacity, a critical impediment in transition metal oxide-based anodes, is augmented in conversion-reaction-involved CoO anodes for lithium-ion batteries, by incorporating a chemically synthesized Ag nanophase. With an increase in the added amount of Ag nanophase from 5 to 15 wt %, the initial capacity loss decreases linearly up to 31.7%. The Ag nanophase maintains its pristine metallic nature without undergoing phase transformations, even during repeated vigorous electrochemical reactions of the active CoO phase. Complementary ex situ chemical/physical analyses suggest that the Ag nanophase promotes the catalytic generation of reversible gel-like/polymeric films wherein lithium ions are stored capacitively in the low-voltage region below 0.7 V during discharging. These scientific findings would provide a heretofore unrecognized pathway to resolving a major issue associated with the critical irreversibility in conversion-type transition metal oxide anodes.</P>