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Lee, Siyoung,Kim, Eunsom,Jhun, Hyunjhung,Hong, Jaewoo,Kwak, Areum,Jo, Seunghyun,Bae, Suyoung,Lee, Jongho,Kim, Busun,Lee, Jungmin,Youn, Sulah,Kim, Somi,Kim, Miyeon,Kim, Hyunwoo,Lee, Youngmin,Choi, Dong American Society for Biochemistry and Molecular Bi 2016 The Journal of biological chemistry Vol.291 No.28
<P>Although it has been established that diabetes increases susceptibility to infections, the role of insulin (INS) in the immune response is unknown. Here, we investigated the immunological function of INS. Proinsulin dimer (pINSd) was a potent immune stimulus that induced inflammatory cytokines, but mature INS was unable to induce an immune response. An affinity-purified rabbit polyclonal antibody raised against mature IL-1α recognized IL-1α and pINS but failed to detect mature INS and IL-1β. Analysis of the pINS sequence revealed the existence of an INS/IL-1α motif in the C-peptide of pINS. Surprisingly, the INS/IL-1α motif was recognized by monoclonal antibody raised against IL-1α. Deleting the INS/IL-1α motif in pINSd and IL-1α changed their activities. To investigate the pINSd receptor, the reconstitution of IL-1 receptor 1 (IL-1R1) in Wish cells restored pINSd activity that was reversed by an IL-1R antagonist. These data suggested that pINSd needs IL-1R1 for inflammatory cytokine induction. Mouse embryo fibroblast cells of IL-1R1-deficient mice further confirmed that pINSd promotes immune responses through IL-1R1.</P>
입자상 물질 수량 규제 대응을 위한 디젤 승용자동차의 국내연구기관간 입자상 물질 배출 상관성 시험 및 평가
이형민(Hyungmin Lee),권상일(Sangil Kwon),이상민(Sangmin Lee),전종익(Jongik Jun),우영민(Youngmin Woo),이민호(Minho Lee),명차리(Cha-Lee Myung),박심수(Simsoo Park) 한국자동차공학회 2009 한국자동차공학회 부문종합 학술대회 Vol.2009 No.4
In early 2008, the ILCE (Inter-Laboratory Correlation Exercise) was performed by the Korea Particle Measurement Program (KPMP) with a domestic diesel passenger vehicle equipped with a catalyzed DPF between three certification laboratories and the research center of an automotive manufacturer to meet EURO 5 and EURO 6 of particle number concentration for light-duty vehicles. This paper focused on measuring the particle number and mass levels from a representative light-duty diesel passenger vehicle during new European driving cycle (NEDC) mode to analyze the repeatability and reproducibility between laboratories in Korea. In addition, particle size distribution characteristics from ILCE test vehicle were compared with LPG, gasoline, and non-DPF diesel vehicles. From the ILCE test results in Korea, the mean total particle number concentration levels ranged from 5.43E+10 #/㎞ to 1.58E+11 #/㎞ and 0.0003 g/㎞ to 0.0036 g/㎞ for particle mass. Repeatability between participating laboratories ranged from 32% to 66% for particle number, 11% to 70% for particle mass; the reproducibility level was 46% for particle number, and 66% for particle mass emission.
MinSoo Byun,Dahyun Yi,JunHo Lee,YoungMin Choe,BoKyung Sohn,JunYoung Lee,HyoJung Choi,Hyewon Baek,YuKyeong Kim,YunSang Lee,ChulHo Sohn,Inhee MookJung,Murim Choi,YuJin Lee,DongWoo Lee,SeungHo Ryu,ShinGy 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6
Objective-The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s disease (KBASE) aimed to recruit 650 individuals, aged from 20 to 90 years, to search for new biomarkers of Alzheimer’s disease (AD) and to investigate how multi-faceted lifetime experiences and bodily changes contribute to the brain changes or brain pathologies related to the AD process. Methods-All participants received comprehensive clinical and neuropsychological evaluations, multi-modal brain imaging, including magnetic resonance imaging, magnetic resonance angiography, [11C]Pittsburgh compound B-positron emission tomography (PET), and [18F]fluorodeoxyglucose-PET, blood and genetic marker analyses at baseline, and a subset of participants underwent actigraph monitoring and completed a sleep diary. Participants are to be followed annually with clinical and neuropsychological assessments, and biannually with the full KBASE assessment, including neuroimaging and laboratory tests. Results-As of March 2017, in total, 758 individuals had volunteered for this study. Among them, in total, 591 participants-291 cognitively normal (CN) old-aged individuals, 74 CN young- and middle-aged individuals, 139 individuals with mild cognitive impairment (MCI), and 87 individuals with AD dementia (ADD)-were enrolled at baseline, after excluding 162 individuals. A subset of participants (n=275) underwent actigraph monitoring. Conclusion-The KBASE cohort is a prospective, longitudinal cohort study that recruited participants with a wide age range and a wide distribution of cognitive status (CN, MCI, and ADD) and it has several strengths in its design and methodologies. Details of the recruitment, study methodology, and baseline sample characteristics are described in this paper.
Lee, Seongeung,Choi, Youngmin,Jeong, Heon Sang,Lee, Junsoo,Sung, Jeehye Korean Society of Food Science and Technology 2018 Food Science and Biotechnology Vol.27 No.2
This study evaluated the effect of different cooking methods including blanching, boiling, microwaving and steaming on the content of vitamins in vegetables. True retention was estimated using the yield expressed as a ratio of the weight of the cooked sample to the weight of the raw sample. The retention of vitamin C ranged from 0.0 to 91.1% for all cooked samples. Generally, higher retention of vitamin C was observed after microwaving with the lowest retention recorded after boiling. Cooked vegetables were occasionally higher contents of fat-soluble vitamins, including ${\alpha}$-tocopherol and ${\beta}$-carotene, than that of their fresh counterparts, but it depends on the type of vegetables. Microwave cooking caused the greatest loss of vitamin K in crown daisy and mallow; in contrast, it caused the least loss of vitamin K in spinach and chard. Cooking may cause changes to the contents of vitamins, but it depends on vegetables and cooking processes.
Three-Dimensionally Printed Stretchable Conductors from Surfactant-Mediated Composite Pastes
Lee, Hoi Sung,Jo, Yejin,Joo, Jong Hoon,Woo, Kyoohee,Zhong, Zhaoyang,Jung, Sungmook,Lee, Su Yeon,Choi, Youngmin,Jeong, Sunho American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.13
<P>A stretchable conductor is a critical prerequisite to achieve various forms of stretchable electronics. In particular, directly printable stretchable conductors have gathered considerable attention with recent growing interest in a variety of large-area, deformable electronics. In this study, we have developed a chemical pathway of incorporating a surfactant with a moderate hydrophilic-lipophilic balance in formulating composite pastes for printed stretchable conductors, with a possibility of a vertically stackable, three-dimensional printing process. We demonstrate that the addition of a nonionic surfactant, sorbitane monooleate (commonly called SPAN 80) in Ag flake-based composite pastes, allows a critical reduction in resistance variation under an external strain. The four-layer stacked, surfactant-added composite conductors show a resistance variation of merely 1.6 at a strain of 0.6 and excellent cycling durability over 1000 cycles. The effectiveness of the methods suggested in this study is demonstrated with basic light-emitting diode circuits and the thermal heating characteristics of stretchable conductors.</P> [FIG OMISSION]</BR>
High-performance piezoelectric nanogenerators based on chemically-reinforced composites
Lee, Eun Jung,Kim, Tae Yun,Kim, Sang-Woo,Jeong, Sunho,Choi, Youngmin,Lee, Su Yeon The Royal Society of Chemistry 2018 ENERGY AND ENVIRONMENTAL SCIENCE Vol.11 No.6
<P>High-performance flexible piezoelectric nanogenerators (PNGs) based on composite thin films comprising amine-functionalized lead zirconate titanate (PZT) nanoparticles (PZT-NH2 NPs) and a thermoplastic triblock copolymer grafted with maleic anhydride are fabricated. The chemically reinforced composite contains a stable dispersion of PZT NPs within the polymer matrix with enhanced stress applied to the PZT NPs. Without additional dispersants, the uniform distribution of PZT-NH2 NPs in the polymer composite improves the piezoelectric power generation compared to that of a PNG device using pristine PZT NPs. This unique composite behavior allows the PZT-NH2 NP-based flexible PNG to exhibit a high output voltage of 65 V and current of 1.6 μA without time-dependent degradation. This alternating energy from the PNG can be used to charge a capacitor and operate light-emitting diodes through a full bridge rectifier. Furthermore, the proposed PNG is demonstrated as a promising energy harvester for potential applications in self-powered systems.</P>